DT-Web: DB00643

Identification

Name

Mebendazole

Accession Number

DB00643 (APRD01086)

Type

small molecule

Description

A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

295.2927

Groups

approved

Monoisotopic Weight

295.095691297

Pharmacology

Indication

For the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.

Mechanism of action

Mebendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

Absorption

Poorly absorbed (approximately 5 to 10%) from gastrointestinal tract. Fatty food increases absorption.

Protein binding

90-95%

Biotransformation

Primarily hepatic. Primary metabolite is 2-amino-5-benzoylbenzimidazole, but also metabolized to inactive hydroxy and hydroxyamino metabolites. All metabolites are devoid of anthelmintic activity.

Route of elimination

In man, approximately 2% of administered mebendazole is excreted in urine and the remainder in the feces as unchanged drug or a primary metabolite.

Toxicity

Acute oral toxicity (LD₅₀): 620 mg/kg [Mouse]. Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.

Affected organisms

Helminthic Microorganisms

Interactions

Drug Interactions

Drug	Mechanism of interaction
Ethotoin	The hydantoin decreases the efficiency of mebendazole
Fosphenytoin	The hydantoin decreases the efficiency of mebendazole
Mephenytoin	The hydantoin decreases the efficiency of mebendazole
Phenytoin	The hydantoin decreases the efficiency of mebendazole

Food Interactions

Take with food.
Lipid rich meals may improve absorption.

Tubulin alpha-3 chain
Name	Tubulin alpha-3 chain
Gene Name	TUBA1A
Pharmacological action	yes
Actions	inhibitor
References	Lubega GW, Geary TG, Klein RD, Prichard RK: Expression of cloned beta-tubulin genes of Haemonchus contortus in Escherichia coli: interaction of recombinant beta-tubulin with native tubulin and mebendazole. Mol Biochem Parasitol. 1993 Dec;62(2):281-92. - Pubmed MacDonald LM, Armson A, Thompson AR, Reynoldson JA: Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum. Mol Biochem Parasitol. 2004 Nov;138(1):89-96. - Pubmed Oxberry ME, Gear TG, Prichard RK: Assessment of benzimidazole binding to individual recombinant tubulin isotypes from Haemonchus contortus. Parasitology. 2001 Jun;122(Pt 6):683-7. - Pubmed Ochola DO, Prichard RK, Lubega GW: Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro. J Parasitol. 2002 Jun;88(3):600-4. - Pubmed Wampande EM, Richard McIntosh J, Lubega GW: Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude. Protein Expr Purif. 2007 Oct;55(2):236-45. Epub 2007 Apr 25. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.3723
Tubulin beta-2C chain
Name	Tubulin beta-2C chain
Gene Name	TUBB2C
Pharmacological action	yes
Actions	inhibitor
References	Lubega GW, Geary TG, Klein RD, Prichard RK: Expression of cloned beta-tubulin genes of Haemonchus contortus in Escherichia coli: interaction of recombinant beta-tubulin with native tubulin and mebendazole. Mol Biochem Parasitol. 1993 Dec;62(2):281-92. - Pubmed MacDonald LM, Armson A, Thompson AR, Reynoldson JA: Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum. Mol Biochem Parasitol. 2004 Nov;138(1):89-96. - Pubmed Oxberry ME, Gear TG, Prichard RK: Assessment of benzimidazole binding to individual recombinant tubulin isotypes from Haemonchus contortus. Parasitology. 2001 Jun;122(Pt 6):683-7. - Pubmed Ochola DO, Prichard RK, Lubega GW: Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro. J Parasitol. 2002 Jun;88(3):600-4. - Pubmed Wampande EM, Richard McIntosh J, Lubega GW: Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude. Protein Expr Purif. 2007 Oct;55(2):236-45. Epub 2007 Apr 25. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.3401

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4254
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.272

