DT-Web: DB00851

Identification

Name

Dacarbazine

Accession Number

DB00851 (APRD00331)

Type

small molecule

Description

An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

182.1832

Groups

approved

Monoisotopic Weight

182.091608972

Pharmacology

Indication

For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents.

Mechanism of action

The mechanism of action is not known, but appears to exert cytotoxic effects via its action as an alkylating agent. Other theories include DNA synthesis inhibition by its action as a purine analog, and interaction with SH groups. Dacarbazine is not cell cycle-phase specific.

Absorption

Erratic, slow and incomplete

Protein binding

Less than 5%

Biotransformation

Hepatic

Route of elimination

Dacarbazine is subject to renal tubular secretion rather than glomerular filtration. In man, dacarbazine is extensively degraded. Besides unchanged dacarbazine, 5-aminoimidazole -4 carboxamide (AIC) is a major metabolite of dacarbazine excreted in the urine.

Toxicity

LD₅₀=350mg/kg (orally in mice)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Bendamustine	Increases toxicity through pharmacodynamic synergism. Additive myelosuppression.
Thiabendazole	The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Dacarbazine by decreasing Dacarbazine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Dacarbazine if Thiabendazole is initiated, discontinued or dose changed.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.

Food Interactions

Not Available

DNA
Name	DNA
Gene Name	Not Available
Pharmacological action	yes
Actions	cross-linking/alkylation
References	Lonn U, Lohn S: Prevention of dacarbazine damage of human neoplastic cell DNA by aphidicolin. Cancer Res. 1987 Jan 1;47(1):26-30. - Pubmed
DTHybrid score	Not Available
DNA polymerase subunit alpha B
Name	DNA polymerase subunit alpha B
Gene Name	POLA2
Pharmacological action	unknown
Actions	other/unknown
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Lonn U, Lohn S: Prevention of dacarbazine damage of human neoplastic cell DNA by aphidicolin. Cancer Res. 1987 Jan 1;47(1):26-30. - Pubmed
DTHybrid score	0.4477
6-phosphogluconate dehydrogenase, decarboxylating
Name	6-phosphogluconate dehydrogenase, decarboxylating
Gene Name	PGD
Pharmacological action	unknown
Actions	inhibitor
References	Akkemik E, Budak H, Ciftci M: Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study. J Enzyme Inhib Med Chem. 2010 Mar 17. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.6468

Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3157
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4031
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.316

