DT-Web

DB04840 - Debrisoquin


Identification
Name Debrisoquin
Accession Number DB04840
Type small molecule
Description An adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 175.2303
Groups approved
Monoisotopic Weight 175.110947431
Pharmacology
Indication For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension.
Mechanism of action Debrisoquin acts at the sympathetic neuroeffector junction by inhibiting or interfering with the release and/or distribution of norepinephrine, rather than acting at the effector cell by inhibiting the association of norepinephrine with its receptors. It is taken up by norepinephrine transporters. It becomes concentrated in NE transmitter vesicles, replacing NE in these vesicles. This leads to a gradual depletion of NE stores in the nerve endings. Once inside the terminal it blocks the release of noradrenaline in response to arrival of an action potential. In contrast to ganglionic blocking agents, debrisoquin suppresses equally the responses mediated by alpha-and beta-adrenergic receptors but does not produce parasympathetic blockade. Since sympathetic blockade results in modest decreases in peripheral resistance and cardiac output, debrisoquin lowers blood pressure in the supine position. It further reduces blood pressure by decreasing the degree of vasoconstriction that normally results from reflex sympathetic nervous activity upon assumption of the upright posture, thus reducing venous return and cardiac output more.
Absorption Not Available
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • Take without regard to meals.

Targets


Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action yes
Actions inducer
References
  • Joyce PI, Rizzi D, Calo G, Rowbotham DJ, Lambert DG: The effect of guanethidine and local anesthetics on the electrically stimulated mouse vas deferens. Anesth Analg. 2002 Nov;95(5):1339-43, table of contents. - Pubmed
  • Bryan-Lluka LJ, Seers H, Sharpe I: Amezinium and debrisoquine are substrates of uptake1 and potent inhibitors of monoamine oxidase in perfused lungs of rats. Naunyn Schmiedebergs Arch Pharmacol. 1996 Apr;353(5):536-44. - Pubmed
  • Mitchell JR, Cavanaugh JH, Arias L, Oates JA: Guanethidine and related agents. 3. Antagonism by drugs which inhibit the norepinephrine pump in man. J Clin Invest. 1970 Aug;49(8):1596-604. - Pubmed
  • Yi E, Love JA: Alpha-adrenergic modulation of synaptic transmission in rabbit pancreatic ganglia. Auton Neurosci. 2005 Oct 30;122(1-2):45-57. Epub 2005 Aug 25. - Pubmed
  • Galli A, Blakely RD, DeFelice LJ: Norepinephrine transporters have channel modes of conduction. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8671-6. - Pubmed
DTHybrid score 0.3475

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3454
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1914

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. - Pubmed
DTHybrid score 0.2917

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2374
4200 Cytochrome P450 1A2 CYP1A2 0.1576
824 Sodium-dependent serotonin transporter SLC6A4 0.1515
713 Sodium-dependent dopamine transporter SLC6A3 0.1208
4757 Cytochrome P450 2C9 CYP2C9 0.1149
6016 Cytochrome P450 2C19 CYP2C19 0.1141
4118 Cytochrome P450 3A5 CYP3A5 0.096
4924 Cytochrome P450 2C8 CYP2C8 0.0903
6030 Cytochrome P450 2B6 CYP2B6 0.0774
556 Alpha-1A adrenergic receptor ADRA1A 0.0741
6013 Cytochrome P450 2E1 CYP2E1 0.0718
6107 Cytochrome P450 3A7 CYP3A7 0.0665
492 Histamine H1 receptor HRH1 0.0541
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0526
5718 Cytochrome P450 2A6 CYP2A6 0.0498
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0463
502 5-hydroxytryptamine 2A receptor HTR2A 0.0442
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0418
193 Beta-1 adrenergic receptor ADRB1 0.0413
766 Beta-2 adrenergic receptor ADRB2 0.0389
318 Alpha-2A adrenergic receptor ADRA2A 0.0366
1898 Cytochrome P450 1B1 CYP1B1 0.0364
632 Alpha-1B adrenergic receptor ADRA1B 0.036
831 D(2) dopamine receptor DRD2 0.0353
587 Serum albumin ALB 0.0346
6145 Solute carrier family 22 member 1 SLC22A1 0.0318
131 Synaptic vesicular amine transporter SLC18A2 0.0309
6144 Solute carrier family 22 member 2 SLC22A2 0.029
3941 Amine oxidase [flavin-containing] A MAOA 0.0284
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0281
590 5-hydroxytryptamine 2C receptor HTR2C 0.0278
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0277
862 Multidrug resistance-associated protein 1 ABCC1 0.0267
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0265
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0263
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0243
320 5-hydroxytryptamine 1A receptor HTR1A 0.0235
3939 Amine oxidase [flavin-containing] B MAOB 0.0232
118 Organic cation/carnitine transporter 2 SLC22A5 0.0227
20 Prostaglandin G/H synthase 1 PTGS1 0.022
629 Alpha-2B adrenergic receptor ADRA2B 0.0216
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0212
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0212
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0204
776 Bile salt export pump ABCB11 0.0204
847 Mu-type opioid receptor OPRM1 0.0201
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0199
6106 Cytochrome P450 2C18 CYP2C18 0.0199
