DT-Web

DB04871 - Lorcaserin


Identification
Name Lorcaserin
Accession Number DB04871
Type small molecule
Description Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is marketed as a salt form called Belviq, which is lorcaserin hydrochloride.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For the treatment of obesity, as an adjunct to a reduced-calorie diet and increased physical activity.
Mechanism of action Although the exact mechanism is unknown, it is believed to involve the selective activation of 5-HT2C receptors in the anorexigenic pro-opiomelanocortin neurons in the arcuate nucleus of the hypothalamus. This results in decreased food intake and satiety by promoting the release of alpha-melanocortin stimulating hormone, which acts on melanocortin-4 receptors.
Absorption Lorcaserin has a peak plasma concentration of about 1.5 - 2 hours, but the bioavailability was not determined.
Protein binding Lorcaserin hydrochloride has a plasma protein binding of approximately 70%.
Biotransformation Lorcaserin has extensive hepatic metabolism producing inactive compounds. Lorcaserin sulfamate (M1) is the major metabolite circulating in the plasma, and N-carbamoyl glucuronide lorcaserin (M5) is the major metabolite in urine. Other minor metabolites that are both excreted in urine are glucuronide or sulfate conjugates.
Route of elimination Lorcaserin is eliminated by hepatic metabolism, and the metabolites are eliminated mostly in the urine (92.3%) and some through feces (2.2%).
Toxicity Most common adverse reactions include hypoglycemia (diabetic patients), headache, back pain,fatigue, decrease in lymphocytes,upper respiratory tract infection, and nasopharyngitis. Moreover, the safety and efficacy of coadministration with other weight loss products has not been established, and cardiovascular effects on mortality and morbidity have not been established.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Ergotamine Avoid all combinations with any ergot derivative such as ergotamine. The combination can increase the risk of developing serotonin syndrome and/or valvular heart disease.
Thioridazine Avoid combination.The combination is likely to reduce the metabolism of Thioridazine.
Food Interactions
  • Administration with or without food has no effect.

Targets


5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action unknown
Actions Not Available
References
  • Halford JC: Obesity drugs in clinical development. Curr Opin Investig Drugs. 2006 Apr;7(4):312-8. - Pubmed
  • Jandacek RJ: APD-356 (Arena). Curr Opin Investig Drugs. 2005 Oct;6(10):1051-6. - Pubmed
DTHybrid score 0.1815

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Usmani KA, Chen WG, Sadeque AJ: Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. doi: 10.1124/dmd.111.043414. Epub 2012 Jan 20. - Pubmed
DTHybrid score 0.5259
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Usmani KA, Chen WG, Sadeque AJ: Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. doi: 10.1124/dmd.111.043414. Epub 2012 Jan 20. - Pubmed
DTHybrid score 0.3567
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Usmani KA, Chen WG, Sadeque AJ: Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. doi: 10.1124/dmd.111.043414. Epub 2012 Jan 20. - Pubmed
DTHybrid score 0.3592
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Usmani KA, Chen WG, Sadeque AJ: Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. doi: 10.1124/dmd.111.043414. Epub 2012 Jan 20. - Pubmed
DTHybrid score 0.4372
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Usmani KA, Chen WG, Sadeque AJ: Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. doi: 10.1124/dmd.111.043414. Epub 2012 Jan 20. - Pubmed
DTHybrid score 0.5685
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Usmani KA, Chen WG, Sadeque AJ: Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. doi: 10.1124/dmd.111.043414. Epub 2012 Jan 20. - Pubmed
DTHybrid score 0.6925
Dimethylaniline monooxygenase [N-oxide-forming] 1
Name Dimethylaniline monooxygenase [N-oxide-forming] 1
Gene Name FMO1
Actions substrate
References
  • Usmani KA, Chen WG, Sadeque AJ: Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. doi: 10.1124/dmd.111.043414. Epub 2012 Jan 20. - Pubmed
DTHybrid score 0.1924
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Usmani KA, Chen WG, Sadeque AJ: Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. doi: 10.1124/dmd.111.043414. Epub 2012 Jan 20. - Pubmed
DTHybrid score 0.3028

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.3727
1588 Multidrug resistance protein 1 ABCB1 0.251
