DT-Web

DB00613 - Amodiaquine


Identification
Name Amodiaquine
Accession Number DB00613 (APRD00796)
Type small molecule
Description A 4-aminoquinoquinoline compound with anti-inflammatory properties. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 355.861
Groups approved
Monoisotopic Weight 355.145140048
Pharmacology
Indication For treatment of acute malarial attacks in non-immune subjects.
Mechanism of action The mechanism of plasmodicidal action of amodiaquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites. The drug binds the free heme preventing the parasite from converting it to a form less toxic. This drug-heme complex is toxic and disrupts membrane function.
Absorption Rapidly absorbed following oral administration.
Protein binding Not Available
Biotransformation Hepatic biotransformation to desethylamodiaquine (the principal biologically active metabolite) is the predominant route of amodiaquine clearance with such a considerable first pass effect that very little orally administered amodiaquine escapes untransformed into the systemic circulation.
Route of elimination Not Available
Toxicity LD50 (mouse, intraperitoneal) 225 mg/kg, LD50 (mouse, oral) 550 mg/kg. Symptoms of overdose include headache, drowsiness, visual disturbances, vomiting, hypokalaemia, cardiovascular collapse and cardiac and respiratory arrest. Hypotension, if not treated, may progress rapidly to shock. Electrocardiograms (ECG) may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, broadening of the QRS complex, and progressive bradycardia leading to ventricular fibrillation and/or arrest.
Affected organisms
  • Plasmodium
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Ferriprotoporphyrin IX
Name Ferriprotoporphyrin IX
Gene Name Not Available
Pharmacological action yes
Actions adduct
References
  • de Villiers KA, Marques HM, Egan TJ: The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials. J Inorg Biochem. 2008 Aug;102(8):1660-7. Epub 2008 Apr 20. - Pubmed
  • Weissbuch I, Leiserowitz L: Interplay between malaria, crystalline hemozoin formation, and antimalarial drug action and design. Chem Rev. 2008 Nov;108(11):4899-914. - Pubmed
  • Sullivan DJ Jr, Gluzman IY, Russell DG, Goldberg DE: On the molecular mechanism of chloroquine's antimalarial action. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11865-70. - Pubmed
  • Schwedhelm KF, Horstmann M, Faber JH, Reichert Y, Bringmann G, Faber C: The novel antimalarial compound dioncophylline C forms a complex with heme in solution. ChemMedChem. 2007 Apr;2(4):541-8. - Pubmed
  • Egan TJ, Ncokazi KK: Effects of solvent composition and ionic strength on the interaction of quinoline antimalarials with ferriprotoporphyrin IX. J Inorg Biochem. 2004 Jan;98(1):144-52. - Pubmed
DTHybrid score Not Available
Histamine N-methyltransferase
Name Histamine N-methyltransferase
Gene Name HNMT
Pharmacological action unknown
Actions inhibitor
References
  • Yokoyama A, Mori S, Takahashi HK, Kanke T, Wake H, Nishibori M: Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84. Epub 2006 Nov 22. - Pubmed
  • Nowak JZ, Zandarowska E: Effect of amodiaquine on histamine level and histamine-methyltransferase activity in the rat brain. Arch Immunol Ther Exp (Warsz). 1980;28(6):927-30. - Pubmed
  • Barth H, Lorenz W, Troidl H: Effect of amodiaquine on gastric histamine methyltransferase and on histamine-stimulated gastric secretion. Br J Pharmacol. 1975 Nov;55(3):321-7. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.655

Enzymes


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Li XQ, Bjorkman A, Andersson TB, Ridderstrom M, Masimirembwa CM: Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407. - Pubmed
  • Walsky RL, Obach RS: Validated assays for human cytochrome P450 activities. Drug Metab Dispos. 2004 Jun;32(6):647-60. - Pubmed
DTHybrid score 0.2931
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2649
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1792
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3847
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3819

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.308
4200 Cytochrome P450 1A2 CYP1A2 0.2203
6016 Cytochrome P450 2C19 CYP2C19 0.2051
1588 Multidrug resistance protein 1 ABCB1 0.1691