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.1783
4119	Cytochrome P450 2D6	CYP2D6	0.1259
4757	Cytochrome P450 2C9	CYP2C9	0.1249
6016	Cytochrome P450 2C19	CYP2C19	0.1093
4924	Cytochrome P450 2C8	CYP2C8	0.0878
1588	Multidrug resistance protein 1	ABCB1	0.0832
6030	Cytochrome P450 2B6	CYP2B6	0.0734
5718	Cytochrome P450 2A6	CYP2A6	0.0673
4118	Cytochrome P450 3A5	CYP3A5	0.0661
2621	Thermoresistant gluconokinase	gntK	0.0571
766	Beta-2 adrenergic receptor	ADRB2	0.0521
6107	Cytochrome P450 3A7	CYP3A7	0.0448
2206	Glucose-6-phosphate isomerase	GPI	0.0429
20	Prostaglandin G/H synthase 1	PTGS1	0.0416
1898	Cytochrome P450 1B1	CYP1B1	0.0398
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0375
587	Serum albumin	ALB	0.0356
290	Prostaglandin G/H synthase 2	PTGS2	0.0316
492	Histamine H1 receptor	HRH1	0.0292
1729	Solute carrier family 22 member 6	SLC22A6	0.0287
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0269
36	Insulin receptor	INSR	0.0258
3811	Cytochrome P450 19A1	CYP19A1	0.0233
2164	Multidrug resistance-associated protein 4	ABCC4	0.0227
118	Organic cation/carnitine transporter 2	SLC22A5	0.0209
468	Cytochrome P450 4A11	CYP4A11	0.0191
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0189
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0189
318	Alpha-2A adrenergic receptor	ADRA2A	0.0189
6106	Cytochrome P450 2C18	CYP2C18	0.0186
6142	Solute carrier family 22 member 8	SLC22A8	0.0182
6145	Solute carrier family 22 member 1	SLC22A1	0.0181
862	Multidrug resistance-associated protein 1	ABCC1	0.0178
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0175
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0174
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0171
831	D(2) dopamine receptor	DRD2	0.0171
556	Alpha-1A adrenergic receptor	ADRA1A	0.0168
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0168
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0163
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.0163
777	Tumor necrosis factor	TNF	0.0162
613	Atrial natriuretic peptide receptor A	NPR1	0.0161
6144	Solute carrier family 22 member 2	SLC22A2	0.0161
3941	Amine oxidase [flavin-containing] A	MAOA	0.016
824	Sodium-dependent serotonin transporter	SLC6A4	0.016
16	Adenosine A1 receptor	ADORA1	0.016
1024	Solute carrier family 22 member 11	SLC22A11	0.0156
776	Bile salt export pump	ABCB11	0.0155
136	Estrogen receptor	ESR1	0.0154
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.015
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.015
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.015
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0148
23	D(1A) dopamine receptor	DRD1	0.0147
817	DNA topoisomerase 2-alpha	TOP2A	0.0144
477	DNA topoisomerase 4 subunit A	parC	0.0144
886	DNA topoisomerase 4 subunit A	parC	0.0144
6226	DNA topoisomerase 4 subunit A	parC	0.0144
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0143
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0142
404	DNA gyrase subunit A	gyrA	0.0141
6224	DNA gyrase subunit A	gyrA	0.0141
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0141
193	Beta-1 adrenergic receptor	ADRB1	0.0141
6014	Cytochrome P450 2A13	CYP2A13	0.014
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.014
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0138
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0136
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0135
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0134
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0129
465	Calmodulin	CALM1	0.0128
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0126
1178	Adenosine A2a receptor	ADORA2A	0.0125
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0124
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0123
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0122
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0122
6147	Solute carrier family 22 member 3	SLC22A3	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
260	Cytochrome P450 51	ERG11	0.0119
761	Cytochrome P450 51	ERG11	0.0119
3163	Cytochrome P450 51	cyp51	0.0119
48	Pyridoxal kinase	PDXK	0.0116
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0114
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0113
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0111
320	5-hydroxytryptamine 1A receptor	HTR1A	0.011
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0108
3939	Amine oxidase [flavin-containing] B	MAOB	0.0107
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0107
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0107
2757	Inorganic pyrophosphatase	ppa	0.0107
6238	Inorganic pyrophosphatase	ppa	0.0107
6968	Inorganic pyrophosphatase	PPA1	0.0107
2383	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
2937	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
4620	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6594	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6609	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6646	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0106
833	Organic cation/carnitine transporter 1	SLC22A4	0.0106
632	Alpha-1B adrenergic receptor	ADRA1B	0.0105
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0105
558	Solute carrier family 12 member 1	SLC12A1	0.0105
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0104
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0102
6148	Multidrug resistance-associated protein 7	ABCC10	0.01
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.01
6220	Aryl hydrocarbon receptor	AHR	0.0099
357	Carbonic anhydrase 2	CA2	0.0099
