DT-Web

DB01092 - Ouabain


Identification
Name Ouabain
Accession Number DB01092 (APRD00135)
Type small molecule
Description A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 584.6525
Groups approved
Monoisotopic Weight 584.283276872
Pharmacology
Indication For the treatment of atrial fibrillation and flutter and heart failure
Mechanism of action Ouabain inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Ouabain also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
Absorption Not Available
Protein binding 60%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Sodium/potassium-transporting ATPase alpha-1 chain
Name Sodium/potassium-transporting ATPase alpha-1 chain
Gene Name ATP1A1
Pharmacological action yes
Actions inhibitor
References
  • Mentre P, Debey P: An unexpected effect of an ouabain-sensitive ATPase activity on the amount of antigen-antibody complexes formed in situ. Cell Mol Biol (Noisy-le-grand). 1999 Sep;45(6):781-91. - Pubmed
  • Qazzaz HM, El-Masri MA, Stolowich NJ, Valdes R Jr: Two biologically active isomers of dihydroouabain isolated from a commercial preparation. Biochim Biophys Acta. 1999 Nov 16;1472(3):486-97. - Pubmed
  • Tao QF, Hollenberg NK, Graves SW: Sodium pump inhibition and regional expression of sodium pump alpha-isoforms in lens. Hypertension. 1999 Nov;34(5):1168-74. - Pubmed
  • Hawke TJ, Willmets RG, Lindinger MI: K+ transport in resting rat hind-limb skeletal muscle in response to paraxanthine, a caffeine metabolite. Can J Physiol Pharmacol. 1999 Nov;77(11):835-43. - Pubmed
  • Almotrefi AA, Basco C, Moorji A, Dzimiri N: Class I antiarrhythmic drug effects on ouabain binding to guinea pig cardiac Na+ -K+ ATPase. Can J Physiol Pharmacol. 1999 Nov;77(11):866-70. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.8385

Enzymes


Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2061

Transporters


Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions substrate,inhibitor
References
  • Li L, Lee TK, Meier PJ, Ballatori N: Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. J Biol Chem. 1998 Jun 26;273(26):16184-91. - Pubmed
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
  • Bossuyt X, Muller M, Meier PJ: Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J Hepatol. 1996 Nov;25(5):733-8. - Pubmed
  • Hagenbuch B, Adler ID, Schmid TE: Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J. 2000 Jan 1;345 Pt 1:115-20. - Pubmed
  • Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. - Pubmed
  • Eckhardt U, Schroeder A, Stieger B, Hochli M, Landmann L, Tynes R, Meier PJ, Hagenbuch B: Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. Am J Physiol. 1999 Apr;276(4 Pt 1):G1037-42. - Pubmed
DTHybrid score 0.3476
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
  • Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
DTHybrid score 0.3083
Solute carrier organic anion transporter family member 4C1
Name Solute carrier organic anion transporter family member 4C1
Gene Name SLCO4C1
Actions substrate
References
  • Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. - Pubmed
DTHybrid score 0.2769
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions substrate
References
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score 0.3234
Solute carrier organic anion transporter family member 1C1
Name Solute carrier organic anion transporter family member 1C1
Gene Name SLCO1C1
Actions substrate
References
  • Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. - Pubmed
DTHybrid score 0.2383
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions substrate
References
  • van Montfoort JE, Schmid TE, Adler ID, Meier PJ, Hagenbuch B: Functional characterization of the mouse organic-anion-transporting polypeptide 2. Biochim Biophys Acta. 2002 Aug 19;1564(1):183-8. - Pubmed
DTHybrid score 0.4122

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.2192
4512 Cytochrome P450 3A4 CYP3A4 0.192
1729 Solute carrier family 22 member 6 SLC22A6 0.1555
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.1524
587 Serum albumin ALB 0.1455
4924 Cytochrome P450 2C8 CYP2C8 0.1295
4200 Cytochrome P450 1A2 CYP1A2 0.1176
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1095
758 Thyroid hormone receptor alpha THRA 0.1082
4757 Cytochrome P450 2C9 CYP2C9 0.1081
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.1025
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1011
1024 Solute carrier family 22 member 11 SLC22A11 0.1003
4118 Cytochrome P450 3A5 CYP3A5 0.0999
