DT-Web

DB00889 - Granisetron


Identification
Name Granisetron
Accession Number DB00889 (APRD01002)
Type small molecule
Description A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 312.4094
Groups approved
Monoisotopic Weight 312.19501141
Pharmacology
Indication For the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy (including high dose cisplatin), postoperation, and radiation (including total body irradiation and daily fractionated abdominal radiation).
Mechanism of action Granisetron is a potent, selective antagonist of 5-HT3 receptors. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.
Absorption Absorption of is rapid and complete, though oral bioavailability is reduced to about 60% as a result of first pass metabolism.
Protein binding 65%
Biotransformation Primarily hepatic; undergoes N -demethylation and aromatic ring oxidation followed by conjugation. Animal studies suggest that some of the metabolites may have 5-HT 3 receptor antagonist activity.
Route of elimination The remainder of the dose is excreted as metabolites, 48% in the urine and 38% in the feces.
Toxicity LD50>2000 mg/kg (rat, oral)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • Take without regard to meals.

Targets


5-hydroxytryptamine 3 receptor
Name 5-hydroxytryptamine 3 receptor
Gene Name HTR3A
Pharmacological action yes
Actions antagonist
References
  • Hillsley K, Grundy D: Plasticity in the mesenteric afferent response to cisplatin following vagotomy in the rat. J Auton Nerv Syst. 1999 May 28;76(2-3):93-8. - Pubmed
  • Turvill JL, Connor P, Farthing MJ: The inhibition of cholera toxin-induced 5-HT release by the 5-HT(3) receptor antagonist, granisetron, in the rat. Br J Pharmacol. 2000 Jul;130(5):1031-6. - Pubmed
  • Cappelli A, Anzini M, Vomero S, Mennuni L, Makovec F, Doucet E, Hamon M, Menziani MC, De Benedetti PG, Giorgi G, Ghelardini C, Collina S: Novel potent 5-HT(3) receptor ligands based on the pyrrolidone structure: synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities. Bioorg Med Chem. 2002 Mar;10(3):779-801. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Gan TJ: Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same? CNS Drugs. 2005;19(3):225-38. - Pubmed
  • Tan M: Granisetron: new insights into its use for the treatment of chemotherapy-induced nausea and vomiting. Expert Opin Pharmacother. 2003 Sep;4(9):1563-71. - Pubmed
  • Ho KY, Gan TJ: Pharmacology, pharmacogenetics, and clinical efficacy of 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Curr Opin Anaesthesiol. 2006 Dec;19(6):606-11. - Pubmed
  • Abdelsayed GG: Management of radiation-induced nausea and vomiting. Exp Hematol. 2007 Apr;35(4 Suppl 1):34-6. - Pubmed
  • Feyer P, Seegenschmiedt MH, Steingraeber M: Granisetron in the control of radiotherapy-induced nausea and vomiting: a comparison with other antiemetic therapies. Support Care Cancer. 2005 Sep;13(9):671-8. Epub 2005 Jul 26. - Pubmed
DTHybrid score 0.1995

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Tan M: Granisetron: new insights into its use for the treatment of chemotherapy-induced nausea and vomiting. Expert Opin Pharmacother. 2003 Sep;4(9):1563-71. - Pubmed
  • Janicki PK: Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Med Sci Monit. 2005 Oct;11(10):RA322-8. Epub 2005 Sep 26. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5038
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Nakamura H, Ariyoshi N, Okada K, Nakasa H, Nakazawa K, Kitada M: CYP1A1 is a major enzyme responsible for the metabolism of granisetron in human liver microsomes. Curr Drug Metab. 2005 Oct;6(5):469-80. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2147
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3927
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2703

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.2133
4757 Cytochrome P450 2C9 CYP2C9 0.1855
1588 Multidrug resistance protein 1 ABCB1 0.1705
6016 Cytochrome P450 2C19 CYP2C19 0.1631
6107 Cytochrome P450 3A7 CYP3A7 0.163
4924 Cytochrome P450 2C8 CYP2C8 0.1301
6013 Cytochrome P450 2E1 CYP2E1 0.1042
6030 Cytochrome P450 2B6 CYP2B6 0.1023
5718 Cytochrome P450 2A6 CYP2A6 0.0718
492 Histamine H1 receptor HRH1 0.0592
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0508
6145 Solute carrier family 22 member 1 SLC22A1 0.0494
502 5-hydroxytryptamine 2A receptor HTR2A 0.0468
1898 Cytochrome P450 1B1 CYP1B1 0.0447
587 Serum albumin ALB 0.0442
824 Sodium-dependent serotonin transporter SLC6A4 0.0432