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0098
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0097
6143	Solute carrier family 22 member 7	SLC22A7	0.0097
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0096
1757	Myeloperoxidase	MPO	0.0096
2755	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	LACZ	0.0095
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0094
4553	Bifunctional adenosylcobalamin biosynthesis protein cobU	cobU	0.0094
2647	RNA-directed RNA polymerase	P2	0.0094
2499	Tubulin beta-2C chain	TUBB2C	0.0094
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0093
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0093
638	D(3) dopamine receptor	DRD3	0.0092
1517	Beta-3 adrenergic receptor	ADRB3	0.0091
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0091
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0091
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.009
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.009
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.009
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.009
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0089
6766	O-GlcNAcase BT_4395	BT_4395	0.0089
3947	Xanthine dehydrogenase/oxidase	XDH	0.0089
482	Glycine receptor subunit alpha-1	GLRA1	0.0089
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0088
3010	Regulatory protein blaR1	blaR1	0.0087
789	Alpha-1D adrenergic receptor	ADRA1D	0.0087
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0087
2149	Angiogenin	ANG	0.0087
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0086
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0086
2449	Tubulin alpha-3 chain	TUBA1A	0.0086
629	Alpha-2B adrenergic receptor	ADRA2B	0.0086
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0086
1010	Cytochrome P450 51A1	CYP51A1	0.0085
2727	S-adenosylmethionine synthetase	metK	0.0084
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0083
2885	Carboxyethyl-arginine beta-lactam-synthase	bls	0.0082
4600	Malonamidase E2	Not Available	0.0082
378	Alpha-2C adrenergic receptor	ADRA2C	0.0081
2717	Folylpolyglutamate synthase	fgs	0.0079
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0078
4122	Histone deacetylase 2	HDAC2	0.0078
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0077
871	Glucocorticoid receptor	NR3C1	0.0076
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0075
6031	Cytochrome P450 3A43	CYP3A43	0.0074
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0074
6395	Myosin-14	MYH14	0.0074
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0074
2428	Thiamine-phosphate pyrophosphorylase	thiE	0.0074
5294	Nucleoside diphosphate kinase A	NME1	0.0072
713	Sodium-dependent dopamine transporter	SLC6A3	0.007
6020	Aldehyde oxidase	AOX1	0.007
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0069
293	Gamma-glutamyl hydrolase	GGH	0.0068
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0068
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0068
6102	Arylamine N-acetyltransferase 2	NAT2	0.0067
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0067
820	Glycine receptor subunit alpha-2	GLRA2	0.0067
3932	Glutathione S-transferase A2	GSTA2	0.0067
571	Melatonin receptor type 1A	MTNR1A	0.0066
362	Melatonin receptor type 1B	MTNR1B	0.0066
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0066
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0064
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
4228	Keratin, type II cytoskeletal 7	KRT7	0.0063
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0063
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0063
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0063
705	Glutamate receptor 1	GRIA1	0.0063
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0063
251	Alcohol dehydrogenase 1A	ADH1A	0.0063
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0062
444	Alcohol dehydrogenase 1B	ADH1B	0.0062
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0062
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0062
1650	Heme carrier protein 1	SLC46A1	0.0061
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0061
432	D(4) dopamine receptor	DRD4	0.006
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.006
3923	Cholinesterase	BCHE	0.006
5818	Folate receptor alpha	FOLR1	0.0059
33	Cystine/glutamate transporter	SLC7A11	0.0058
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0058
365	Dihydrofolate reductase	DHFR	0.0057
2381	Dihydrofolate reductase	DFR1	0.0057
2833	Dihydrofolate reductase	Not Available	0.0057
2931	Dihydrofolate reductase	folA	0.0057
3544	Dihydrofolate reductase	folA	0.0057
3682	Dihydrofolate reductase	folA	0.0057
6642	Dihydrofolate reductase	folA	0.0057
6756	Dihydrofolate reductase	dfrA	0.0057
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0057
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0057
94	5-hydroxytryptamine 4 receptor	HTR4	0.0057
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0057
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0056
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0056
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0055
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0053
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0053
122	P2Y purinoceptor 12	P2RY12	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
1714	Mitogen-activated protein kinase 3	MAPK3	0.0052
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0051
373	Transthyretin	TTR	0.005
6146	High affinity copper uptake protein 1	SLC31A1	0.0049
1192	Sulfotransferase 1A1	SULT1A1	0.0049
517	Alcohol dehydrogenase 1C	ADH1C	0.0048