789 Alpha-1D adrenergic receptor ADRA1D 0.0198
23 D(1A) dopamine receptor DRD1 0.0197
1729 Solute carrier family 22 member 6 SLC22A6 0.0193
6147 Solute carrier family 22 member 3 SLC22A3 0.0186
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0183
467 Delta-type opioid receptor OPRD1 0.018
696 Kappa-type opioid receptor OPRK1 0.0173
378 Alpha-2C adrenergic receptor ADRA2C 0.0171
3923 Cholinesterase BCHE 0.017
871 Glucocorticoid receptor NR3C1 0.0169
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0169
1517 Beta-3 adrenergic receptor ADRB3 0.0168
436 5-hydroxytryptamine 2B receptor HTR2B 0.0162
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0162
136 Estrogen receptor ESR1 0.015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0149
833 Organic cation/carnitine transporter 1 SLC22A4 0.0143
341 5-hydroxytryptamine 3 receptor HTR3A 0.0143
468 Cytochrome P450 4A11 CYP4A11 0.0143
465 Calmodulin CALM1 0.0143
6182 Cytochrome P450 2J2 CYP2J2 0.0142
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0142
474 Acetylcholinesterase ACHE 0.0137
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0135
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0134
3811 Cytochrome P450 19A1 CYP19A1 0.0131
885 5-hydroxytryptamine 1B receptor HTR1B 0.0129
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0124
638 D(3) dopamine receptor DRD3 0.0123
817 DNA topoisomerase 2-alpha TOP2A 0.0122
1636 Trace amine-associated receptor 1 TAAR1 0.0119
6142 Solute carrier family 22 member 8 SLC22A8 0.0117
48 Pyridoxal kinase PDXK 0.0116
777 Tumor necrosis factor TNF 0.0114
290 Prostaglandin G/H synthase 2 PTGS2 0.0114
2449 Tubulin alpha-3 chain TUBA1A 0.0113
2499 Tubulin beta-2C chain TUBB2C 0.011
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0106
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0106
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0105
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0103
725 5-hydroxytryptamine 1D receptor HTR1D 0.0102
844 Epidermal growth factor receptor EGFR 0.0102
731 HIV-1 protease HIV-1 protease 0.0102
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0101
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0101
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.01
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.01
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0099
6014 Cytochrome P450 2A13 CYP2A13 0.0098
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0097
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0097
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0089
1757 Myeloperoxidase MPO 0.0086
6143 Solute carrier family 22 member 7 SLC22A7 0.0086
1192 Sulfotransferase 1A1 SULT1A1 0.0085
2112 Toll-like receptor 9 TLR9 0.0085
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
124 Histamine H2 receptor HRH2 0.0083
6148 Multidrug resistance-associated protein 7 ABCC10 0.0081
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0081
380 Cytochrome P450 17A1 CYP17A1 0.0079
2164 Multidrug resistance-associated protein 4 ABCC4 0.0079
6432 Transporter snf 0.0078
432 D(4) dopamine receptor DRD4 0.0076
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0075
4604 Liver carboxylesterase 1 CES1 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0072
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0071
244 Angiotensin-converting enzyme ACE 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.007
504 Mast/stem cell growth factor receptor KIT 0.007
4120 NADPH--cytochrome P450 reductase POR 0.0069
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0068
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0066
146 Androgen receptor AR 0.0064
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0064
3932 Glutathione S-transferase A2 GSTA2 0.0064
161 Tubulin beta chain TUBB 0.0063
312 Tubulin beta chain TUB2 0.0063
4203 Histamine N-methyltransferase HNMT 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6141 Sodium/bile acid cotransporter SLC10A1 0.0063
1656 CYP2B protein CYP2B 0.0063
6137 Multidrug resistance-associated protein 6 ABCC6 0.0063
122 P2Y purinoceptor 12 P2RY12 0.0063
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0062
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0062
260 Cytochrome P450 51 ERG11 0.0062
761 Cytochrome P450 51 ERG11 0.0062
3163 Cytochrome P450 51 cyp51 0.0062
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0062
3947 Xanthine dehydrogenase/oxidase XDH 0.0061
482 Glycine receptor subunit alpha-1 GLRA1 0.006
4228 Keratin, type II cytoskeletal 7 KRT7 0.006
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.006
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.006
614 Progesterone receptor PGR 0.0059
373 Transthyretin TTR 0.0058
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0058
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0058
1010 Cytochrome P450 51A1 CYP51A1 0.0058
790 DNA polymerase subunit alpha B POLA2 0.0058
952 Dipeptidyl peptidase 4 DPP4 0.0057
6031 Cytochrome P450 3A43 CYP3A43 0.0057
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0057
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0056
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0056
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0056
6766 O-GlcNAcase BT_4395 BT_4395 0.0056