831 D(2) dopamine receptor DRD2 0.0409
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0408
6144 Solute carrier family 22 member 2 SLC22A2 0.0407
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0406
713 Sodium-dependent dopamine transporter SLC6A3 0.0402
320 5-hydroxytryptamine 1A receptor HTR1A 0.0396
556 Alpha-1A adrenergic receptor ADRA1A 0.0393
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0391
318 Alpha-2A adrenergic receptor ADRA2A 0.0381
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0378
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0377
847 Mu-type opioid receptor OPRM1 0.0367
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0365
590 5-hydroxytryptamine 2C receptor HTR2C 0.0346
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0338
20 Prostaglandin G/H synthase 1 PTGS1 0.0329
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0324
862 Multidrug resistance-associated protein 1 ABCC1 0.0308
766 Beta-2 adrenergic receptor ADRB2 0.0306
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0299
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0299
871 Glucocorticoid receptor NR3C1 0.0295
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0288
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0284
632 Alpha-1B adrenergic receptor ADRA1B 0.0284
696 Kappa-type opioid receptor OPRK1 0.0283
193 Beta-1 adrenergic receptor ADRB1 0.0281
23 D(1A) dopamine receptor DRD1 0.0277
6106 Cytochrome P450 2C18 CYP2C18 0.0277
885 5-hydroxytryptamine 1B receptor HTR1B 0.0274
638 D(3) dopamine receptor DRD3 0.0269
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0268
467 Delta-type opioid receptor OPRD1 0.0257
3923 Cholinesterase BCHE 0.0256
776 Bile salt export pump ABCB11 0.025
3811 Cytochrome P450 19A1 CYP19A1 0.0239
629 Alpha-2B adrenergic receptor ADRA2B 0.023
1729 Solute carrier family 22 member 6 SLC22A6 0.023
378 Alpha-2C adrenergic receptor ADRA2C 0.0229
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0217
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0216
432 D(4) dopamine receptor DRD4 0.0213
118 Organic cation/carnitine transporter 2 SLC22A5 0.0211
450 Muscarinic acetylcholine receptor M4 CHRM4 0.021
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0209
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0209
725 5-hydroxytryptamine 1D receptor HTR1D 0.0196
136 Estrogen receptor ESR1 0.0196
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0195
468 Cytochrome P450 4A11 CYP4A11 0.0192
6031 Cytochrome P450 3A43 CYP3A43 0.0192
94 5-hydroxytryptamine 4 receptor HTR4 0.0187
474 Acetylcholinesterase ACHE 0.0186
716 5-hydroxytryptamine 7 receptor HTR7 0.0181
731 HIV-1 protease HIV-1 protease 0.018
1256 5-hydroxytryptamine 6 receptor HTR6 0.0179
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0178
528 5-hydroxytryptamine 1E receptor HTR1E 0.0168
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0164
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0164
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.016
6147 Solute carrier family 22 member 3 SLC22A3 0.0158
163 D(1B) dopamine receptor DRD5 0.0158
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0157
290 Prostaglandin G/H synthase 2 PTGS2 0.0155
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0155
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0154
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0151
6182 Cytochrome P450 2J2 CYP2J2 0.015
833 Organic cation/carnitine transporter 1 SLC22A4 0.0146
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0143
6142 Solute carrier family 22 member 8 SLC22A8 0.0142
817 DNA topoisomerase 2-alpha TOP2A 0.014
232 Corticosteroid-binding globulin SERPINA6 0.0139
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0139
465 Calmodulin CALM1 0.0138
777 Tumor necrosis factor TNF 0.0137
789 Alpha-1D adrenergic receptor ADRA1D 0.0135
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0131
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0128
614 Progesterone receptor PGR 0.0123
6014 Cytochrome P450 2A13 CYP2A13 0.0121
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0121
844 Epidermal growth factor receptor EGFR 0.012
260 Cytochrome P450 51 ERG11 0.012
761 Cytochrome P450 51 ERG11 0.012
3163 Cytochrome P450 51 cyp51 0.012
48 Pyridoxal kinase PDXK 0.0116
6148 Multidrug resistance-associated protein 7 ABCC10 0.0115
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0115
6143 Solute carrier family 22 member 7 SLC22A7 0.0114