823	Fibroblast growth factor receptor 2	FGFR2	0.0047
4311	tRNA	TRDMT1	0.0047
4325	tRNA	trmD	0.0047
4328	tRNA	trmD	0.0047
844	Epidermal growth factor receptor	EGFR	0.0047
869	Estrogen receptor beta	ESR2	0.0047
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0046
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0045
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0045
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0045
390	Adenosine A3 receptor	ADORA3	0.0044
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0044
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0043
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0043
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0043
4604	Liver carboxylesterase 1	CES1	0.0043
2230	Catalase	CAT	0.0043
3249	Catalase	katA	0.0043
3625	Catalase	katA	0.0043
4539	Catalase	katA	0.0043
4941	Catalase	katB	0.0043
714	Glutathione reductase, mitochondrial	GSR	0.0042
904	Glutathione S-transferase P	GSTP1	0.0042
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0042
2236	Casein kinase II subunit alpha	CSNK2A1	0.0041
811	Translocator protein	TSPO	0.0041
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0041
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0041
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.004
921	Glutamate receptor 2	GRIA2	0.004
3957	Adenosine deaminase	ADA	0.0039
3823	Cytokine receptor common gamma chain	IL2RG	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
908	Glutathione S-transferase theta-1	GSTT1	0.0039
295	Carbonic anhydrase 1	CA1	0.0038
24	Thymidylate synthase	TMP1	0.0038
359	Thymidylate synthase	TYMS	0.0038
2626	Thymidylate synthase	thyA	0.0038
2729	Thymidylate synthase	thyA	0.0038
5352	Thymidylate synthase	THYA	0.0038
976	Platelet glycoprotein IX	GP9	0.0038
1176	Mitogen-activated protein kinase 1	MAPK1	0.0038
6141	Sodium/bile acid cotransporter	SLC10A1	0.0038
400	Coagulation factor IX	F9	0.0037
5461	Coagulation factor IX	F9	0.0037
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0037
1374	Natriuretic peptides B	NPPB	0.0037
1827	Gap junction alpha-1 protein	GJA1	0.0037
1908	Vascular cell adhesion protein 1	VCAM1	0.0037
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0037
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0037
6136	Multidrug resistance-associated protein 5	ABCC5	0.0037
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0037
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0037
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0036
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0036
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0036
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0036
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0036
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0036
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0036
716	5-hydroxytryptamine 7 receptor	HTR7	0.0036
6043	Putative G-protein coupled receptor 44	GPR44	0.0036
461	Glycine receptor subunit alpha-3	GLRA3	0.0035
814	Ryanodine receptor 1	RYR1	0.0035
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0035
3937	Fatty-acid amide hydrolase	FAAH	0.0035
380	Cytochrome P450 17A1	CYP17A1	0.0035
738	Monocarboxylate transporter 1	SLC16A1	0.0035
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0035
3810	Catechol O-methyltransferase	COMT	0.0035
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0035
6126	Carbonic anhydrase 7	CA7	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0035
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0034
273	Apoptosis regulator Bcl-2	BCL2	0.0034
604	Vitamin K-dependent protein Z	PROZ	0.0034
163	D(1B) dopamine receptor	DRD5	0.0034
724	Interleukin-2 receptor alpha chain	IL2RA	0.0034
717	Interleukin-2 receptor subunit beta	IL2RB	0.0034
565	Extracellular calcium-sensing receptor	CASR	0.0034
2178	Metabotropic glutamate receptor 5	GRM5	0.0034
712	Tubulin alpha chain	TUB1	0.0034
4203	Histamine N-methyltransferase	HNMT	0.0034
153	Dopamine beta-hydroxylase	DBH	0.0034
4116	Dihydropteroate synthetase	Not Available	0.0033
3426	Glutamine synthetase	glnA	0.0033
3987	Glutamine synthetase	GLUL	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0033
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0033
4192	DNA topoisomerase 2-beta	TOP2B	0.0032
518	Peroxidase/catalase T	katG	0.0032
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0032
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0032
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0032
146	Androgen receptor	AR	0.0032
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
268	Adenosine A2b receptor	ADORA2B	0.0031
422	Vitamin K-dependent protein C	PROC	0.0031
1245	Vitamin K-dependent protein S	PROS1	0.0031
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0031
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0031
1629	Transcription factor AP-1	JUN	0.0031
634	Squalene monooxygenase	SQLE	0.0031
7196	Squalene monooxygenase	ERG1	0.0031
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0031
818	50S ribosomal protein L10	rplJ	0.003
563	Thyroid peroxidase	TPO	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
173	Toll-like receptor 7	TLR7	0.003
731	HIV-1 protease	HIV-1 protease	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
84	Nuclear receptor 0B1	NR0B1	0.003
2112	Toll-like receptor 9	TLR9	0.0029
504	Mast/stem cell growth factor receptor	KIT	0.0029
183	Vascular endothelial growth factor A	VEGFA	0.0029
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
275	Arachidonate 5-lipoxygenase	ALOX5	0.0028