4118 Cytochrome P450 3A5 CYP3A5 0.1445
6013 Cytochrome P450 2E1 CYP2E1 0.1169
6030 Cytochrome P450 2B6 CYP2B6 0.1145
2417 Chloramphenicol acetyltransferase cat 0.1024
3278 Chloramphenicol acetyltransferase cat 0.1024
6107 Cytochrome P450 3A7 CYP3A7 0.0935
5718 Cytochrome P450 2A6 CYP2A6 0.0828
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0774
20 Prostaglandin G/H synthase 1 PTGS1 0.0721
587 Serum albumin ALB 0.0598
492 Histamine H1 receptor HRH1 0.0526
6144 Solute carrier family 22 member 2 SLC22A2 0.0491
6106 Cytochrome P450 2C18 CYP2C18 0.0483
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0443
862 Multidrug resistance-associated protein 1 ABCC1 0.0406
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0403
290 Prostaglandin G/H synthase 2 PTGS2 0.0399
6145 Solute carrier family 22 member 1 SLC22A1 0.0385
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0385
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0365
824 Sodium-dependent serotonin transporter SLC6A4 0.0353
776 Bile salt export pump ABCB11 0.0346
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0335
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0316
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0312
1770 Phospholipase C PLCL1 0.0312
2841 Phospholipase C plc 0.0312
6147 Solute carrier family 22 member 3 SLC22A3 0.0308
1729 Solute carrier family 22 member 6 SLC22A6 0.0305
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0302
831 D(2) dopamine receptor DRD2 0.0288
468 Cytochrome P450 4A11 CYP4A11 0.0286
502 5-hydroxytryptamine 2A receptor HTR2A 0.0285
118 Organic cation/carnitine transporter 2 SLC22A5 0.0284
136 Estrogen receptor ESR1 0.0284
766 Beta-2 adrenergic receptor ADRB2 0.0282
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0281
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0281
3947 Xanthine dehydrogenase/oxidase XDH 0.0277
3811 Cytochrome P450 19A1 CYP19A1 0.027
193 Beta-1 adrenergic receptor ADRB1 0.0253
556 Alpha-1A adrenergic receptor ADRA1A 0.0243
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0239
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0236
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0229
164 Histamine H4 receptor HRH4 0.0216
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0215
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0214
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0211
6142 Solute carrier family 22 member 8 SLC22A8 0.0211
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0208
1341 Histamine H3 receptor HRH3 0.0208
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0208
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0205
341 5-hydroxytryptamine 3 receptor HTR3A 0.02
723 Cytosolic phospholipase A2 PLA2G4A 0.0197
713 Sodium-dependent dopamine transporter SLC6A3 0.0197
590 5-hydroxytryptamine 2C receptor HTR2C 0.0197
318 Alpha-2A adrenergic receptor ADRA2A 0.0193
847 Mu-type opioid receptor OPRM1 0.0189
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0187
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0183
817 DNA topoisomerase 2-alpha TOP2A 0.018
6143 Solute carrier family 22 member 7 SLC22A7 0.0179
465 Calmodulin CALM1 0.0178
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0178
2164 Multidrug resistance-associated protein 4 ABCC4 0.0177
6148 Multidrug resistance-associated protein 7 ABCC10 0.0176
146 Androgen receptor AR 0.0168
124 Histamine H2 receptor HRH2 0.0167
320 5-hydroxytryptamine 1A receptor HTR1A 0.0167
696 Kappa-type opioid receptor OPRK1 0.0167
467 Delta-type opioid receptor OPRD1 0.0166
23 D(1A) dopamine receptor DRD1 0.0165
3941 Amine oxidase [flavin-containing] A MAOA 0.0164
4228 Keratin, type II cytoskeletal 7 KRT7 0.0164
632 Alpha-1B adrenergic receptor ADRA1B 0.016
891 Dihydropteroate synthase folP 0.0158
5359 Dihydropteroate synthase folP 0.0158
7175 Dihydropteroate synthase sulI 0.0158
6031 Cytochrome P450 3A43 CYP3A43 0.0152
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0152
833 Organic cation/carnitine transporter 1 SLC22A4 0.0145
6014 Cytochrome P450 2A13 CYP2A13 0.0142
380 Cytochrome P450 17A1 CYP17A1 0.014
80 Peroxisome proliferator-activated receptor alpha PPARA 0.014
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0139
