DT-Web

DB00553 - Methoxsalen


Identification
Name Methoxsalen
Accession Number DB00553 (APRD00157)
Type small molecule
Description A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 216.1895
Groups approved
Monoisotopic Weight 216.042258744
Pharmacology
Indication For the treatment of psoriasis and vitiligo
Mechanism of action After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination In both mice and man, methoxsalen is rapidly metabolized. Approximately 95% of the drug is excreted as a series of metabolites in the urine within 24 hours (Pathak et al. 1977).
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Ethotoin The hydantoin decreases the effect of psoralene
Fosphenytoin The hydantoin decreases the effect of psoralene
Mephenytoin The hydantoin decreases the effect of psoralene
Phenytoin The hydantoin decreases the effect of psoralene
Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by strong CYP1A2 inhibitors such as Methoxsalen. Consider modifying therapy to avoid Tacrine toxicity. Monitor the efficacy and toxicity of Tacrine if Methoxsalen is initiated, discontinued or if the dose is changed.
Thiothixene The strong CYP1A2 inhibitor, Methoxsalen, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Methoxsalen is initiated, discontinued or dose changed.
Tizanidine Methoxsalen may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Food Interactions
  • Take with food or milk, or in two divided doses 30 minutes apart to decrease nausea.

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions intercalation
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Smith SI, Brodbelt JS: Rapid characterization of cross-links, mono-adducts, and non-covalent binding of psoralens to deoxyoligonucleotides by LC-UV/ESI-MS and IRMPD mass spectrometry. Analyst. 2010 May;135(5):943-52. Epub 2010 Feb 12. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3922
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.336
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.287
Cytochrome P450 2A13
Name Cytochrome P450 2A13
Gene Name CYP2A13
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1634
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4357

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.1955
4757 Cytochrome P450 2C9 CYP2C9 0.1837
6016 Cytochrome P450 2C19 CYP2C19 0.1658
6013 Cytochrome P450 2E1 CYP2E1 0.1401
1588 Multidrug resistance protein 1 ABCB1 0.1373
4924 Cytochrome P450 2C8 CYP2C8 0.1229
4118 Cytochrome P450 3A5 CYP3A5 0.1195
6030 Cytochrome P450 2B6 CYP2B6 0.1183
6107 Cytochrome P450 3A7 CYP3A7 0.0821
20 Prostaglandin G/H synthase 1 PTGS1 0.057
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0532
1898 Cytochrome P450 1B1 CYP1B1 0.0512
587 Serum albumin ALB 0.0461
3811 Cytochrome P450 19A1 CYP19A1 0.0452
1729 Solute carrier family 22 member 6 SLC22A6 0.041
6106 Cytochrome P450 2C18 CYP2C18 0.0341
6145 Solute carrier family 22 member 1 SLC22A1 0.0335
3941 Amine oxidase [flavin-containing] A MAOA 0.0312
492 Histamine H1 receptor HRH1 0.0308
6147 Solute carrier family 22 member 3 SLC22A3 0.0295
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0291
6144 Solute carrier family 22 member 2 SLC22A2 0.0286
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0283
118 Organic cation/carnitine transporter 2 SLC22A5 0.0271
136 Estrogen receptor ESR1 0.027
871 Glucocorticoid receptor NR3C1 0.0269
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0265
36 Insulin receptor INSR 0.0258
833 Organic cation/carnitine transporter 1 SLC22A4 0.0255
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0253
318 Alpha-2A adrenergic receptor ADRA2A 0.0241
468 Cytochrome P450 4A11 CYP4A11 0.0234
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0232
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0227
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0224
766 Beta-2 adrenergic receptor ADRB2 0.0224
290 Prostaglandin G/H synthase 2 PTGS2 0.0222
502 5-hydroxytryptamine 2A receptor HTR2A 0.0221
862 Multidrug resistance-associated protein 1 ABCC1 0.0212
556 Alpha-1A adrenergic receptor ADRA1A 0.021
831 D(2) dopamine receptor DRD2 0.021
824 Sodium-dependent serotonin transporter SLC6A4 0.0209
776 Bile salt export pump ABCB11 0.0208
590 5-hydroxytryptamine 2C receptor HTR2C 0.0198
6031 Cytochrome P450 3A43 CYP3A43 0.0196
6142 Solute carrier family 22 member 8 SLC22A8 0.0194
3939 Amine oxidase [flavin-containing] B MAOB 0.0194
341 5-hydroxytryptamine 3 receptor HTR3A 0.0192
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0188
6143 Solute carrier family 22 member 7 SLC22A7 0.0188
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0187
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0183
477 DNA topoisomerase 4 subunit A parC 0.0182
886 DNA topoisomerase 4 subunit A parC 0.0182
6226 DNA topoisomerase 4 subunit A parC 0.0182
404 DNA gyrase subunit A gyrA 0.0179
6224 DNA gyrase subunit A gyrA 0.0179
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0179
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0178
817 DNA topoisomerase 2-alpha TOP2A 0.0175
193 Beta-1 adrenergic receptor ADRB1 0.017
320 5-hydroxytryptamine 1A receptor HTR1A 0.0168
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0166
