DT-Web: DB00396

Identification

Name

Progesterone

Accession Number

DB00396 (APRD00700)

Type

small molecule

Description

The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands, and the brain. It is required in embryo implantation, pregnancy maintenance, and the development of mammary tissue for milk production. Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

314.4617

Groups

approved

Monoisotopic Weight

314.224580204

Pharmacology

Indication

For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used for the reduction of the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy, as well as treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer.

Mechanism of action

Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity.

Absorption

Progesterone absorption is prolonged with an absorption half-life of approximately 25-50 hours.

Protein binding

96%-99%

Biotransformation

Progesterone is metabolized primarily by the liver largely to pregnanediols and pregnanolones.

Route of elimination

The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the urine and bile. Progesterone metabolites which are excreted in the bile may undergo enterohepatic recycling or may be excreted in the feces. Progesterone metabolites are excreted mainly by the kidneys.

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Topotecan	The p-glycoprotein inhibitor, Progesterone, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.

Food Interactions

Take with food.
Avoid excessive quantities of coffee or tea (Caffeine).
Avoid alcohol.
Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin.
Take at the same time everyday.

Progesterone receptor
Name	Progesterone receptor
Gene Name	PGR
Pharmacological action	yes
Actions	agonist
References	Madauss KP, Stewart EL, Williams SP: The evolution of progesterone receptor ligands. Med Res Rev. 2007 May;27(3):374-400. - Pubmed Gizard F, Robillard R, Gross B, Barbier O, Revillion F, Peyrat JP, Torpier G, Hum DW, Staels B: TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone. Mol Cell Biol. 2006 Oct;26(20):7632-44. - Pubmed Wu HB, Fabian S, Jenab S, Quinones-Jenab V: Progesterone receptors activation after acute cocaine administration. Brain Res. 2006 Dec 18;1126(1):188-92. Epub 2006 Nov 15. - Pubmed Boonyaratanakornkit V, McGowan E, Sherman L, Mancini MA, Cheskis BJ, Edwards DP: The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle. Mol Endocrinol. 2007 Feb;21(2):359-75. Epub 2006 Nov 30. - Pubmed Tranguch S, Smith DF, Dey SK: Progesterone receptor requires a co-chaperone for signalling in uterine biology and implantation. Reprod Biomed Online. 2006 Nov;13(5):651-60. - Pubmed Luconi M, Bonaccorsi L, Maggi M, Pecchioli P, Krausz C, Forti G, Baldi E: Identification and characterization of functional nongenomic progesterone receptors on human sperm membrane. J Clin Endocrinol Metab. 1998 Mar;83(3):877-85. - Pubmed
DTHybrid score	0.7198
Estrogen receptor
Name	Estrogen receptor
Gene Name	ESR1
Pharmacological action	yes
Actions	agonist
References	Kumar AS, Cureton E, Shim V, Sakata T, Moore DH, Benz CC, Esserman LJ, Hwang ES: Type and duration of exogenous hormone use affects breast cancer histology. Ann Surg Oncol. 2007 Feb;14(2):695-703. Epub 2006 Nov 14. - Pubmed Lessey BA, Palomino WA, Apparao K, Young SL, Lininger RA: Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women. Reprod Biol Endocrinol. 2006 Oct 9;4 Suppl 1:S9. - Pubmed Yuri T, Tsukamoto R, Uehara N, Matsuoka Y, Tsubura A: Effects of different durations of estrogen and progesterone treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats. In Vivo. 2006 Nov-Dec;20(6B):829-36. - Pubmed Montero Girard G, Vanzulli SI, Cerliani JP, Bottino MC, Bolado J, Vela J, Becu-Villalobos D, Benavides F, Gutkind S, Patel V, Molinolo A, Lanari C: Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment. Breast Cancer Res. 2007;9(2):R22. - Pubmed Ghebeh H, Tulbah A, Mohammed S, Elkum N, Bin Amer SM, Al-Tweigeri T, Dermime S: Expression of B7-H1 in breast cancer patients is strongly associated with high proliferative Ki-67-expressing tumor cells. Int J Cancer. 2007 Aug 15;121(4):751-8. - Pubmed
DTHybrid score	0.9117
Mineralocorticoid receptor
Name	Mineralocorticoid receptor
Gene Name	NR3C2
Pharmacological action	yes
Actions	antagonist
References	Rupprecht R, Reul JM, van Steensel B, Spengler D, Soder M, Berning B, Holsboer F, Damm K: Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur J Pharmacol. 1993 Oct 15;247(2):145-54. - Pubmed
DTHybrid score	0.4846
Cytochrome P450 17A1
Name	Cytochrome P450 17A1
Gene Name	CYP17A1
Pharmacological action	unknown
Actions	inhibitor
References	Haidar S, Hartmann RW: C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-C17, 20-lyase: synthesis and biological evaluation. Arch Pharm (Weinheim). 2002;335(11-12):526-34. - Pubmed
DTHybrid score	0.2165

Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6806
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8035
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5353
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Lin Y, Lu P, Tang C, Mei Q, Sandig G, Rodrigues AD, Rushmore TH, Shou M: Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):368-74. - Pubmed
DTHybrid score	0.6834
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor,inducer
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.2304
Cytochrome P450 17A1
Name	Cytochrome P450 17A1
Gene Name	CYP17A1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2165
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4616
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7332
Cytochrome P450 1B1
Name	Cytochrome P450 1B1
Gene Name	CYP1B1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2646
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.424
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6258
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8243