4148 Serine/threonine-protein kinase mTOR MTOR 0.011
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0109
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0109
3941 Amine oxidase [flavin-containing] A MAOA 0.0109
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0106
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0103
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0102
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0102
6220 Aryl hydrocarbon receptor AHR 0.0102
2164 Multidrug resistance-associated protein 4 ABCC4 0.0101
2449 Tubulin alpha-3 chain TUBA1A 0.01
1517 Beta-3 adrenergic receptor ADRB3 0.0099
2112 Toll-like receptor 9 TLR9 0.0098
2499 Tubulin beta-2C chain TUBB2C 0.0098
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0098
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0098
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0098
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0097
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0095
146 Androgen receptor AR 0.0094
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
737 Mineralocorticoid receptor NR3C2 0.0094
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0093
613 Atrial natriuretic peptide receptor A NPR1 0.009
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0089
3932 Glutathione S-transferase A2 GSTA2 0.0088
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0088
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0088
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0088
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0087
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0087
504 Mast/stem cell growth factor receptor KIT 0.0087
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0086
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0085
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0083
436 5-hydroxytryptamine 2B receptor HTR2B 0.0081
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0081
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.008
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.008
952 Dipeptidyl peptidase 4 DPP4 0.0079
4203 Histamine N-methyltransferase HNMT 0.0079
1010 Cytochrome P450 51A1 CYP51A1 0.0079
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0076
3939 Amine oxidase [flavin-containing] B MAOB 0.0076
131 Synaptic vesicular amine transporter SLC18A2 0.0076
380 Cytochrome P450 17A1 CYP17A1 0.0075
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0075
122 P2Y purinoceptor 12 P2RY12 0.0075
818 50S ribosomal protein L10 rplJ 0.0074
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0074
3947 Xanthine dehydrogenase/oxidase XDH 0.0073
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0073
756 Sex hormone-binding globulin SHBG 0.0073
705 Glutamate receptor 1 GRIA1 0.0072
4604 Liver carboxylesterase 1 CES1 0.0071
4228 Keratin, type II cytoskeletal 7 KRT7 0.007
6137 Multidrug resistance-associated protein 6 ABCC6 0.0069
29 Tubulin beta-1 chain TUBB1 0.0068
161 Tubulin beta chain TUBB 0.0068
312 Tubulin beta chain TUB2 0.0068
228 Beta platelet-derived growth factor receptor PDGFRB 0.0067
811 Translocator protein TSPO 0.0065
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0065
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0065
407 Vascular endothelial growth factor receptor 2 KDR 0.0064
814 Ryanodine receptor 1 RYR1 0.0064
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0064
124 Histamine H2 receptor HRH2 0.0063
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0063
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0063
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0063
33 Cystine/glutamate transporter SLC7A11 0.0062
1656 CYP2B protein CYP2B 0.0061
1178 Adenosine A2a receptor ADORA2A 0.0061
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.006
68 Cannabinoid receptor 1 CNR1 0.006
6020 Aldehyde oxidase AOX1 0.006
4311 tRNA TRDMT1 0.006
4325 tRNA trmD 0.006
4328 tRNA trmD 0.006
477 DNA topoisomerase 4 subunit A parC 0.0059
886 DNA topoisomerase 4 subunit A parC 0.0059
6226 DNA topoisomerase 4 subunit A parC 0.0059
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0058
404 DNA gyrase subunit A gyrA 0.0058
6224 DNA gyrase subunit A gyrA 0.0058
26 Vascular endothelial growth factor receptor 3 FLT4 0.0058
1024 Solute carrier family 22 member 11 SLC22A11 0.0058
790 DNA polymerase subunit alpha B POLA2 0.0058
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0058