4924 Cytochrome P450 2C8 CYP2C8 0.2363
4118 Cytochrome P450 3A5 CYP3A5 0.229
6013 Cytochrome P450 2E1 CYP2E1 0.2174
6107 Cytochrome P450 3A7 CYP3A7 0.1697
502 5-hydroxytryptamine 2A receptor HTR2A 0.1218
492 Histamine H1 receptor HRH1 0.1032
824 Sodium-dependent serotonin transporter SLC6A4 0.0986
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0945
587 Serum albumin ALB 0.0907
831 D(2) dopamine receptor DRD2 0.0905
20 Prostaglandin G/H synthase 1 PTGS1 0.0875
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0871
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0771
318 Alpha-2A adrenergic receptor ADRA2A 0.0754
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0731
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0723
556 Alpha-1A adrenergic receptor ADRA1A 0.071
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0704
23 D(1A) dopamine receptor DRD1 0.0701
6106 Cytochrome P450 2C18 CYP2C18 0.0696
320 5-hydroxytryptamine 1A receptor HTR1A 0.0673
1898 Cytochrome P450 1B1 CYP1B1 0.0651
436 5-hydroxytryptamine 2B receptor HTR2B 0.0651
3811 Cytochrome P450 19A1 CYP19A1 0.0617
638 D(3) dopamine receptor DRD3 0.0524
862 Multidrug resistance-associated protein 1 ABCC1 0.0514
632 Alpha-1B adrenergic receptor ADRA1B 0.0513
6145 Solute carrier family 22 member 1 SLC22A1 0.0498
6144 Solute carrier family 22 member 2 SLC22A2 0.0494
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0492
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0492
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0491
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0486
629 Alpha-2B adrenergic receptor ADRA2B 0.048
766 Beta-2 adrenergic receptor ADRB2 0.048
713 Sodium-dependent dopamine transporter SLC6A3 0.0476
885 5-hydroxytryptamine 1B receptor HTR1B 0.0473
260 Cytochrome P450 51 ERG11 0.0472
761 Cytochrome P450 51 ERG11 0.0472
3163 Cytochrome P450 51 cyp51 0.0472
1729 Solute carrier family 22 member 6 SLC22A6 0.0463
378 Alpha-2C adrenergic receptor ADRA2C 0.0458
432 D(4) dopamine receptor DRD4 0.0456
725 5-hydroxytryptamine 1D receptor HTR1D 0.0456
776 Bile salt export pump ABCB11 0.0428
118 Organic cation/carnitine transporter 2 SLC22A5 0.0424
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0415
341 5-hydroxytryptamine 3 receptor HTR3A 0.0406
136 Estrogen receptor ESR1 0.0399
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0398
193 Beta-1 adrenergic receptor ADRB1 0.0392
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0391
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0386
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0381
468 Cytochrome P450 4A11 CYP4A11 0.0362
3941 Amine oxidase [flavin-containing] A MAOA 0.036
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0353
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0342
789 Alpha-1D adrenergic receptor ADRA1D 0.0342
844 Epidermal growth factor receptor EGFR 0.0335
716 5-hydroxytryptamine 7 receptor HTR7 0.0321
290 Prostaglandin G/H synthase 2 PTGS2 0.032
6147 Solute carrier family 22 member 3 SLC22A3 0.0316
163 D(1B) dopamine receptor DRD5 0.0314
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0314
847 Mu-type opioid receptor OPRM1 0.0308
871 Glucocorticoid receptor NR3C1 0.0305
6014 Cytochrome P450 2A13 CYP2A13 0.0291
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0291
731 HIV-1 protease HIV-1 protease 0.0281
833 Organic cation/carnitine transporter 1 SLC22A4 0.0279
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0278
465 Calmodulin CALM1 0.0278
6142 Solute carrier family 22 member 8 SLC22A8 0.0275
696 Kappa-type opioid receptor OPRK1 0.0271
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.027
183 Vascular endothelial growth factor A VEGFA 0.0269
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0268
5787 Angiopoietin-1 receptor TEK 0.0259
36 Insulin receptor INSR 0.0258
467 Delta-type opioid receptor OPRD1 0.0255
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0253
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0251
3939 Amine oxidase [flavin-containing] B MAOB 0.0249
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0245
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0242
6143 Solute carrier family 22 member 7 SLC22A7 0.0241
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0241
817 DNA topoisomerase 2-alpha TOP2A 0.024
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0239
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0238
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0238
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0235
