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DB08513 - [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID


Identification
Name [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
Accession Number DB08513
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 377.3966
Groups experimental
Monoisotopic Weight 377.148789499
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Mitogen-activated protein kinase 1
Name Mitogen-activated protein kinase 1
Gene Name MAPK1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3508
Insulin receptor
Name Insulin receptor
Gene Name INSR
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0856
Insulin receptor substrate 1
Name Insulin receptor substrate 1
Gene Name IRS1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.815

Predictions


Id Partner name Gene Name Score
958 Insulin-like growth factor 1 receptor IGF1R 0.175
4200 Cytochrome P450 1A2 CYP1A2 0.1676
1540 Mitogen-activated protein kinase 14 MAPK14 0.09
1350 Insulin-like growth factor-binding protein 3 IGFBP3 0.0625
1836 Mitogen-activated protein kinase 10 MAPK10 0.0554
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0501
1714 Mitogen-activated protein kinase 3 MAPK3 0.0352
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0323
3847 Neuroendocrine convertase 2 PCSK2 0.0323
2009 Protein NOV homolog NOV 0.0323
3850 Synaptotagmin-like protein 4 SYTL4 0.0323
1949 Carboxypeptidase E CPE 0.0323
3846 Retinoblastoma-associated protein RB1 0.0323
3848 Neuroendocrine convertase 1 PCSK1 0.0323
587 Serum albumin ALB 0.0297
2155 Insulin-degrading enzyme IDE 0.029
3959 Cell division protein kinase 4 CDK4 0.0284
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0276
1742 D-HSCDK2 CDK2deltaT 0.0274
1771 Cell division control protein 2 homolog CDK1 0.0274
3321 Cell division control protein 2 homolog CRK2 0.0274
2240 Cell division protein kinase 2 CDK2 0.0269
1058 Cell division protein kinase 5 CDK5 0.0266
1243 Cathepsin D CTSD 0.0245
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.023
4750 Protein S100-A11 S100A11 0.0216
3482 Cell division protein kinase 7 CDK7 0.0189
4751 Mitogen-activated protein kinase 12 MAPK12 0.0189
3005 Threonine-phosphate decarboxylase cobD 0.0188
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0181
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0179
2530 Protein kinase C theta type PRKCQ 0.0174
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0173
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0173
2621 Thermoresistant gluconokinase gntK 0.0168
5466 Putative sugar kinase STM4066 0.0167
4517 Probable butyrate kinase 2 buk2 0.0167
2878 Probable serine/threonine-protein kinase pknB pknB 0.0167
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0154
5312 Kinesin-like protein KIF1A KIF1A 0.0154
3669 Ribokinase rbsK 0.0146
2615 Chemotaxis protein cheA cheA 0.0146
2717 Folylpolyglutamate synthase fgs 0.0139
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0139
1422 Serine/threonine-protein kinase 6 AURKA 0.0135
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0134
48 Pyridoxal kinase PDXK 0.0131
1517 Beta-3 adrenergic receptor ADRB3 0.0127
2207 Rhodopsin RHO 0.0122
6024 Cytochrome P450 1A1 CYP1A1 0.0115
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0109
1569 G1/S-specific cyclin-D1 CCND1 0.0106
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0102
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0102
1629 Transcription factor AP-1 JUN 0.0086
193 Beta-1 adrenergic receptor ADRB1 0.0086
766 Beta-2 adrenergic receptor ADRB2 0.0083
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0082
1898 Cytochrome P450 1B1 CYP1B1 0.0056
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0048
1588 Multidrug resistance protein 1 ABCB1 0.0038
4512 Cytochrome P450 3A4 CYP3A4 0.0033
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