DT-Web: DB00262

Identification

Name

Carmustine

Accession Number

DB00262 (APRD00006)

Type

small molecule

Description

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

214.05

Groups

approved

Monoisotopic Weight

213.007181961

Pharmacology

Indication

For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.

Mechanism of action

Carmustine causes cross-links in DNA and RNA, leading to the inhibition of DNA synthesis, RNA production and RNA translation (protein synthesis). Carmustine also binds to and modifies (carbamoylates) glutathione reductase. This leads to cell death.

Absorption

5 to 28% bioavailability

Protein binding

80%

Biotransformation

Hepatic and rapid with active metabolites. Metabolites may persist in the plasma for several days.

Route of elimination

Approximately 60% to 70% of a total dose is excreted in the urine in 96 hours and about 10% as respiratory CO2.

Toxicity

The oral LD₅₀s in rat and mouse are 20 mg/kg and 45 mg/kg, respectively. Side effects include leukopenia, thrombocytopenia, nausea. Toxic effects include pulmonary fibrosis (20-0%) and bone marrow toxicity.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Bendamustine	Increases toxicity through pharmacodynamic synergism. Additive myelosuppression.
Cimetidine	Increases myelosuppression caused by carmustine
Digoxin	The antineoplasic agent decreases the effect of digoxin
Fosphenytoin	The antineoplasic agent decreases the effect of hydantoin
Leflunomide	Immunosuppressants such as carmustine may enhance the adverse/toxic effect of leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity. Also, patients receiving both leflunomide and another immunosuppressive medication should be monitored for bone marrow suppression at least monthly throughout the duration of concurrent therapy.
Natalizumab	Immunosuppressants such as carmustine may enhance the adverse/toxic effect of natalizumab. Specifically, the risk of concurrent infection may be increased. Patients receiving natalizumab should not use concurrent immunosuppressants.
Phenytoin	The antineoplasic agent decreases the effect of hydantoin
Pimecrolimus	Pimecrolimus may enhance the adverse/toxic effect of immunosuppressants such as carmustine. Avoid use of pimecrolimus cream in patients receiving immunosuppressants.
Roflumilast	Roflumilast may enhance the immunosuppressive effect of immunosuppressants such as carmustine. The Canadian roflumilast product monograph recommends avoiding concurrent use of roflumilast with any immunosuppressant medications due to the antiinflammatory/immune altering effects of roflumilast and the lack of relevant clinical experience with such use. Of note, this recommendation to avoid concurrent use does not apply to either inhaled corticosteroids (which have much more limited systemic immune-suppressing actions) or short-term systemic corticosteroid use. U.S. prescribing information does not contain this warning; but it appears prudent to avoid this combination when possible.
Tacrolimus	Tacrolimus (Topical) may enhance the adverse/toxic effect of immunosuppressants such as carmustine. Avoid use of tacrolimus ointment in patients receiving immunosuppressants.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.