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Romiti N, Tramonti G, Chieli E: Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91. - Pubmed Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed Leonessa F, Kim JH, Ghiorghis A, Kulawiec RJ, Hammer C, Talebian A, Clarke R: C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump. J Med Chem. 2002 Jan 17;45(2):390-8. - Pubmed Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R: Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem. 1992 Dec 5;267(34):24248-52. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M, Lin JH: In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results. J Pharmacol Exp Ther. 2001 Mar;296(3):723-35. - Pubmed Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed Borgnia MJ, Eytan GD, Assaraf YG: Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem. 1996 Feb 9;271(6):3163-71. - Pubmed Kim WY, Benet LZ: P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. - Pubmed
DTHybrid score	0.8378
Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Hayer-Zillgen M, Bruss M, Bonisch H: Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36. - Pubmed Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score	0.355
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Hayer-Zillgen M, Bruss M, Bonisch H: Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36. - Pubmed Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score	0.4194
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	inhibitor
References	Hayer-Zillgen M, Bruss M, Bonisch H: Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36. - Pubmed Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score	0.2643
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	inhibitor
References	Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed
DTHybrid score	0.3073
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Payen L, Delugin L, Courtois A, Trinquart Y, Guillouzo A, Fardel O: Reversal of MRP-mediated multidrug resistance in human lung cancer cells by the antiprogestatin drug RU486. Biochem Biophys Res Commun. 1999 May 19;258(3):513-8. - Pubmed
DTHybrid score	0.3378
Sodium/bile acid cotransporter
Name	Sodium/bile acid cotransporter
Gene Name	SLC10A1
Actions	inhibitor
References	Schroeder A, Eckhardt U, Stieger B, Tynes R, Schteingart CD, Hofmann AF, Meier PJ, Hagenbuch B: Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. Am J Physiol. 1998 Feb;274(2 Pt 1):G370-5. - Pubmed
DTHybrid score	0.2116