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
DTHybrid score	0.3586

Id	Partner name	Gene Name	Score
2342	Tubulin alpha-ubiquitous chain	TUBA1B	0.1785
2536	Tubulin alpha-6 chain	TUBA1C	0.1778
4200	Cytochrome P450 1A2	CYP1A2	0.1678
4119	Cytochrome P450 2D6	CYP2D6	0.1373
2565	Tubulin beta-4 chain	TUBB4	0.1269
2601	Tubulin alpha-2 chain	TUBA3C	0.123
2444	Tubulin beta-4q chain	TUBB4Q	0.1227
2480	Tubulin alpha-8 chain	TUBA8	0.1211
2578	Tubulin beta-3 chain	TUBB3	0.1183
4118	Cytochrome P450 3A5	CYP3A5	0.1103
161	Tubulin beta chain	TUBB	0.1073
312	Tubulin beta chain	TUB2	0.1073
4757	Cytochrome P450 2C9	CYP2C9	0.1006
2539	Tubulin alpha-1 chain	TUBA4A	0.0981
6016	Cytochrome P450 2C19	CYP2C19	0.096
29	Tubulin beta-1 chain	TUBB1	0.0893
4924	Cytochrome P450 2C8	CYP2C8	0.0875
6107	Cytochrome P450 3A7	CYP3A7	0.07
6013	Cytochrome P450 2E1	CYP2E1	0.0671
5812	Tubulin beta-2B chain	TUBB2B	0.0665
6030	Cytochrome P450 2B6	CYP2B6	0.0656
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0559
6506	Stathmin-4	STMN4	0.0529
5718	Cytochrome P450 2A6	CYP2A6	0.0462
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0397
587	Serum albumin	ALB	0.0396
862	Multidrug resistance-associated protein 1	ABCC1	0.0381
1898	Cytochrome P450 1B1	CYP1B1	0.037
776	Bile salt export pump	ABCB11	0.0323
871	Glucocorticoid receptor	NR3C1	0.0314
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0301
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0297
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0295
6144	Solute carrier family 22 member 2	SLC22A2	0.0285
136	Estrogen receptor	ESR1	0.0248
20	Prostaglandin G/H synthase 1	PTGS1	0.0248
492	Histamine H1 receptor	HRH1	0.0236
3811	Cytochrome P450 19A1	CYP19A1	0.0236
1729	Solute carrier family 22 member 6	SLC22A6	0.0229
6145	Solute carrier family 22 member 1	SLC22A1	0.0227
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0226
556	Alpha-1A adrenergic receptor	ADRA1A	0.0219
6211	Tubulin epsilon chain	TUBE1	0.0213
6212	Tubulin gamma-1 chain	TUBG1	0.0212
6210	Tubulin delta chain	TUBD1	0.0212
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0203
1629	Transcription factor AP-1	JUN	0.0195
193	Beta-1 adrenergic receptor	ADRB1	0.0194
6137	Multidrug resistance-associated protein 6	ABCC6	0.0193
824	Sodium-dependent serotonin transporter	SLC6A4	0.0192
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0186
6106	Cytochrome P450 2C18	CYP2C18	0.0185
831	D(2) dopamine receptor	DRD2	0.0183
766	Beta-2 adrenergic receptor	ADRB2	0.0174
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0172
318	Alpha-2A adrenergic receptor	ADRA2A	0.0166
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0164
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.016
468	Cytochrome P450 4A11	CYP4A11	0.016
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0159
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0156
290	Prostaglandin G/H synthase 2	PTGS2	0.0155
6142	Solute carrier family 22 member 8	SLC22A8	0.0149
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0139
118	Organic cation/carnitine transporter 2	SLC22A5	0.0138
3923	Cholinesterase	BCHE	0.0138
731	HIV-1 protease	HIV-1 protease	0.0137
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0135
847	Mu-type opioid receptor	OPRM1	0.0132
632	Alpha-1B adrenergic receptor	ADRA1B	0.013
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0128
777	Tumor necrosis factor	TNF	0.0127
817	DNA topoisomerase 2-alpha	TOP2A	0.0126
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0122
6147	Solute carrier family 22 member 3	SLC22A3	0.0122
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0122
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0121
260	Cytochrome P450 51	ERG11	0.0121
761	Cytochrome P450 51	ERG11	0.0121
3163	Cytochrome P450 51	cyp51	0.0121
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0117
23	D(1A) dopamine receptor	DRD1	0.0117
48	Pyridoxal kinase	PDXK	0.0116
467	Delta-type opioid receptor	OPRD1	0.0113
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0113
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0111
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0111
614	Progesterone receptor	PGR	0.011
789	Alpha-1D adrenergic receptor	ADRA1D	0.0109
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0109
6014	Cytochrome P450 2A13	CYP2A13	0.0108
6143	Solute carrier family 22 member 7	SLC22A7	0.0108
844	Epidermal growth factor receptor	EGFR	0.0107
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0107
6182	Cytochrome P450 2J2	CYP2J2	0.0104
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0104
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0103
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0103
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.01
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0099
833	Organic cation/carnitine transporter 1	SLC22A4	0.0098
465	Calmodulin	CALM1	0.0097
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0097
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0096
6148	Multidrug resistance-associated protein 7	ABCC10	0.0096