6016 Cytochrome P450 2C19 CYP2C19 0.0925
346 Thyroid hormone receptor beta-1 THRB 0.0919
6141 Sodium/bile acid cotransporter SLC10A1 0.0888
4119 Cytochrome P450 2D6 CYP2D6 0.0828
862 Multidrug resistance-associated protein 1 ABCC1 0.0827
6143 Solute carrier family 22 member 7 SLC22A7 0.0807
594 Thyroxine-binding globulin SERPINA7 0.0789
776 Bile salt export pump ABCB11 0.0764
2164 Multidrug resistance-associated protein 4 ABCC4 0.0762
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0749
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0731
6145 Solute carrier family 22 member 1 SLC22A1 0.0603
6167 Organic solute transporter subunit beta OSTB 0.06
6166 Organic solute transporter subunit alpha OSTA 0.06
6030 Cytochrome P450 2B6 CYP2B6 0.0575
6107 Cytochrome P450 3A7 CYP3A7 0.0567
566 Serotransferrin TF 0.0538
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0524
3587 Gastrotropin FABP6 0.051
373 Transthyretin TTR 0.0504
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0468
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0458
558 Solute carrier family 12 member 1 SLC12A1 0.0444
20 Prostaglandin G/H synthase 1 PTGS1 0.044
6013 Cytochrome P450 2E1 CYP2E1 0.0438
199 Monocarboxylate transporter 8 SLC16A2 0.0423
1898 Cytochrome P450 1B1 CYP1B1 0.0408
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0383
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.037
118 Organic cation/carnitine transporter 2 SLC22A5 0.0366
6148 Multidrug resistance-associated protein 7 ABCC10 0.0362
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0357
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0357
6144 Solute carrier family 22 member 2 SLC22A2 0.0356
290 Prostaglandin G/H synthase 2 PTGS2 0.0344
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.034
33 Cystine/glutamate transporter SLC7A11 0.0336
563 Thyroid peroxidase TPO 0.0332
738 Monocarboxylate transporter 1 SLC16A1 0.033
5718 Cytochrome P450 2A6 CYP2A6 0.0326
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0325
70 Type-1 angiotensin II receptor AGTR1 0.0324
295 Carbonic anhydrase 1 CA1 0.0314
6151 Monocarboxylate transporter 10 SLC16A10 0.0306
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0284
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0281
136 Estrogen receptor ESR1 0.0281
6136 Multidrug resistance-associated protein 5 ABCC5 0.0261
833 Organic cation/carnitine transporter 1 SLC22A4 0.025
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0249
357 Carbonic anhydrase 2 CA2 0.0244
592 Carbonic anhydrase 4 CA4 0.0223
275 Arachidonate 5-lipoxygenase ALOX5 0.0219
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0219
3932 Glutathione S-transferase A2 GSTA2 0.0217
952 Dipeptidyl peptidase 4 DPP4 0.0214
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0207
6147 Solute carrier family 22 member 3 SLC22A3 0.0202
3811 Cytochrome P450 19A1 CYP19A1 0.0201
1405 Thiopurine S-methyltransferase TPMT 0.0194
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0192
6149 Solute carrier family 22 member 10 SLC22A10 0.0187
3426 Glutamine synthetase glnA 0.0184
3987 Glutamine synthetase GLUL 0.0184
468 Cytochrome P450 4A11 CYP4A11 0.0184
6020 Aldehyde oxidase AOX1 0.0182
756 Sex hormone-binding globulin SHBG 0.0179
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0176
6106 Cytochrome P450 2C18 CYP2C18 0.0175
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0175
5818 Folate receptor alpha FOLR1 0.0169
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0165
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0164
4604 Liver carboxylesterase 1 CES1 0.0164
29 Tubulin beta-1 chain TUBB1 0.0151
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0149
293 Gamma-glutamyl hydrolase GGH 0.0147
871 Glucocorticoid receptor NR3C1 0.0139
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0138
731 HIV-1 protease HIV-1 protease 0.0136
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0134
244 Angiotensin-converting enzyme ACE 0.0133
1650 Heme carrier protein 1 SLC46A1 0.013
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0129
4205 Carbonic anhydrase 9 CA9 0.0129
3007 Carbonic anhydrase 12 CA12 0.0129
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0129
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0128
492 Histamine H1 receptor HRH1 0.0127
869 Estrogen receptor beta ESR2 0.0125
904 Glutathione S-transferase P GSTP1 0.0125
3947 Xanthine dehydrogenase/oxidase XDH 0.0124
466 Solute carrier family 12 member 3 SLC12A3 0.0124