Id	Partner name	Gene Name	Score
6030	Cytochrome P450 2B6	CYP2B6	0.3461
6013	Cytochrome P450 2E1	CYP2E1	0.3287
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.2863
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.2786
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.2702
6241	Nuclear receptor coactivator 2	NCOA2	0.2548
587	Serum albumin	ALB	0.2162
118	Organic cation/carnitine transporter 2	SLC22A5	0.1759
146	Androgen receptor	AR	0.1707
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1677
1729	Solute carrier family 22 member 6	SLC22A6	0.156
3811	Cytochrome P450 19A1	CYP19A1	0.1555
20	Prostaglandin G/H synthase 1	PTGS1	0.1485
871	Glucocorticoid receptor	NR3C1	0.1479
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1409
6106	Cytochrome P450 2C18	CYP2C18	0.1387
6142	Solute carrier family 22 member 8	SLC22A8	0.137
492	Histamine H1 receptor	HRH1	0.1213
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.1141
869	Estrogen receptor beta	ESR2	0.1108
833	Organic cation/carnitine transporter 1	SLC22A4	0.1105
831	D(2) dopamine receptor	DRD2	0.1061
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.1048
290	Prostaglandin G/H synthase 2	PTGS2	0.1038
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1022
824	Sodium-dependent serotonin transporter	SLC6A4	0.1015
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.1015
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0991
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0979
556	Alpha-1A adrenergic receptor	ADRA1A	0.0963
6143	Solute carrier family 22 member 7	SLC22A7	0.0952
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0951
2164	Multidrug resistance-associated protein 4	ABCC4	0.0946
766	Beta-2 adrenergic receptor	ADRB2	0.094
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0899
756	Sex hormone-binding globulin	SHBG	0.0894
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0892
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0859
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0845
6148	Multidrug resistance-associated protein 7	ABCC10	0.0836
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0828
817	DNA topoisomerase 2-alpha	TOP2A	0.082
318	Alpha-2A adrenergic receptor	ADRA2A	0.0761
193	Beta-1 adrenergic receptor	ADRB1	0.0751
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0748
3923	Cholinesterase	BCHE	0.0725
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.072
468	Cytochrome P450 4A11	CYP4A11	0.0692
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0685
6031	Cytochrome P450 3A43	CYP3A43	0.0677
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0674
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0672
1024	Solute carrier family 22 member 11	SLC22A11	0.0658
713	Sodium-dependent dopamine transporter	SLC6A3	0.0654
632	Alpha-1B adrenergic receptor	ADRA1B	0.065
23	D(1A) dopamine receptor	DRD1	0.0639
341	5-hydroxytryptamine 3 receptor	HTR3A	0.063
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0626
731	HIV-1 protease	HIV-1 protease	0.062
847	Mu-type opioid receptor	OPRM1	0.0613
378	Alpha-2C adrenergic receptor	ADRA2C	0.0597
3941	Amine oxidase [flavin-containing] A	MAOA	0.0586
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0582
6137	Multidrug resistance-associated protein 6	ABCC6	0.0577
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0574
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0569
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0567
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0556
2202	Steryl-sulfatase	STS	0.0552
629	Alpha-2B adrenergic receptor	ADRA2B	0.0552
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0549
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0538
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0533
465	Calmodulin	CALM1	0.0525
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0512
467	Delta-type opioid receptor	OPRD1	0.0487
3947	Xanthine dehydrogenase/oxidase	XDH	0.0482
3939	Amine oxidase [flavin-containing] B	MAOB	0.0476
6228	Nuclear receptor coactivator 1	NCOA1	0.0472
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0462
696	Kappa-type opioid receptor	OPRK1	0.0459
260	Cytochrome P450 51	ERG11	0.0457
761	Cytochrome P450 51	ERG11	0.0457
3163	Cytochrome P450 51	cyp51	0.0457
789	Alpha-1D adrenergic receptor	ADRA1D	0.0454
6014	Cytochrome P450 2A13	CYP2A13	0.0452
638	D(3) dopamine receptor	DRD3	0.0449
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0448
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0433
6136	Multidrug resistance-associated protein 5	ABCC5	0.0428
232	Corticosteroid-binding globulin	SERPINA6	0.0422
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0421
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0421
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0416
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0414
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0414
124	Histamine H2 receptor	HRH2	0.0412
723	Cytosolic phospholipase A2	PLA2G4A	0.0411
450	Muscarinic acetylcholine receptor M4	CHRM4	0.041
94	5-hydroxytryptamine 4 receptor	HTR4	0.0408
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0402
161	Tubulin beta chain	TUBB	0.0402
312	Tubulin beta chain	TUB2	0.0402
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0401
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0399
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0397
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0396
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0396
6220	Aryl hydrocarbon receptor	AHR	0.0386
477	DNA topoisomerase 4 subunit A	parC	0.0386
886	DNA topoisomerase 4 subunit A	parC	0.0386
6226	DNA topoisomerase 4 subunit A	parC	0.0386
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0381
404	DNA gyrase subunit A	gyrA	0.038
6224	DNA gyrase subunit A	gyrA	0.038
1050	Bile salt sulfotransferase	SULT2A1	0.037
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0365
4604	Liver carboxylesterase 1	CES1	0.036
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0358
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0356
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0355
6182	Cytochrome P450 2J2	CYP2J2	0.0348
844	Epidermal growth factor receptor	EGFR	0.0345
131	Synaptic vesicular amine transporter	SLC18A2	0.0344
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0339
373	Transthyretin	TTR	0.0338
29	Tubulin beta-1 chain	TUBB1	0.0338
4203	Histamine N-methyltransferase	HNMT	0.0336
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0335
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0333
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.032
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0316
432	D(4) dopamine receptor	DRD4	0.0315
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0311
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0309
738	Monocarboxylate transporter 1	SLC16A1	0.0306
474	Acetylcholinesterase	ACHE	0.0304
4120	NADPH--cytochrome P450 reductase	POR	0.0301
504	Mast/stem cell growth factor receptor	KIT	0.0299
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0297
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0295
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0295
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0293
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0287
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0287
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0286
7	Nitric oxide synthase, inducible	NOS2	0.0277
1757	Myeloperoxidase	MPO	0.0277
1852	Microtubule-associated protein 2	MAP2	0.0277
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0275
777	Tumor necrosis factor	TNF	0.0268
122	P2Y purinoceptor 12	P2RY12	0.0265
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0264
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0259
36	Insulin receptor	INSR	0.0258
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0257
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0257
273	Apoptosis regulator Bcl-2	BCL2	0.0252