6220 Aryl hydrocarbon receptor AHR 0.0139
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0139
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0137
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0136
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0136
871 Glucocorticoid receptor NR3C1 0.0135
844 Epidermal growth factor receptor EGFR 0.0133
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0132
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0132
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0129
1757 Myeloperoxidase MPO 0.0128
731 HIV-1 protease HIV-1 protease 0.0128
122 P2Y purinoceptor 12 P2RY12 0.0125
638 D(3) dopamine receptor DRD3 0.0124
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0122
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0122
1178 Adenosine A2a receptor ADORA2A 0.0121
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0121
1024 Solute carrier family 22 member 11 SLC22A11 0.012
777 Tumor necrosis factor TNF 0.012
6182 Cytochrome P450 2J2 CYP2J2 0.0119
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0118
4311 tRNA TRDMT1 0.0118
4325 tRNA trmD 0.0118
4328 tRNA trmD 0.0118
6141 Sodium/bile acid cotransporter SLC10A1 0.0116
48 Pyridoxal kinase PDXK 0.0116
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0114
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0114
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0114
16 Adenosine A1 receptor ADORA1 0.0113
504 Mast/stem cell growth factor receptor KIT 0.0112
3939 Amine oxidase [flavin-containing] B MAOB 0.0111
70 Type-1 angiotensin II receptor AGTR1 0.0111
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0109
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0108
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0108
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0108
1629 Transcription factor AP-1 JUN 0.0107
885 5-hydroxytryptamine 1B receptor HTR1B 0.0106
1010 Cytochrome P450 51A1 CYP51A1 0.0106
6137 Multidrug resistance-associated protein 6 ABCC6 0.0105
4120 NADPH--cytochrome P450 reductase POR 0.0104
260 Cytochrome P450 51 ERG11 0.0101
761 Cytochrome P450 51 ERG11 0.0101
3163 Cytochrome P450 51 cyp51 0.0101
373 Transthyretin TTR 0.01
629 Alpha-2B adrenergic receptor ADRA2B 0.0099
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0098
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0098
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0096
29 Tubulin beta-1 chain TUBB1 0.0095
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0092
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.009
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.009
2112 Toll-like receptor 9 TLR9 0.009
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0089
6102 Arylamine N-acetyltransferase 2 NAT2 0.0088
1998 Protein-L-isoaspartate(D-aspartate) O-methyltransferase PCMT1 0.0088
4330 Hypothetical protein TTHA0667 TTHA0667 0.0088
2551 Cobalt-precorrin-4 C(11)-methyltransferase cbiF 0.0088
3724 Protein methyltransferase hemK hemK 0.0088
4313 Probable tRNA/rRNA methyltransferase HI0766 trmL 0.0088
4316 Mycolic acid synthase pcaA 0.0088
4309 S-adenosyl-L-methionine-dependent methyltransferase mraW rsmH 0.0088
4333 Protein-L-isoaspartate O-methyltransferase pcm 0.0088
4323 Modification methylase HhaI hhaIM 0.0088
4324 Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 SETD7 0.0088
4315 DNA adenine methylase DAM 0.0088
4329 Uroporphyrinogen-III C-methyltransferase cobA 0.0088
4331 Chemotaxis protein methyltransferase cheR 0.0088
4314 Modification methylase PvuII pvuIIM 0.0088
432 D(4) dopamine receptor DRD4 0.0088
4116 Dihydropteroate synthetase Not Available 0.0087
1714 Mitogen-activated protein kinase 3 MAPK3 0.0086
869 Estrogen receptor beta ESR2 0.0086
378 Alpha-2C adrenergic receptor ADRA2C 0.0086
365 Dihydrofolate reductase DHFR 0.0085
2381 Dihydrofolate reductase DFR1 0.0085
2833 Dihydrofolate reductase Not Available 0.0085
2931 Dihydrofolate reductase folA 0.0085
3544 Dihydrofolate reductase folA 0.0085
3682 Dihydrofolate reductase folA 0.0085
6642 Dihydrofolate reductase folA 0.0085
6756 Dihydrofolate reductase dfrA 0.0085
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0085
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