Food Interactions

Echinacea

DNA
Name	DNA
Gene Name	Not Available
Pharmacological action	yes
Actions	other/unknown
References	Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Johannessen TC, Bjerkvig R, Tysnes BB: DNA repair and cancer stem-like cells--potential partners in glioma drug resistance? Cancer Treat Rev. 2008 Oct;34(6):558-67. Epub 2008 May 22. - Pubmed Lin SH, Kleinberg LR: Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies. Expert Rev Anticancer Ther. 2008 Mar;8(3):343-59. - Pubmed Drablos F, Feyzi E, Aas PA, Vaagbo CB, Kavli B, Bratlie MS, Pena-Diaz J, Otterlei M, Slupphaug G, Krokan HE: Alkylation damage in DNA and RNA--repair mechanisms and medical significance. DNA Repair (Amst). 2004 Nov 2;3(11):1389-407. - Pubmed Zhang Q, Ohannesian DW, Kreklau EL, Erickson LC: Modulation of 1,3-bis-(2-chloroethyl)-1-nitrosourea resistance in human tumor cells using hammerhead ribozymes designed to degrade O6-methylguanine DNA methyltransferase mRNA. J Pharmacol Exp Ther. 2001 Jul;298(1):141-7. - Pubmed He YH, Xu Y, Kobune M, Wu M, Kelley MR, Martin WJ 2nd: Escherichia coli FPG and human OGG1 reduce DNA damage and cytotoxicity by BCNU in human lung cells. Am J Physiol Lung Cell Mol Physiol. 2002 Jan;282(1):L50-5. - Pubmed
DTHybrid score	Not Available
Glutathione reductase, mitochondrial
Name	Glutathione reductase, mitochondrial
Gene Name	GSR
Pharmacological action	yes
Actions	inhibitor
References	Akella SS, Harris C: Pyridine nucleotide flux and glutathione oxidation in the cultured rat conceptus. Reprod Toxicol. 1999 May-Jun;13(3):203-13. - Pubmed Kirsch JD, Yi AK, Spitz DR, Krieg AM: Accumulation of glutathione disulfide mediates NF-kappaB activation during immune stimulation with CpG DNA. Antisense Nucleic Acid Drug Dev. 2002 Oct;12(5):327-40. - Pubmed Vallyathan V, Mega JF, Shi X, Dalal NS: Enhanced generation of free radicals from phagocytes induced by mineral dusts. Am J Respir Cell Mol Biol. 1992 Apr;6(4):404-13. - Pubmed Brodie AE, Reed DJ: Glutathione disulfide reduction in tumor mitochondria after t-butyl hydroperoxide treatment. Chem Biol Interact. 1992 Sep 28;84(2):125-32. - Pubmed Jopperi-Davis KS, Park MS, Rogers LK, Backes CH Jr, Lim IK, Smith CV: Compartmental inhibition of hepatic glutathione reductase activities by 1,3-bis(2-chloroethyl)-N-nitrosourea (BCNU) in Sprague-Dawley and Fischer-344 rats. Toxicol Lett. 2004 Mar 7;147(3):219-28. - Pubmed Doroshenko N, Doroshenko P: The glutathione reductase inhibitor carmustine induces an influx of Ca2+ in PC12 cells. Eur J Pharmacol. 2004 Aug 16;497(1):17-24. - Pubmed Powell SR, Puglia CD: Effect of inhibition of glutathione reductase by carmustine on central nervous system oxygen toxicity. J Pharmacol Exp Ther. 1987 Jan;240(1):111-7. - Pubmed Puglia CD, Powell SR: Inhibition of cellular antioxidants: a possible mechanism of toxic cell injury. Environ Health Perspect. 1984 Aug;57:307-11. - Pubmed
DTHybrid score	0.9422
RNA
Name	RNA
Gene Name	Not Available
Pharmacological action	yes
Actions	other/unknown
References	Lin SH, Kleinberg LR: Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies. Expert Rev Anticancer Ther. 2008 Mar;8(3):343-59. - Pubmed
DTHybrid score	Not Available

Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2297

Id	Partner name	Gene Name	Score
2165	Glutathione S-transferase Mu 2	GSTM2	0.0736
4512	Cytochrome P450 3A4	CYP3A4	0.064
4119	Cytochrome P450 2D6	CYP2D6	0.0492
4757	Cytochrome P450 2C9	CYP2C9	0.0467
6016	Cytochrome P450 2C19	CYP2C19	0.0429
6024	Cytochrome P450 1A1	CYP1A1	0.038
1588	Multidrug resistance protein 1	ABCB1	0.0302
6013	Cytochrome P450 2E1	CYP2E1	0.03
6030	Cytochrome P450 2B6	CYP2B6	0.027
4924	Cytochrome P450 2C8	CYP2C8	0.0262
36	Insulin receptor	INSR	0.0258
4118	Cytochrome P450 3A5	CYP3A5	0.0244
6107	Cytochrome P450 3A7	CYP3A7	0.0177
5718	Cytochrome P450 2A6	CYP2A6	0.0176
4602	Osmotically inducible protein C	tthHB8IM	0.0149
2664	S-ribosylhomocysteine lyase	luxS	0.0149
2725	S-ribosylhomocysteine lyase	luxS	0.0149
2670	Pyridoxamine kinase	pdxY	0.0149
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0135
3599	Peroxiredoxin-2	PRDX2	0.013
4601	HMG-CoA synthase	mvaS	0.013
20	Prostaglandin G/H synthase 1	PTGS1	0.013
2688	Peptide deformylase	def	0.013
2708	Peptide deformylase	def	0.013
3004	Peptide deformylase	def	0.013
4337	Peptide deformylase	def	0.013
4338	Peptide deformylase	def	0.013
5368	Peptide deformylase	def	0.013
5371	Peptide deformylase	def	0.013
6375	Peptide deformylase	def	0.013
6378	Peptide deformylase	def	0.013
6379	Peptide deformylase	def	0.013
6776	Peptide deformylase	def	0.013
6900	Peptide deformylase	def	0.013
2378	Carboxymethylenebutenolidase	clcD	0.013
2705	Dimethyl sulfoxide reductase	dmsA	0.0129
587	Serum albumin	ALB	0.0127
477	DNA topoisomerase 4 subunit A	parC	0.0127
886	DNA topoisomerase 4 subunit A	parC	0.0127
6226	DNA topoisomerase 4 subunit A	parC	0.0127
404	DNA gyrase subunit A	gyrA	0.0125
6224	DNA gyrase subunit A	gyrA	0.0125
2714	Chorismate mutase	aroH	0.012
4611	Chorismate mutase	aroG	0.012
2603	Beta-lactamase II	blm	0.0119
318	Alpha-2A adrenergic receptor	ADRA2A	0.0116
4600	Malonamidase E2	Not Available	0.0113
3941	Amine oxidase [flavin-containing] A	MAOA	0.0112
492	Histamine H1 receptor	HRH1	0.0108
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0107
831	D(2) dopamine receptor	DRD2	0.01
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
817	DNA topoisomerase 2-alpha	TOP2A	0.0096
290	Prostaglandin G/H synthase 2	PTGS2	0.009
556	Alpha-1A adrenergic receptor	ADRA1A	0.009
885	5-hydroxytryptamine 1B receptor	HTR1B	0.009
23	D(1A) dopamine receptor	DRD1	0.0089
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0089
1898	Cytochrome P450 1B1	CYP1B1	0.0088
3811	Cytochrome P450 19A1	CYP19A1	0.0086
6145	Solute carrier family 22 member 1	SLC22A1	0.0084
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0083
824	Sodium-dependent serotonin transporter	SLC6A4	0.0082
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0081
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.008
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0079
1729	Solute carrier family 22 member 6	SLC22A6	0.0078
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0077
3939	Amine oxidase [flavin-containing] B	MAOB	0.0077
6106	Cytochrome P450 2C18	CYP2C18	0.0076
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0076
862	Multidrug resistance-associated protein 1	ABCC1	0.007
118	Organic cation/carnitine transporter 2	SLC22A5	0.007
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0069
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0068
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0066
16	Adenosine A1 receptor	ADORA1	0.0066
6144	Solute carrier family 22 member 2	SLC22A2	0.0064
193	Beta-1 adrenergic receptor	ADRB1	0.0063
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0063
629	Alpha-2B adrenergic receptor	ADRA2B	0.0062
632	Alpha-1B adrenergic receptor	ADRA1B	0.0062
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.006
341	5-hydroxytryptamine 3 receptor	HTR3A	0.006
1178	Adenosine A2a receptor	ADORA2A	0.0053
638	D(3) dopamine receptor	DRD3	0.0052
571	Melatonin receptor type 1A	MTNR1A	0.0052
362	Melatonin receptor type 1B	MTNR1B	0.0052
713	Sodium-dependent dopamine transporter	SLC6A3	0.0052
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0051
789	Alpha-1D adrenergic receptor	ADRA1D	0.0051
378	Alpha-2C adrenergic receptor	ADRA2C	0.005
3947	Xanthine dehydrogenase/oxidase	XDH	0.005
136	Estrogen receptor	ESR1	0.0049
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0049
2164	Multidrug resistance-associated protein 4	ABCC4	0.0047
766	Beta-2 adrenergic receptor	ADRB2	0.0047
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0046
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0045
465	Calmodulin	CALM1	0.0045
6220	Aryl hydrocarbon receptor	AHR	0.0045
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0044
3923	Cholinesterase	BCHE	0.0044
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0044
777	Tumor necrosis factor	TNF	0.0044
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0043
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0043
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0042
6143	Solute carrier family 22 member 7	SLC22A7	0.0041
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0041
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.004
