DT-Web

DB00428 - Streptozocin


Identification
Name Streptozocin
Accession Number DB00428 (APRD00209)
Type small molecule
Description An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 265.2206
Groups approved
Monoisotopic Weight 265.090999849
Pharmacology
Indication For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).
Mechanism of action Although its mechanism of action is not completely clear, streptozocin is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Its cytotoxic action is probably due to cross-linking of strands of DNA, resulting in inhibition of DNA synthesis.
Absorption Poor oral absorption (17-25%)
Protein binding Not Available
Biotransformation Primarily hepatic
Route of elimination As much as 20% of the drug (or metabolites containing an N-nitrosourea group) is metabolized and/or excreted by the kidney.
Toxicity Symptoms of overdose include nausea and vomiting, anorexia, myelosuppression; and nephrotoxicity.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Bendamustine Increases toxicity through pharmacodynamic synergism. Additive myelosuppression.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions cross-linking/alkylation
References
  • Bennett RA, Pegg AE: Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90. - Pubmed
DTHybrid score Not Available
Solute carrier family 2, facilitated glucose transporter member 2
Name Solute carrier family 2, facilitated glucose transporter member 2
Gene Name SLC2A2
Pharmacological action unknown
Actions ligand
References
  • Wang Z, Gleichmann H: GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice. Diabetes. 1998 Jan;47(1):50-6. - Pubmed
  • Schnedl WJ, Ferber S, Johnson JH, Newgard CB: STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes. 1994 Nov;43(11):1326-33. - Pubmed
DTHybrid score 0.4428
O-GlcNAcase BT_4395
Name O-GlcNAcase BT_4395
Gene Name BT_4395
Pharmacological action yes
Actions antagonist
References
  • He Y, Martinez-Fleites C, Bubb A, Gloster TM, Davies GJ: Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase. Carbohydr Res. 2009 Mar 31;344(5):627-31. doi: 10.1016/j.carres.2008.12.007. Epub 2008 Dec 13. - Pubmed
DTHybrid score 1.1981

Enzymes


Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inducer
References
  • Choi YH, Lee AK, Bae SK, Kim SO, Lee MG: Pharmacokinetics of 5-fluorouracil in rats with diabetes mellitus induced by streptozotocin. Biopharm Drug Dispos. 2005 Apr;26(3):93-8. - Pubmed
DTHybrid score 0.3323
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inducer
References
  • Choi YH, Lee AK, Bae SK, Kim SO, Lee MG: Pharmacokinetics of 5-fluorouracil in rats with diabetes mellitus induced by streptozotocin. Biopharm Drug Dispos. 2005 Apr;26(3):93-8. - Pubmed
DTHybrid score 0.4313
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inducer
References
  • Kataoka S, Yasui H, Hiromura M, Sakurai H: Effect of insulin-mimetic vanadyl sulfate on cytochrome P450 2E1-dependent p-nitrophenol hydroxylation in the liver microsomes of streptozotocin-induced type 1 diabetic rats. Life Sci. 2005 Oct 14;77(22):2814-29. - Pubmed
DTHybrid score 0.3297

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inducer
References
  • Brady JM, Cherrington NJ, Hartley DP, Buist SC, Li N, Klaassen CD: Tissue distribution and chemical induction of multiple drug resistance genes in rats. Drug Metab Dispos. 2002 Jul;30(7):838-44. - Pubmed
DTHybrid score 0.363

Predictions


Id Partner name Gene Name Score
6371 Beta-hexosaminidase nagZ 0.2786
4512 Cytochrome P450 3A4 CYP3A4 0.243
4119 Cytochrome P450 2D6 CYP2D6 0.1625
4757 Cytochrome P450 2C9 CYP2C9 0.1437
6016 Cytochrome P450 2C19 CYP2C19 0.1375
4924 Cytochrome P450 2C8 CYP2C8 0.1074
4118 Cytochrome P450 3A5 CYP3A5 0.102
6030 Cytochrome P450 2B6 CYP2B6 0.0917
5718 Cytochrome P450 2A6 CYP2A6 0.0764
6107 Cytochrome P450 3A7 CYP3A7 0.0684
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0635
1898 Cytochrome P450 1B1 CYP1B1 0.0465
587 Serum albumin ALB 0.0435
20 Prostaglandin G/H synthase 1 PTGS1 0.0367
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0361
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0312
862 Multidrug resistance-associated protein 1 ABCC1 0.0309
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0303
492 Histamine H1 receptor HRH1 0.03
3811 Cytochrome P450 19A1 CYP19A1 0.0291
6145 Solute carrier family 22 member 1 SLC22A1 0.0287
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0284
1729 Solute carrier family 22 member 6 SLC22A6 0.0278
556 Alpha-1A adrenergic receptor ADRA1A 0.0276
36 Insulin receptor INSR 0.0258
831 D(2) dopamine receptor DRD2 0.0258
824 Sodium-dependent serotonin transporter SLC6A4 0.0252