5923 Microtubule-associated protein tau MAPT 0.0083
5924 Microtubule-associated protein 4 MAP4 0.0083
273 Apoptosis regulator Bcl-2 BCL2 0.0082
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0082
1517 Beta-3 adrenergic receptor ADRB3 0.0082
228 Beta platelet-derived growth factor receptor PDGFRB 0.0081
6146 High affinity copper uptake protein 1 SLC31A1 0.0081
789 Alpha-1D adrenergic receptor ADRA1D 0.0081
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.008
6136 Multidrug resistance-associated protein 5 ABCC5 0.0079
1569 G1/S-specific cyclin-D1 CCND1 0.0079
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0079
2499 Tubulin beta-2C chain TUBB2C 0.0079
2449 Tubulin alpha-3 chain TUBA1A 0.0078
436 5-hydroxytryptamine 2B receptor HTR2B 0.0078
94 5-hydroxytryptamine 4 receptor HTR4 0.0078
4604 Liver carboxylesterase 1 CES1 0.0078
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0078
6085 Fatty acid-binding protein, intestinal FABP2 0.0077
4318 Siroheme synthase cysG 0.0077
1852 Microtubule-associated protein 2 MAP2 0.0077
4332 Modification methylase TaqI taqIM 0.0077
4310 rRNA adenine N-6-methyltransferase ermC' 0.0077
3117 Carminomycin 4-O-methyltransferase dnrK 0.0077
4302 METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 mmaA2 0.0076
2242 Cyclopropane-fatty-acyl-phospholipid synthase 2 cmaA2 0.0076
4306 HemK protein TM_0488 0.0076
2297 Genome polyprotein Not Available 0.0076
2322 Genome polyprotein Not Available 0.0076
2694 Genome polyprotein Not Available 0.0076
2719 Genome polyprotein Not Available 0.0076
2860 Genome polyprotein Not Available 0.0076
2928 Genome polyprotein Not Available 0.0076
3160 Genome polyprotein Not Available 0.0076
3260 Genome polyprotein Not Available 0.0076
4783 Genome polyprotein Not Available 0.0076
5726 Genome polyprotein Not Available 0.0076
5779 Genome polyprotein Not Available 0.0076
5867 Genome polyprotein Not Available 0.0076
6253 Genome polyprotein Not Available 0.0076
6301 Genome polyprotein Not Available 0.0076
6380 Genome polyprotein Not Available 0.0076
6381 Genome polyprotein Not Available 0.0076
6437 Genome polyprotein Not Available 0.0076
6520 Genome polyprotein Not Available 0.0076
6521 Genome polyprotein Not Available 0.0076
6652 Genome polyprotein Not Available 0.0076
6734 Genome polyprotein Not Available 0.0076
6735 Genome polyprotein Not Available 0.0076
6736 Genome polyprotein Not Available 0.0076
6737 Genome polyprotein Not Available 0.0076
6738 Genome polyprotein Not Available 0.0076
6739 Genome polyprotein Not Available 0.0076
6744 Genome polyprotein Not Available 0.0076
6748 Genome polyprotein Not Available 0.0076
6894 Genome polyprotein Not Available 0.0076
6898 Genome polyprotein Not Available 0.0076
725 5-hydroxytryptamine 1D receptor HTR1D 0.0075
814 Ryanodine receptor 1 RYR1 0.0075
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0075
756 Sex hormone-binding globulin SHBG 0.0075
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0074
1192 Sulfotransferase 1A1 SULT1A1 0.0074
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0073
571 Melatonin receptor type 1A MTNR1A 0.0073
362 Melatonin receptor type 1B MTNR1B 0.0073
1176 Mitogen-activated protein kinase 1 MAPK1 0.0073
4122 Histone deacetylase 2 HDAC2 0.0072
613 Atrial natriuretic peptide receptor A NPR1 0.0072
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0071
84 Nuclear receptor 0B1 NR0B1 0.0071
2653 Modification methylase RsrI rsrIM 0.0071
4327 RdmB rdmB 0.007
614 Progesterone receptor PGR 0.007
3830 Calreticulin CALR 0.007
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.007
2236 Casein kinase II subunit alpha CSNK2A1 0.0069
3932 Glutathione S-transferase A2 GSTA2 0.0068
268 Adenosine A2b receptor ADORA2B 0.0067
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
737 Mineralocorticoid receptor NR3C2 0.0067
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0067
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0067
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0066
295 Carbonic anhydrase 1 CA1 0.0066
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0066
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0066
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0066
811 Translocator protein TSPO 0.0065
6034 Hydroxyindole O-methyltransferase ASMT 0.0065