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0095
696	Kappa-type opioid receptor	OPRK1	0.0095
2164	Multidrug resistance-associated protein 4	ABCC4	0.0095
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0094
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0094
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0091
1517	Beta-3 adrenergic receptor	ADRB3	0.0091
232	Corticosteroid-binding globulin	SERPINA6	0.0091
122	P2Y purinoceptor 12	P2RY12	0.0091
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.009
613	Atrial natriuretic peptide receptor A	NPR1	0.009
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.009
629	Alpha-2B adrenergic receptor	ADRA2B	0.009
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0086
638	D(3) dopamine receptor	DRD3	0.0085
818	50S ribosomal protein L10	rplJ	0.0085
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0084
4604	Liver carboxylesterase 1	CES1	0.0084
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0084
605	Fumarate reductase flavoprotein subunit	frdA	0.0083
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0083
3673	Fumarate reductase flavoprotein subunit	fccA	0.0083
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0083
6549	Fumarate reductase flavoprotein subunit	frdA	0.0083
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0083
1192	Sulfotransferase 1A1	SULT1A1	0.0082
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0082
146	Androgen receptor	AR	0.0079
378	Alpha-2C adrenergic receptor	ADRA2C	0.0079
952	Dipeptidyl peptidase 4	DPP4	0.0077
869	Estrogen receptor beta	ESR2	0.0076
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0076
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0075
3932	Glutathione S-transferase A2	GSTA2	0.0075
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0075
474	Acetylcholinesterase	ACHE	0.0073
1024	Solute carrier family 22 member 11	SLC22A11	0.0073
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0073
4120	NADPH--cytochrome P450 reductase	POR	0.0072
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0072
756	Sex hormone-binding globulin	SHBG	0.0072
6031	Cytochrome P450 3A43	CYP3A43	0.0071
6141	Sodium/bile acid cotransporter	SLC10A1	0.0071
477	DNA topoisomerase 4 subunit A	parC	0.007
886	DNA topoisomerase 4 subunit A	parC	0.007
6226	DNA topoisomerase 4 subunit A	parC	0.007
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.007
3947	Xanthine dehydrogenase/oxidase	XDH	0.007
68	Cannabinoid receptor 1	CNR1	0.007
504	Mast/stem cell growth factor receptor	KIT	0.007
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.007
404	DNA gyrase subunit A	gyrA	0.0069
6224	DNA gyrase subunit A	gyrA	0.0069
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0069
713	Sodium-dependent dopamine transporter	SLC6A3	0.0069
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0069
244	Angiotensin-converting enzyme	ACE	0.0068
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0068
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0068
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0066
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0066
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0065
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0065
3941	Amine oxidase [flavin-containing] A	MAOA	0.0064
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0064
373	Transthyretin	TTR	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0063
1353	DNA topoisomerase 1	TOP1	0.0063
3552	DNA topoisomerase 1	topA	0.0063
124	Histamine H2 receptor	HRH2	0.0062
4237	50S ribosomal protein L22	rplV	0.0062
380	Cytochrome P450 17A1	CYP17A1	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
1010	Cytochrome P450 51A1	CYP51A1	0.0059
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
737	Mineralocorticoid receptor	NR3C2	0.0058
790	DNA polymerase subunit alpha B	POLA2	0.0058
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0058
6043	Putative G-protein coupled receptor 44	GPR44	0.0058
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
6766	O-GlcNAcase BT_4395	BT_4395	0.0056
716	5-hydroxytryptamine 7 receptor	HTR7	0.0056
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0055
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0055
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0055
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0055
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0055
814	Ryanodine receptor 1	RYR1	0.0055
6136	Multidrug resistance-associated protein 5	ABCC5	0.0055
461	Glycine receptor subunit alpha-3	GLRA3	0.0055
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0054
6220	Aryl hydrocarbon receptor	AHR	0.0054
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0054
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0054
4203	Histamine N-methyltransferase	HNMT	0.0054
4228	Keratin, type II cytoskeletal 7	KRT7	0.0054
1714	Mitogen-activated protein kinase 3	MAPK3	0.0054
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0053
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0053
820	Glycine receptor subunit alpha-2	GLRA2	0.0053