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0229
124 Histamine H2 receptor HRH2 0.022
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0219
571 Melatonin receptor type 1A MTNR1A 0.0213
362 Melatonin receptor type 1B MTNR1B 0.0213
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0209
1256 5-hydroxytryptamine 6 receptor HTR6 0.0203
3923 Cholinesterase BCHE 0.0196
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0193
6031 Cytochrome P450 3A43 CYP3A43 0.0192
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0188
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0187
477 DNA topoisomerase 4 subunit A parC 0.0182
886 DNA topoisomerase 4 subunit A parC 0.0182
6226 DNA topoisomerase 4 subunit A parC 0.0182
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0181
777 Tumor necrosis factor TNF 0.018
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0179
404 DNA gyrase subunit A gyrA 0.0179
6224 DNA gyrase subunit A gyrA 0.0179
122 P2Y purinoceptor 12 P2RY12 0.0178
2164 Multidrug resistance-associated protein 4 ABCC4 0.0176
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0174
1192 Sulfotransferase 1A1 SULT1A1 0.0174
869 Estrogen receptor beta ESR2 0.0169
4604 Liver carboxylesterase 1 CES1 0.0166
131 Synaptic vesicular amine transporter SLC18A2 0.0165
6220 Aryl hydrocarbon receptor AHR 0.0164
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0163
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0162
146 Androgen receptor AR 0.0157
528 5-hydroxytryptamine 1E receptor HTR1E 0.0151
94 5-hydroxytryptamine 4 receptor HTR4 0.0151
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0149
1024 Solute carrier family 22 member 11 SLC22A11 0.0148
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0145
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0145
482 Glycine receptor subunit alpha-1 GLRA1 0.0144
1656 CYP2B protein CYP2B 0.014
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0139
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0139
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0139
6182 Cytochrome P450 2J2 CYP2J2 0.0138
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0135
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0135
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0134
818 50S ribosomal protein L10 rplJ 0.0134
6102 Arylamine N-acetyltransferase 2 NAT2 0.0134
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0133
1010 Cytochrome P450 51A1 CYP51A1 0.0131
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0131
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0131
474 Acetylcholinesterase ACHE 0.013
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0129
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0128
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0127
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0125
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0125
232 Corticosteroid-binding globulin SERPINA6 0.0125
3932 Glutathione S-transferase A2 GSTA2 0.0123
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0123
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0123
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0123
613 Atrial natriuretic peptide receptor A NPR1 0.0122
1517 Beta-3 adrenergic receptor ADRB3 0.0122
380 Cytochrome P450 17A1 CYP17A1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
3947 Xanthine dehydrogenase/oxidase XDH 0.0121
6136 Multidrug resistance-associated protein 5 ABCC5 0.012
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.012
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.012
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0119
891 Dihydropteroate synthase folP 0.0118
5359 Dihydropteroate synthase folP 0.0118
7175 Dihydropteroate synthase sulI 0.0118
4120 NADPH--cytochrome P450 reductase POR 0.0117
48 Pyridoxal kinase PDXK 0.0116
1757 Myeloperoxidase MPO 0.0115
504 Mast/stem cell growth factor receptor KIT 0.0115
705 Glutamate receptor 1 GRIA1 0.0114
537 ATP synthase delta chain, mitochondrial ATP5D 0.0113
2449 Tubulin alpha-3 chain TUBA1A 0.0113
2499 Tubulin beta-2C chain TUBB2C 0.0113
6148 Multidrug resistance-associated protein 7 ABCC10 0.0112
16 Adenosine A1 receptor ADORA1 0.0111
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.011
373 Transthyretin TTR 0.0109
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0108
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0107
6432 Transporter snf 0.0106
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0106