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0252
1010	Cytochrome P450 51A1	CYP51A1	0.0248
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0248
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0245
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0242
84	Nuclear receptor 0B1	NR0B1	0.0237
1517	Beta-3 adrenergic receptor	ADRB3	0.0237
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0235
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0233
4773	Deoxycytidine kinase	DCK	0.0233
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0231
1629	Transcription factor AP-1	JUN	0.0231
6167	Organic solute transporter subunit beta	OSTB	0.0229
6166	Organic solute transporter subunit alpha	OSTA	0.0229
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0228
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0227
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0226
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0226
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0226
2449	Tubulin alpha-3 chain	TUBA1A	0.0226
891	Dihydropteroate synthase	folP	0.0226
5359	Dihydropteroate synthase	folP	0.0226
7175	Dihydropteroate synthase	sulI	0.0226
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0226
6102	Arylamine N-acetyltransferase 2	NAT2	0.0224
1192	Sulfotransferase 1A1	SULT1A1	0.0222
469	Annexin A1	ANXA1	0.0221
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0219
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0219
1178	Adenosine A2a receptor	ADORA2A	0.0218
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0217
163	D(1B) dopamine receptor	DRD5	0.0217
3810	Catechol O-methyltransferase	COMT	0.0217
2539	Tubulin alpha-1 chain	TUBA4A	0.0216
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0216
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0215
16	Adenosine A1 receptor	ADORA1	0.0215
811	Translocator protein	TSPO	0.0215
33	Cystine/glutamate transporter	SLC7A11	0.0214
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0213
5923	Microtubule-associated protein tau	MAPT	0.0212
5924	Microtubule-associated protein 4	MAP4	0.0212
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0212
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0211
6085	Fatty acid-binding protein, intestinal	FABP2	0.021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0209
49	Endothelin B receptor	EDNRB	0.0209
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0207
70	Type-1 angiotensin II receptor	AGTR1	0.0206
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0204
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0203
683	Potassium transporter	GK0582	0.0203
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0201
716	5-hydroxytryptamine 7 receptor	HTR7	0.0201
407	Vascular endothelial growth factor receptor 2	KDR	0.02
952	Dipeptidyl peptidase 4	DPP4	0.0198
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0197
578	Endothelin-1 receptor	EDNRA	0.0197
6070	Nischarin	NISCH	0.0196
4237	50S ribosomal protein L22	rplV	0.0195
4228	Keratin, type II cytoskeletal 7	KRT7	0.0194
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0192
4238	50S ribosomal protein L4	rplD	0.0191
5578	50S ribosomal protein L4	rplD	0.0191
6173	50S ribosomal protein L4	rplD	0.0191
6219	50S ribosomal protein L4	rplD	0.0191
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.019
571	Melatonin receptor type 1A	MTNR1A	0.019
362	Melatonin receptor type 1B	MTNR1B	0.019
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0189
1636	Trace amine-associated receptor 1	TAAR1	0.0189
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0189
6149	Solute carrier family 22 member 10	SLC22A10	0.0186
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0186
6146	High affinity copper uptake protein 1	SLC31A1	0.0186
6020	Aldehyde oxidase	AOX1	0.0186
164	Histamine H4 receptor	HRH4	0.0183
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0183
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0183
2808	Chloramphenicol acetyltransferase 3	cat3	0.0182
5626	Nucleoside diphosphate kinase B	NME2	0.0182
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0182
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0182
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0182
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0182
3809	Estrogen-related receptor gamma	ESRRG	0.018
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.018
1649	Small inducible cytokine A2	CCL2	0.018
26	Vascular endothelial growth factor receptor 3	FLT4	0.018
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.018
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0179
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0179
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0176
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0174
4192	DNA topoisomerase 2-beta	TOP2B	0.0173
908	Glutathione S-transferase theta-1	GSTT1	0.0172
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0172
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0172
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0172
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0172
32	Vascular endothelial growth factor receptor 1	FLT1	0.0171
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0171
904	Glutathione S-transferase P	GSTP1	0.0171
818	50S ribosomal protein L10	rplJ	0.0165
6138	Multidrug resistance protein 3	ABCB4	0.0165
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0165
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0164
3587	Gastrotropin	FABP6	0.0161
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0161
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0159
6010	Thiamine transporter 1	SLC19A2	0.0159
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0159
6432	Transporter	snf	0.0158
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0158
2472	Voltage-gated potassium channel	kcsA	0.0157
6366	Voltage-gated potassium channel	kcsA	0.0157
594	Thyroxine-binding globulin	SERPINA7	0.0156
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0156
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0154
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0154
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0152
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0152
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0152
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0151
226	Gonadotropin-releasing hormone receptor	GNRHR	0.015
1256	5-hydroxytryptamine 6 receptor	HTR6	0.015
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.015
3868	Calcineurin subunit B isoform 2	PPP3R2	0.015
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0149
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0149
427	Substance-P receptor	TACR1	0.0149
5294	Nucleoside diphosphate kinase A	NME1	0.0147
4122	Histone deacetylase 2	HDAC2	0.0146
3932	Glutathione S-transferase A2	GSTA2	0.0146
758	Thyroid hormone receptor alpha	THRA	0.0145
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0145
365	Dihydrofolate reductase	DHFR	0.0144
2381	Dihydrofolate reductase	DFR1	0.0144
2833	Dihydrofolate reductase	Not Available	0.0144
2931	Dihydrofolate reductase	folA	0.0144
3544	Dihydrofolate reductase	folA	0.0144
3682	Dihydrofolate reductase	folA	0.0144
6642	Dihydrofolate reductase	folA	0.0144
6756	Dihydrofolate reductase	dfrA	0.0144
2499	Tubulin beta-2C chain	TUBB2C	0.0144
814	Ryanodine receptor 1	RYR1	0.0143
1656	CYP2B protein	CYP2B	0.0143
921	Glutamate receptor 2	GRIA2	0.0143
175	Thiamin pyrophosphokinase 1	TPK1	0.0142
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0141
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.014
1341	Histamine H3 receptor	HRH3	0.014
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0139
976	Platelet glycoprotein IX	GP9	0.0137
6163	Copper-transporting ATPase 2	ATP7B	0.0137
6165	Copper-transporting ATPase 1	ATP7A	0.0137
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0136
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0135
275	Arachidonate 5-lipoxygenase	ALOX5	0.0135