290 Prostaglandin G/H synthase 2 PTGS2 0.025
6144 Solute carrier family 22 member 2 SLC22A2 0.0248
776 Bile salt export pump ABCB11 0.0246
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0245
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0238
502 5-hydroxytryptamine 2A receptor HTR2A 0.0237
6106 Cytochrome P450 2C18 CYP2C18 0.0236
318 Alpha-2A adrenergic receptor ADRA2A 0.0234
193 Beta-1 adrenergic receptor ADRB1 0.0233
136 Estrogen receptor ESR1 0.0226
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0215
468 Cytochrome P450 4A11 CYP4A11 0.0212
817 DNA topoisomerase 2-alpha TOP2A 0.0209
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0204
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0196
23 D(1A) dopamine receptor DRD1 0.0194
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0194
3941 Amine oxidase [flavin-containing] A MAOA 0.0194
777 Tumor necrosis factor TNF 0.0189
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0187
118 Organic cation/carnitine transporter 2 SLC22A5 0.0187
766 Beta-2 adrenergic receptor ADRB2 0.0183
477 DNA topoisomerase 4 subunit A parC 0.0179
886 DNA topoisomerase 4 subunit A parC 0.0179
6226 DNA topoisomerase 4 subunit A parC 0.0179
404 DNA gyrase subunit A gyrA 0.0176
6224 DNA gyrase subunit A gyrA 0.0176
871 Glucocorticoid receptor NR3C1 0.0175
465 Calmodulin CALM1 0.0174
885 5-hydroxytryptamine 1B receptor HTR1B 0.0167
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0166
16 Adenosine A1 receptor ADORA1 0.0165
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0164
590 5-hydroxytryptamine 2C receptor HTR2C 0.0164
632 Alpha-1B adrenergic receptor ADRA1B 0.0163
260 Cytochrome P450 51 ERG11 0.0162
761 Cytochrome P450 51 ERG11 0.0162
3163 Cytochrome P450 51 cyp51 0.0162
6147 Solute carrier family 22 member 3 SLC22A3 0.0161
613 Atrial natriuretic peptide receptor A NPR1 0.0161
320 5-hydroxytryptamine 1A receptor HTR1A 0.016
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0148
3923 Cholinesterase BCHE 0.0146
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0144
6142 Solute carrier family 22 member 8 SLC22A8 0.0144
6014 Cytochrome P450 2A13 CYP2A13 0.0144
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0143
341 5-hydroxytryptamine 3 receptor HTR3A 0.0143
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0142
3939 Amine oxidase [flavin-containing] B MAOB 0.0139
1178 Adenosine A2a receptor ADORA2A 0.0139
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0139
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0138
789 Alpha-1D adrenergic receptor ADRA1D 0.0137
833 Organic cation/carnitine transporter 1 SLC22A4 0.0137
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0136
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0135
725 5-hydroxytryptamine 1D receptor HTR1D 0.0134
790 DNA polymerase subunit alpha B POLA2 0.0129
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0129
6143 Solute carrier family 22 member 7 SLC22A7 0.0128
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0128
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0127
2164 Multidrug resistance-associated protein 4 ABCC4 0.0126
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0126
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0125
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0125
2499 Tubulin beta-2C chain TUBB2C 0.0125
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0123
638 D(3) dopamine receptor DRD3 0.0123
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
2449 Tubulin alpha-3 chain TUBA1A 0.0121
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.012
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.012
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0119
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0116
48 Pyridoxal kinase PDXK 0.0116
629 Alpha-2B adrenergic receptor ADRA2B 0.0115
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0113
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0111
6148 Multidrug resistance-associated protein 7 ABCC10 0.0109
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0108
3947 Xanthine dehydrogenase/oxidase XDH 0.0108
1517 Beta-3 adrenergic receptor ADRB3 0.0106
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0104
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0104
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0104
1192 Sulfotransferase 1A1 SULT1A1 0.0103
6220 Aryl hydrocarbon receptor AHR 0.0103
378 Alpha-2C adrenergic receptor ADRA2C 0.0102
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0102
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0101
1757 Myeloperoxidase MPO 0.0098
1010 Cytochrome P450 51A1 CYP51A1 0.0098
