DT-Web: DB00184

Identification
Name	Nicotine
Accession Number	DB00184 (APRD00200, EXPT02315)
Type	small molecule
Description	Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. [PubChem]
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)	Anti-craving Agents Central Nervous System Agents Autonomic drugs Nicotinic Agonists Ganglionic Stimulants
Molecular Weight	162.2316
Groups	approved
Monoisotopic Weight	162.115698458
Pharmacology
Indication	For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Mechanism of action	Nicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed up of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. This leads to depolarization, which activates voltage-gated calcium channels and allows more calcium to enter the axon terminal. Calcium stimulates vesicle trafficking towards the plasma membrane and the release of dopamine into the synapse. Dopamine binding to its receptors is responsible the euphoric and addictive properties of nicotine. Nicotine also binds to nicotinic acetylcholine receptors on the chromaffin cells in the adrenal medulla. Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels. Calcium triggers the release of epinephrine from intracellular vesicles into the bloodstream, which causes vasoconstriction, increased blood pressure, increased heart rate, and increased blood sugar.
Absorption	Absorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.
Protein binding	Less than 5%
Biotransformation	Primarily hepatic, cotinine is the primary metabolite.
Route of elimination	About 10% of the nicotine absorbed is excreted unchanged in the urine.
Toxicity	Symptoms of overdose include nausea, abdominal pain, vomiting, diarrhea, diaphoresis, flushing, dizziness, disturbed hearing and vision, confusion, weakness, palpitations, altered respiration and hypotension. LD₅₀= 24 mg/kg (orally in mice).
Affected organisms	Humans and other mammals
Interactions
Drug Interactions	Not Available
Food Interactions	Not Available

Neuronal acetylcholine receptor subunit alpha-4
Name	Neuronal acetylcholine receptor subunit alpha-4
Gene Name	CHRNA4
Pharmacological action	yes
Actions	agonist
References	Espeseth T, Endestad T, Rootwelt H, Reinvang I: Nicotine receptor gene CHRNA4 modulates early event-related potentials in auditory and visual oddball target detection tasks. Neuroscience. 2007 Jul 29;147(4):974-85. Epub 2007 Jun 27. - Pubmed Winterer G, Musso F, Konrad A, Vucurevic G, Stoeter P, Sander T, Gallinat J: Association of attentional network function with exon 5 variations of the CHRNA4 gene. Hum Mol Genet. 2007 Sep 15;16(18):2165-74. Epub 2007 Jul 5. - Pubmed Ehringer MA, Clegg HV, Collins AC, Corley RP, Crowley T, Hewitt JK, Hopfer CJ, Krauter K, Lessem J, Rhee SH, Schlaepfer I, Smolen A, Stallings MC, Young SE, Zeiger JS: Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144(5):596-604. - Pubmed Klaassen A, Glykys J, Maguire J, Labarca C, Mody I, Boulter J: Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19152-7. Epub 2006 Dec 4. - Pubmed De Luca V, Voineskos S, Wong G, Kennedy JL: Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. Exp Brain Res. 2006 Sep;174(2):292-6. Epub 2006 Apr 25. - Pubmed Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. - Pubmed Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. - Pubmed Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. - Pubmed Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. - Pubmed
DTHybrid score	0.6014
Neuronal acetylcholine receptor subunit alpha-7
Name	Neuronal acetylcholine receptor subunit alpha-7
Gene Name	CHRNA7
Pharmacological action	yes
Actions	agonist
References	Mexal S, Jenkins PM, Lautner MA, Iacob E, Crouch EL, Stitzel JA: alpha7 nicotinic receptor gene promoter polymorphisms in inbred mice affect expression in a cell type-specific fashion. J Biol Chem. 2007 May 4;282(18):13220-7. Epub 2007 Mar 14. - Pubmed Olincy A, Harris JG, Johnson LL, Pender V, Kongs S, Allensworth D, Ellis J, Zerbe GO, Leonard S, Stevens KE, Stevens JO, Martin L, Adler LE, Soti F, Kem WR, Freedman R: Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch Gen Psychiatry. 2006 Jun;63(6):630-8. - Pubmed Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. - Pubmed Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. - Pubmed Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. - Pubmed Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. - Pubmed
DTHybrid score	0.5937
Neuronal acetylcholine receptor subunit beta-2
Name	Neuronal acetylcholine receptor subunit beta-2
Gene Name	CHRNB2
Pharmacological action	yes
Actions	agonist
References	Ehringer MA, Clegg HV, Collins AC, Corley RP, Crowley T, Hewitt JK, Hopfer CJ, Krauter K, Lessem J, Rhee SH, Schlaepfer I, Smolen A, Stallings MC, Young SE, Zeiger JS: Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144(5):596-604. - Pubmed De Luca V, Voineskos S, Wong G, Kennedy JL: Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. Exp Brain Res. 2006 Sep;174(2):292-6. Epub 2006 Apr 25. - Pubmed Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. - Pubmed Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. - Pubmed Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. - Pubmed Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. - Pubmed
DTHybrid score	0.4617
Neuronal acetylcholine receptor subunit alpha-2
Name	Neuronal acetylcholine receptor subunit alpha-2
Gene Name	CHRNA2
Pharmacological action	unknown
Actions	agonist
References	Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. - Pubmed Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. - Pubmed Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. - Pubmed Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. - Pubmed Sullivan PF, Neale BM, van den Oord E, Miles MF, Neale MC, Bulik CM, Joyce PR, Straub RE, Kendler KS: Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126(1):23-36. - Pubmed
DTHybrid score	0.8189
Neuronal acetylcholine receptor subunit alpha-3
Name	Neuronal acetylcholine receptor subunit alpha-3
Gene Name	CHRNA3
Pharmacological action	unknown
Actions	agonist
References	Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. - Pubmed Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. - Pubmed Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. - Pubmed Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. - Pubmed
DTHybrid score	0.9125
Neuronal acetylcholine receptor subunit alpha-5
Name	Neuronal acetylcholine receptor subunit alpha-5
Gene Name	CHRNA5
Pharmacological action	unknown
Actions	agonist
References	Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. - Pubmed Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. - Pubmed Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. - Pubmed Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. - Pubmed
DTHybrid score	0.4637
Neuronal acetylcholine receptor subunit alpha-6
Name	Neuronal acetylcholine receptor subunit alpha-6