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0134
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0134
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0134
5934	Cytochrome P450 26A1	CYP26A1	0.0134
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0134
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0133
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0132
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0132
823	Fibroblast growth factor receptor 2	FGFR2	0.0132
346	Thyroid hormone receptor beta-1	THRB	0.0131
295	Carbonic anhydrase 1	CA1	0.0131
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.013
3307	Acriflavine resistance protein B	acrB	0.013
1353	DNA topoisomerase 1	TOP1	0.0129
3552	DNA topoisomerase 1	topA	0.0129
6212	Tubulin gamma-1 chain	TUBG1	0.0129
6210	Tubulin delta chain	TUBD1	0.0129
6211	Tubulin epsilon chain	TUBE1	0.0129
6043	Putative G-protein coupled receptor 44	GPR44	0.0128
6048	Troponin C, skeletal muscle	TNNC2	0.0128
153	Dopamine beta-hydroxylase	DBH	0.0128
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0127
2112	Toll-like receptor 9	TLR9	0.0126
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0125
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0125
672	Prostaglandin F2-alpha receptor	PTGFR	0.0125
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0125
5126	Arginase	rocF	0.0125
165	FL cytokine receptor	FLT3	0.0125
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0124
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0124
705	Glutamate receptor 1	GRIA1	0.0123
896	Glutathione S-transferase Mu 1	GSTM1	0.0123
613	Atrial natriuretic peptide receptor A	NPR1	0.0122
68	Cannabinoid receptor 1	CNR1	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
992	Protein tyrosine kinase 2 beta	PTK2B	0.0121
183	Vascular endothelial growth factor A	VEGFA	0.012
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.012
3270	Elongation factor G	fusA	0.0119
687	Tyrosine-protein phosphatase non-receptor type 1	PTPN1	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
828	Phenylalanine-4-hydroxylase	PAH	0.0118
3109	Phenylalanine-4-hydroxylase	phhA	0.0118
284	DNA-directed RNA polymerase beta chain	rpoB	0.0117
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0117
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0117
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0117
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0117
482	Glycine receptor subunit alpha-1	GLRA1	0.0117
517	Alcohol dehydrogenase 1C	ADH1C	0.0116
48	Pyridoxal kinase	PDXK	0.0116
6218	Pannexin-1	PANX1	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
558	Solute carrier family 12 member 1	SLC12A1	0.0114
3830	Calreticulin	CALR	0.0113
1618	High affinity nerve growth factor receptor	NTRK1	0.0113
5787	Angiopoietin-1 receptor	TEK	0.0113
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0112
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.011
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0109
1714	Mitogen-activated protein kinase 3	MAPK3	0.0109
239	Coagulation factor X	F10	0.0108
702	UMP-CMP kinase	CMPK1	0.0108
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0107
88	Retinoic acid receptor RXR-beta	RXRB	0.0106
2107	Microtubule-associated protein 1A	MAP1A	0.0106
4311	tRNA	TRDMT1	0.0105
4325	tRNA	trmD	0.0105
4328	tRNA	trmD	0.0105
887	DNA gyrase subunit B	gyrB	0.0105
4150	DNA gyrase subunit B	gyrB	0.0105
6225	DNA gyrase subunit B	gyrB	0.0105
2300	Lysozyme	E	0.0105
3633	Lysozyme	R	0.0105
5597	Lysozyme	17	0.0105
6035	Nuclear receptor ROR-beta	RORB	0.0105
6034	Hydroxyindole O-methyltransferase	ASMT	0.0105
592	Carbonic anhydrase 4	CA4	0.0105
6036	Eosinophil peroxidase	EPX	0.0105
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0104
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0104
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0102
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0102
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0102
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0102
6174	50S ribosomal protein L32	rpmF	0.0102
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0101
1770	Phospholipase C	PLCL1	0.0101
2841	Phospholipase C	plc	0.0101
1830	5'-nucleotidase	NT5E	0.01
489	Monocarboxylate transporter 2	SLC16A7	0.01
461	Glycine receptor subunit alpha-3	GLRA3	0.01
518	Peroxidase/catalase T	katG	0.01
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.01
24	Thymidylate synthase	TMP1	0.01
359	Thymidylate synthase	TYMS	0.01
2626	Thymidylate synthase	thyA	0.01
2729	Thymidylate synthase	thyA	0.01
5352	Thymidylate synthase	THYA	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
751	Potassium channel subfamily K member 6	KCNK6	0.0099
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0099
106	Cannabinoid receptor 2	CNR2	0.0098
694	Matrix protein 2	M	0.0098
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0097
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0097
624	Guanidinoacetate N-methyltransferase	GAMT	0.0097
4116	Dihydropteroate synthetase	Not Available	0.0097
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0097
5300	Antigen peptide transporter 1	TAP1	0.0096
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0096
3856	Fibroblast growth factor receptor 3	FGFR3	0.0096
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0095
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0095
251	Alcohol dehydrogenase 1A	ADH1A	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0095
3611	Cytidine deaminase	cdd	0.0095
3707	Cytidine deaminase	cdd	0.0095
4211	Cytidine deaminase	CDA	0.0095
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0094
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0094
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0094
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0094
1569	G1/S-specific cyclin-D1	CCND1	0.0094
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0094
780	Retinoic acid receptor RXR-gamma	RXRG	0.0094
381	Prolactin receptor	PRLR	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
765	Indoleamine 2,3-dioxygenase	IDO1	0.0091
172	Potassium channel subfamily K member 1	KCNK1	0.0091
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0091
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.009
6151	Monocarboxylate transporter 10	SLC16A10	0.009
936	Ephrin type-A receptor 2	EPHA2	0.0089
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
444	Alcohol dehydrogenase 1B	ADH1B	0.0088
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0088
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0088
54	Prothrombin	F2	0.0088
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0088
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
319	Opioid receptor, sigma 1	OPRS1	0.0087
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0086
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
1275	Estrogen sulfotransferase	SULT1E1	0.0085
484	Tyrosine-protein kinase ABL2	ABL2	0.0085
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0084
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0084
790	DNA polymerase subunit alpha B	POLA2	0.0084
569	Retinal dehydrogenase 2	ALDH1A2	0.0084
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0084
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0084
663	Solute carrier family 12 member 4	SLC12A4	0.0084
53	Solute carrier family 12 member 5	SLC12A5	0.0084
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0083
1176	Mitogen-activated protein kinase 1	MAPK1	0.0083
4103	Proteasome subunit beta type 2	PSMB2	0.0083
4102	Proteasome subunit beta type 5	PSMB5	0.0083
4101	Proteasome subunit beta type 1	PSMB1	0.0083
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0082
2236	Casein kinase II subunit alpha	CSNK2A1	0.0082
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0082
6044	Serum paraoxonase/lactonase 3	PON3	0.0082
527	Prostacyclin receptor	PTGIR	0.0082
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0081