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0053
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0053
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
3939	Amine oxidase [flavin-containing] B	MAOB	0.0052
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0052
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0051
407	Vascular endothelial growth factor receptor 2	KDR	0.0051
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0051
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0051
70	Type-1 angiotensin II receptor	AGTR1	0.0051
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.005
1178	Adenosine A2a receptor	ADORA2A	0.0049
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0049
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0049
856	Vitamin D3 receptor	VDR	0.0049
2112	Toll-like receptor 9	TLR9	0.0048
1176	Mitogen-activated protein kinase 1	MAPK1	0.0047
26	Vascular endothelial growth factor receptor 3	FLT4	0.0047
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0047
4238	50S ribosomal protein L4	rplD	0.0047
5578	50S ribosomal protein L4	rplD	0.0047
6173	50S ribosomal protein L4	rplD	0.0047
6219	50S ribosomal protein L4	rplD	0.0047
432	D(4) dopamine receptor	DRD4	0.0047
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
33	Cystine/glutamate transporter	SLC7A11	0.0046
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0046
295	Carbonic anhydrase 1	CA1	0.0046
32	Vascular endothelial growth factor receptor 1	FLT1	0.0045
6020	Aldehyde oxidase	AOX1	0.0045
811	Translocator protein	TSPO	0.0044
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0044
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0044
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0044
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0044
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0044
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0044
4103	Proteasome subunit beta type 2	PSMB2	0.0044
4102	Proteasome subunit beta type 5	PSMB5	0.0044
4101	Proteasome subunit beta type 1	PSMB1	0.0044
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0044
1820	Beta-nerve growth factor	NGF	0.0044
1757	Myeloperoxidase	MPO	0.0043
106	Cannabinoid receptor 2	CNR2	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0042
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0042
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0042
768	FK506-binding protein 1A	FKBP1A	0.0042
1852	Microtubule-associated protein 2	MAP2	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
16	Adenosine A1 receptor	ADORA1	0.0041
1656	CYP2B protein	CYP2B	0.0041
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
592	Carbonic anhydrase 4	CA4	0.004
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.004
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.004
3426	Glutamine synthetase	glnA	0.0039
3987	Glutamine synthetase	GLUL	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0038
1569	G1/S-specific cyclin-D1	CCND1	0.0038
239	Coagulation factor X	F10	0.0038
4311	tRNA	TRDMT1	0.0037
4325	tRNA	trmD	0.0037
4328	tRNA	trmD	0.0037
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0037
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0036
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0036
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0036
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
904	Glutathione S-transferase P	GSTP1	0.0035
6146	High affinity copper uptake protein 1	SLC31A1	0.0035
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
823	Fibroblast growth factor receptor 2	FGFR2	0.0034
581	Cytochrome P450 2R1	CYP2R1	0.0034
6102	Arylamine N-acetyltransferase 2	NAT2	0.0034
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0034
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0034
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0033
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0033
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0033
1050	Bile salt sulfotransferase	SULT2A1	0.0033
284	DNA-directed RNA polymerase beta chain	rpoB	0.0032
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0032
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0032
6085	Fatty acid-binding protein, intestinal	FABP2	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
84	Nuclear receptor 0B1	NR0B1	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
2236	Casein kinase II subunit alpha	CSNK2A1	0.0031
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0031
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0031
780	Retinoic acid receptor RXR-gamma	RXRG	0.0031
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0031
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
357	Carbonic anhydrase 2	CA2	0.003
738	Monocarboxylate transporter 1	SLC16A1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.003
4122	Histone deacetylase 2	HDAC2	0.003
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0029
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0029
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0029