844 Epidermal growth factor receptor EGFR 0.0097
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0097
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
4604 Liver carboxylesterase 1 CES1 0.0096
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0094
713 Sodium-dependent dopamine transporter SLC6A3 0.0093
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.009
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0089
482 Glycine receptor subunit alpha-1 GLRA1 0.0089
6031 Cytochrome P450 3A43 CYP3A43 0.0089
869 Estrogen receptor beta ESR2 0.0088
122 P2Y purinoceptor 12 P2RY12 0.0088
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0087
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0086
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0086
4122 Histone deacetylase 2 HDAC2 0.0082
436 5-hydroxytryptamine 2B receptor HTR2B 0.0081
6141 Sodium/bile acid cotransporter SLC10A1 0.008
731 HIV-1 protease HIV-1 protease 0.008
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0078
6182 Cytochrome P450 2J2 CYP2J2 0.0077
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0075
3932 Glutathione S-transferase A2 GSTA2 0.0075
1024 Solute carrier family 22 member 11 SLC22A11 0.0075
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0075
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0074
373 Transthyretin TTR 0.0073
6137 Multidrug resistance-associated protein 6 ABCC6 0.0072
432 D(4) dopamine receptor DRD4 0.0072
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0072
6102 Arylamine N-acetyltransferase 2 NAT2 0.0072
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
847 Mu-type opioid receptor OPRM1 0.0071
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.007
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.007
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0069
124 Histamine H2 receptor HRH2 0.0069
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0068
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0067
820 Glycine receptor subunit alpha-2 GLRA2 0.0067
444 Alcohol dehydrogenase 1B ADH1B 0.0066
6136 Multidrug resistance-associated protein 5 ABCC5 0.0066
571 Melatonin receptor type 1A MTNR1A 0.0066
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0066
362 Melatonin receptor type 1B MTNR1B 0.0066
537 ATP synthase delta chain, mitochondrial ATP5D 0.0066
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0065
504 Mast/stem cell growth factor receptor KIT 0.0065
380 Cytochrome P450 17A1 CYP17A1 0.0064
1820 Beta-nerve growth factor NGF 0.0064
4228 Keratin, type II cytoskeletal 7 KRT7 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
705 Glutamate receptor 1 GRIA1 0.0063
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0063
251 Alcohol dehydrogenase 1A ADH1A 0.0063
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0062
33 Cystine/glutamate transporter SLC7A11 0.0061
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0061
1714 Mitogen-activated protein kinase 3 MAPK3 0.0059
4120 NADPH--cytochrome P450 reductase POR 0.0059
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0059
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0058
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0058
228 Beta platelet-derived growth factor receptor PDGFRB 0.0058
467 Delta-type opioid receptor OPRD1 0.0058
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0058
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0057
716 5-hydroxytryptamine 7 receptor HTR7 0.0057
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0057
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0057
818 50S ribosomal protein L10 rplJ 0.0057
94 5-hydroxytryptamine 4 receptor HTR4 0.0057
904 Glutathione S-transferase P GSTP1 0.0056
146 Androgen receptor AR 0.0056
756 Sex hormone-binding globulin SHBG 0.0056
823 Fibroblast growth factor receptor 2 FGFR2 0.0056
696 Kappa-type opioid receptor OPRK1 0.0056
474 Acetylcholinesterase ACHE 0.0055
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0055
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0055
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0055
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0055
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0055
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0054
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0053
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0053
161 Tubulin beta chain TUBB 0.0053
312 Tubulin beta chain TUB2 0.0053
6146 High affinity copper uptake protein 1 SLC31A1 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
511 5-hydroxytryptamine 1F receptor HTR1F 0.0052
614 Progesterone receptor PGR 0.0052