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0081
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0081
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0081
2391	Ferrochelatase	hemH	0.0081
6502	Ferrochelatase	DKFZp686P18130	0.0081
1591	Ferrochelatase, mitochondrial	FECH	0.0081
125	DNA polymerase beta	POLB	0.0081
162	Retinoic acid receptor gamma-1	RARG	0.0081
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
1864	RET proto-oncogene	RET	0.008
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.008
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.008
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.008
1196	Complement decay-accelerating factor	CD55	0.008
6171	Solute carrier family 28 member 3	SLC28A3	0.0079
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0079
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0079
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0079
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0079
611	Retinal dehydrogenase 1	ALDH1A1	0.0079
173	Toll-like receptor 7	TLR7	0.0079
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0079
267	Plasminogen activator inhibitor 1	SERPINE1	0.0078
357	Carbonic anhydrase 2	CA2	0.0078
3957	Adenosine deaminase	ADA	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
4217	Telomerase reverse transcriptase	TERT	0.0078
563	Thyroid peroxidase	TPO	0.0078
310	Solute carrier family 12 member 2	SLC12A2	0.0077
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
268	Adenosine A2b receptor	ADORA2B	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0076
244	Angiotensin-converting enzyme	ACE	0.0076
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0076
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0076
199	Monocarboxylate transporter 8	SLC16A2	0.0076
3937	Fatty-acid amide hydrolase	FAAH	0.0076
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0076
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0074
1541	Metalloproteinase	mmp20	0.0074
6766	O-GlcNAcase BT_4395	BT_4395	0.0074
856	Vitamin D3 receptor	VDR	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0073
174	Sigma 1-type opioid receptor	SIGMAR1	0.0073
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0072
820	Glycine receptor subunit alpha-2	GLRA2	0.0072
6824	Tyrosine-protein kinase Lyn	LYN	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
634	Squalene monooxygenase	SQLE	0.0071
7196	Squalene monooxygenase	ERG1	0.0071
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0071
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.007
6221	Steroid hormone receptor ERR1	ESRRA	0.007
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.007
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.007
177	Biotin--protein ligase	HLCS	0.007
690	Acetyl-CoA carboxylase 1	ACACA	0.007
2216	Fibroblast growth factor receptor 4	FGFR4	0.007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.007
6126	Carbonic anhydrase 7	CA7	0.007
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.007
3927	Choline transporter-like protein 3	SLC44A3	0.007
3926	Choline transporter-like protein 2	SLC44A2	0.007
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.007
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.007
1686	Choline transporter-like protein 1	SLC44A1	0.007
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.007
861	Choline kinase alpha	CHKA	0.007
769	High-affinity choline transporter 1	SLC5A7	0.007
581	Cytochrome P450 2R1	CYP2R1	0.007
3925	Choline transporter-like protein 4	SLC44A4	0.007
700	Choline dehydrogenase, mitochondrial	CHDH	0.007
576	Choline O-acetyltransferase	CHAT	0.007
3922	Phospholipase D2	PLD2	0.007
3924	Phospholipase D1	PLD1	0.007
5682	Ribonuclease pancreatic	RNASE1	0.0069
6042	Prostaglandin reductase 2	PTGR2	0.0069
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0069
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0069
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0069
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0069
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0069
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0069
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0069
719	Retinoic acid receptor responder protein 1	RARRES1	0.0069
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0069
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0069
770	Retinoic acid-induced protein 3	GPRC5A	0.0069
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0069
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0069
6559	Cytochrome c oxidase subunit 2	ctaC	0.0069
6669	Cytochrome c oxidase subunit 2	ctaC	0.0069
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0069
6558	Cytochrome c oxidase subunit 1	ctaD	0.0069
2230	Catalase	CAT	0.0069
3249	Catalase	katA	0.0069
3625	Catalase	katA	0.0069
4539	Catalase	katA	0.0069
4941	Catalase	katB	0.0069
3086	Plasmepsin-2	Not Available	0.0068
1483	Membrane copper amine oxidase	AOC3	0.0067
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0067
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0067
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
1630	Integrin beta-2	ITGB2	0.0066
6168	Solute carrier family 22 member 16	SLC22A16	0.0066
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0066
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0066
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0066
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0066
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0066
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0065
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0064
2540	Choloylglycine hydrolase	cbh	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
3601	Dihydropteroate synthase 1	folP1	0.0063
3807	Dihydropteroate synthase 1	folP1	0.0063
3808	Dihydropteroate synthase 2	folP2	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
1648	Elastin	ELN	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
4210	Toll-like receptor 4	TLR4	0.0063
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0063
133	Dihydropterate synthase	sulI	0.0063
2810	Dr hemagglutinin structural subunit	draA	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
1291	cAMP response element-binding protein	CREB1	0.0061
1313	Lactoylglutathione lyase	GLO1	0.0061
291	Nitric-oxide synthase, endothelial	NOS3	0.006
2320	Thymidine kinase, cytosolic	TK1	0.006
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
6501	Fatty acid-binding protein, liver	FABP1	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
714	Glutathione reductase, mitochondrial	GSR	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
1992	Vitamin D-binding protein	GC	0.0056
771	Pyruvate carboxylase, mitochondrial	PC	0.0056
6506	Stathmin-4	STMN4	0.0055
5998	Toll-like receptor 8	TLR8	0.0053
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0053
712	Tubulin alpha chain	TUB1	0.0052
3426	Glutamine synthetase	glnA	0.0052
3987	Glutamine synthetase	GLUL	0.0052
3913	Glutamic acid decarboxylase	GAD65	0.0052
775	Acetyl-CoA carboxylase 2	ACACB	0.0052
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
572	Integrin alpha-L	ITGAL	0.005
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.005
2599	Tyrosine-protein kinase HCK	HCK	0.005
6500	Phospholipase A2	PLA2G1B	0.0049
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
1374	Natriuretic peptides B	NPPB	0.0048
1827	Gap junction alpha-1 protein	GJA1	0.0048
1908	Vascular cell adhesion protein 1	VCAM1	0.0048
2616	Ganglioside GM2 activator	GM2A	0.0047
1525	Heparin-binding growth factor 2	FGF2	0.0046
2021	Thrombomodulin	THBD	0.0045
76	Nitric-oxide synthase, brain	NOS1	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
400	Coagulation factor IX	F9	0.0044
5461	Coagulation factor IX	F9	0.0044
3639	Thymidine phosphorylase	deoA	0.0044
3936	Thymidine phosphorylase	TYMP	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
1039	Histone deacetylase 9	HDAC9	0.0043
117	Sterol O-acyltransferase 1	SOAT1	0.0043
3904	Alanine aminotransferase 2	GPT2	0.0043