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
146 Androgen receptor AR 0.0116
48 Pyridoxal kinase PDXK 0.0116
3917 Methylenetetrahydrofolate reductase MTHFR 0.0116
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0115
2016 Dipeptidase 1 DPEP1 0.0115
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0114
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0112
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0112
6014 Cytochrome P450 2A13 CYP2A13 0.0107
6085 Fatty acid-binding protein, intestinal FABP2 0.0106
465 Calmodulin CALM1 0.0104
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0103
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0103
159 Penicillin-binding protein 2B penA 0.0102
6121 Penicillin-binding protein 2B penA 0.0102
1517 Beta-3 adrenergic receptor ADRB3 0.0101
22 30S ribosomal protein S4 rpsD 0.0101
6714 30S ribosomal protein S4 rpsD 0.0101
338 DNA polymerase UL30 0.01
379 DNA polymerase UL54 0.01
697 DNA polymerase ORF28 0.01
2482 DNA polymerase 43 0.01
4104 DNA polymerase BALF5 0.01
2539 Tubulin alpha-1 chain TUBA4A 0.0099
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0098
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
140 30S ribosomal protein S9 rpsI 0.0095
6719 30S ribosomal protein S9 rpsI 0.0095
6725 30S ribosomal protein S9 rpsI 0.0095
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0095
24 Thymidylate synthase TMP1 0.0095
359 Thymidylate synthase TYMS 0.0095
2626 Thymidylate synthase thyA 0.0095
2729 Thymidylate synthase thyA 0.0095
5352 Thymidylate synthase THYA 0.0095
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0093
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0091
365 Dihydrofolate reductase DHFR 0.009
2381 Dihydrofolate reductase DFR1 0.009
2833 Dihydrofolate reductase Not Available 0.009
2931 Dihydrofolate reductase folA 0.009
3544 Dihydrofolate reductase folA 0.009
3682 Dihydrofolate reductase folA 0.009
6642 Dihydrofolate reductase folA 0.009
6756 Dihydrofolate reductase dfrA 0.009
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0088
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0087
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0087
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0087
273 Apoptosis regulator Bcl-2 BCL2 0.0087
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0086
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0086
543 Penicillin-binding protein 1B mrcB 0.0086
6186 Penicillin-binding protein 1B ponB 0.0086
6822 Penicillin-binding protein 1b pbp1b 0.0086
6844 Penicillin-binding protein 1b pbp1b 0.0086
124 Histamine H2 receptor HRH2 0.0086
645 Penicillin-binding protein 1A mrcA 0.0084
5805 Penicillin-binding protein 1A ponA 0.0084
6185 Penicillin-binding protein 1A mrcA 0.0084
6799 Penicillin-binding protein 1A pbpA 0.0084
737 Mineralocorticoid receptor NR3C2 0.0084
341 5-hydroxytryptamine 3 receptor HTR3A 0.0084
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0084
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0081
5880 Thrombopoietin receptor MPL 0.0081
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0081
6220 Aryl hydrocarbon receptor AHR 0.008
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.008
2499 Tubulin beta-2C chain TUBB2C 0.0079
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0079
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0078
6031 Cytochrome P450 3A43 CYP3A43 0.0078
777 Tumor necrosis factor TNF 0.0077
1757 Myeloperoxidase MPO 0.0076
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0076
6218 Pannexin-1 PANX1 0.0075
3810 Catechol O-methyltransferase COMT 0.0075
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0074
6137 Multidrug resistance-associated protein 6 ABCC6 0.0074
5923 Microtubule-associated protein tau MAPT 0.0074
5924 Microtubule-associated protein 4 MAP4 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0072
2449 Tubulin alpha-3 chain TUBA1A 0.0072
3941 Amine oxidase [flavin-containing] A MAOA 0.0072
438 Taste receptor type 1 member 2 TAS1R2 0.0071
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.007
380 Cytochrome P450 17A1 CYP17A1 0.0068
1852 Microtubule-associated protein 2 MAP2 0.0068
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0067
193 Beta-1 adrenergic receptor ADRB1 0.0067
511 5-hydroxytryptamine 1F receptor HTR1F 0.0067
5626 Nucleoside diphosphate kinase B NME2 0.0067
3686 Acyl-CoA thioesterase I precursor tesA 0.0065
6033 High affinity interleukin-8 receptor A CXCR1 0.0064