Gene Name	CHRNA6
Pharmacological action	unknown
Actions	agonist
References	Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. - Pubmed Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. - Pubmed Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. - Pubmed Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. - Pubmed
DTHybrid score	0.6314
Neuronal acetylcholine receptor subunit alpha-9
Name	Neuronal acetylcholine receptor subunit alpha-9
Gene Name	CHRNA9
Pharmacological action	unknown
Actions	agonist
References	Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. - Pubmed Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. - Pubmed Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. - Pubmed Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. - Pubmed
DTHybrid score	0.486
Neuronal acetylcholine receptor subunit alpha-10
Name	Neuronal acetylcholine receptor subunit alpha-10
Gene Name	CHRNA10
Pharmacological action	unknown
Actions	agonist
References	Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. - Pubmed Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. - Pubmed Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. - Pubmed Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. - Pubmed
DTHybrid score	0.7144
Neuronal acetylcholine receptor subunit beta-3
Name	Neuronal acetylcholine receptor subunit beta-3
Gene Name	CHRNB3
Pharmacological action	unknown
Actions	agonist
References	Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. - Pubmed Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. - Pubmed Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. - Pubmed Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. - Pubmed
DTHybrid score	0.4639
Neuronal acetylcholine receptor subunit beta-4
Name	Neuronal acetylcholine receptor subunit beta-4
Gene Name	CHRNB4
Pharmacological action	unknown
Actions	agonist
References	Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. - Pubmed Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. - Pubmed Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. - Pubmed Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. - Pubmed
DTHybrid score	0.7058

Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5711
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5523
Cytochrome P450 2A13
Name	Cytochrome P450 2A13
Gene Name	CYP2A13
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2992
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5567
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.492
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8478
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7356
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.579
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8183
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.9484
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.1294
Amine oxidase [flavin-containing] A
Name	Amine oxidase [flavin-containing] A
Gene Name	MAOA
Actions	inhibitor
References	Lewis AJ, Truman P, Hosking MR, Miller JH: Monoamine oxidase inhibitory activity in tobacco smoke varies with tobacco type. Tob Control. 2011 Jun 2. - Pubmed Leroy C, Bragulat V, Berlin I, Gregoire MC, Bottlaender M, Roumenov D, Dolle F, Bourgeois S, Penttila J, Artiges E, Martinot JL, Trichard C: Cerebral monoamine oxidase A inhibition in tobacco smokers confirmed with PET and [11C]befloxatone. J Clin Psychopharmacol. 2009 Feb;29(1):86-8. - Pubmed
DTHybrid score	0.6884
Amine oxidase [flavin-containing] B
Name	Amine oxidase [flavin-containing] B
Gene Name	MAOB
Actions	inhibitor
References	Lewis AJ, Truman P, Hosking MR, Miller JH: Monoamine oxidase inhibitory activity in tobacco smoke varies with tobacco type. Tob Control. 2011 Jun 2. - Pubmed
DTHybrid score	1.0775

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. - Pubmed Okuda M, Urakami Y, Saito H, Inui K: Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta. 1999 Mar 4;1417(2):224-31. - Pubmed
DTHybrid score	0.4725
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. - Pubmed
DTHybrid score	0.5668
Solute carrier family 22 member 3
Name	Solute carrier family 22 member 3
Gene Name	SLC22A3
Actions	inhibitor
References	Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V: Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem. 1998 Jun 26;273(26):15971-9. - Pubmed
DTHybrid score	0.3939
Organic cation/carnitine transporter 2
Name	Organic cation/carnitine transporter 2
Gene Name	SLC22A5
Actions	inhibitor
References	Wu X, Prasad PD, Leibach FH, Ganapathy V: cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 1998 May 29;246(3):589-95. - Pubmed Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. - Pubmed
DTHybrid score	0.4766
Organic cation/carnitine transporter 1
Name	Organic cation/carnitine transporter 1
Gene Name	SLC22A4
Actions	inhibitor
References	Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V: Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta. 2000 Jun 1;1466(1-2):315-27. - Pubmed
DTHybrid score	0.3899

Id	Partner name	Gene Name	Score
1588	Multidrug resistance protein 1	ABCB1	0.4672
4118	Cytochrome P450 3A5	CYP3A5	0.374
3923	Cholinesterase	BCHE	0.3142
6107	Cytochrome P450 3A7	CYP3A7	0.2923
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.2012
617	Muscarinic acetylcholine receptor M2	CHRM2	0.2
474	Acetylcholinesterase	ACHE	0.1963
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.1949
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.1923
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.1911
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.1868
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.1859
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.1843
713	Sodium-dependent dopamine transporter	SLC6A3	0.168
921	Glutamate receptor 2	GRIA2	0.1661
824	Sodium-dependent serotonin transporter	SLC6A4	0.1653
20	Prostaglandin G/H synthase 1	PTGS1	0.1628
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1598
587	Serum albumin	ALB	0.1563
3811	Cytochrome P450 19A1	CYP19A1	0.1538
6142	Solute carrier family 22 member 8	SLC22A8	0.1517
1729	Solute carrier family 22 member 6	SLC22A6	0.148
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.142
492	Histamine H1 receptor	HRH1	0.1359
6106	Cytochrome P450 2C18	CYP2C18	0.1314
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1272
51	Muscarinic acetylcholine receptor M3	CHRM3	0.1267
103	Muscarinic acetylcholine receptor M1	CHRM1	0.125
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.119
1181	Alpha-1-acid glycoprotein 1	ORM1	0.117
341	5-hydroxytryptamine 3 receptor	HTR3A	0.1125
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1118
556	Alpha-1A adrenergic receptor	ADRA1A	0.1112
862	Multidrug resistance-associated protein 1	ABCC1	0.1068
1898	Cytochrome P450 1B1	CYP1B1	0.1061
318	Alpha-2A adrenergic receptor	ADRA2A	0.1034
1075	Alkaline phosphatase, placental-like	ALPPL2	0.1024
766	Beta-2 adrenergic receptor	ADRB2	0.0961