735	Alanine aminotransferase 1	GPT	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0043
4226	Uridine phosphorylase 2	UPP2	0.0043
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0042
6837	Serine/threonine-protein kinase 17B	STK17B	0.0042
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0042
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0042
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0041
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0041
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0041
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0041
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0041
229	Retinoic acid receptor beta	RARB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0041
604	Vitamin K-dependent protein Z	PROZ	0.0041
123	Diamine acetyltransferase 1	SAT1	0.004
730	Retinoic acid receptor alpha	RARA	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
2298	Cytochrome P450-cam	camC	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
4225	Uridine phosphorylase 1	UPP1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0038
85	Growth hormone receptor	GHR	0.0038
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
422	Vitamin K-dependent protein C	PROC	0.0037
1245	Vitamin K-dependent protein S	PROS1	0.0037
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
413	Amidophosphoribosyltransferase	PPAT	0.0037
2515	Amidophosphoribosyltransferase	purF	0.0037
3714	Amidophosphoribosyltransferase	purF	0.0037
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
1074	Urokinase-type plasminogen activator	PLAU	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
1262	Corticotropin-lipotropin	POMC	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0034
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0033
277	Purine nucleoside phosphorylase	PNP	0.0033
2870	Purine nucleoside phosphorylase	punA	0.0033
2945	Purine nucleoside phosphorylase	punA	0.0033
4659	Purine nucleoside phosphorylase	TM_1596	0.0033
4825	Purine nucleoside phosphorylase	TTHA1435	0.0033
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0033
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0033
65	Matrix metalloproteinase-9	Not Available	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
473	L-lactate dehydrogenase A chain	LDHA	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
1792	Tissue-type plasminogen activator	PLAT	0.0031
822	Aldose reductase	AKR1B1	0.0031
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.003
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.003
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
2207	Rhodopsin	RHO	0.003
798	Osteocalcin	BGLAP	0.003
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0028
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
369	Coagulation factor VII	F7	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
1650	Heme carrier protein 1	SLC46A1	0.0027
5798	Mitogen-activated protein kinase 11	MAPK11	0.0027
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0027
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0026
1268	Neuropeptide S receptor	NPSR1	0.0026
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0026
6131	Carbonic anhydrase 14	CA14	0.0026
6859	Protein S100-A4	S100A4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
340	Apoptotic protease-activating factor 1	APAF1	0.0024
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0024
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6122	Carbonic anhydrase 3	CA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
760	Fibroblast growth factor 1	FGF1	0.0024
627	11-cis retinol dehydrogenase	RDH5	0.0024
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0024
6073	Potassium channel subfamily K member 9	KCNK9	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
6072	Potassium channel subfamily K member 3	KCNK3	0.0023
5816	Cadherin-5	CDH5	0.0023
707	72 kDa type IV collagenase	MMP2	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0022
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0022
825	Arsenical pump-driving ATPase	ASNA1	0.0022
3435	Arsenical pump-driving ATPase	arsA	0.0022
2232	Interleukin-5	IL5	0.0022
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0021
154	AFG3-like protein 2	AFG3L2	0.0021
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0021
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0021
733	Activin receptor type 1B	ACVR1B	0.0021
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0021
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0021
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0021
395	ALK tyrosine kinase receptor	Not Available	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0021
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6459	Glycodelin	PAEP	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
292	Activin receptor type-1	ACVR1	0.002
849	Activated CDC42 kinase 1	TNK2	0.002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0019
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0019
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0019
297	Adenylate cyclase type 1	ADCY1	0.0019
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0019
5818	Folate receptor alpha	FOLR1	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
4041	Microsomal glutathione S-transferase 2	MGST2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
2408	Tyrosine-protein kinase SYK	SYK	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
293	Gamma-glutamyl hydrolase	GGH	0.0016
1243	Cathepsin D	CTSD	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
3007	Carbonic anhydrase 12	CA12	0.0016
4205	Carbonic anhydrase 9	CA9	0.0016
740	Argininosuccinate synthase	ASS1	0.0016
865	Argininosuccinate synthase	ASS1	0.0016
2680	Argininosuccinate synthase	argG	0.0016
3194	Argininosuccinate synthase	argG	0.0016
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0016
816	Biliverdin reductase A	BLVRA	0.0016
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0016
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
661	ADP/ATP translocase 1	SLC25A4	0.0016
6021	Adenosine kinase	ADK	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0015
6677	Myelin P2 protein	PMP2	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
4031	Glutathione S-transferase A1	GSTA1	0.0014
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0014
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0014
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0014
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0014
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0014
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0014
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0014
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0014
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0014
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0014
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0014
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0014
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0014
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0014
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0014
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0014
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0014
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0014
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0014
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0014
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0014
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0014
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0014
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0014
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0014
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0014
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0014
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0014
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0014
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0014