2391 Ferrochelatase hemH 0.0063
6502 Ferrochelatase DKFZp686P18130 0.0063
1591 Ferrochelatase, mitochondrial FECH 0.0063
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0063
3809 Estrogen-related receptor gamma ESRRG 0.0063
885 5-hydroxytryptamine 1B receptor HTR1B 0.0062
2981 Phospholipase A2, membrane associated PLA2G2A 0.0061
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0059
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0058
790 DNA polymerase subunit alpha B POLA2 0.0058
887 DNA gyrase subunit B gyrB 0.0057
4150 DNA gyrase subunit B gyrB 0.0057
6225 DNA gyrase subunit B gyrB 0.0057
320 5-hydroxytryptamine 1A receptor HTR1A 0.0056
766 Beta-2 adrenergic receptor ADRB2 0.0056
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0055
26 Vascular endothelial growth factor receptor 3 FLT4 0.0055
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0055
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0055
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0055
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0055
6493 Cytochrome c oxidase subunit 6C COX6C 0.0055
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0055
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0055
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0055
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0055
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0055
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0055
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0055
6559 Cytochrome c oxidase subunit 2 ctaC 0.0055
6669 Cytochrome c oxidase subunit 2 ctaC 0.0055
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0055
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0055
6558 Cytochrome c oxidase subunit 1 ctaD 0.0055
5294 Nucleoside diphosphate kinase A NME1 0.0055
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0054
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0054
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0054
751 Potassium channel subfamily K member 6 KCNK6 0.0054
5353 Glutamate decarboxylase alpha gadA 0.0054
663 Solute carrier family 12 member 4 SLC12A4 0.0053
53 Solute carrier family 12 member 5 SLC12A5 0.0053
32 Vascular endothelial growth factor receptor 1 FLT1 0.0053
725 5-hydroxytryptamine 1D receptor HTR1D 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
469 Annexin A1 ANXA1 0.0051
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.005
2540 Choloylglycine hydrolase cbh 0.005
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.005
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.005
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.005
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.005
820 Glycine receptor subunit alpha-2 GLRA2 0.005
172 Potassium channel subfamily K member 1 KCNK1 0.005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0049
310 Solute carrier family 12 member 2 SLC12A2 0.0049
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0049
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
1630 Integrin beta-2 ITGB2 0.0049
489 Monocarboxylate transporter 2 SLC16A7 0.0048
1010 Cytochrome P450 51A1 CYP51A1 0.0048
6043 Putative G-protein coupled receptor 44 GPR44 0.0048
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0048
6501 Fatty acid-binding protein, liver FABP1 0.0047
6168 Solute carrier family 22 member 16 SLC22A16 0.0047
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0047
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0047
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0046
551 Carnitine O-acetyltransferase CRAT 0.0046
633 Penicillin-binding proteins 1A/1B pbpA 0.0046
332 Beta-lactamase blaZ 0.0046
2478 Beta-lactamase ampC 0.0046
2613 Beta-lactamase ampC 0.0046
2635 Beta-lactamase ampC 0.0046
2700 Beta-lactamase penP 0.0046
5445 Beta-lactamase blaB 0.0046
6019 Beta-lactamase SHV-7 0.0046
6701 Beta-lactamase cphA 0.0046
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0046
517 Alcohol dehydrogenase 1C ADH1C 0.0045
284 DNA-directed RNA polymerase beta chain rpoB 0.0045
5773 DNA-directed RNA polymerase beta chain rpoB 0.0045
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0045
4122 Histone deacetylase 2 HDAC2 0.0045
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0044
1820 Beta-nerve growth factor NGF 0.0044
4228 Keratin, type II cytoskeletal 7 KRT7 0.0044
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0043
407 Vascular endothelial growth factor receptor 2 KDR 0.0043