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0956
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0939
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0918
831	D(2) dopamine receptor	DRD2	0.0899
847	Mu-type opioid receptor	OPRM1	0.0878
193	Beta-1 adrenergic receptor	ADRB1	0.083
2472	Voltage-gated potassium channel	kcsA	0.08
6366	Voltage-gated potassium channel	kcsA	0.08
776	Bile salt export pump	ABCB11	0.0786
378	Alpha-2C adrenergic receptor	ADRA2C	0.0707
290	Prostaglandin G/H synthase 2	PTGS2	0.0688
131	Synaptic vesicular amine transporter	SLC18A2	0.0688
23	D(1A) dopamine receptor	DRD1	0.0681
629	Alpha-2B adrenergic receptor	ADRA2B	0.0673
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0671
6143	Solute carrier family 22 member 7	SLC22A7	0.0659
632	Alpha-1B adrenergic receptor	ADRA1B	0.0638
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0637
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0631
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.06
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0597
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0585
136	Estrogen receptor	ESR1	0.0584
817	DNA topoisomerase 2-alpha	TOP2A	0.0559
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0556
1024	Solute carrier family 22 member 11	SLC22A11	0.0544
468	Cytochrome P450 4A11	CYP4A11	0.0536
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0536
789	Alpha-1D adrenergic receptor	ADRA1D	0.0532
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0527
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0526
477	DNA topoisomerase 4 subunit A	parC	0.0521
886	DNA topoisomerase 4 subunit A	parC	0.0521
6226	DNA topoisomerase 4 subunit A	parC	0.0521
2164	Multidrug resistance-associated protein 4	ABCC4	0.0521
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0515
404	DNA gyrase subunit A	gyrA	0.0513
6224	DNA gyrase subunit A	gyrA	0.0513
6031	Cytochrome P450 3A43	CYP3A43	0.0513
146	Androgen receptor	AR	0.0505
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0493
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0487
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0481
465	Calmodulin	CALM1	0.0474
3810	Catechol O-methyltransferase	COMT	0.0468
1757	Myeloperoxidase	MPO	0.0452
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0445
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0433
260	Cytochrome P450 51	ERG11	0.0425
761	Cytochrome P450 51	ERG11	0.0425
3163	Cytochrome P450 51	cyp51	0.0425
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0424
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0424
731	HIV-1 protease	HIV-1 protease	0.0412
467	Delta-type opioid receptor	OPRD1	0.0405
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0404
124	Histamine H2 receptor	HRH2	0.0403
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0403
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0392
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.039
638	D(3) dopamine receptor	DRD3	0.0386
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0383
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0373
6141	Sodium/bile acid cotransporter	SLC10A1	0.0367
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0364
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0362
871	Glucocorticoid receptor	NR3C1	0.0361
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0358
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0351
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0344
1636	Trace amine-associated receptor 1	TAAR1	0.0343
756	Sex hormone-binding globulin	SHBG	0.0336
6148	Multidrug resistance-associated protein 7	ABCC10	0.0325
696	Kappa-type opioid receptor	OPRK1	0.0322
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0321
6136	Multidrug resistance-associated protein 5	ABCC5	0.0318
3947	Xanthine dehydrogenase/oxidase	XDH	0.0313
432	D(4) dopamine receptor	DRD4	0.0304
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0303
6164	POU domain, class 5, transcription factor 1	POU5F1	0.03
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0295
1517	Beta-3 adrenergic receptor	ADRB3	0.0293
122	P2Y purinoceptor 12	P2RY12	0.0291
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.028
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.028
891	Dihydropteroate synthase	folP	0.0276
5359	Dihydropteroate synthase	folP	0.0276
7175	Dihydropteroate synthase	sulI	0.0276
6137	Multidrug resistance-associated protein 6	ABCC6	0.0276
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0271
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0268
380	Cytochrome P450 17A1	CYP17A1	0.0267
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0264
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0259
36	Insulin receptor	INSR	0.0258
4203	Histamine N-methyltransferase	HNMT	0.0256
777	Tumor necrosis factor	TNF	0.0254
738	Monocarboxylate transporter 1	SLC16A1	0.025
6010	Thiamine transporter 1	SLC19A2	0.0248
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0246
723	Cytosolic phospholipase A2	PLA2G4A	0.0243
4604	Liver carboxylesterase 1	CES1	0.0243
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0242
163	D(1B) dopamine receptor	DRD5	0.0242
6102	Arylamine N-acetyltransferase 2	NAT2	0.0242
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0241
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.024
436	5-hydroxytryptamine 2B receptor	HTR2B	0.024
2864	Penton protein	PIII	0.0236
7	Nitric oxide synthase, inducible	NOS2	0.0234
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0233
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0233
482	Glycine receptor subunit alpha-1	GLRA1	0.0233
449	Ornithine decarboxylase	ODC1	0.0233
161	Tubulin beta chain	TUBB	0.0231
312	Tubulin beta chain	TUB2	0.0231
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0229
624	Guanidinoacetate N-methyltransferase	GAMT	0.0225
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0224
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0223
5126	Arginase	rocF	0.0223
175	Thiamin pyrophosphokinase 1	TPK1	0.0222
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.022
869	Estrogen receptor beta	ESR2	0.022
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0219
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0218
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0216
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0216
6220	Aryl hydrocarbon receptor	AHR	0.0215
6432	Transporter	snf	0.0215
273	Apoptosis regulator Bcl-2	BCL2	0.0214
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0214
3560	Gentamicin 3'-acetyltransferase	aacC1	0.021
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0208
6182	Cytochrome P450 2J2	CYP2J2	0.0208
5841	Insulin-like growth factor IB	IGF1	0.0206
2429	Putrescine-binding periplasmic protein	potF	0.0206
16	Adenosine A1 receptor	ADORA1	0.0204
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0204
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0203