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0029
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0029
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0029
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0029
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0029
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0029
5934	Cytochrome P450 26A1	CYP26A1	0.0029
936	Ephrin type-A receptor 2	EPHA2	0.0028
319	Opioid receptor, sigma 1	OPRS1	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0028
163	D(1B) dopamine receptor	DRD5	0.0028
4192	DNA topoisomerase 2-beta	TOP2B	0.0028
88	Retinoic acid receptor RXR-beta	RXRB	0.0028
976	Platelet glycoprotein IX	GP9	0.0028
24	Thymidylate synthase	TMP1	0.0027
359	Thymidylate synthase	TYMS	0.0027
2626	Thymidylate synthase	thyA	0.0027
2729	Thymidylate synthase	thyA	0.0027
5352	Thymidylate synthase	THYA	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1374	Natriuretic peptides B	NPPB	0.0027
1827	Gap junction alpha-1 protein	GJA1	0.0027
1908	Vascular cell adhesion protein 1	VCAM1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
469	Annexin A1	ANXA1	0.0027
569	Retinal dehydrogenase 2	ALDH1A2	0.0027
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0027
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0027
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0027
183	Vascular endothelial growth factor A	VEGFA	0.0027
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0027
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0026
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0026
6824	Tyrosine-protein kinase Lyn	LYN	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
571	Melatonin receptor type 1A	MTNR1A	0.0026
5300	Antigen peptide transporter 1	TAP1	0.0026
362	Melatonin receptor type 1B	MTNR1B	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0026
49	Endothelin B receptor	EDNRB	0.0026
427	Substance-P receptor	TACR1	0.0026
54	Prothrombin	F2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0025
611	Retinal dehydrogenase 1	ALDH1A1	0.0025
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0025
484	Tyrosine-protein kinase ABL2	ABL2	0.0024
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0024
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0024
705	Glutamate receptor 1	GRIA1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
365	Dihydrofolate reductase	DHFR	0.0024
2381	Dihydrofolate reductase	DFR1	0.0024
2833	Dihydrofolate reductase	Not Available	0.0024
2931	Dihydrofolate reductase	folA	0.0024
3544	Dihydrofolate reductase	folA	0.0024
3682	Dihydrofolate reductase	folA	0.0024
6642	Dihydrofolate reductase	folA	0.0024
6756	Dihydrofolate reductase	dfrA	0.0024
275	Arachidonate 5-lipoxygenase	ALOX5	0.0024
482	Glycine receptor subunit alpha-1	GLRA1	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
3809	Estrogen-related receptor gamma	ESRRG	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
165	FL cytokine receptor	FLT3	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0023
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0023
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0023
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0023
6126	Carbonic anhydrase 7	CA7	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
1992	Vitamin D-binding protein	GC	0.0022
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0022
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0022
908	Glutathione S-transferase theta-1	GSTT1	0.0022
4773	Deoxycytidine kinase	DCK	0.0022
6131	Carbonic anhydrase 14	CA14	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
298	Renin	REN	0.0021
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0021
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0021
3957	Adenosine deaminase	ADA	0.0021
896	Glutathione S-transferase Mu 1	GSTM1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
6432	Transporter	snf	0.002
6122	Carbonic anhydrase 3	CA3	0.002
3856	Fibroblast growth factor receptor 3	FGFR3	0.002
444	Alcohol dehydrogenase 1B	ADH1B	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
273	Apoptosis regulator Bcl-2	BCL2	0.002
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0019
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0019
5787	Angiopoietin-1 receptor	TEK	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
1275	Estrogen sulfotransferase	SULT1E1	0.0019
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0019
6149	Solute carrier family 22 member 10	SLC22A10	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0019
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0019
6167	Organic solute transporter subunit beta	OSTB	0.0019
6166	Organic solute transporter subunit alpha	OSTA	0.0019
251	Alcohol dehydrogenase 1A	ADH1A	0.0019
162	Retinoic acid receptor gamma-1	RARG	0.0019
3830	Calreticulin	CALR	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
5923	Microtubule-associated protein tau	MAPT	0.0018
5924	Microtubule-associated protein 4	MAP4	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
921	Glutamate receptor 2	GRIA2	0.0018