6035 Nuclear receptor ROR-beta RORB 0.0065
6036 Eosinophil peroxidase EPX 0.0065
474 Acetylcholinesterase ACHE 0.0064
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0064
5934 Cytochrome P450 26A1 CYP26A1 0.0063
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0063
133 Dihydropterate synthase sulI 0.0063
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0062
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0061
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0061
476 RAC-alpha serine/threonine-protein kinase AKT1 0.006
411 Glycine N-methyltransferase GNMT 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
1541 Metalloproteinase mmp20 0.006
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0059
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0059
624 Guanidinoacetate N-methyltransferase GAMT 0.0059
1275 Estrogen sulfotransferase SULT1E1 0.0058
2557 Cap-specific mRNA PAPS 0.0058
790 DNA polymerase subunit alpha B POLA2 0.0058
3810 Catechol O-methyltransferase COMT 0.0057
765 Indoleamine 2,3-dioxygenase IDO1 0.0056
716 5-hydroxytryptamine 7 receptor HTR7 0.0056
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0056
1063 Signal transducer and activator of transcription 5B STAT5B 0.0056
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0056
771 Pyruvate carboxylase, mitochondrial PC 0.0056
820 Glycine receptor subunit alpha-2 GLRA2 0.0055
88 Retinoic acid receptor RXR-beta RXRB 0.0055
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0055
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0055
936 Ephrin type-A receptor 2 EPHA2 0.0055
469 Annexin A1 ANXA1 0.0054
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0054
163 D(1B) dopamine receptor DRD5 0.0053
974 Phenylethanolamine N-methyltransferase PNMT 0.0053
131 Synaptic vesicular amine transporter SLC18A2 0.0053
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0052
1050 Bile salt sulfotransferase SULT2A1 0.0052
407 Vascular endothelial growth factor receptor 2 KDR 0.0052
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
1256 5-hydroxytryptamine 6 receptor HTR6 0.0051
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0051
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0051
823 Fibroblast growth factor receptor 2 FGFR2 0.005
275 Arachidonate 5-lipoxygenase ALOX5 0.005
528 5-hydroxytryptamine 1E receptor HTR1E 0.005
592 Carbonic anhydrase 4 CA4 0.005
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.005
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0049
4192 DNA topoisomerase 2-beta TOP2B 0.0049
208 DNA-directed RNA polymerase beta' chain rpoC 0.0049
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0049
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0049
908 Glutathione S-transferase theta-1 GSTT1 0.0049
3923 Cholinesterase BCHE 0.0049
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0049
24 Thymidylate synthase TMP1 0.0048
359 Thymidylate synthase TYMS 0.0048
2626 Thymidylate synthase thyA 0.0048
2729 Thymidylate synthase thyA 0.0048
5352 Thymidylate synthase THYA 0.0048
7 Nitric oxide synthase, inducible NOS2 0.0048
952 Dipeptidyl peptidase 4 DPP4 0.0048
738 Monocarboxylate transporter 1 SLC16A1 0.0048
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0048
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0048
3937 Fatty-acid amide hydrolase FAAH 0.0047
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0047
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0047
6163 Copper-transporting ATPase 2 ATP7B 0.0047
6165 Copper-transporting ATPase 1 ATP7A 0.0047
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0046
33 Cystine/glutamate transporter SLC7A11 0.0045
581 Cytochrome P450 2R1 CYP2R1 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0045
484 Tyrosine-protein kinase ABL2 ABL2 0.0045
921 Glutamate receptor 2 GRIA2 0.0045
482 Glycine receptor subunit alpha-1 GLRA1 0.0044
6126 Carbonic anhydrase 7 CA7 0.0044
1820 Beta-nerve growth factor NGF 0.0044
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0044
49 Endothelin B receptor EDNRB 0.0044
3957 Adenosine deaminase ADA 0.0043
634 Squalene monooxygenase SQLE 0.0043
7196 Squalene monooxygenase ERG1 0.0043
904 Glutathione S-transferase P GSTP1 0.0043