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0106
614 Progesterone receptor PGR 0.0106
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0106
1178 Adenosine A2a receptor ADORA2A 0.0106
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0103
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0103
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0103
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0103
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0102
68 Cannabinoid receptor 1 CNR1 0.0102
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0101
174 Sigma 1-type opioid receptor SIGMAR1 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.01
4237 50S ribosomal protein L22 rplV 0.01
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.01
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.01
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.01
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.01
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.01
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0099
921 Glutamate receptor 2 GRIA2 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
756 Sex hormone-binding globulin SHBG 0.0095
6020 Aldehyde oxidase AOX1 0.0095
6137 Multidrug resistance-associated protein 6 ABCC6 0.0093
161 Tubulin beta chain TUBB 0.0093
312 Tubulin beta chain TUB2 0.0093
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0092
4228 Keratin, type II cytoskeletal 7 KRT7 0.009
251 Alcohol dehydrogenase 1A ADH1A 0.0089
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0089
4238 50S ribosomal protein L4 rplD 0.0088
5578 50S ribosomal protein L4 rplD 0.0088
6173 50S ribosomal protein L4 rplD 0.0088
6219 50S ribosomal protein L4 rplD 0.0088
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0087
811 Translocator protein TSPO 0.0087
228 Beta platelet-derived growth factor receptor PDGFRB 0.0087
563 Thyroid peroxidase TPO 0.0087
26 Vascular endothelial growth factor receptor 3 FLT4 0.0086
790 DNA polymerase subunit alpha B POLA2 0.0084
32 Vascular endothelial growth factor receptor 1 FLT1 0.0083
295 Carbonic anhydrase 1 CA1 0.0082
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0081
407 Vascular endothelial growth factor receptor 2 KDR 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
2112 Toll-like receptor 9 TLR9 0.008
444 Alcohol dehydrogenase 1B ADH1B 0.008
84 Nuclear receptor 0B1 NR0B1 0.0079
173 Toll-like receptor 7 TLR7 0.0079
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0078
820 Glycine receptor subunit alpha-2 GLRA2 0.0077
106 Cannabinoid receptor 2 CNR2 0.0077
904 Glutathione S-transferase P GSTP1 0.0077
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0076
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0076
275 Arachidonate 5-lipoxygenase ALOX5 0.0075
518 Peroxidase/catalase T katG 0.0074
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
511 5-hydroxytryptamine 1F receptor HTR1F 0.0073
6141 Sodium/bile acid cotransporter SLC10A1 0.0073
4122 Histone deacetylase 2 HDAC2 0.0073
856 Vitamin D3 receptor VDR 0.0071
592 Carbonic anhydrase 4 CA4 0.007
6043 Putative G-protein coupled receptor 44 GPR44 0.007
427 Substance-P receptor TACR1 0.007
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0069
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0069
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0069
4311 tRNA TRDMT1 0.0069
4325 tRNA trmD 0.0069
4328 tRNA trmD 0.0069
952 Dipeptidyl peptidase 4 DPP4 0.0069
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
517 Alcohol dehydrogenase 1C ADH1C 0.0069
284 DNA-directed RNA polymerase beta chain rpoB 0.0069
5773 DNA-directed RNA polymerase beta chain rpoB 0.0069
2230 Catalase CAT 0.0068
3249 Catalase katA 0.0068
3625 Catalase katA 0.0068
4539 Catalase katA 0.0068
4941 Catalase katB 0.0068
33 Cystine/glutamate transporter SLC7A11 0.0068
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
70 Type-1 angiotensin II receptor AGTR1 0.0067
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0066
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0066
581 Cytochrome P450 2R1 CYP2R1 0.0066
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0065
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0065
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0065
6146 High affinity copper uptake protein 1 SLC31A1 0.0065
1820 Beta-nerve growth factor NGF 0.0064
4203 Histamine N-methyltransferase HNMT 0.0064
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0063
823 Fibroblast growth factor receptor 2 FGFR2 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0062