342 P protein [Includes: DNA-directed DNA polymerase P 0.0042
612 P protein [Includes: DNA-directed DNA polymerase P 0.0042
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0042
1714 Mitogen-activated protein kinase 3 MAPK3 0.0041
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0041
318 Alpha-2A adrenergic receptor ADRA2A 0.0041
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0041
976 Platelet glycoprotein IX GP9 0.0041
3830 Calreticulin CALR 0.004
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.004
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.004
6766 O-GlcNAcase BT_4395 BT_4395 0.004
232 Corticosteroid-binding globulin SERPINA6 0.004
1867 Major prion protein PRNP 0.0039
6044 Serum paraoxonase/lactonase 3 PON3 0.0039
6500 Phospholipase A2 PLA2G1B 0.0039
5482 Sialidase-2 NEU2 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0039
3685 Catabolite gene activator crp 0.0038
4655 Adenylate cyclase cyaC 0.0038
4759 Adenylate cyclase cyaB2 0.0038
1176 Mitogen-activated protein kinase 1 MAPK1 0.0038
6034 Hydroxyindole O-methyltransferase ASMT 0.0037
6035 Nuclear receptor ROR-beta RORB 0.0037
6036 Eosinophil peroxidase EPX 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
5934 Cytochrome P450 26A1 CYP26A1 0.0037
572 Integrin alpha-L ITGAL 0.0037
84 Nuclear receptor 0B1 NR0B1 0.0036
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0036
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0036
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0036
130 Prostacyclin synthase PTGIS 0.0036
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0036
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0035
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0035
4148 Serine/threonine-protein kinase mTOR MTOR 0.0035
4238 50S ribosomal protein L4 rplD 0.0035
5578 50S ribosomal protein L4 rplD 0.0035
6173 50S ribosomal protein L4 rplD 0.0035
6219 50S ribosomal protein L4 rplD 0.0035
115 Penicillin-binding protein 2 mrdA 0.0035
6069 Penicillin-binding protein 2 mrdA 0.0035
6118 Penicillin-binding protein 2 penA 0.0035
6187 Penicillin-binding protein 2 pbpA 0.0035
6686 Penicillin-binding protein 2 pbp2 0.0035
6939 Penicillin-binding protein 2 mrdA 0.0035
7163 Penicillin-binding protein 2 pbpA 0.0035
509 Thymidine kinase TK 0.0035
570 Thymidine kinase TK 0.0035
2559 Thymidine kinase TK 0.0035
3430 Thymidine kinase tdk 0.0035
3518 Thymidine kinase TK 0.0035
5301 Thymidine kinase tdk 0.0035
5771 Thymidine kinase ORF36 0.0035
7009 Thymidine kinase ORF36 0.0035
2021 Thrombomodulin THBD 0.0034
844 Epidermal growth factor receptor EGFR 0.0034
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0034
6209 30S ribosomal protein S19 rpsS 0.0034
6712 30S ribosomal protein S19 rpsS 0.0034
6726 30S ribosomal protein S19 rpsS 0.0034
183 Vascular endothelial growth factor A VEGFA 0.0034
6207 30S ribosomal protein S14 rpsN 0.0034
4203 Histamine N-methyltransferase HNMT 0.0034
3923 Cholinesterase BCHE 0.0034
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
1525 Heparin-binding growth factor 2 FGF2 0.0033
2249 Aspartate aminotransferase aspC 0.0033
2671 Aspartate aminotransferase aspC 0.0033
5490 Aspartate aminotransferase Not Available 0.0033
4760 Mll3241 protein mll3241 0.0032
1 Peptidoglycan synthetase ftsI ftsI 0.0032
4155 Peptidoglycan synthetase ftsI ftsI 0.0032
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0032
1291 cAMP response element-binding protein CREB1 0.0032
765 Indoleamine 2,3-dioxygenase IDO1 0.0032
4237 50S ribosomal protein L22 rplV 0.0032
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0032
1760 Aminopeptidase N ANPEP 0.0032
6843 Aminopeptidase N pepN 0.0032
4210 Toll-like receptor 4 TLR4 0.0032
228 Beta platelet-derived growth factor receptor PDGFRB 0.003
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
571 Melatonin receptor type 1A MTNR1A 0.003
362 Melatonin receptor type 1B MTNR1B 0.003
267 Plasminogen activator inhibitor 1 SERPINE1 0.003
2112 Toll-like receptor 9 TLR9 0.0029
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0029
527 Prostacyclin receptor PTGIR 0.0029
1198 Serum paraoxonase/arylesterase 1 PON1 0.0029
6223 Penicillin-binding protein 1C pbpC 0.0029
768 FK506-binding protein 1A FKBP1A 0.0029
672 Prostaglandin F2-alpha receptor PTGFR 0.0028
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0028
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0028
504 Mast/stem cell growth factor receptor KIT 0.0028
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0028