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0203
164	Histamine H4 receptor	HRH4	0.0203
1010	Cytochrome P450 51A1	CYP51A1	0.0202
844	Epidermal growth factor receptor	EGFR	0.0202
1656	CYP2B protein	CYP2B	0.02
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0199
153	Dopamine beta-hydroxylase	DBH	0.0199
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0198
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0197
6070	Nischarin	NISCH	0.0196
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0193
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0192
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0192
504	Mast/stem cell growth factor receptor	KIT	0.019
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.019
976	Platelet glycoprotein IX	GP9	0.0189
3937	Fatty-acid amide hydrolase	FAAH	0.0189
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0188
159	Penicillin-binding protein 2B	penA	0.0187
6121	Penicillin-binding protein 2B	penA	0.0187
811	Translocator protein	TSPO	0.0186
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0185
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0184
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0183
94	5-hydroxytryptamine 4 receptor	HTR4	0.0182
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0182
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0182
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.018
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.018
614	Progesterone receptor	PGR	0.0179
4120	NADPH--cytochrome P450 reductase	POR	0.0179
613	Atrial natriuretic peptide receptor A	NPR1	0.0179
1178	Adenosine A2a receptor	ADORA2A	0.0177
4773	Deoxycytidine kinase	DCK	0.0177
705	Glutamate receptor 1	GRIA1	0.0176
174	Sigma 1-type opioid receptor	SIGMAR1	0.0176
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0175
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0175
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0175
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0174
1341	Histamine H3 receptor	HRH3	0.0174
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0174
150	Cationic amino acid transporter 3	SLC7A3	0.0173
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.0173
58	Cationic amino acid transporter 4	SLC7A4	0.0173
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0173
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0172
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0172
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0172
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0172
70	Type-1 angiotensin II receptor	AGTR1	0.017
6146	High affinity copper uptake protein 1	SLC31A1	0.017
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.017
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0169
737	Mineralocorticoid receptor	NR3C2	0.0169
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0168
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0162
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0162
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0162
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0162
295	Carbonic anhydrase 1	CA1	0.0161
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0158
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0157
828	Phenylalanine-4-hydroxylase	PAH	0.0156
3109	Phenylalanine-4-hydroxylase	phhA	0.0156
5626	Nucleoside diphosphate kinase B	NME2	0.0156
29	Tubulin beta-1 chain	TUBB1	0.0156
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0156
3932	Glutathione S-transferase A2	GSTA2	0.0155
716	5-hydroxytryptamine 7 receptor	HTR7	0.0155
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0154
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0153
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0153
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0152
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0151
2300	Lysozyme	E	0.0151
3633	Lysozyme	R	0.0151
5597	Lysozyme	17	0.0151
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.015
373	Transthyretin	TTR	0.0149
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0147
592	Carbonic anhydrase 4	CA4	0.0145
694	Matrix protein 2	M	0.0145
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0145
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0144
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0143
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0143
303	Diamine acetyltransferase 2	SAT2	0.0141
1317	Spermine synthase	SMS	0.0141
623	Spermine oxidase	SMOX	0.0141
228	Beta platelet-derived growth factor receptor	PDGFRB	0.014
633	Penicillin-binding proteins 1A/1B	pbpA	0.0139
6138	Multidrug resistance protein 3	ABCB4	0.0138
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0138
6020	Aldehyde oxidase	AOX1	0.0138
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0136
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0136
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0136
251	Alcohol dehydrogenase 1A	ADH1A	0.0136
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0136
571	Melatonin receptor type 1A	MTNR1A	0.0136
904	Glutathione S-transferase P	GSTP1	0.0136
362	Melatonin receptor type 1B	MTNR1B	0.0136
2449	Tubulin alpha-3 chain	TUBA1A	0.0135
818	50S ribosomal protein L10	rplJ	0.0134
1483	Membrane copper amine oxidase	AOC3	0.0133
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0132
908	Glutathione S-transferase theta-1	GSTT1	0.0132
365	Dihydrofolate reductase	DHFR	0.0131
2381	Dihydrofolate reductase	DFR1	0.0131
2833	Dihydrofolate reductase	Not Available	0.0131
2931	Dihydrofolate reductase	folA	0.0131
3544	Dihydrofolate reductase	folA	0.0131
3682	Dihydrofolate reductase	folA	0.0131
6642	Dihydrofolate reductase	folA	0.0131
6756	Dihydrofolate reductase	dfrA	0.0131
4116	Dihydropteroate synthetase	Not Available	0.0131
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.013
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0129
4122	Histone deacetylase 2	HDAC2	0.0129
790	DNA polymerase subunit alpha B	POLA2	0.0129
357	Carbonic anhydrase 2	CA2	0.0129
444	Alcohol dehydrogenase 1B	ADH1B	0.0128
6085	Fatty acid-binding protein, intestinal	FABP2	0.0128
123	Diamine acetyltransferase 1	SAT1	0.0127
751	Potassium channel subfamily K member 6	KCNK6	0.0126
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0126
672	Prostaglandin F2-alpha receptor	PTGFR	0.0125
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0125
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0125
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0125
769	High-affinity choline transporter 1	SLC5A7	0.0125
3927	Choline transporter-like protein 3	SLC44A3	0.0125
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0125
1686	Choline transporter-like protein 1	SLC44A1	0.0125
3926	Choline transporter-like protein 2	SLC44A2	0.0125
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0125
861	Choline kinase alpha	CHKA	0.0125
700	Choline dehydrogenase, mitochondrial	CHDH	0.0125
