DT-Web

DB08059 - (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE


Identification
Name (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
Accession Number DB08059
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 428.4319
Groups experimental
Monoisotopic Weight 428.147117744
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Name Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Gene Name PIK3CG
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.6008
Serine/threonine-protein kinase PLK1
Name Serine/threonine-protein kinase PLK1
Gene Name PLK1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9947
Phosphatidylinositol 3-kinase regulatory subunit alpha
Name Phosphatidylinositol 3-kinase regulatory subunit alpha
Gene Name PIK3R1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7376
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Name Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Gene Name PIK3CA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.873

Predictions


Id Partner name Gene Name Score
1422 Serine/threonine-protein kinase 6 AURKA 0.1456
4171 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform PIK3CD 0.117
6229 Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 0.1167
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.1066
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.1038
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0784
1517 Beta-3 adrenergic receptor ADRB3 0.061
1176 Mitogen-activated protein kinase 1 MAPK1 0.0583
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0542
193 Beta-1 adrenergic receptor ADRB1 0.0415
766 Beta-2 adrenergic receptor ADRB2 0.0407
862 Multidrug resistance-associated protein 1 ABCC1 0.0405
6024 Cytochrome P450 1A1 CYP1A1 0.0326
2473 Tyrosine-protein kinase CSK CSK 0.0179
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0179
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0156
2530 Protein kinase C theta type PRKCQ 0.0144
2408 Tyrosine-protein kinase SYK SYK 0.0125
6837 Serine/threonine-protein kinase 17B STK17B 0.0123
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0123
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0118
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0107
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0104
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0104
6599 HTH-type transcriptional regulator ttgR ttgR 0.0099
1721 Glycogen synthase kinase-3 beta GSK3B 0.0096
2599 Tyrosine-protein kinase HCK HCK 0.0093
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0089
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0089
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0089
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0077
1588 Multidrug resistance protein 1 ABCB1 0.0068
489 Monocarboxylate transporter 2 SLC16A7 0.0068
2240 Cell division protein kinase 2 CDK2 0.0067
738 Monocarboxylate transporter 1 SLC16A1 0.0051
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0046
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0036
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0035
4924 Cytochrome P450 2C8 CYP2C8 0.003
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