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0058
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0058
723 Cytosolic phospholipase A2 PLA2G4A 0.0058
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0057
295 Carbonic anhydrase 1 CA1 0.0057
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0056
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0056
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0055
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0055
32 Vascular endothelial growth factor receptor 1 FLT1 0.0055
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0055
6506 Stathmin-4 STMN4 0.0055
373 Transthyretin TTR 0.0055
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0055
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0054
6043 Putative G-protein coupled receptor 44 GPR44 0.0054
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0054
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0054
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0054
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0054
856 Vitamin D3 receptor VDR 0.0054
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0054
820 Glycine receptor subunit alpha-2 GLRA2 0.0053
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0053
16 Adenosine A1 receptor ADORA1 0.0053
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0053
1757 Myeloperoxidase MPO 0.0053
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0052
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.005
823 Fibroblast growth factor receptor 2 FGFR2 0.005
768 FK506-binding protein 1A FKBP1A 0.005
1629 Transcription factor AP-1 JUN 0.005
4120 NADPH--cytochrome P450 reductase POR 0.005
6102 Arylamine N-acetyltransferase 2 NAT2 0.005
4237 50S ribosomal protein L22 rplV 0.0049
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0049
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0049
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0049
173 Toll-like receptor 7 TLR7 0.0049
6136 Multidrug resistance-associated protein 5 ABCC5 0.0048
164 Histamine H4 receptor HRH4 0.0048
6141 Sodium/bile acid cotransporter SLC10A1 0.0048
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0048
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0047
239 Coagulation factor X F10 0.0047
592 Carbonic anhydrase 4 CA4 0.0047
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0047
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
1714 Mitogen-activated protein kinase 3 MAPK3 0.0046
3086 Plasmepsin-2 Not Available 0.0046
2539 Tubulin alpha-1 chain TUBA4A 0.0046
84 Nuclear receptor 0B1 NR0B1 0.0045
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
1820 Beta-nerve growth factor NGF 0.0044
869 Estrogen receptor beta ESR2 0.0044
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0044
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0044
461 Glycine receptor subunit alpha-3 GLRA3 0.0043
54 Prothrombin F2 0.0042
1050 Bile salt sulfotransferase SULT2A1 0.0042
1176 Mitogen-activated protein kinase 1 MAPK1 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0041
581 Cytochrome P450 2R1 CYP2R1 0.0041
4122 Histone deacetylase 2 HDAC2 0.0041
1192 Sulfotransferase 1A1 SULT1A1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
165 FL cytokine receptor FLT3 0.004
6766 O-GlcNAcase BT_4395 BT_4395 0.004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.004
3426 Glutamine synthetase glnA 0.0039
3987 Glutamine synthetase GLUL 0.0039
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0039
976 Platelet glycoprotein IX GP9 0.0038
70 Type-1 angiotensin II receptor AGTR1 0.0038
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0038
891 Dihydropteroate synthase folP 0.0037
5359 Dihydropteroate synthase folP 0.0037
7175 Dihydropteroate synthase sulI 0.0037
6146 High affinity copper uptake protein 1 SLC31A1 0.0037
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
469 Annexin A1 ANXA1 0.0037
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0036
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0036
427 Substance-P receptor TACR1 0.0036
738 Monocarboxylate transporter 1 SLC16A1 0.0036
153 Dopamine beta-hydroxylase DBH 0.0036
5934 Cytochrome P450 26A1 CYP26A1 0.0035
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0035
5300 Antigen peptide transporter 1 TAP1 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0035
357 Carbonic anhydrase 2 CA2 0.0035
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0035
939 50S ribosomal protein L3 rplC 0.0035