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0014
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0014
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0014
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0014
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0014
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0014
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0014
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0014
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0014
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0014
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0014
644	Heme oxygenase 2	HMOX2	0.0014
4982	Heme oxygenase 2	pbsA2	0.0014
167	L-lactate dehydrogenase C chain	LDHC	0.0014
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0014
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0014
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0014
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0014
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0014
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0014
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0014
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0014
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0014
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0014
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0014
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0014
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0014
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0014
729	GDP-L-fucose synthetase	TSTA3	0.0014
3463	GDP-L-fucose synthetase	fcl	0.0014
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0014
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0014
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0014
34	7-dehydrocholesterol reductase	DHCR7	0.0014
711	UDP-glucose 6-dehydrogenase	UGDH	0.0014
3672	UDP-glucose 6-dehydrogenase	hasB	0.0014
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0014
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0014
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0014
107	C-4 methylsterol oxidase	SC4MOL	0.0014
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0014
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0014
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0014
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0014
206	3-keto-steroid reductase	HSD17B7	0.0014
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0014
643	Peroxisomal bifunctional enzyme	EHHADH	0.0014
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0014
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0014
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0014
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0014
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0014
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0014
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0014
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0014
396	Alcohol dehydrogenase 4	ADH4	0.0014
328	Sorbitol dehydrogenase	SORD	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
597	Dihydropteridine reductase	QDPR	0.0014
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0014
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0014
666	NADP-dependent malic enzyme	ME1	0.0014
857	Malate dehydrogenase, mitochondrial	MDH2	0.0013
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0013
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0013
77	L-lactate dehydrogenase B chain	LDHB	0.0013
12	Alcohol dehydrogenase class 3	ADH5	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0013
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0013
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0013
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
810	Heme oxygenase 1	HMOX1	0.0013
3391	Heme oxygenase 1	pbsA1	0.0013
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0013
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
6026	Alcohol dehydrogenase 6	ADH6	0.0012
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0012
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0012
13	Aminomethyltransferase, mitochondrial	AMT	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0012
3221	Cytochrome c4	cc4	0.0012
1295	Fatty acid synthase	FASN	0.0012
626	Cysteine dioxygenase type 1	CDO1	0.0012
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0012
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0012
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
654	Flavin reductase	BLVRB	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
279	Tyrosinase	TYR	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
345	Plasma retinol-binding protein	RBP4	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
1928	Leukotriene C4 synthase	LTC4S	0.001
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.001
4034	Glutaredoxin-1	GLRX	0.001
910	Epididymal secretory glutathione peroxidase	GPX5	0.001
4036	Glutathione peroxidase 6	GPX6	0.001
4037	Hypothetical protein	GPX1	0.001
4297	Hypothetical protein	SP_1951	0.001
4521	Hypothetical protein	BC_2969	0.001
4540	Hypothetical protein	TM_1070	0.001
4555	Hypothetical protein	MT1739	0.001
4569	Hypothetical protein	mshD	0.001
4578	Hypothetical protein	PA3270	0.001
4747	Hypothetical protein	PA3967	0.001
5177	Hypothetical protein	TM_0096	0.001
5194	Hypothetical protein	PA1204	0.001
5240	Hypothetical protein	Rv2991	0.001
5370	Hypothetical protein	TM_1158	0.001
5710	Hypothetical protein	Tb927.5.1360	0.001
4029	Microsomal glutathione S-transferase 3	MGST3	0.001
900	Glutathione S-transferase A4	GSTA4	0.001
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.001
911	Glutathione peroxidase 3	GPX3	0.001
4040	Glutathione peroxidase 7	GPX7	0.001
907	Glutathione peroxidase 2	GPX2	0.001
4032	Microsomal glutathione S-transferase 1	MGST1	0.001
906	Glutathione peroxidase 1	GPX1	0.001
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.001
4035	Glutathione S-transferase Mu 5	GSTM5	0.001
903	Glutathione S-transferase A5	GSTA5	0.001
4042	Glutathione transferase omega-2	GSTO2	0.001
4033	S-formylglutathione hydrolase	ESD	0.001
4038	Glutathione peroxidase 4	GPX4	0.001
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.001
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.001
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0009
898	Glutathione S-transferase A3	GSTA3	0.0009
897	Glutathione S-transferase kappa 1	GSTK1	0.0009
909	Maleylacetoacetate isomerase	GSTZ1	0.0009
2132	Protein S100-B	S100B	0.0009
899	Glutathione S-transferase Mu 3	GSTM3	0.0008
905	Glutathione transferase omega-1	GSTO1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
4386	Hemoglobin-like protein HbN	glbN	0.0008
1867	Major prion protein	PRNP	0.0008
2165	Glutathione S-transferase Mu 2	GSTM2	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
207	Glutathione synthetase	GSS	0.0008
5269	Glutathione synthetase	gshB	0.0008
1025	Aquaporin-1	AQP1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
901	Glutathione S-transferase Mu 4	GSTM4	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
1507	Cytochrome c	CYCS	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4916	Cyanoglobin	glbN	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4943	Cytochrome c6	petJ	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
5000	HemO	hemO	0.0005
4984	Neuroglobin	NGB	0.0005
4909	CooA protein	cooA	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4910	Cytoglobin	CYGB	0.0005
4961	Hemophore HasA	hasA	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
4972	P450cin	cinA	0.0005
4952	Catalase/peroxidase	katA	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
2802	Endoglucanase G	celCCG	0.0004
4920	Peroxidase/catalase	katG	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
358	Cystathionine beta-synthase	CBS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00396 - Progesterone

Targets

Enzymes

Transporters

Predictions