814 Ryanodine receptor 1 RYR1 0.0062
1629 Transcription factor AP-1 JUN 0.0062
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0062
1050 Bile salt sulfotransferase SULT2A1 0.0061
5934 Cytochrome P450 26A1 CYP26A1 0.0061
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0061
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0061
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0059
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0058
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0058
6766 O-GlcNAcase BT_4395 BT_4395 0.0058
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
1714 Mitogen-activated protein kinase 3 MAPK3 0.0056
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0056
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0056
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0056
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6506 Stathmin-4 STMN4 0.0055
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0055
737 Mineralocorticoid receptor NR3C2 0.0055
29 Tubulin beta-1 chain TUBB1 0.0055
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0054
7 Nitric oxide synthase, inducible NOS2 0.0054
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0053
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0052
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0052
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
1992 Vitamin D-binding protein GC 0.0052
357 Carbonic anhydrase 2 CA2 0.0052
49 Endothelin B receptor EDNRB 0.0052
780 Retinoic acid receptor RXR-gamma RXRG 0.0052
712 Tubulin alpha chain TUB1 0.0052
3426 Glutamine synthetase glnA 0.0052
3987 Glutamine synthetase GLUL 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0052
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0052
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0052
164 Histamine H4 receptor HRH4 0.0051
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0051
569 Retinal dehydrogenase 2 ALDH1A2 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
3937 Fatty-acid amide hydrolase FAAH 0.005
6174 50S ribosomal protein L32 rpmF 0.005
365 Dihydrofolate reductase DHFR 0.005
2381 Dihydrofolate reductase DFR1 0.005
2833 Dihydrofolate reductase Not Available 0.005
2931 Dihydrofolate reductase folA 0.005
3544 Dihydrofolate reductase folA 0.005
3682 Dihydrofolate reductase folA 0.005
6642 Dihydrofolate reductase folA 0.005
6756 Dihydrofolate reductase dfrA 0.005
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0049
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0049
1618 High affinity nerve growth factor receptor NTRK1 0.0049
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0048
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0048
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0048
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0048
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0048
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0048
611 Retinal dehydrogenase 1 ALDH1A1 0.0048
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0048
634 Squalene monooxygenase SQLE 0.0048
7196 Squalene monooxygenase ERG1 0.0048
88 Retinoic acid receptor RXR-beta RXRB 0.0047
239 Coagulation factor X F10 0.0046
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0046
3809 Estrogen-related receptor gamma ESRRG 0.0046
719 Retinoic acid receptor responder protein 1 RARRES1 0.0046
770 Retinoic acid-induced protein 3 GPRC5A 0.0046
273 Apoptosis regulator Bcl-2 BCL2 0.0045
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0045
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0045
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
400 Coagulation factor IX F9 0.0044
5461 Coagulation factor IX F9 0.0044
6126 Carbonic anhydrase 7 CA7 0.0044
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0044
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0044
976 Platelet glycoprotein IX GP9 0.0044
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0044
6044 Serum paraoxonase/lactonase 3 PON3 0.0043
461 Glycine receptor subunit alpha-3 GLRA3 0.0043
2539 Tubulin alpha-1 chain TUBA4A 0.0043
4103 Proteasome subunit beta type 2 PSMB2 0.0043
4102 Proteasome subunit beta type 5 PSMB5 0.0043
4101 Proteasome subunit beta type 1 PSMB1 0.0043
3917 Methylenetetrahydrofolate reductase MTHFR 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
738 Monocarboxylate transporter 1 SLC16A1 0.0042
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0042
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0042