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0028
6146 High affinity copper uptake protein 1 SLC31A1 0.0028
5126 Arginase rocF 0.0027
6221 Steroid hormone receptor ERR1 ESRRA 0.0027
867 Penicillin-binding protein 3 pbpC 0.0027
6119 Penicillin-binding protein 3 pbp3 0.0027
7154 Penicillin-binding protein 3 pbp3 0.0027
7157 Penicillin-binding protein 3 LMHCC_2184 0.0027
7162 Penicillin-binding protein 3 pbpB 0.0027
7172 Penicillin-binding protein 3 pbp3 0.0027
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0027
4311 tRNA TRDMT1 0.0027
4325 tRNA trmD 0.0027
4328 tRNA trmD 0.0027
2236 Casein kinase II subunit alpha CSNK2A1 0.0027
1654 Interleukin-1 beta IL1B 0.0026
106 Cannabinoid receptor 2 CNR2 0.0026
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0026
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0026
6042 Prostaglandin reductase 2 PTGR2 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0025
3856 Fibroblast growth factor receptor 3 FGFR3 0.0025
68 Cannabinoid receptor 1 CNR1 0.0025
817 DNA topoisomerase 2-alpha TOP2A 0.0024
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
1792 Tissue-type plasminogen activator PLAT 0.0024
16 Adenosine A1 receptor ADORA1 0.0024
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0024
1178 Adenosine A2a receptor ADORA2A 0.0023
1569 G1/S-specific cyclin-D1 CCND1 0.0023
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0023
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
611 Retinal dehydrogenase 1 ALDH1A1 0.0022
824 Sodium-dependent serotonin transporter SLC6A4 0.0022
494 Caspase-1 CASP1 0.0022
1192 Sulfotransferase 1A1 SULT1A1 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
260 Cytochrome P450 51 ERG11 0.0021
761 Cytochrome P450 51 ERG11 0.0021
3163 Cytochrome P450 51 cyp51 0.0021
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0021
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0021
823 Fibroblast growth factor receptor 2 FGFR2 0.0021
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0021
1507 Cytochrome c CYCS 0.0021
590 5-hydroxytryptamine 2C receptor HTR2C 0.002
831 D(2) dopamine receptor DRD2 0.002
556 Alpha-1A adrenergic receptor ADRA1A 0.002
1313 Lactoylglutathione lyase GLO1 0.002
950 Alpha platelet-derived growth factor receptor PDGFRA 0.002
606 Cytochrome P450 27, mitochondrial CYP27A1 0.002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.002
3760 Penicillin-binding protein 5 precursor dacA 0.0019
1629 Transcription factor AP-1 JUN 0.0019
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
122 P2Y purinoceptor 12 P2RY12 0.0019
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
467 Delta-type opioid receptor OPRD1 0.0019
696 Kappa-type opioid receptor OPRK1 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
2077 Caspase-3 CASP3 0.0018
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0018
847 Mu-type opioid receptor OPRM1 0.0018
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0018
65 Matrix metalloproteinase-9 Not Available 0.0018
1992 Vitamin D-binding protein GC 0.0018
1353 DNA topoisomerase 1 TOP1 0.0018
3552 DNA topoisomerase 1 topA 0.0018
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0018
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0018
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0018
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0017
819 Penicillin-binding protein 4 dacB 0.0017
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
400 Coagulation factor IX F9 0.0017
5461 Coagulation factor IX F9 0.0017
1374 Natriuretic peptides B NPPB 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
477 DNA topoisomerase 4 subunit A parC 0.0016
886 DNA topoisomerase 4 subunit A parC 0.0016
6226 DNA topoisomerase 4 subunit A parC 0.0016
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0016
1063 Signal transducer and activator of transcription 5B STAT5B 0.0016
4103 Proteasome subunit beta type 2 PSMB2 0.0016
4102 Proteasome subunit beta type 5 PSMB5 0.0016
4101 Proteasome subunit beta type 1 PSMB1 0.0016
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
404 DNA gyrase subunit A gyrA 0.0016
6224 DNA gyrase subunit A gyrA 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0016
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0016
814 Ryanodine receptor 1 RYR1 0.0016
6182 Cytochrome P450 2J2 CYP2J2 0.0016
378 Alpha-2C adrenergic receptor ADRA2C 0.0016
822 Aldose reductase AKR1B1 0.0016
629 Alpha-2B adrenergic receptor ADRA2B 0.0016