811 Translocator protein TSPO 0.0051
26 Vascular endothelial growth factor receptor 3 FLT4 0.0051
4311 tRNA TRDMT1 0.0051
4325 tRNA trmD 0.0051
4328 tRNA trmD 0.0051
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.005
517 Alcohol dehydrogenase 1C ADH1C 0.005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0049
32 Vascular endothelial growth factor receptor 1 FLT1 0.0049
3957 Adenosine deaminase ADA 0.0049
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0049
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0049
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0049
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0049
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0049
273 Apoptosis regulator Bcl-2 BCL2 0.0048
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0047
4103 Proteasome subunit beta type 2 PSMB2 0.0047
4102 Proteasome subunit beta type 5 PSMB5 0.0047
461 Glycine receptor subunit alpha-3 GLRA3 0.0047
4101 Proteasome subunit beta type 1 PSMB1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
908 Glutathione S-transferase theta-1 GSTT1 0.0046
6138 Multidrug resistance protein 3 ABCB4 0.0046
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0046
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0046
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0046
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0045
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0045
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0045
1629 Transcription factor AP-1 JUN 0.0045
976 Platelet glycoprotein IX GP9 0.0044
390 Adenosine A3 receptor ADORA3 0.0044
4203 Histamine N-methyltransferase HNMT 0.0044
1176 Mitogen-activated protein kinase 1 MAPK1 0.0044
1374 Natriuretic peptides B NPPB 0.0044
1827 Gap junction alpha-1 protein GJA1 0.0044
1908 Vascular cell adhesion protein 1 VCAM1 0.0044
70 Type-1 angiotensin II receptor AGTR1 0.0043
3810 Catechol O-methyltransferase COMT 0.0043
407 Vascular endothelial growth factor receptor 2 KDR 0.0043
239 Coagulation factor X F10 0.0043
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
4192 DNA topoisomerase 2-beta TOP2B 0.0042
814 Ryanodine receptor 1 RYR1 0.0042
1256 5-hydroxytryptamine 6 receptor HTR6 0.0042
921 Glutamate receptor 2 GRIA2 0.0042
2236 Casein kinase II subunit alpha CSNK2A1 0.0041
295 Carbonic anhydrase 1 CA1 0.0041
163 D(1B) dopamine receptor DRD5 0.0041
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0041
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0041
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0041
2112 Toll-like receptor 9 TLR9 0.0041
3917 Methylenetetrahydrofolate reductase MTHFR 0.0041
4238 50S ribosomal protein L4 rplD 0.004
5578 50S ribosomal protein L4 rplD 0.004
6173 50S ribosomal protein L4 rplD 0.004
6219 50S ribosomal protein L4 rplD 0.004
29 Tubulin beta-1 chain TUBB1 0.004
737 Mineralocorticoid receptor NR3C2 0.0039
3823 Cytokine receptor common gamma chain IL2RG 0.0039
6432 Transporter snf 0.0039
6043 Putative G-protein coupled receptor 44 GPR44 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
117 Sterol O-acyltransferase 1 SOAT1 0.0038
6020 Aldehyde oxidase AOX1 0.0038
319 Opioid receptor, sigma 1 OPRS1 0.0038
400 Coagulation factor IX F9 0.0037
5461 Coagulation factor IX F9 0.0037
4237 50S ribosomal protein L22 rplV 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0037
365 Dihydrofolate reductase DHFR 0.0037
2381 Dihydrofolate reductase DFR1 0.0037
2833 Dihydrofolate reductase Not Available 0.0037
2931 Dihydrofolate reductase folA 0.0037
3544 Dihydrofolate reductase folA 0.0037
3682 Dihydrofolate reductase folA 0.0037
6642 Dihydrofolate reductase folA 0.0037
6756 Dihydrofolate reductase dfrA 0.0037
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0037
106 Cannabinoid receptor 2 CNR2 0.0037
952 Dipeptidyl peptidase 4 DPP4 0.0037
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0037
1656 CYP2B protein CYP2B 0.0037
3937 Fatty-acid amide hydrolase FAAH 0.0035
6126 Carbonic anhydrase 7 CA7 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0034
68 Cannabinoid receptor 1 CNR1 0.0034
604 Vitamin K-dependent protein Z PROZ 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
712 Tubulin alpha chain TUB1 0.0034
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0034
153 Dopamine beta-hydroxylase DBH 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0034
183 Vascular endothelial growth factor A VEGFA 0.0034
4116 Dihydropteroate synthetase Not Available 0.0033
84 Nuclear receptor 0B1 NR0B1 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0033
6044 Serum paraoxonase/lactonase 3 PON3 0.0033
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0033