885 5-hydroxytryptamine 1B receptor HTR1B 0.0164
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0164
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0162
23 D(1A) dopamine receptor DRD1 0.0162
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0156
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0156
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0153
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0149
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0148
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0148
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0148
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0147
756 Sex hormone-binding globulin SHBG 0.0147
777 Tumor necrosis factor TNF 0.0144
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0144
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0144
725 5-hydroxytryptamine 1D receptor HTR1D 0.014
632 Alpha-1B adrenergic receptor ADRA1B 0.0138
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0138
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0136
713 Sodium-dependent dopamine transporter SLC6A3 0.0136
146 Androgen receptor AR 0.0136
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0134
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0131
260 Cytochrome P450 51 ERG11 0.0131
761 Cytochrome P450 51 ERG11 0.0131
3163 Cytochrome P450 51 cyp51 0.0131
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.013
6141 Sodium/bile acid cotransporter SLC10A1 0.0128
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0128
629 Alpha-2B adrenergic receptor ADRA2B 0.0128
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0128
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0125
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0124
465 Calmodulin CALM1 0.0123
613 Atrial natriuretic peptide receptor A NPR1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0121
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.012
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.012
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.012
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0119
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0118
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0117
48 Pyridoxal kinase PDXK 0.0116
2499 Tubulin beta-2C chain TUBB2C 0.0113
232 Corticosteroid-binding globulin SERPINA6 0.0113
378 Alpha-2C adrenergic receptor ADRA2C 0.0112
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0112
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0112
638 D(3) dopamine receptor DRD3 0.0111
789 Alpha-1D adrenergic receptor ADRA1D 0.011
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0109
847 Mu-type opioid receptor OPRM1 0.0108
731 HIV-1 protease HIV-1 protease 0.0108
2449 Tubulin alpha-3 chain TUBA1A 0.0107
6102 Arylamine N-acetyltransferase 2 NAT2 0.0105
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0105
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0104
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0104
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0102
16 Adenosine A1 receptor ADORA1 0.0102
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0101
1517 Beta-3 adrenergic receptor ADRB3 0.0101
4237 50S ribosomal protein L22 rplV 0.01
2164 Multidrug resistance-associated protein 4 ABCC4 0.01
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0098
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0098
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
3932 Glutathione S-transferase A2 GSTA2 0.0096
6220 Aryl hydrocarbon receptor AHR 0.0096
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0095
3923 Cholinesterase BCHE 0.0095
3947 Xanthine dehydrogenase/oxidase XDH 0.0095
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0093
467 Delta-type opioid receptor OPRD1 0.0092
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.009
68 Cannabinoid receptor 1 CNR1 0.009
818 50S ribosomal protein L10 rplJ 0.0089
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0088
4238 50S ribosomal protein L4 rplD 0.0088
5578 50S ribosomal protein L4 rplD 0.0088
6173 50S ribosomal protein L4 rplD 0.0088
6219 50S ribosomal protein L4 rplD 0.0088
1178 Adenosine A2a receptor ADORA2A 0.0088
844 Epidermal growth factor receptor EGFR 0.0086
790 DNA polymerase subunit alpha B POLA2 0.0084
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0084
614 Progesterone receptor PGR 0.0082
432 D(4) dopamine receptor DRD4 0.008
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0079
696 Kappa-type opioid receptor OPRK1 0.0079
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0079
482 Glycine receptor subunit alpha-1 GLRA1 0.0079
571 Melatonin receptor type 1A MTNR1A 0.0078
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0078
362 Melatonin receptor type 1B MTNR1B 0.0078
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0077
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0077
869 Estrogen receptor beta ESR2 0.0077
6148 Multidrug resistance-associated protein 7 ABCC10 0.0077
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0076
1010 Cytochrome P450 51A1 CYP51A1 0.0075
1757 Myeloperoxidase MPO 0.0074
716 5-hydroxytryptamine 7 receptor HTR7 0.0074