592	Carbonic anhydrase 4	CA4	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
6163	Copper-transporting ATPase 2	ATP7B	0.0028
6165	Copper-transporting ATPase 1	ATP7A	0.0028
6044	Serum paraoxonase/lactonase 3	PON3	0.0028
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0028
6137	Multidrug resistance-associated protein 6	ABCC6	0.0028
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0028
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0027
3404	Exotoxin A	eta	0.0027
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0027
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
3830	Calreticulin	CALR	0.0027
5934	Cytochrome P450 26A1	CYP26A1	0.0027
6432	Transporter	snf	0.0026
106	Cannabinoid receptor 2	CNR2	0.0026
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
1275	Estrogen sulfotransferase	SULT1E1	0.0026
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0026
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0026
284	DNA-directed RNA polymerase beta chain	rpoB	0.0026
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0026
756	Sex hormone-binding globulin	SHBG	0.0025
891	Dihydropteroate synthase	folP	0.0025
5359	Dihydropteroate synthase	folP	0.0025
7175	Dihydropteroate synthase	sulI	0.0025
798	Osteocalcin	BGLAP	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
6034	Hydroxyindole O-methyltransferase	ASMT	0.0025
6182	Cytochrome P450 2J2	CYP2J2	0.0025
6035	Nuclear receptor ROR-beta	RORB	0.0025
6036	Eosinophil peroxidase	EPX	0.0025
1050	Bile salt sulfotransferase	SULT2A1	0.0025
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0025
124	Histamine H2 receptor	HRH2	0.0025
68	Cannabinoid receptor 1	CNR1	0.0025
751	Potassium channel subfamily K member 6	KCNK6	0.0025
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0024
239	Coagulation factor X	F10	0.0024
569	Retinal dehydrogenase 2	ALDH1A2	0.0024
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0024
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0024
4103	Proteasome subunit beta type 2	PSMB2	0.0024
4102	Proteasome subunit beta type 5	PSMB5	0.0024
4101	Proteasome subunit beta type 1	PSMB1	0.0024
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0024
6070	Nischarin	NISCH	0.0024
473	L-lactate dehydrogenase A chain	LDHA	0.0024
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1569	G1/S-specific cyclin-D1	CCND1	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
847	Mu-type opioid receptor	OPRM1	0.0023
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0023
6131	Carbonic anhydrase 14	CA14	0.0023
369	Coagulation factor VII	F7	0.0023
822	Aldose reductase	AKR1B1	0.0023
358	Cystathionine beta-synthase	CBS	0.0023
896	Glutathione S-transferase Mu 1	GSTM1	0.0023
172	Potassium channel subfamily K member 1	KCNK1	0.0022
611	Retinal dehydrogenase 1	ALDH1A1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
26	Vascular endothelial growth factor receptor 3	FLT4	0.0022
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0022
765	Indoleamine 2,3-dioxygenase	IDO1	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2290	ADP-ribosyl cyclase 2	BST1	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0022
65	Matrix metalloproteinase-9	Not Available	0.0021
3809	Estrogen-related receptor gamma	ESRRG	0.0021
997	Protein kinase C beta type	PRKCB	0.0021
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0021
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0021
6122	Carbonic anhydrase 3	CA3	0.0021
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0021
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
32	Vascular endothelial growth factor receptor 1	FLT1	0.0021
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0021
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0021
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.002
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.002
859	Cellular retinoic acid-binding protein 2	CRABP2	0.002
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.002
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.002
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.002
2298	Cytochrome P450-cam	camC	0.002
1970	Protein kinase C alpha type	PRKCA	0.002
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.002
780	Retinoic acid receptor RXR-gamma	RXRG	0.002
3007	Carbonic anhydrase 12	CA12	0.002
4205	Carbonic anhydrase 9	CA9	0.002
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.002
936	Ephrin type-A receptor 2	EPHA2	0.002
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0019
2408	Tyrosine-protein kinase SYK	SYK	0.0019
581	Cytochrome P450 2R1	CYP2R1	0.0019
484	Tyrosine-protein kinase ABL2	ABL2	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0019
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0019
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0019
723	Cytosolic phospholipase A2	PLA2G4A	0.0019
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0019
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0019
6138	Multidrug resistance protein 3	ABCB4	0.0019
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0019
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0019
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0018
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0018
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0018
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0018
1992	Vitamin D-binding protein	GC	0.0018
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0018
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0018
88	Retinoic acid receptor RXR-beta	RXRB	0.0018
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0017