3925	Choline transporter-like protein 4	SLC44A4	0.0125
576	Choline O-acetyltransferase	CHAT	0.0125
3922	Phospholipase D2	PLD2	0.0125
3924	Phospholipase D1	PLD1	0.0125
232	Corticosteroid-binding globulin	SERPINA6	0.0125
5682	Ribonuclease pancreatic	RNASE1	0.0125
5294	Nucleoside diphosphate kinase A	NME1	0.0125
319	Opioid receptor, sigma 1	OPRS1	0.0124
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0124
275	Arachidonate 5-lipoxygenase	ALOX5	0.0124
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0123
407	Vascular endothelial growth factor receptor 2	KDR	0.0122
518	Peroxidase/catalase T	katG	0.0122
1192	Sulfotransferase 1A1	SULT1A1	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
6126	Carbonic anhydrase 7	CA7	0.012
3913	Glutamic acid decarboxylase	GAD65	0.012
6165	Copper-transporting ATPase 1	ATP7A	0.012
6163	Copper-transporting ATPase 2	ATP7B	0.012
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0117
6151	Monocarboxylate transporter 10	SLC16A10	0.0116
48	Pyridoxal kinase	PDXK	0.0116
563	Thyroid peroxidase	TPO	0.0116
172	Potassium channel subfamily K member 1	KCNK1	0.0115
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0115
26	Vascular endothelial growth factor receptor 3	FLT4	0.0114
2230	Catalase	CAT	0.0114
3249	Catalase	katA	0.0114
3625	Catalase	katA	0.0114
4539	Catalase	katA	0.0114
4941	Catalase	katB	0.0114
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
2499	Tubulin beta-2C chain	TUBB2C	0.0113
221	Lysyl-tRNA synthetase	KARS	0.0112
68	Cannabinoid receptor 1	CNR1	0.0112
1629	Transcription factor AP-1	JUN	0.0111
427	Substance-P receptor	TACR1	0.0111
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.011
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.011
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0109
32	Vascular endothelial growth factor receptor 1	FLT1	0.0109
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0108
84	Nuclear receptor 0B1	NR0B1	0.0108
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0106
5698	Riboflavin synthase alpha chain	ribE	0.0105
517	Alcohol dehydrogenase 1C	ADH1C	0.0105
823	Fibroblast growth factor receptor 2	FGFR2	0.0104
896	Glutathione S-transferase Mu 1	GSTM1	0.0104
1618	High affinity nerve growth factor receptor	NTRK1	0.0103
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0102
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0102
408	Riboflavin kinase	RFK	0.0101
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
1256	5-hydroxytryptamine 6 receptor	HTR6	0.01
1830	5'-nucleotidase	NT5E	0.01
4237	50S ribosomal protein L22	rplV	0.01
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.01
115	Penicillin-binding protein 2	mrdA	0.0099
6069	Penicillin-binding protein 2	mrdA	0.0099
6118	Penicillin-binding protein 2	penA	0.0099
6187	Penicillin-binding protein 2	pbpA	0.0099
6686	Penicillin-binding protein 2	pbp2	0.0099
6939	Penicillin-binding protein 2	mrdA	0.0099
7163	Penicillin-binding protein 2	pbpA	0.0099
2539	Tubulin alpha-1 chain	TUBA4A	0.0099
735	Alanine aminotransferase 1	GPT	0.0098
3904	Alanine aminotransferase 2	GPT2	0.0098
619	Low-affinity cationic amino acid transporter 2	SLC7A2	0.0098
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0097
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0097
2112	Toll-like receptor 9	TLR9	0.0097
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
1050	Bile salt sulfotransferase	SULT2A1	0.0097
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0097
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0096
952	Dipeptidyl peptidase 4	DPP4	0.0096
49	Endothelin B receptor	EDNRB	0.0096
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0095
820	Glycine receptor subunit alpha-2	GLRA2	0.0094
88	Retinoic acid receptor RXR-beta	RXRB	0.0093
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0093
4311	tRNA	TRDMT1	0.0093
4325	tRNA	trmD	0.0093
4328	tRNA	trmD	0.0093
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0092
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0091
578	Endothelin-1 receptor	EDNRA	0.009
1275	Estrogen sulfotransferase	SULT1E1	0.009
183	Vascular endothelial growth factor A	VEGFA	0.009
814	Ryanodine receptor 1	RYR1	0.009
4228	Keratin, type II cytoskeletal 7	KRT7	0.009
6766	O-GlcNAcase BT_4395	BT_4395	0.0089
499	Arginine decarboxylase	ADC	0.0089
291	Nitric-oxide synthase, endothelial	NOS3	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
4238	50S ribosomal protein L4	rplD	0.0088
5578	50S ribosomal protein L4	rplD	0.0088
6173	50S ribosomal protein L4	rplD	0.0088
6219	50S ribosomal protein L4	rplD	0.0088
6168	Solute carrier family 22 member 16	SLC22A16	0.0088
106	Cannabinoid receptor 2	CNR2	0.0088
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0087
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0087
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0087
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0086
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0086
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
3611	Cytidine deaminase	cdd	0.0085
3707	Cytidine deaminase	cdd	0.0085
4211	Cytidine deaminase	CDA	0.0085
577	Argininosuccinate lyase	ASL	0.0085
581	Cytochrome P450 2R1	CYP2R1	0.0085
834	Arginase-2, mitochondrial	ARG2	0.0084
856	Vitamin D3 receptor	VDR	0.0084
284	DNA-directed RNA polymerase beta chain	rpoB	0.0084
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0084
3809	Estrogen-related receptor gamma	ESRRG	0.0084
33	Cystine/glutamate transporter	SLC7A11	0.0083
1	Peptidoglycan synthetase ftsI	ftsI	0.0083
4155	Peptidoglycan synthetase ftsI	ftsI	0.0083
558	Solute carrier family 12 member 1	SLC12A1	0.0082
527	Prostacyclin receptor	PTGIR	0.0082
125	DNA polymerase beta	POLB	0.0081
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0081
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.008
565	Extracellular calcium-sensing receptor	CASR	0.008
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
634	Squalene monooxygenase	SQLE	0.0079
7196	Squalene monooxygenase	ERG1	0.0079
645	Penicillin-binding protein 1A	mrcA	0.0079
5805	Penicillin-binding protein 1A	ponA	0.0079
6185	Penicillin-binding protein 1A	mrcA	0.0079
6799	Penicillin-binding protein 1A	pbpA	0.0079
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0079
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0079
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0079
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0079
780	Retinoic acid receptor RXR-gamma	RXRG	0.0079
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0079
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0079
173	Toll-like receptor 7	TLR7	0.0079
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0078
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0078
867	Penicillin-binding protein 3	pbpC	0.0077
6119	Penicillin-binding protein 3	pbp3	0.0077
7154	Penicillin-binding protein 3	pbp3	0.0077
7157	Penicillin-binding protein 3	LMHCC_2184	0.0077