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0074
4228 Keratin, type II cytoskeletal 7 KRT7 0.0074
122 P2Y purinoceptor 12 P2RY12 0.0073
6020 Aldehyde oxidase AOX1 0.0073
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0072
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0072
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.007
251 Alcohol dehydrogenase 1A ADH1A 0.007
373 Transthyretin TTR 0.007
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.007
436 5-hydroxytryptamine 2B receptor HTR2B 0.0069
705 Glutamate receptor 1 GRIA1 0.0069
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0069
2230 Catalase CAT 0.0066
3249 Catalase katA 0.0066
3625 Catalase katA 0.0066
4539 Catalase katA 0.0066
4941 Catalase katB 0.0066
275 Arachidonate 5-lipoxygenase ALOX5 0.0065
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0065
6136 Multidrug resistance-associated protein 5 ABCC5 0.0065
6043 Putative G-protein coupled receptor 44 GPR44 0.0065
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0065
380 Cytochrome P450 17A1 CYP17A1 0.0064
106 Cannabinoid receptor 2 CNR2 0.0064
1024 Solute carrier family 22 member 11 SLC22A11 0.0064
1820 Beta-nerve growth factor NGF 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
1192 Sulfotransferase 1A1 SULT1A1 0.0063
444 Alcohol dehydrogenase 1B ADH1B 0.0062
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0062
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0062
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0061
537 ATP synthase delta chain, mitochondrial ATP5D 0.0061
33 Cystine/glutamate transporter SLC7A11 0.0061
6182 Cytochrome P450 2J2 CYP2J2 0.0061
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0061
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.006
820 Glycine receptor subunit alpha-2 GLRA2 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
511 5-hydroxytryptamine 1F receptor HTR1F 0.0059
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0059
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0059
4122 Histone deacetylase 2 HDAC2 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0058
284 DNA-directed RNA polymerase beta chain rpoB 0.0058
5773 DNA-directed RNA polymerase beta chain rpoB 0.0058
6766 O-GlcNAcase BT_4395 BT_4395 0.0058
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0057
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0057
1714 Mitogen-activated protein kinase 3 MAPK3 0.0056
295 Carbonic anhydrase 1 CA1 0.0056
814 Ryanodine receptor 1 RYR1 0.0056
811 Translocator protein TSPO 0.0056
517 Alcohol dehydrogenase 1C ADH1C 0.0054
84 Nuclear receptor 0B1 NR0B1 0.0054
921 Glutamate receptor 2 GRIA2 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
94 5-hydroxytryptamine 4 receptor HTR4 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
504 Mast/stem cell growth factor receptor KIT 0.0051
891 Dihydropteroate synthase folP 0.0051
5359 Dihydropteroate synthase folP 0.0051
7175 Dihydropteroate synthase sulI 0.0051
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0051
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0049
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0049
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0049
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0049
518 Peroxidase/catalase T katG 0.0049
163 D(1B) dopamine receptor DRD5 0.0049
528 5-hydroxytryptamine 1E receptor HTR1E 0.0049
4604 Liver carboxylesterase 1 CES1 0.0049
474 Acetylcholinesterase ACHE 0.0049
856 Vitamin D3 receptor VDR 0.0049
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0048
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0048
228 Beta platelet-derived growth factor receptor PDGFRB 0.0048
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0047
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0047
1050 Bile salt sulfotransferase SULT2A1 0.0047
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0047
563 Thyroid peroxidase TPO 0.0046
1629 Transcription factor AP-1 JUN 0.0046
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0046
173 Toll-like receptor 7 TLR7 0.0046
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0046
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0046
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0046
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0046
4311 tRNA TRDMT1 0.0045
4325 tRNA trmD 0.0045
4328 tRNA trmD 0.0045
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0045
1256 5-hydroxytryptamine 6 receptor HTR6 0.0045
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0044
400 Coagulation factor IX F9 0.0044
5461 Coagulation factor IX F9 0.0044
4203 Histamine N-methyltransferase HNMT 0.0044
780 Retinoic acid receptor RXR-gamma RXRG 0.0044
737 Mineralocorticoid receptor NR3C2 0.0044
6146 High affinity copper uptake protein 1 SLC31A1 0.0044
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0044
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0043
461 Glycine receptor subunit alpha-3 GLRA3 0.0043
5934 Cytochrome P450 26A1 CYP26A1 0.0042
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0042
3917 Methylenetetrahydrofolate reductase MTHFR 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