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0017
7	Nitric oxide synthase, inducible	NOS2	0.0017
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0017
162	Retinoic acid receptor gamma-1	RARG	0.0017
1648	Elastin	ELN	0.0017
1656	CYP2B protein	CYP2B	0.0017
407	Vascular endothelial growth factor receptor 2	KDR	0.0017
1830	5'-nucleotidase	NT5E	0.0016
696	Kappa-type opioid receptor	OPRK1	0.0016
1243	Cathepsin D	CTSD	0.0016
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0016
4120	NADPH--cytochrome P450 reductase	POR	0.0016
469	Annexin A1	ANXA1	0.0016
474	Acetylcholinesterase	ACHE	0.0016
3601	Dihydropteroate synthase 1	folP1	0.0016
3807	Dihydropteroate synthase 1	folP1	0.0016
3808	Dihydropteroate synthase 2	folP2	0.0016
427	Substance-P receptor	TACR1	0.0016
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0016
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0016
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0015
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0015
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0015
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0015
70	Type-1 angiotensin II receptor	AGTR1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
3913	Glutamic acid decarboxylase	GAD65	0.0015
164	Histamine H4 receptor	HRH4	0.0015
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0014
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0014
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0014
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0014
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0014
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0014
29	Tubulin beta-1 chain	TUBB1	0.0014
467	Delta-type opioid receptor	OPRD1	0.0014
161	Tubulin beta chain	TUBB	0.0014
312	Tubulin beta chain	TUB2	0.0014
54	Prothrombin	F2	0.0014
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
1618	High affinity nerve growth factor receptor	NTRK1	0.0014
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0014
1483	Membrane copper amine oxidase	AOC3	0.0014
319	Opioid receptor, sigma 1	OPRS1	0.0014
856	Vitamin D3 receptor	VDR	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0013
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0013
543	Penicillin-binding protein 1B	mrcB	0.0013
6186	Penicillin-binding protein 1B	ponB	0.0013
6822	Penicillin-binding protein 1b	pbp1b	0.0013
6844	Penicillin-binding protein 1b	pbp1b	0.0013
645	Penicillin-binding protein 1A	mrcA	0.0013
5805	Penicillin-binding protein 1A	ponA	0.0013
6185	Penicillin-binding protein 1A	mrcA	0.0013
6799	Penicillin-binding protein 1A	pbpA	0.0013
159	Penicillin-binding protein 2B	penA	0.0013
6121	Penicillin-binding protein 2B	penA	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0012
267	Plasminogen activator inhibitor 1	SERPINE1	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0012
737	Mineralocorticoid receptor	NR3C2	0.0012
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
174	Sigma 1-type opioid receptor	SIGMAR1	0.0012
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0012
828	Phenylalanine-4-hydroxylase	PAH	0.0011
3109	Phenylalanine-4-hydroxylase	phhA	0.0011
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0011
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
6221	Steroid hormone receptor ERR1	ESRRA	0.0011
614	Progesterone receptor	PGR	0.0011
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.001
4237	50S ribosomal protein L22	rplV	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
6085	Fatty acid-binding protein, intestinal	FABP2	0.001
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.001
345	Plasma retinol-binding protein	RBP4	0.001
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
229	Retinoic acid receptor beta	RARB	0.0009
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0009
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0009
1268	Neuropeptide S receptor	NPSR1	0.0009
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
3221	Cytochrome c4	cc4	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0008
6459	Glycodelin	PAEP	0.0008
6167	Organic solute transporter subunit beta	OSTB	0.0008
6073	Potassium channel subfamily K member 9	KCNK9	0.0008
6166	Organic solute transporter subunit alpha	OSTA	0.0008
6072	Potassium channel subfamily K member 3	KCNK3	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
4226	Uridine phosphorylase 2	UPP2	0.0007
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0007
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0007
2802	Endoglucanase G	celCCG	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
291	Nitric-oxide synthase, endothelial	NOS3	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
2207	Rhodopsin	RHO	0.0006
1864	RET proto-oncogene	RET	0.0006
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0006
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0006
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0006
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
1039	Histone deacetylase 9	HDAC9	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0004
6149	Solute carrier family 22 member 10	SLC22A10	0.0004
165	FL cytokine receptor	FLT3	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0004
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0004
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0004
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0004
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0004
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0003
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00851 - Dacarbazine

Targets

Enzymes

Predictions