569 Retinal dehydrogenase 2 ALDH1A2 0.0035
1483 Membrane copper amine oxidase AOC3 0.0035
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0035
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0034
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0034
284 DNA-directed RNA polymerase beta chain rpoB 0.0034
5773 DNA-directed RNA polymerase beta chain rpoB 0.0034
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0033
4238 50S ribosomal protein L4 rplD 0.0033
5578 50S ribosomal protein L4 rplD 0.0033
6173 50S ribosomal protein L4 rplD 0.0033
6219 50S ribosomal protein L4 rplD 0.0033
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
4192 DNA topoisomerase 2-beta TOP2B 0.0033
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0033
106 Cannabinoid receptor 2 CNR2 0.0033
174 Sigma 1-type opioid receptor SIGMAR1 0.0033
611 Retinal dehydrogenase 1 ALDH1A1 0.0032
1852 Microtubule-associated protein 2 MAP2 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
482 Glycine receptor subunit alpha-1 GLRA1 0.0032
275 Arachidonate 5-lipoxygenase ALOX5 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
2236 Casein kinase II subunit alpha CSNK2A1 0.0031
365 Dihydrofolate reductase DHFR 0.0031
2381 Dihydrofolate reductase DFR1 0.0031
2833 Dihydrofolate reductase Not Available 0.0031
2931 Dihydrofolate reductase folA 0.0031
3544 Dihydrofolate reductase folA 0.0031
3682 Dihydrofolate reductase folA 0.0031
6642 Dihydrofolate reductase folA 0.0031
6756 Dihydrofolate reductase dfrA 0.0031
904 Glutathione S-transferase P GSTP1 0.0031
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0031
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0031
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
6126 Carbonic anhydrase 7 CA7 0.003
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.003
1063 Signal transducer and activator of transcription 5B STAT5B 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
1992 Vitamin D-binding protein GC 0.0029
780 Retinoic acid receptor RXR-gamma RXRG 0.0029
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0029
1569 G1/S-specific cyclin-D1 CCND1 0.0029
3856 Fibroblast growth factor receptor 3 FGFR3 0.0028
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0028
4773 Deoxycytidine kinase DCK 0.0027
936 Ephrin type-A receptor 2 EPHA2 0.0027
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0027
1374 Natriuretic peptides B NPPB 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
1827 Gap junction alpha-1 protein GJA1 0.0027
1908 Vascular cell adhesion protein 1 VCAM1 0.0027
4103 Proteasome subunit beta type 2 PSMB2 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
770 Retinoic acid-induced protein 3 GPRC5A 0.0027
719 Retinoic acid receptor responder protein 1 RARRES1 0.0027
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0026
183 Vascular endothelial growth factor A VEGFA 0.0026
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0026
88 Retinoic acid receptor RXR-beta RXRB 0.0026
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0026
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0026
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0026
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0026
634 Squalene monooxygenase SQLE 0.0026
7196 Squalene monooxygenase ERG1 0.0026
49 Endothelin B receptor EDNRB 0.0026
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0025
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0025
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0025
484 Tyrosine-protein kinase ABL2 ABL2 0.0025
5924 Microtubule-associated protein 4 MAP4 0.0024
5923 Microtubule-associated protein tau MAPT 0.0024
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0024
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
1618 High affinity nerve growth factor receptor NTRK1 0.0024
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
267 Plasminogen activator inhibitor 1 SERPINE1 0.0023
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
6174 50S ribosomal protein L32 rpmF 0.0022
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
5787 Angiopoietin-1 receptor TEK 0.0022
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0022
319 Opioid receptor, sigma 1 OPRS1 0.0022
273 Apoptosis regulator Bcl-2 BCL2 0.0022
6131 Carbonic anhydrase 14 CA14 0.0022
3404 Exotoxin A eta 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
1196 Complement decay-accelerating factor CD55 0.0022
298 Renin REN 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