1569 G1/S-specific cyclin-D1 CCND1 0.0032
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0032
518 Peroxidase/catalase T katG 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
6163 Copper-transporting ATPase 2 ATP7B 0.0032
6165 Copper-transporting ATPase 1 ATP7A 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
268 Adenosine A2b receptor ADORA2B 0.0031
422 Vitamin K-dependent protein C PROC 0.0031
1245 Vitamin K-dependent protein S PROS1 0.0031
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0031
65 Matrix metalloproteinase-9 Not Available 0.0031
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0031
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0031
275 Arachidonate 5-lipoxygenase ALOX5 0.0031
5934 Cytochrome P450 26A1 CYP26A1 0.0031
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0031
1275 Estrogen sulfotransferase SULT1E1 0.0031
634 Squalene monooxygenase SQLE 0.0031
7196 Squalene monooxygenase ERG1 0.0031
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0031
528 5-hydroxytryptamine 1E receptor HTR1E 0.0031
3809 Estrogen-related receptor gamma ESRRG 0.003
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.003
1063 Signal transducer and activator of transcription 5B STAT5B 0.003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.003
563 Thyroid peroxidase TPO 0.003
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.003
173 Toll-like receptor 7 TLR7 0.003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.003
1050 Bile salt sulfotransferase SULT2A1 0.0029
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0029
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0029
6085 Fatty acid-binding protein, intestinal FABP2 0.0029
936 Ephrin type-A receptor 2 EPHA2 0.0029
284 DNA-directed RNA polymerase beta chain rpoB 0.0029
5773 DNA-directed RNA polymerase beta chain rpoB 0.0029
751 Potassium channel subfamily K member 6 KCNK6 0.0029
723 Cytosolic phospholipase A2 PLA2G4A 0.0029
683 Potassium transporter GK0582 0.0029
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
592 Carbonic anhydrase 4 CA4 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0028
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0028
780 Retinoic acid receptor RXR-gamma RXRG 0.0028
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0028
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0028
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0027
484 Tyrosine-protein kinase ABL2 ABL2 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
3404 Exotoxin A eta 0.0027
469 Annexin A1 ANXA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
3830 Calreticulin CALR 0.0027
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0027
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0026
172 Potassium channel subfamily K member 1 KCNK1 0.0026
427 Substance-P receptor TACR1 0.0026
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
2408 Tyrosine-protein kinase SYK SYK 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
896 Glutathione S-transferase Mu 1 GSTM1 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
6859 Protein S100-A4 S100A4 0.0025
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0025
738 Monocarboxylate transporter 1 SLC16A1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
798 Osteocalcin BGLAP 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6034 Hydroxyindole O-methyltransferase ASMT 0.0025
6035 Nuclear receptor ROR-beta RORB 0.0025
6036 Eosinophil peroxidase EPX 0.0025
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0025
88 Retinoic acid receptor RXR-beta RXRB 0.0025
24 Thymidylate synthase TMP1 0.0025
359 Thymidylate synthase TYMS 0.0025
2626 Thymidylate synthase thyA 0.0025
2729 Thymidylate synthase thyA 0.0025
5352 Thymidylate synthase THYA 0.0025
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0025
162 Retinoic acid receptor gamma-1 RARG 0.0025
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0025
1618 High affinity nerve growth factor receptor NTRK1 0.0024
185 Vasopressin V1a receptor AVPR1A 0.0024
7 Nitric oxide synthase, inducible NOS2 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0024
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0024
6070 Nischarin NISCH 0.0024
473 L-lactate dehydrogenase A chain LDHA 0.0024
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0023
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
369 Coagulation factor VII F7 0.0023
822 Aldose reductase AKR1B1 0.0023
54 Prothrombin F2 0.0023
358 Cystathionine beta-synthase CBS 0.0023
611 Retinal dehydrogenase 1 ALDH1A1 0.0022
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0022