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0015
604 Vitamin K-dependent protein Z PROZ 0.0015
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
251 Alcohol dehydrogenase 1A ADH1A 0.0015
632 Alpha-1B adrenergic receptor ADRA1B 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0014
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
422 Vitamin K-dependent protein C PROC 0.0014
1245 Vitamin K-dependent protein S PROS1 0.0014
6645 D-amino-acid oxidase DAO 0.0014
7 Nitric oxide synthase, inducible NOS2 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0014
638 D(3) dopamine receptor DRD3 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0013
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0013
856 Vitamin D3 receptor VDR 0.0013
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
484 Tyrosine-protein kinase ABL2 ABL2 0.0013
444 Alcohol dehydrogenase 1B ADH1B 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0013
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
4192 DNA topoisomerase 2-beta TOP2B 0.0013
6163 Copper-transporting ATPase 2 ATP7B 0.0013
6165 Copper-transporting ATPase 1 ATP7A 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0012
23 D(1A) dopamine receptor DRD1 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
789 Alpha-1D adrenergic receptor ADRA1D 0.0012
997 Protein kinase C beta type PRKCB 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0012
1275 Estrogen sulfotransferase SULT1E1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0012
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0012
502 5-hydroxytryptamine 2A receptor HTR2A 0.0011
634 Squalene monooxygenase SQLE 0.0011
7196 Squalene monooxygenase ERG1 0.0011
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
908 Glutathione S-transferase theta-1 GSTT1 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0011
798 Osteocalcin BGLAP 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
6102 Arylamine N-acetyltransferase 2 NAT2 0.0011
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
1050 Bile salt sulfotransferase SULT2A1 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
4120 NADPH--cytochrome P450 reductase POR 0.0011
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0011
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
6126 Carbonic anhydrase 7 CA7 0.001
780 Retinoic acid receptor RXR-gamma RXRG 0.001
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
369 Coagulation factor VII F7 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
896 Glutathione S-transferase Mu 1 GSTM1 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
3937 Fatty-acid amide hydrolase FAAH 0.001
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.001
345 Plasma retinol-binding protein RBP4 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
88 Retinoic acid receptor RXR-beta RXRB 0.0009
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0009
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0009
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0009
3957 Adenosine deaminase ADA 0.0009
162 Retinoic acid receptor gamma-1 RARG 0.0009
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0009
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0008
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0008
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0008
239 Coagulation factor X F10 0.0008
614 Progesterone receptor PGR 0.0007
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0007
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0007
164 Histamine H4 receptor HRH4 0.0007
54 Prothrombin F2 0.0006
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0006
528 5-hydroxytryptamine 1E receptor HTR1E 0.0005
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0005
3939 Amine oxidase [flavin-containing] B MAOB 0.0005
1256 5-hydroxytryptamine 6 receptor HTR6 0.0005
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0005
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0005
921 Glutamate receptor 2 GRIA2 0.0005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0005
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0005
716 5-hydroxytryptamine 7 receptor HTR7 0.0005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0005
432 D(4) dopamine receptor DRD4 0.0004
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0004
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0004
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0003
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