103	Muscarinic acetylcholine receptor M1	CHRM1	0.004
432	D(4) dopamine receptor	DRD4	0.004
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.004
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.004
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.004
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0039
833	Organic cation/carnitine transporter 1	SLC22A4	0.0039
468	Cytochrome P450 4A11	CYP4A11	0.0039
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0037
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0037
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0037
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0035
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0035
5117	Dihydrolipoyl dehydrogenase	lpd	0.0035
4486	Phenol 2-hydroxylase component B	pheA2	0.0035
4439	Ferredoxin reductase	bphA4	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
904	Glutathione S-transferase P	GSTP1	0.0034
273	Apoptosis regulator Bcl-2	BCL2	0.0034
1757	Myeloperoxidase	MPO	0.0034
565	Extracellular calcium-sensing receptor	CASR	0.0034
897	Glutathione S-transferase kappa 1	GSTK1	0.0034
1928	Leukotriene C4 synthase	LTC4S	0.0034
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0034
4035	Glutathione S-transferase Mu 5	GSTM5	0.0034
4037	Hypothetical protein	GPX1	0.0034
4297	Hypothetical protein	SP_1951	0.0034
4521	Hypothetical protein	BC_2969	0.0034
4540	Hypothetical protein	TM_1070	0.0034
4555	Hypothetical protein	MT1739	0.0034
4569	Hypothetical protein	mshD	0.0034
4578	Hypothetical protein	PA3270	0.0034
4747	Hypothetical protein	PA3967	0.0034
5177	Hypothetical protein	TM_0096	0.0034
5194	Hypothetical protein	PA1204	0.0034
5240	Hypothetical protein	Rv2991	0.0034
5370	Hypothetical protein	TM_1158	0.0034
5710	Hypothetical protein	Tb927.5.1360	0.0034
4029	Microsomal glutathione S-transferase 3	MGST3	0.0034
4032	Microsomal glutathione S-transferase 1	MGST1	0.0034
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0034
4040	Glutathione peroxidase 7	GPX7	0.0034
4034	Glutaredoxin-1	GLRX	0.0034
907	Glutathione peroxidase 2	GPX2	0.0034
906	Glutathione peroxidase 1	GPX1	0.0034
900	Glutathione S-transferase A4	GSTA4	0.0034
903	Glutathione S-transferase A5	GSTA5	0.0034
911	Glutathione peroxidase 3	GPX3	0.0034
4042	Glutathione transferase omega-2	GSTO2	0.0034
4036	Glutathione peroxidase 6	GPX6	0.0034
712	Tubulin alpha chain	TUB1	0.0034
161	Tubulin beta chain	TUBB	0.0034
312	Tubulin beta chain	TUB2	0.0034
4033	S-formylglutathione hydrolase	ESD	0.0034
4038	Glutathione peroxidase 4	GPX4	0.0034
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0034
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0034
910	Epididymal secretory glutathione peroxidase	GPX5	0.0034
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0034
6014	Cytochrome P450 2A13	CYP2A13	0.0034
898	Glutathione S-transferase A3	GSTA3	0.0034
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0034
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0033
909	Maleylacetoacetate isomerase	GSTZ1	0.0033
4122	Histone deacetylase 2	HDAC2	0.0033
908	Glutathione S-transferase theta-1	GSTT1	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
6147	Solute carrier family 22 member 3	SLC22A3	0.0032
6142	Solute carrier family 22 member 8	SLC22A8	0.0032
4440	NADH peroxidase	npr	0.0032
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0031
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0031
818	50S ribosomal protein L10	rplJ	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
173	Toll-like receptor 7	TLR7	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
901	Glutathione S-transferase Mu 4	GSTM4	0.003
327	Glutathione reductase	gor	0.0029
5110	Glutathione reductase	GR2	0.0029
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0029
6136	Multidrug resistance-associated protein 5	ABCC5	0.0029
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0029
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
899	Glutathione S-transferase Mu 3	GSTM3	0.0028
776	Bile salt export pump	ABCB11	0.0028
905	Glutathione transferase omega-1	GSTO1	0.0028
4041	Microsomal glutathione S-transferase 2	MGST2	0.0028
163	D(1B) dopamine receptor	DRD5	0.0028
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0028
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0028
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0028
6044	Serum paraoxonase/lactonase 3	PON3	0.0028
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0028
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0028
207	Glutathione synthetase	GSS	0.0027
5269	Glutathione synthetase	gshB	0.0027
896	Glutathione S-transferase Mu 1	GSTM1	0.0027
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0027
1313	Lactoylglutathione lyase	GLO1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0026
6020	Aldehyde oxidase	AOX1	0.0026
4031	Glutathione S-transferase A1	GSTA1	0.0026
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0025
94	5-hydroxytryptamine 4 receptor	HTR4	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
5122	Mersacidin decarboxylase	mrsD	0.0024
526	Thioredoxin reductase	trxB	0.0024