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
765 Indoleamine 2,3-dioxygenase IDO1 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2290 ADP-ribosyl cyclase 2 BST1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
997 Protein kinase C beta type PRKCB 0.0021
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0021
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
6167 Organic solute transporter subunit beta OSTB 0.0021
6166 Organic solute transporter subunit alpha OSTA 0.0021
357 Carbonic anhydrase 2 CA2 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.002
2981 Phospholipase A2, membrane associated PLA2G2A 0.002
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.002
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.002
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.002
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.002
2298 Cytochrome P450-cam camC 0.002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.002
3856 Fibroblast growth factor receptor 3 FGFR3 0.002
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.002
293 Gamma-glutamyl hydrolase GGH 0.002
1970 Protein kinase C alpha type PRKCA 0.002
3007 Carbonic anhydrase 12 CA12 0.002
4205 Carbonic anhydrase 9 CA9 0.002
606 Cytochrome P450 27, mitochondrial CYP27A1 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
6459 Glycodelin PAEP 0.0019
165 FL cytokine receptor FLT3 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0019
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0019
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0019
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0019
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0019
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0019
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0019
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0019
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0019
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0019
5626 Nucleoside diphosphate kinase B NME2 0.0018
1992 Vitamin D-binding protein GC 0.0018
1650 Heme carrier protein 1 SLC46A1 0.0018
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
174 Sigma 1-type opioid receptor SIGMAR1 0.0017
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0017
229 Retinoic acid receptor beta RARB 0.0017
164 Histamine H4 receptor HRH4 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
1648 Elastin ELN 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
1830 5'-nucleotidase NT5E 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
1243 Cathepsin D CTSD 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
3601 Dihydropteroate synthase 1 folP1 0.0016
3807 Dihydropteroate synthase 1 folP1 0.0016
3808 Dihydropteroate synthase 2 folP2 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0015
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
3913 Glutamic acid decarboxylase GAD65 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
2091 Endoplasmin HSP90B1 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0014
1483 Membrane copper amine oxidase AOC3 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
3221 Cytochrome c4 cc4 0.0013
856 Vitamin D3 receptor VDR 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
4773 Deoxycytidine kinase DCK 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2207 Rhodopsin RHO 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
2802 Endoglucanase G celCCG 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
131 Synaptic vesicular amine transporter SLC18A2 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
1864 RET proto-oncogene RET 0.001
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.001
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.001
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.001
6174 50S ribosomal protein L32 rpmF 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
345 Plasma retinol-binding protein RBP4 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
760 Fibroblast growth factor 1 FGF1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
5787 Angiopoietin-1 receptor TEK 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
4226 Uridine phosphorylase 2 UPP2 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
3587 Gastrotropin FABP6 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
1630 Integrin beta-2 ITGB2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2021 Thrombomodulin THBD 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
572 Integrin alpha-L ITGAL 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
6218 Pannexin-1 PANX1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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