751	Potassium channel subfamily K member 6	KCNK6	0.0018
770	Retinoic acid-induced protein 3	GPRC5A	0.0018
719	Retinoic acid receptor responder protein 1	RARRES1	0.0018
2408	Tyrosine-protein kinase SYK	SYK	0.0018
268	Adenosine A2b receptor	ADORA2B	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
1618	High affinity nerve growth factor receptor	NTRK1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
6034	Hydroxyindole O-methyltransferase	ASMT	0.0017
6035	Nuclear receptor ROR-beta	RORB	0.0017
131	Synaptic vesicular amine transporter	SLC18A2	0.0017
6036	Eosinophil peroxidase	EPX	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
7	Nitric oxide synthase, inducible	NOS2	0.0017
634	Squalene monooxygenase	SQLE	0.0017
7196	Squalene monooxygenase	ERG1	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
400	Coagulation factor IX	F9	0.0017
5461	Coagulation factor IX	F9	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
3937	Fatty-acid amide hydrolase	FAAH	0.0016
172	Potassium channel subfamily K member 1	KCNK1	0.0016
6174	50S ribosomal protein L32	rpmF	0.0016
6163	Copper-transporting ATPase 2	ATP7B	0.0016
6165	Copper-transporting ATPase 1	ATP7A	0.0016
517	Alcohol dehydrogenase 1C	ADH1C	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0016
164	Histamine H4 receptor	HRH4	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
822	Aldose reductase	AKR1B1	0.0016
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0016
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0016
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0016
267	Plasminogen activator inhibitor 1	SERPINE1	0.0015
3233	Bile acid receptor	NR1H4	0.0015
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0015
604	Vitamin K-dependent protein Z	PROZ	0.0015
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0015
6755	Poliovirus receptor	PVR	0.0015
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0015
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0015
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0015
765	Indoleamine 2,3-dioxygenase	IDO1	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0014
1541	Metalloproteinase	mmp20	0.0014
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0014
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0014
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0014
422	Vitamin K-dependent protein C	PROC	0.0014
1245	Vitamin K-dependent protein S	PROS1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
6221	Steroid hormone receptor ERR1	ESRRA	0.0014
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
3810	Catechol O-methyltransferase	COMT	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
3007	Carbonic anhydrase 12	CA12	0.0013
4205	Carbonic anhydrase 9	CA9	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0012
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
6859	Protein S100-A4	S100A4	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
798	Osteocalcin	BGLAP	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
6459	Glycodelin	PAEP	0.0011
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0011
1630	Integrin beta-2	ITGB2	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
4217	Telomerase reverse transcriptase	TERT	0.001
369	Coagulation factor VII	F7	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
345	Plasma retinol-binding protein	RBP4	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
174	Sigma 1-type opioid receptor	SIGMAR1	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
153	Dopamine beta-hydroxylase	DBH	0.0009
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
6044	Serum paraoxonase/lactonase 3	PON3	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
489	Monocarboxylate transporter 2	SLC16A7	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
94	5-hydroxytryptamine 4 receptor	HTR4	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
572	Integrin alpha-L	ITGAL	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
1867	Major prion protein	PRNP	0.0008
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0008
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
1864	RET proto-oncogene	RET	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0008
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0008
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
291	Nitric-oxide synthase, endothelial	NOS3	0.0008
760	Fibroblast growth factor 1	FGF1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2207	Rhodopsin	RHO	0.0007
6218	Pannexin-1	PANX1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0006
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
563	Thyroid peroxidase	TPO	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
5626	Nucleoside diphosphate kinase B	NME2	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2021	Thrombomodulin	THBD	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
1650	Heme carrier protein 1	SLC46A1	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
1039	Histone deacetylase 9	HDAC9	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00643 - Mebendazole

Targets

Enzymes

Transporters

Predictions