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0043
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0043
161 Tubulin beta chain TUBB 0.0043
312 Tubulin beta chain TUB2 0.0043
1992 Vitamin D-binding protein GC 0.0042
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0042
183 Vascular endothelial growth factor A VEGFA 0.0042
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0041
427 Substance-P receptor TACR1 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0041
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0041
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0041
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.004
976 Platelet glycoprotein IX GP9 0.004
6766 O-GlcNAcase BT_4395 BT_4395 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
4103 Proteasome subunit beta type 2 PSMB2 0.0039
162 Retinoic acid receptor gamma-1 RARG 0.0039
4102 Proteasome subunit beta type 5 PSMB5 0.0039
4101 Proteasome subunit beta type 1 PSMB1 0.0039
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0039
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0038
518 Peroxidase/catalase T katG 0.0038
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0038
780 Retinoic acid receptor RXR-gamma RXRG 0.0037
1648 Elastin ELN 0.0037
896 Glutathione S-transferase Mu 1 GSTM1 0.0037
106 Cannabinoid receptor 2 CNR2 0.0037
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0037
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0037
26 Vascular endothelial growth factor receptor 3 FLT4 0.0037
357 Carbonic anhydrase 2 CA2 0.0037
130 Prostacyclin synthase PTGIS 0.0037
569 Retinal dehydrogenase 2 ALDH1A2 0.0036
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
3086 Plasmepsin-2 Not Available 0.0036
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0036
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0035
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
32 Vascular endothelial growth factor receptor 1 FLT1 0.0035
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0035
1656 CYP2B protein CYP2B 0.0035
174 Sigma 1-type opioid receptor SIGMAR1 0.0035
68 Cannabinoid receptor 1 CNR1 0.0035
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0034
611 Retinal dehydrogenase 1 ALDH1A1 0.0034
3809 Estrogen-related receptor gamma ESRRG 0.0034
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0034
6506 Stathmin-4 STMN4 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0033
173 Toll-like receptor 7 TLR7 0.0033
5880 Thrombopoietin receptor MPL 0.0033
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0033
54 Prothrombin F2 0.0033
856 Vitamin D3 receptor VDR 0.0032
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0031
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0031
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
6103 Arylamine N-acetyltransferase 1 NAT1 0.003
1374 Natriuretic peptides B NPPB 0.003
1827 Gap junction alpha-1 protein GJA1 0.003
1908 Vascular cell adhesion protein 1 VCAM1 0.003
3856 Fibroblast growth factor receptor 3 FGFR3 0.003
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0028
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0028
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0028
719 Retinoic acid receptor responder protein 1 RARRES1 0.0028
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0028
770 Retinoic acid-induced protein 3 GPRC5A 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
6043 Putative G-protein coupled receptor 44 GPR44 0.0028
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0028
1618 High affinity nerve growth factor receptor NTRK1 0.0028
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0028
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0027
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0027
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0027
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0027
2981 Phospholipase A2, membrane associated PLA2G2A 0.0027
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0027
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0027
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0026
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0026
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0026
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0026