407 Vascular endothelial growth factor receptor 2 KDR 0.0042
569 Retinal dehydrogenase 2 ALDH1A2 0.0042
6137 Multidrug resistance-associated protein 6 ABCC6 0.0042
1176 Mitogen-activated protein kinase 1 MAPK1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0041
604 Vitamin K-dependent protein Z PROZ 0.0041
273 Apoptosis regulator Bcl-2 BCL2 0.004
592 Carbonic anhydrase 4 CA4 0.004
29 Tubulin beta-1 chain TUBB1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
952 Dipeptidyl peptidase 4 DPP4 0.004
88 Retinoic acid receptor RXR-beta RXRB 0.004
26 Vascular endothelial growth factor receptor 3 FLT4 0.004
2236 Casein kinase II subunit alpha CSNK2A1 0.004
3426 Glutamine synthetase glnA 0.0039
3987 Glutamine synthetase GLUL 0.0039
611 Retinal dehydrogenase 1 ALDH1A1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
239 Coagulation factor X F10 0.0039
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
2298 Cytochrome P450-cam camC 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
32 Vascular endothelial growth factor receptor 1 FLT1 0.0038
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0038
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0038
1656 CYP2B protein CYP2B 0.0038
70 Type-1 angiotensin II receptor AGTR1 0.0037
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0037
124 Histamine H2 receptor HRH2 0.0037
422 Vitamin K-dependent protein C PROC 0.0037
1245 Vitamin K-dependent protein S PROS1 0.0037
6174 50S ribosomal protein L32 rpmF 0.0037
2112 Toll-like receptor 9 TLR9 0.0036
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0036
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0036
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0036
823 Fibroblast growth factor receptor 2 FGFR2 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0036
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0035
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0035
131 Synaptic vesicular amine transporter SLC18A2 0.0035
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
770 Retinoic acid-induced protein 3 GPRC5A 0.0035
719 Retinoic acid receptor responder protein 1 RARRES1 0.0035
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0035
904 Glutathione S-transferase P GSTP1 0.0034
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0034
3809 Estrogen-related receptor gamma ESRRG 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
3957 Adenosine deaminase ADA 0.0034
4120 NADPH--cytochrome P450 reductase POR 0.0034
1275 Estrogen sulfotransferase SULT1E1 0.0034
581 Cytochrome P450 2R1 CYP2R1 0.0034
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0033
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
3937 Fatty-acid amide hydrolase FAAH 0.0033
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0033
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0033
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0033
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0032
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0032
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0031
6432 Transporter snf 0.0031
6044 Serum paraoxonase/lactonase 3 PON3 0.0031
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0031
427 Substance-P receptor TACR1 0.0031
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0031
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0031
162 Retinoic acid receptor gamma-1 RARG 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
357 Carbonic anhydrase 2 CA2 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
798 Osteocalcin BGLAP 0.003
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
4192 DNA topoisomerase 2-beta TOP2B 0.0029
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0029
976 Platelet glycoprotein IX GP9 0.0029
1569 G1/S-specific cyclin-D1 CCND1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
3810 Catechol O-methyltransferase COMT 0.0028
1374 Natriuretic peptides B NPPB 0.0028
1827 Gap junction alpha-1 protein GJA1 0.0028
1908 Vascular cell adhesion protein 1 VCAM1 0.0028
4103 Proteasome subunit beta type 2 PSMB2 0.0028
4102 Proteasome subunit beta type 5 PSMB5 0.0028
4101 Proteasome subunit beta type 1 PSMB1 0.0028
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0028
1063 Signal transducer and activator of transcription 5B STAT5B 0.0028
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0028
634 Squalene monooxygenase SQLE 0.0027
7196 Squalene monooxygenase ERG1 0.0027
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0027
183 Vascular endothelial growth factor A VEGFA 0.0027
54 Prothrombin F2 0.0027
369 Coagulation factor VII F7 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
7 Nitric oxide synthase, inducible NOS2 0.0027
4226 Uridine phosphorylase 2 UPP2 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
3830 Calreticulin CALR 0.0027
469 Annexin A1 ANXA1 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
1648 Elastin ELN 0.0026
49 Endothelin B receptor EDNRB 0.0026
936 Ephrin type-A receptor 2 EPHA2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0025
6034 Hydroxyindole O-methyltransferase ASMT 0.0025
6035 Nuclear receptor ROR-beta RORB 0.0025
6036 Eosinophil peroxidase EPX 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