7162	Penicillin-binding protein 3	pbpB	0.0077
7172	Penicillin-binding protein 3	pbp3	0.0077
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0076
740	Argininosuccinate synthase	ASS1	0.0076
865	Argininosuccinate synthase	ASS1	0.0076
2680	Argininosuccinate synthase	argG	0.0076
3194	Argininosuccinate synthase	argG	0.0076
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0076
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0076
6174	50S ribosomal protein L32	rpmF	0.0075
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0075
654	Flavin reductase	BLVRB	0.0075
1541	Metalloproteinase	mmp20	0.0074
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0074
6043	Putative G-protein coupled receptor 44	GPR44	0.0073
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0073
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0073
551	Carnitine O-acetyltransferase	CRAT	0.0073
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0072
5934	Cytochrome P450 26A1	CYP26A1	0.0072
702	UMP-CMP kinase	CMPK1	0.0072
4217	Telomerase reverse transcriptase	TERT	0.0072
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0071
1074	Urokinase-type plasminogen activator	PLAU	0.0071
24	Thymidylate synthase	TMP1	0.0071
359	Thymidylate synthase	TYMS	0.0071
2626	Thymidylate synthase	thyA	0.0071
2729	Thymidylate synthase	thyA	0.0071
5352	Thymidylate synthase	THYA	0.0071
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0071
6171	Solute carrier family 28 member 3	SLC28A3	0.007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.007
1992	Vitamin D-binding protein	GC	0.007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0069
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0069
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0068
6149	Solute carrier family 22 member 10	SLC22A10	0.0068
6131	Carbonic anhydrase 14	CA14	0.0068
162	Retinoic acid receptor gamma-1	RARG	0.0068
469	Annexin A1	ANXA1	0.0068
239	Coagulation factor X	F10	0.0068
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0067
6218	Pannexin-1	PANX1	0.0067
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0066
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0066
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0065
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0064
6122	Carbonic anhydrase 3	CA3	0.0064
860	Nicotinamide N-methyltransferase	NNMT	0.0064
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0064
1770	Phospholipase C	PLCL1	0.0064
2841	Phospholipase C	plc	0.0064
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0064
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0064
699	Nicotinic acid receptor 1	GPR109A	0.0064
928	Nicotinic acid receptor 2	GPR109B	0.0064
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0064
569	Retinal dehydrogenase 2	ALDH1A2	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
192	Creatine kinase, ubiquitous mitochondrial	CKMT1A	0.0063
456	Creatine kinase, sarcomeric mitochondrial	CKMT2	0.0063
92	Creatine kinase B-type	CKB	0.0063
414	Sodium- and chloride-dependent creatine transporter 1	SLC6A8	0.0063
1648	Elastin	ELN	0.0063
4192	DNA topoisomerase 2-beta	TOP2B	0.0063
133	Dihydropterate synthase	sulI	0.0063
1039	Histone deacetylase 9	HDAC9	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
2298	Cytochrome P450-cam	camC	0.0061
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0061
611	Retinal dehydrogenase 1	ALDH1A1	0.006
719	Retinoic acid receptor responder protein 1	RARRES1	0.006
770	Retinoic acid-induced protein 3	GPRC5A	0.006
4103	Proteasome subunit beta type 2	PSMB2	0.0059
332	Beta-lactamase	blaZ	0.0059
2478	Beta-lactamase	ampC	0.0059
2613	Beta-lactamase	ampC	0.0059
2635	Beta-lactamase	ampC	0.0059
2700	Beta-lactamase	penP	0.0059
5445	Beta-lactamase	blaB	0.0059
6019	Beta-lactamase	SHV-7	0.0059
6701	Beta-lactamase	cphA	0.0059
4102	Proteasome subunit beta type 5	PSMB5	0.0059
4101	Proteasome subunit beta type 1	PSMB1	0.0059
54	Prothrombin	F2	0.0059
1864	RET proto-oncogene	RET	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
6067	Penicillin binding protein 2a	mecA	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0058
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0058
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0058
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0057
400	Coagulation factor IX	F9	0.0057
5461	Coagulation factor IX	F9	0.0057
788	Creatine kinase M-type	CKM	0.0057
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0057
6044	Serum paraoxonase/lactonase 3	PON3	0.0057
1714	Mitogen-activated protein kinase 3	MAPK3	0.0056
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0055
2320	Thymidine kinase, cytosolic	TK1	0.0055
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0055
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0055
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0055
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0055
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0055
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0055
6506	Stathmin-4	STMN4	0.0055
5300	Antigen peptide transporter 1	TAP1	0.0055
1374	Natriuretic peptides B	NPPB	0.0054
1827	Gap junction alpha-1 protein	GJA1	0.0054
1908	Vascular cell adhesion protein 1	VCAM1	0.0054
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0054
3957	Adenosine deaminase	ADA	0.0054
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0054
268	Adenosine A2b receptor	ADORA2B	0.0054
1353	DNA topoisomerase 1	TOP1	0.0053
3552	DNA topoisomerase 1	topA	0.0053
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0052
604	Vitamin K-dependent protein Z	PROZ	0.0052
714	Glutathione reductase, mitochondrial	GSR	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
3007	Carbonic anhydrase 12	CA12	0.0052
4205	Carbonic anhydrase 9	CA9	0.0052
712	Tubulin alpha chain	TUB1	0.0052
3426	Glutamine synthetase	glnA	0.0052
3987	Glutamine synthetase	GLUL	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
3090	Chitosanase	csn	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
3808	Dihydropteroate synthase 2	folP2	0.0051
3601	Dihydropteroate synthase 1	folP1	0.0051
3807	Dihydropteroate synthase 1	folP1	0.0051
165	FL cytokine receptor	FLT3	0.005
6167	Organic solute transporter subunit beta	OSTB	0.005
6166	Organic solute transporter subunit alpha	OSTA	0.005
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
2981	Phospholipase A2, membrane associated	PLA2G2A	0.005
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0049
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0049
3404	Exotoxin A	eta	0.0049
1630	Integrin beta-2	ITGB2	0.0048
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0048
422	Vitamin K-dependent protein C	PROC	0.0048
1245	Vitamin K-dependent protein S	PROS1	0.0048
489	Monocarboxylate transporter 2	SLC16A7	0.0048
936	Ephrin type-A receptor 2	EPHA2	0.0048
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0047
1253	Interferon gamma	IFNG	0.0046