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0026
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0026
751 Potassium channel subfamily K member 6 KCNK6 0.0026
6168 Solute carrier family 22 member 16 SLC22A16 0.0026
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0026
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0026
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0026
6174 50S ribosomal protein L32 rpmF 0.0025
4238 50S ribosomal protein L4 rplD 0.0025
5578 50S ribosomal protein L4 rplD 0.0025
6173 50S ribosomal protein L4 rplD 0.0025
6219 50S ribosomal protein L4 rplD 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0025
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0025
1196 Complement decay-accelerating factor CD55 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
267 Plasminogen activator inhibitor 1 SERPINE1 0.0025
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0025
165 FL cytokine receptor FLT3 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
153 Dopamine beta-hydroxylase DBH 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0024
6138 Multidrug resistance protein 3 ABCB4 0.0024
5300 Antigen peptide transporter 1 TAP1 0.0024
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0024
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0024
172 Potassium channel subfamily K member 1 KCNK1 0.0024
229 Retinoic acid receptor beta RARB 0.0024
6020 Aldehyde oxidase AOX1 0.0023
730 Retinoic acid receptor alpha RARA 0.0023
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
1630 Integrin beta-2 ITGB2 0.0023
239 Coagulation factor X F10 0.0023
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0022
6221 Steroid hormone receptor ERR1 ESRRA 0.0022
2808 Chloramphenicol acetyltransferase 3 cat3 0.0022
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0022
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0021
1262 Corticotropin-lipotropin POMC 0.0021
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0021
251 Alcohol dehydrogenase 1A ADH1A 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
5787 Angiopoietin-1 receptor TEK 0.002
291 Nitric-oxide synthase, endothelial NOS3 0.002
3808 Dihydropteroate synthase 2 folP2 0.002
3601 Dihydropteroate synthase 1 folP1 0.002
3807 Dihydropteroate synthase 1 folP1 0.002
3917 Methylenetetrahydrofolate reductase MTHFR 0.002
6048 Troponin C, skeletal muscle TNNC2 0.002
2810 Dr hemagglutinin structural subunit draA 0.002
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.002
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.002
563 Thyroid peroxidase TPO 0.0019
6044 Serum paraoxonase/lactonase 3 PON3 0.0019
444 Alcohol dehydrogenase 1B ADH1B 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0018
76 Nitric-oxide synthase, brain NOS1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0018
572 Integrin alpha-L ITGAL 0.0017
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0017
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0017
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
400 Coagulation factor IX F9 0.0017
5461 Coagulation factor IX F9 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
6149 Solute carrier family 22 member 10 SLC22A10 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
477 DNA topoisomerase 4 subunit A parC 0.0016
886 DNA topoisomerase 4 subunit A parC 0.0016
6226 DNA topoisomerase 4 subunit A parC 0.0016
404 DNA gyrase subunit A gyrA 0.0016
6224 DNA gyrase subunit A gyrA 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
4217 Telomerase reverse transcriptase TERT 0.0016
822 Aldose reductase AKR1B1 0.0016
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
2216 Fibroblast growth factor receptor 4 FGFR4 0.0015
758 Thyroid hormone receptor alpha THRA 0.0015
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0015
604 Vitamin K-dependent protein Z PROZ 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4773 Deoxycytidine kinase DCK 0.0014
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0014
2539 Tubulin alpha-1 chain TUBA4A 0.0014
422 Vitamin K-dependent protein C PROC 0.0014
1245 Vitamin K-dependent protein S PROS1 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
2207 Rhodopsin RHO 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