1176 Mitogen-activated protein kinase 1 MAPK1 0.0041
469 Annexin A1 ANXA1 0.0041
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0041
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0041
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0041
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0041
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0041
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0041
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0041
604 Vitamin K-dependent protein Z PROZ 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
2236 Casein kinase II subunit alpha CSNK2A1 0.004
2298 Cytochrome P450-cam camC 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
1275 Estrogen sulfotransferase SULT1E1 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
936 Ephrin type-A receptor 2 EPHA2 0.0038
6085 Fatty acid-binding protein, intestinal FABP2 0.0038
3957 Adenosine deaminase ADA 0.0038
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0038
162 Retinoic acid receptor gamma-1 RARG 0.0038
85 Growth hormone receptor GHR 0.0038
1360 Sphingomyelin phosphodiesterase SMPD1 0.0037
422 Vitamin K-dependent protein C PROC 0.0037
1245 Vitamin K-dependent protein S PROS1 0.0037
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0037
3810 Catechol O-methyltransferase COMT 0.0037
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0036
3830 Calreticulin CALR 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
1374 Natriuretic peptides B NPPB 0.0035
939 50S ribosomal protein L3 rplC 0.0035
1827 Gap junction alpha-1 protein GJA1 0.0035
1908 Vascular cell adhesion protein 1 VCAM1 0.0035
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0035
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0035
1039 Histone deacetylase 9 HDAC9 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
6138 Multidrug resistance protein 3 ABCB4 0.0034
165 FL cytokine receptor FLT3 0.0034
319 Opioid receptor, sigma 1 OPRS1 0.0034
6034 Hydroxyindole O-methyltransferase ASMT 0.0034
6035 Nuclear receptor ROR-beta RORB 0.0034
6036 Eosinophil peroxidase EPX 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0033
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0033
1483 Membrane copper amine oxidase AOC3 0.0033
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0033
1630 Integrin beta-2 ITGB2 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
267 Plasminogen activator inhibitor 1 SERPINE1 0.0031
751 Potassium channel subfamily K member 6 KCNK6 0.0031
4217 Telomerase reverse transcriptase TERT 0.0031
908 Glutathione S-transferase theta-1 GSTT1 0.0031
1262 Corticotropin-lipotropin POMC 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.003
1268 Neuropeptide S receptor NPSR1 0.003
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.003
798 Osteocalcin BGLAP 0.003
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0029
291 Nitric-oxide synthase, endothelial NOS3 0.0029
4192 DNA topoisomerase 2-beta TOP2B 0.0029
765 Indoleamine 2,3-dioxygenase IDO1 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
1569 G1/S-specific cyclin-D1 CCND1 0.0029
172 Potassium channel subfamily K member 1 KCNK1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
896 Glutathione S-transferase Mu 1 GSTM1 0.0028
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0028
6221 Steroid hormone receptor ERR1 ESRRA 0.0028
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0028
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0028
1063 Signal transducer and activator of transcription 5B STAT5B 0.0028
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0028
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0027
54 Prothrombin F2 0.0027
6073 Potassium channel subfamily K member 9 KCNK9 0.0027
6072 Potassium channel subfamily K member 3 KCNK3 0.0027
369 Coagulation factor VII F7 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
3856 Fibroblast growth factor receptor 3 FGFR3 0.0027
4226 Uridine phosphorylase 2 UPP2 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0026
1648 Elastin ELN 0.0026
6163 Copper-transporting ATPase 2 ATP7B 0.0026
6165 Copper-transporting ATPase 1 ATP7A 0.0026
6131 Carbonic anhydrase 14 CA14 0.0026
5880 Thrombopoietin receptor MPL 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
4225 Uridine phosphorylase 1 UPP1 0.0024
2320 Thymidine kinase, cytosolic TK1 0.0024
153 Dopamine beta-hydroxylase DBH 0.0024
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6122 Carbonic anhydrase 3 CA3 0.0024
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0024