2207	Rhodopsin	RHO	0.0046
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0046
2236	Casein kinase II subunit alpha	CSNK2A1	0.0046
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0045
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
3086	Plasmepsin-2	Not Available	0.0045
6134	Sodium channel subunit beta-3	SCN3B	0.0045
6133	Sodium channel subunit beta-2	SCN2B	0.0045
6132	Sodium channel subunit beta-1	SCN1B	0.0045
6135	Sodium channel subunit beta-4	SCN4B	0.0045
6127	Carbonic anhydrase-related protein	CA8	0.0045
3856	Fibroblast growth factor receptor 3	FGFR3	0.0045
6129	Carbonic anhydrase-related protein 11	CA11	0.0045
6128	Carbonic anhydrase-related protein 10	CA10	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
65	Matrix metalloproteinase-9	Not Available	0.0044
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0044
3639	Thymidine phosphorylase	deoA	0.0044
3936	Thymidine phosphorylase	TYMP	0.0044
1196	Complement decay-accelerating factor	CD55	0.0044
1268	Neuropeptide S receptor	NPSR1	0.0044
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0044
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0044
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
1262	Corticotropin-lipotropin	POMC	0.0044
5787	Angiopoietin-1 receptor	TEK	0.0044
267	Plasminogen activator inhibitor 1	SERPINE1	0.0044
6211	Tubulin epsilon chain	TUBE1	0.0044
6212	Tubulin gamma-1 chain	TUBG1	0.0044
6210	Tubulin delta chain	TUBD1	0.0044
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
3830	Calreticulin	CALR	0.0043
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0043
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
4226	Uridine phosphorylase 2	UPP2	0.0043
461	Glycine receptor subunit alpha-3	GLRA3	0.0043
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0042
6130	Carbonic anhydrase 13	CA13	0.0042
1176	Mitogen-activated protein kinase 1	MAPK1	0.0041
459	Retinoic acid receptor RXR-alpha	RXRA	0.0041
6034	Hydroxyindole O-methyltransferase	ASMT	0.0041
6035	Nuclear receptor ROR-beta	RORB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6036	Eosinophil peroxidase	EPX	0.0041
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
6073	Potassium channel subfamily K member 9	KCNK9	0.004
6072	Potassium channel subfamily K member 3	KCNK3	0.004
500	Monocarboxylate transporter 4	SLC16A3	0.004
6221	Steroid hormone receptor ERR1	ESRRA	0.0039
4225	Uridine phosphorylase 1	UPP1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
798	Osteocalcin	BGLAP	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
2808	Chloramphenicol acetyltransferase 3	cat3	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0038
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0038
85	Growth hormone receptor	GHR	0.0038
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0037
413	Amidophosphoribosyltransferase	PPAT	0.0037
2515	Amidophosphoribosyltransferase	purF	0.0037
3714	Amidophosphoribosyltransferase	purF	0.0037
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0036
765	Indoleamine 2,3-dioxygenase	IDO1	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
369	Coagulation factor VII	F7	0.0035
2417	Chloramphenicol acetyltransferase	cat	0.0035
3278	Chloramphenicol acetyltransferase	cat	0.0035
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
2810	Dr hemagglutinin structural subunit	draA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0034
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0033
229	Retinoic acid receptor beta	RARB	0.0033
277	Purine nucleoside phosphorylase	PNP	0.0033
2870	Purine nucleoside phosphorylase	punA	0.0033
2945	Purine nucleoside phosphorylase	punA	0.0033
4659	Purine nucleoside phosphorylase	TM_1596	0.0033
4825	Purine nucleoside phosphorylase	TTHA1435	0.0033
327	Glutathione reductase	gor	0.0033
5110	Glutathione reductase	GR2	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
730	Retinoic acid receptor alpha	RARA	0.0032
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
5798	Mitogen-activated protein kinase 11	MAPK11	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
1569	G1/S-specific cyclin-D1	CCND1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0028
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0028
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
1852	Microtubule-associated protein 2	MAP2	0.0028
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
572	Integrin alpha-L	ITGAL	0.0027
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0027
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0027
358	Cystathionine beta-synthase	CBS	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0027
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
2268	Cholesterol oxidase	choB	0.0025
2822	Cholesterol oxidase	choA	0.0025
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6048	Troponin C, skeletal muscle	TNNC2	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0023
822	Aldose reductase	AKR1B1	0.0023
484	Tyrosine-protein kinase ABL2	ABL2	0.0022
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
6824	Tyrosine-protein kinase Lyn	LYN	0.0021
997	Protein kinase C beta type	PRKCB	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
76	Nitric-oxide synthase, brain	NOS1	0.0021
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0021
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.002
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.002
3102	Flavohemoprotein	hmp	0.002
4969	Flavohemoprotein	hmp	0.002
594	Thyroxine-binding globulin	SERPINA7	0.002
2021	Thrombomodulin	THBD	0.002
6677	Myelin P2 protein	PMP2	0.002
1970	Protein kinase C alpha type	PRKCA	0.002
5923	Microtubule-associated protein tau	MAPT	0.0019
5924	Microtubule-associated protein 4	MAP4	0.0019
2216	Fibroblast growth factor receptor 4	FGFR4	0.0019
2408	Tyrosine-protein kinase SYK	SYK	0.0019
1291	cAMP response element-binding protein	CREB1	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
760	Fibroblast growth factor 1	FGF1	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
4210	Toll-like receptor 4	TLR4	0.0018
3221	Cytochrome c4	cc4	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
683	Potassium transporter	GK0582	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
6459	Glycodelin	PAEP	0.0018
199	Monocarboxylate transporter 8	SLC16A2	0.0018
4486	Phenol 2-hydroxylase component B	pheA2	0.0018
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0018
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0018
5117	Dihydrolipoyl dehydrogenase	lpd	0.0018
4439	Ferredoxin reductase	bphA4	0.0018
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0018
526	Thioredoxin reductase	trxB	0.0018
3767	Thioredoxin reductase	trxB	0.0018
5122	Mersacidin decarboxylase	mrsD	0.0017
5095	Putidaredoxin reductase	camA	0.0017
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0017
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0017
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0017