4225 Uridine phosphorylase 1 UPP1 0.0024
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0024
908 Glutathione S-transferase theta-1 GSTT1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
164 Histamine H4 receptor HRH4 0.0024
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
268 Adenosine A2b receptor ADORA2B 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
4217 Telomerase reverse transcriptase TERT 0.0023
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0023
413 Amidophosphoribosyltransferase PPAT 0.0023
2515 Amidophosphoribosyltransferase purF 0.0023
3714 Amidophosphoribosyltransferase purF 0.0023
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0023
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0023
822 Aldose reductase AKR1B1 0.0023
6126 Carbonic anhydrase 7 CA7 0.0023
484 Tyrosine-protein kinase ABL2 ABL2 0.0022
1992 Vitamin D-binding protein GC 0.0022
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0022
896 Glutathione S-transferase Mu 1 GSTM1 0.0022
24 Thymidylate synthase TMP1 0.0022
359 Thymidylate synthase TYMS 0.0022
2626 Thymidylate synthase thyA 0.0022
2729 Thymidylate synthase thyA 0.0022
5352 Thymidylate synthase THYA 0.0022
6131 Carbonic anhydrase 14 CA14 0.0022
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0022
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0022
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0022
765 Indoleamine 2,3-dioxygenase IDO1 0.0022
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0022
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0022
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
1039 Histone deacetylase 9 HDAC9 0.002
6122 Carbonic anhydrase 3 CA3 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.002
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
1360 Sphingomyelin phosphodiesterase SMPD1 0.002
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.002
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
751 Potassium channel subfamily K member 6 KCNK6 0.0019
6163 Copper-transporting ATPase 2 ATP7B 0.0018
6165 Copper-transporting ATPase 1 ATP7A 0.0018
2320 Thymidine kinase, cytosolic TK1 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0018
683 Potassium transporter GK0582 0.0018
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0018
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0018
459 Retinoic acid receptor RXR-alpha RXRA 0.0018
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
738 Monocarboxylate transporter 1 SLC16A1 0.0017
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
172 Potassium channel subfamily K member 1 KCNK1 0.0017
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0017
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0017
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0017
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0017
1268 Neuropeptide S receptor NPSR1 0.0017
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0017
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0016
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0016
6085 Fatty acid-binding protein, intestinal FABP2 0.0016
1243 Cathepsin D CTSD 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0016
267 Plasminogen activator inhibitor 1 SERPINE1 0.0015
3233 Bile acid receptor NR1H4 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0015
3856 Fibroblast growth factor receptor 3 FGFR3 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1618 High affinity nerve growth factor receptor NTRK1 0.0015
1541 Metalloproteinase mmp20 0.0014
153 Dopamine beta-hydroxylase DBH 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0014
6859 Protein S100-A4 S100A4 0.0014
165 FL cytokine receptor FLT3 0.0013
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
3007 Carbonic anhydrase 12 CA12 0.0013
4205 Carbonic anhydrase 9 CA9 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
2207 Rhodopsin RHO 0.0011
2981 Phospholipase A2, membrane associated PLA2G2A 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
5787 Angiopoietin-1 receptor TEK 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
345 Plasma retinol-binding protein RBP4 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
4773 Deoxycytidine kinase DCK 0.0009
229 Retinoic acid receptor beta RARB 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6149 Solute carrier family 22 member 10 SLC22A10 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
1864 RET proto-oncogene RET 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0008
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0008
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
760 Fibroblast growth factor 1 FGF1 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
319 Opioid receptor, sigma 1 OPRS1 0.0004
1630 Integrin beta-2 ITGB2 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
174 Sigma 1-type opioid receptor SIGMAR1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
572 Integrin alpha-L ITGAL 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0003
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0002
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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