2232 Interleukin-5 IL5 0.0014
1291 cAMP response element-binding protein CREB1 0.0014
1593 Mucin-2 MUC2 0.0014
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0013
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0013
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0013
2021 Thrombomodulin THBD 0.0013
3404 Exotoxin A eta 0.0013
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
4210 Toll-like receptor 4 TLR4 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0013
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0013
489 Monocarboxylate transporter 2 SLC16A7 0.0013
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0013
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
5798 Mitogen-activated protein kinase 11 MAPK11 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0012
2320 Thymidine kinase, cytosolic TK1 0.0012
511 5-hydroxytryptamine 1F receptor HTR1F 0.0012
6432 Transporter snf 0.0012
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
997 Protein kinase C beta type PRKCB 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
705 Glutamate receptor 1 GRIA1 0.0012
6824 Tyrosine-protein kinase Lyn LYN 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0011
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
798 Osteocalcin BGLAP 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
6218 Pannexin-1 PANX1 0.0011
760 Fibroblast growth factor 1 FGF1 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
3913 Glutamic acid decarboxylase GAD65 0.0011
3007 Carbonic anhydrase 12 CA12 0.0011
4205 Carbonic anhydrase 9 CA9 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
1039 Histone deacetylase 9 HDAC9 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
1483 Membrane copper amine oxidase AOC3 0.001
369 Coagulation factor VII F7 0.001
283 SEC14-like protein 2 SEC14L2 0.001
345 Plasma retinol-binding protein RBP4 0.001
144 Hemoglobin subunit alpha HBA1 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
1864 RET proto-oncogene RET 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.001
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.001
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0009
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
735 Alanine aminotransferase 1 GPT 0.0009
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0009
3904 Alanine aminotransferase 2 GPT2 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4948 Cytochrome c-553 Not Available 0.0009
4923 Cytochrome c3 DvMF_2499 0.0009
4945 Cytochrome c3 Not Available 0.0009
4949 Cytochrome c3 DVU_3171 0.0009
4968 Cytochrome c3 cytc3 0.0009
4997 Cytochrome c3 SO_2727 0.0009
5219 Cytochrome c3 cyd 0.0009
4902 Nine-heme cytochrome c Ddes_2038 0.0009
3189 High-molecular-weight cytochrome c hmcA 0.0009
6677 Myelin P2 protein PMP2 0.0009
284 DNA-directed RNA polymerase beta chain rpoB 0.0008
5773 DNA-directed RNA polymerase beta chain rpoB 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
3221 Cytochrome c4 cc4 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
1507 Cytochrome c CYCS 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
828 Phenylalanine-4-hydroxylase PAH 0.0006
3109 Phenylalanine-4-hydroxylase phhA 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0005
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4916 Cyanoglobin glbN 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4943 Cytochrome c6 petJ 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4984 Neuroglobin NGB 0.0004
4909 CooA protein cooA 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4961 Hemophore HasA hasA 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4910 Cytoglobin CYGB 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
3116 Bacterioferritin bfr 0.0004
4906 Bacterioferritin bfr 0.0004
4965 Bacterioferritin bfr 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4972 P450cin cinA 0.0004
3093 Catalase HPII katE 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4952 Catalase/peroxidase katA 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
1313 Lactoylglutathione lyase GLO1 0.0003
4920 Peroxidase/catalase katG 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
2298 Cytochrome P450-cam camC 0.0002
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