2981 Phospholipase A2, membrane associated PLA2G2A 0.0056
869 Estrogen receptor beta ESR2 0.0056
1178 Adenosine A2a receptor ADORA2A 0.0056
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0055
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0055
716 5-hydroxytryptamine 7 receptor HTR7 0.0055
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0055
163 D(1B) dopamine receptor DRD5 0.0054
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0054
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0054
1024 Solute carrier family 22 member 11 SLC22A11 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
477 DNA topoisomerase 4 subunit A parC 0.0052
886 DNA topoisomerase 4 subunit A parC 0.0052
6226 DNA topoisomerase 4 subunit A parC 0.0052
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0052
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0052
404 DNA gyrase subunit A gyrA 0.0051
6224 DNA gyrase subunit A gyrA 0.0051
228 Beta platelet-derived growth factor receptor PDGFRB 0.005
820 Glycine receptor subunit alpha-2 GLRA2 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
1629 Transcription factor AP-1 JUN 0.0049
1714 Mitogen-activated protein kinase 3 MAPK3 0.0049
6220 Aryl hydrocarbon receptor AHR 0.0049
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0049
6136 Multidrug resistance-associated protein 5 ABCC5 0.0049
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0048
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0048
904 Glutathione S-transferase P GSTP1 0.0048
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
461 Glycine receptor subunit alpha-3 GLRA3 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0047
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0046
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0046
4103 Proteasome subunit beta type 2 PSMB2 0.0046
4102 Proteasome subunit beta type 5 PSMB5 0.0046
4101 Proteasome subunit beta type 1 PSMB1 0.0046
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0044
1820 Beta-nerve growth factor NGF 0.0044
1176 Mitogen-activated protein kinase 1 MAPK1 0.0044
828 Phenylalanine-4-hydroxylase PAH 0.0043
3109 Phenylalanine-4-hydroxylase phhA 0.0043
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0043
756 Sex hormone-binding globulin SHBG 0.0043
33 Cystine/glutamate transporter SLC7A11 0.0043
737 Mineralocorticoid receptor NR3C2 0.0042
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0042
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0042
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0042
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0041
4311 tRNA TRDMT1 0.0041
4325 tRNA trmD 0.0041
4328 tRNA trmD 0.0041
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0041
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.004
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.004
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.004
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0039
26 Vascular endothelial growth factor receptor 3 FLT4 0.0039
1256 5-hydroxytryptamine 6 receptor HTR6 0.0038
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0038
16 Adenosine A1 receptor ADORA1 0.0038
6146 High affinity copper uptake protein 1 SLC31A1 0.0037
32 Vascular endothelial growth factor receptor 1 FLT1 0.0037
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0037
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0037
407 Vascular endothelial growth factor receptor 2 KDR 0.0037
106 Cannabinoid receptor 2 CNR2 0.0037
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0036
70 Type-1 angiotensin II receptor AGTR1 0.0036
738 Monocarboxylate transporter 1 SLC16A1 0.0036
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0036
528 5-hydroxytryptamine 1E receptor HTR1E 0.0036
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0036
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0034
68 Cannabinoid receptor 1 CNR1 0.0034
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0034
823 Fibroblast growth factor receptor 2 FGFR2 0.0034
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0033
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0033
6506 Stathmin-4 STMN4 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
94 5-hydroxytryptamine 4 receptor HTR4 0.0033
173 Toll-like receptor 7 TLR7 0.0033
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0033
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0033
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0033
365 Dihydrofolate reductase DHFR 0.0032
2381 Dihydrofolate reductase DFR1 0.0032
2833 Dihydrofolate reductase Not Available 0.0032
2931 Dihydrofolate reductase folA 0.0032
3544 Dihydrofolate reductase folA 0.0032
3682 Dihydrofolate reductase folA 0.0032
6642 Dihydrofolate reductase folA 0.0032
6756 Dihydrofolate reductase dfrA 0.0032
1569 G1/S-specific cyclin-D1 CCND1 0.0032
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0032
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0032
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0031
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0031
319 Opioid receptor, sigma 1 OPRS1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
976 Platelet glycoprotein IX GP9 0.003
1050 Bile salt sulfotransferase SULT2A1 0.003