1630 Integrin beta-2 ITGB2 0.0021
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0021
908 Glutathione S-transferase theta-1 GSTT1 0.0021
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
1353 DNA topoisomerase 1 TOP1 0.0021
3552 DNA topoisomerase 1 topA 0.0021
6221 Steroid hormone receptor ERR1 ESRRA 0.0021
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
7 Nitric oxide synthase, inducible NOS2 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
3937 Fatty-acid amide hydrolase FAAH 0.002
6122 Carbonic anhydrase 3 CA3 0.002
3809 Estrogen-related receptor gamma ESRRG 0.002
6432 Transporter snf 0.002
859 Cellular retinoic acid-binding protein 2 CRABP2 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
1525 Heparin-binding growth factor 2 FGF2 0.0019
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0019
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0019
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
1275 Estrogen sulfotransferase SULT1E1 0.0019
921 Glutamate receptor 2 GRIA2 0.0019
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
251 Alcohol dehydrogenase 1A ADH1A 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
3830 Calreticulin CALR 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
751 Potassium channel subfamily K member 6 KCNK6 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0018
896 Glutathione S-transferase Mu 1 GSTM1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6085 Fatty acid-binding protein, intestinal FABP2 0.0017
6034 Hydroxyindole O-methyltransferase ASMT 0.0017
6035 Nuclear receptor ROR-beta RORB 0.0017
6036 Eosinophil peroxidase EPX 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
3601 Dihydropteroate synthase 1 folP1 0.0017
3807 Dihydropteroate synthase 1 folP1 0.0017
3808 Dihydropteroate synthase 2 folP2 0.0017
6044 Serum paraoxonase/lactonase 3 PON3 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
162 Retinoic acid receptor gamma-1 RARG 0.0017
400 Coagulation factor IX F9 0.0017
5461 Coagulation factor IX F9 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0017
518 Peroxidase/catalase T katG 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
444 Alcohol dehydrogenase 1B ADH1B 0.0016
172 Potassium channel subfamily K member 1 KCNK1 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
572 Integrin alpha-L ITGAL 0.0016
822 Aldose reductase AKR1B1 0.0016
3233 Bile acid receptor NR1H4 0.0015
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
604 Vitamin K-dependent protein Z PROZ 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
1864 RET proto-oncogene RET 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
563 Thyroid peroxidase TPO 0.0015
765 Indoleamine 2,3-dioxygenase IDO1 0.0015
3957 Adenosine deaminase ADA 0.0015
1541 Metalloproteinase mmp20 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0014
422 Vitamin K-dependent protein C PROC 0.0014
1245 Vitamin K-dependent protein S PROS1 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1341 Histamine H3 receptor HRH3 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
3904 Alanine aminotransferase 2 GPT2 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
3007 Carbonic anhydrase 12 CA12 0.0013
4205 Carbonic anhydrase 9 CA9 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6163 Copper-transporting ATPase 2 ATP7B 0.0013
6165 Copper-transporting ATPase 1 ATP7A 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0012
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
1295 Fatty acid synthase FASN 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0012
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0011
798 Osteocalcin BGLAP 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
369 Coagulation factor VII F7 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
345 Plasma retinol-binding protein RBP4 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
511 5-hydroxytryptamine 1F receptor HTR1F 0.001
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1039 Histone deacetylase 9 HDAC9 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2981 Phospholipase A2, membrane associated PLA2G2A 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
2298 Cytochrome P450-cam camC 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
1360 Sphingomyelin phosphodiesterase SMPD1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
2207 Rhodopsin RHO 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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