5109	Outer membrane protein p64k or PM-6	m-6	0.0017
5115	FkbI	fkbI	0.0017
3133	UDP-galactopyranose mutase	glf	0.0017
5099	UDP-galactopyranose mutase	glf	0.0017
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0017
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0017
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0017
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0017
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0017
5111	Phenylacetone monooxygenase	pamO	0.0017
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0017
5083	Cryptochrome DASH	cry	0.0017
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0017
5081	L-aspartate oxidase	nadB	0.0017
1410	Oxidoreductase	HSD17B6	0.0017
4725	Oxidoreductase	Not Available	0.0017
5124	Oxidoreductase	Not Available	0.0017
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
293	Gamma-glutamyl hydrolase	GGH	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
1243	Cathepsin D	CTSD	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
4440	NADH peroxidase	npr	0.0015
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0015
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0015
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0015
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0015
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0015
5072	N,N-dimethylglycine oxidase	dmg	0.0015
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0015
2470	Pyruvate oxidase	pox5	0.0015
5073	Ferredoxin--NADP reductase	petH	0.0015
5076	Ferredoxin--NADP reductase	fpr	0.0015
5119	Ferredoxin--NADP reductase	petH	0.0015
5121	Ferredoxin--NADP reductase	fpr	0.0015
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0015
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0015
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0015
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0015
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0015
2526	NADPH-ferredoxin reductase fprA	fprA	0.0015
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0015
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.0015
6689	TraN protein	traN	0.0015
6672	Destrin	DSTN	0.0015
6680	Cofilin-1	CFL1	0.0015
6670	Ig kappa chain V-I region Bi	Not Available	0.0015
6671	Ig heavy chain V-III region VH26	Not Available	0.0015
6688	TraF protein	traF	0.0015
6404	Rhomboid protease glpG	glpG	0.0015
6797	Rhomboid protease glpG	glpG	0.0015
3710	Acyl-CoA thioesterase 2	tesB	0.0015
6685	Outer membrane protein II	porB	0.0015
6690	BenF-like porin	PFL_1329	0.0015
6681	Probable N-acetylneuraminic acid outer membrane channel protein nanC	nanC	0.0015
6687	TraO protein	traO	0.0015
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0015
6559	Cytochrome c oxidase subunit 2	ctaC	0.0015
6669	Cytochrome c oxidase subunit 2	ctaC	0.0015
6668	Cytochrome c oxidase subunit 1-beta	ctaDII	0.0015
6679	Colicin-Ia	cia	0.0015
6676	Fe(3+)-pyochelin receptor	fptA	0.0015
6674	Nuclear factor erythroid 2-related factor 1	NFE2L1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1650	Heme carrier protein 1	SLC46A1	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0015
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0015
126	D-lactate dehydrogenase	dld	0.0014
3545	D-lactate dehydrogenase	Not Available	0.0014
4510	D-lactate dehydrogenase	ldhA	0.0014
2599	Tyrosine-protein kinase HCK	HCK	0.0014
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.0014
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0014
2893	Glycine oxidase	thiO	0.0014
6859	Protein S100-A4	S100A4	0.0014
1792	Tissue-type plasminogen activator	PLAT	0.0014
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0013
2567	Thymidylate synthase thyX	thyX	0.0013
2823	Trypanothione reductase	TPR	0.0013
2769	P-hydroxybenzoate hydroxylase	pobA	0.0013
2809	P-hydroxybenzoate hydroxylase	pobA	0.0013
244	Angiotensin-converting enzyme	ACE	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0013
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0013
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0013
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0013
4760	Mll3241 protein	mll3241	0.0013
3395	Iron(III) dicitrate transport protein fecA	fecA	0.0013
6385	H subunit of photosynthetic reaction center complex	puhA	0.0013
6474	Outer membrane protein W	ompW	0.0013
6678	Colicin I receptor	cirA	0.0013
3578	Protein crcA	crcA	0.0013
6675	Colicin-E3	ceaC	0.0013
2925	Long-chain fatty acid transport protein	fadL	0.0013
6480	Outer membrane usher protein papC	papC	0.0013
6438	Outer membrane protein G	ompG	0.0013
2447	Ammonia channel	amtB	0.0013
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0013
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
2380	Monomeric sarcosine oxidase	soxA	0.0012
6645	D-amino-acid oxidase	DAO	0.0012
3587	Gastrotropin	FABP6	0.0012
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.0012
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.0012
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
1295	Fatty acid synthase	FASN	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
6524	Protein tonB	tonB	0.0012
2679	Vitamin B12 transporter btuB	btuB	0.0012
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
283	SEC14-like protein 2	SEC14L2	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6352	Reaction center protein H chain	puhA	0.001
6456	Reaction center protein H chain	puhA	0.001
6682	Reaction center protein H chain	puhA	0.001
6353	Reaction center protein L chain	pufL	0.001
6454	Reaction center protein L chain	pufL	0.001
6683	Reaction center protein L chain	pufL	0.001
6354	Reaction center protein M chain	pufM	0.001
6455	Reaction center protein M chain	pufM	0.001
6684	Reaction center protein M chain	pufM	0.001
6351	Photosynthetic reaction center cytochrome c subunit	pufC	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
2828	Squalene--hopene cyclase	shc	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
6042	Prostaglandin reductase 2	PTGR2	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4943	Cytochrome c6	petJ	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4984	Neuroglobin	NGB	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
5000	HemO	hemO	0.0008
4910	Cytoglobin	CYGB	0.0008
4909	CooA protein	cooA	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4972	P450cin	cinA	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
3093	Catalase HPII	katE	0.0008
4952	Catalase/peroxidase	katA	0.0008
1867	Major prion protein	PRNP	0.0008
1507	Cytochrome c	CYCS	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
2802	Endoglucanase G	celCCG	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
1313	Lactoylglutathione lyase	GLO1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
4920	Peroxidase/catalase	katG	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
2240	Cell division protein kinase 2	CDK2	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00184 - Nicotine

Targets

Enzymes

Transporters

Predictions