5934 Cytochrome P450 26A1 CYP26A1 0.003
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.003
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.003
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
1374 Natriuretic peptides B NPPB 0.003
84 Nuclear receptor 0B1 NR0B1 0.003
1827 Gap junction alpha-1 protein GJA1 0.0029
1908 Vascular cell adhesion protein 1 VCAM1 0.0029
6151 Monocarboxylate transporter 10 SLC16A10 0.0029
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0029
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0029
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0029
1618 High affinity nerve growth factor receptor NTRK1 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
683 Potassium transporter GK0582 0.0029
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0028
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
295 Carbonic anhydrase 1 CA1 0.0028
814 Ryanodine receptor 1 RYR1 0.0028
6043 Putative G-protein coupled receptor 44 GPR44 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0027
6102 Arylamine N-acetyltransferase 2 NAT2 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0027
2236 Casein kinase II subunit alpha CSNK2A1 0.0027
581 Cytochrome P450 2R1 CYP2R1 0.0026
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0026
818 50S ribosomal protein L10 rplJ 0.0026
239 Coagulation factor X F10 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0026
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6085 Fatty acid-binding protein, intestinal FABP2 0.0026
174 Sigma 1-type opioid receptor SIGMAR1 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0026
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0025
4122 Histone deacetylase 2 HDAC2 0.0025
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0025
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0025
1360 Sphingomyelin phosphodiesterase SMPD1 0.0025
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0025
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0025
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0025
1992 Vitamin D-binding protein GC 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0024
3856 Fibroblast growth factor receptor 3 FGFR3 0.0024
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0024
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0024
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0024
469 Annexin A1 ANXA1 0.0023
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0023
232 Corticosteroid-binding globulin SERPINA6 0.0023
1063 Signal transducer and activator of transcription 5B STAT5B 0.0023
936 Ephrin type-A receptor 2 EPHA2 0.0023
183 Vascular endothelial growth factor A VEGFA 0.0023
165 FL cytokine receptor FLT3 0.0023
611 Retinal dehydrogenase 1 ALDH1A1 0.0022
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
3957 Adenosine deaminase ADA 0.0022
4192 DNA topoisomerase 2-beta TOP2B 0.0022
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0022
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0022
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0022
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0022
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0022
511 5-hydroxytryptamine 1F receptor HTR1F 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0021
484 Tyrosine-protein kinase ABL2 ABL2 0.0021
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0021
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0021
1275 Estrogen sulfotransferase SULT1E1 0.0021
6824 Tyrosine-protein kinase Lyn LYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
24 Thymidylate synthase TMP1 0.0021
359 Thymidylate synthase TYMS 0.0021
2626 Thymidylate synthase thyA 0.0021
2729 Thymidylate synthase thyA 0.0021
5352 Thymidylate synthase THYA 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.002
144 Hemoglobin subunit alpha HBA1 0.002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.002
634 Squalene monooxygenase SQLE 0.002
7196 Squalene monooxygenase ERG1 0.002
564 Cellular retinoic acid-binding protein 1 CRABP1 0.002
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.002
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.002
164 Histamine H4 receptor HRH4 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
751 Potassium channel subfamily K member 6 KCNK6 0.0019
268 Adenosine A2b receptor ADORA2B 0.0019
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0019
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0019
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0019
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0019
4773 Deoxycytidine kinase DCK 0.0019
7 Nitric oxide synthase, inducible NOS2 0.0019
908 Glutathione S-transferase theta-1 GSTT1 0.0019
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0019
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
3830 Calreticulin CALR 0.0018
856 Vitamin D3 receptor VDR 0.0018
780 Retinoic acid receptor RXR-gamma RXRG 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
6126 Carbonic anhydrase 7 CA7 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0018
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
172 Potassium channel subfamily K member 1 KCNK1 0.0018
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0018
3809 Estrogen-related receptor gamma ESRRG 0.0018