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
2981 Phospholipase A2, membrane associated PLA2G2A 0.0024
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
413 Amidophosphoribosyltransferase PPAT 0.0023
2515 Amidophosphoribosyltransferase purF 0.0023
3714 Amidophosphoribosyltransferase purF 0.0023
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0023
822 Aldose reductase AKR1B1 0.0023
484 Tyrosine-protein kinase ABL2 ABL2 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0022
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0022
24 Thymidylate synthase TMP1 0.0022
359 Thymidylate synthase TYMS 0.0022
2626 Thymidylate synthase thyA 0.0022
2729 Thymidylate synthase thyA 0.0022
5352 Thymidylate synthase THYA 0.0022
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0022
3404 Exotoxin A eta 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
2207 Rhodopsin RHO 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
1864 RET proto-oncogene RET 0.0019
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0019
5798 Mitogen-activated protein kinase 11 MAPK11 0.0019
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0019
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0019
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0019
1196 Complement decay-accelerating factor CD55 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
558 Solute carrier family 12 member 1 SLC12A1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
459 Retinoic acid receptor RXR-alpha RXRA 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0017
2808 Chloramphenicol acetyltransferase 3 cat3 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4773 Deoxycytidine kinase DCK 0.0016
1243 Cathepsin D CTSD 0.0016
3007 Carbonic anhydrase 12 CA12 0.0016
4205 Carbonic anhydrase 9 CA9 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
3233 Bile acid receptor NR1H4 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0015
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0015
3601 Dihydropteroate synthase 1 folP1 0.0015
3807 Dihydropteroate synthase 1 folP1 0.0015
3808 Dihydropteroate synthase 2 folP2 0.0015
2417 Chloramphenicol acetyltransferase cat 0.0015
3278 Chloramphenicol acetyltransferase cat 0.0015
2810 Dr hemagglutinin structural subunit draA 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6824 Tyrosine-protein kinase Lyn LYN 0.0014
1541 Metalloproteinase mmp20 0.0014
572 Integrin alpha-L ITGAL 0.0014
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0014
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0014
3913 Glutamic acid decarboxylase GAD65 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
1341 Histamine H3 receptor HRH3 0.0014
6859 Protein S100-A4 S100A4 0.0014
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
244 Angiotensin-converting enzyme ACE 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
1295 Fatty acid synthase FASN 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
76 Nitric-oxide synthase, brain NOS1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
6218 Pannexin-1 PANX1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
2021 Thrombomodulin THBD 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
489 Monocarboxylate transporter 2 SLC16A7 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4916 Cyanoglobin glbN 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4943 Cytochrome c6 petJ 0.0004
4984 Neuroglobin NGB 0.0004
3116 Bacterioferritin bfr 0.0004
4906 Bacterioferritin bfr 0.0004
4965 Bacterioferritin bfr 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4910 Cytoglobin CYGB 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
4909 CooA protein cooA 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4972 P450cin cinA 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4961 Hemophore HasA hasA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4952 Catalase/peroxidase katA 0.0004
3093 Catalase HPII katE 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
4920 Peroxidase/catalase katG 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
4948 Cytochrome c-553 Not Available 0.0003
4923 Cytochrome c3 DvMF_2499 0.0003
4945 Cytochrome c3 Not Available 0.0003
4949 Cytochrome c3 DVU_3171 0.0003
4968 Cytochrome c3 cytc3 0.0003
4997 Cytochrome c3 SO_2727 0.0003
5219 Cytochrome c3 cyd 0.0003
4902 Nine-heme cytochrome c Ddes_2038 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
3189 High-molecular-weight cytochrome c hmcA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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