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
6034 Hydroxyindole O-methyltransferase ASMT 0.0017
6035 Nuclear receptor ROR-beta RORB 0.0017
6036 Eosinophil peroxidase EPX 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
1262 Corticotropin-lipotropin POMC 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
400 Coagulation factor IX F9 0.0017
5461 Coagulation factor IX F9 0.0017
444 Alcohol dehydrogenase 1B ADH1B 0.0017
88 Retinoic acid receptor RXR-beta RXRB 0.0017
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
162 Retinoic acid receptor gamma-1 RARG 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
6211 Tubulin epsilon chain TUBE1 0.0016
6212 Tubulin gamma-1 chain TUBG1 0.0016
6210 Tubulin delta chain TUBD1 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
822 Aldose reductase AKR1B1 0.0016
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0016
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0015
604 Vitamin K-dependent protein Z PROZ 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0015
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0015
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0015
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0015
765 Indoleamine 2,3-dioxygenase IDO1 0.0015
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0015
251 Alcohol dehydrogenase 1A ADH1A 0.0015
54 Prothrombin F2 0.0015
592 Carbonic anhydrase 4 CA4 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0015
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
3086 Plasmepsin-2 Not Available 0.0014
422 Vitamin K-dependent protein C PROC 0.0014
1245 Vitamin K-dependent protein S PROS1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
571 Melatonin receptor type 1A MTNR1A 0.0014
362 Melatonin receptor type 1B MTNR1B 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
3937 Fatty-acid amide hydrolase FAAH 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
273 Apoptosis regulator Bcl-2 BCL2 0.0013
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0013
517 Alcohol dehydrogenase 1C ADH1C 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
3404 Exotoxin A eta 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
1630 Integrin beta-2 ITGB2 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
5787 Angiopoietin-1 receptor TEK 0.0013
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0012
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
2216 Fibroblast growth factor receptor 4 FGFR4 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0012
694 Matrix protein 2 M 0.0012
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
997 Protein kinase C beta type PRKCB 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
3917 Methylenetetrahydrofolate reductase MTHFR 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
6859 Protein S100-A4 S100A4 0.0012
3810 Catechol O-methyltransferase COMT 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
798 Osteocalcin BGLAP 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
6048 Troponin C, skeletal muscle TNNC2 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
6020 Aldehyde oxidase AOX1 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
3007 Carbonic anhydrase 12 CA12 0.0011
4205 Carbonic anhydrase 9 CA9 0.0011
357 Carbonic anhydrase 2 CA2 0.0011
6459 Glycodelin PAEP 0.0011
427 Substance-P receptor TACR1 0.0011
6044 Serum paraoxonase/lactonase 3 PON3 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
369 Coagulation factor VII F7 0.001
6174 50S ribosomal protein L32 rpmF 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
811 Translocator protein TSPO 0.001
345 Plasma retinol-binding protein RBP4 0.001
572 Integrin alpha-L ITGAL 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
518 Peroxidase/catalase T katG 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
1864 RET proto-oncogene RET 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
563 Thyroid peroxidase TPO 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
275 Arachidonate 5-lipoxygenase ALOX5 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
760 Fibroblast growth factor 1 FGF1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
291 Nitric-oxide synthase, endothelial NOS3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
1341 Histamine H3 receptor HRH3 0.0008
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0008
2207 Rhodopsin RHO 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0007
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
6168 Solute carrier family 22 member 16 SLC22A16 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
3587 Gastrotropin FABP6 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
921 Glutamate receptor 2 GRIA2 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
4217 Telomerase reverse transcriptase TERT 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
2021 Thrombomodulin THBD 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
153 Dopamine beta-hydroxylase DBH 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
6218 Pannexin-1 PANX1 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
284 DNA-directed RNA polymerase beta chain rpoB 0.0003
5773 DNA-directed RNA polymerase beta chain rpoB 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
↑