3767	Thioredoxin reductase	trxB	0.0024
3133	UDP-galactopyranose mutase	glf	0.0024
5099	UDP-galactopyranose mutase	glf	0.0024
5095	Putidaredoxin reductase	camA	0.0024
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0024
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0024
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0024
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0024
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0024
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0024
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0024
5109	Outer membrane protein p64k or PM-6	m-6	0.0024
5115	FkbI	fkbI	0.0024
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0024
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0024
5083	Cryptochrome DASH	cry	0.0024
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0024
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0024
5081	L-aspartate oxidase	nadB	0.0024
5111	Phenylacetone monooxygenase	pamO	0.0024
1410	Oxidoreductase	HSD17B6	0.0024
4725	Oxidoreductase	Not Available	0.0024
5124	Oxidoreductase	Not Available	0.0024
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0024
1517	Beta-3 adrenergic receptor	ADRB3	0.0024
6070	Nischarin	NISCH	0.0024
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0023
251	Alcohol dehydrogenase 1A	ADH1A	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
3957	Adenosine deaminase	ADA	0.0023
6148	Multidrug resistance-associated protein 7	ABCC10	0.0023
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0023
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0023
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0022
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0022
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0022
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0022
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0022
816	Biliverdin reductase A	BLVRA	0.0022
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
26	Vascular endothelial growth factor receptor 3	FLT4	0.0022
444	Alcohol dehydrogenase 1B	ADH1B	0.0022
3932	Glutathione S-transferase A2	GSTA2	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
731	HIV-1 protease	HIV-1 protease	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
5073	Ferredoxin--NADP reductase	petH	0.0021
5076	Ferredoxin--NADP reductase	fpr	0.0021
5119	Ferredoxin--NADP reductase	petH	0.0021
5121	Ferredoxin--NADP reductase	fpr	0.0021
2526	NADPH-ferredoxin reductase fprA	fprA	0.0021
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0021
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0021
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0021
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0021
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0021
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0021
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0021
5072	N,N-dimethylglycine oxidase	dmg	0.0021
260	Cytochrome P450 51	ERG11	0.0021
761	Cytochrome P450 51	ERG11	0.0021
3163	Cytochrome P450 51	cyp51	0.0021
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0021
2470	Pyruvate oxidase	pox5	0.0021
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.0021
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0021
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0021
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0021
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0021
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0021
2268	Cholesterol oxidase	choB	0.0021
2822	Cholesterol oxidase	choA	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0021
32	Vascular endothelial growth factor receptor 1	FLT1	0.0021
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0021
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0021
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0021
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0021
869	Estrogen receptor beta	ESR2	0.0021
597	Dihydropteridine reductase	QDPR	0.0021
328	Sorbitol dehydrogenase	SORD	0.0021
396	Alcohol dehydrogenase 4	ADH4	0.0021
871	Glucocorticoid receptor	NR3C1	0.0021
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.002
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.002
3102	Flavohemoprotein	hmp	0.002
4969	Flavohemoprotein	hmp	0.002
380	Cytochrome P450 17A1	CYP17A1	0.002
1820	Beta-nerve growth factor	NGF	0.002
12	Alcohol dehydrogenase class 3	ADH5	0.002
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.002
77	L-lactate dehydrogenase B chain	LDHB	0.002
4228	Keratin, type II cytoskeletal 7	KRT7	0.002
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.002
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.002
2893	Glycine oxidase	thiO	0.002
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.002
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.002
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.002
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0019
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0019
716	5-hydroxytryptamine 7 receptor	HTR7	0.0019
517	Alcohol dehydrogenase 1C	ADH1C	0.0019
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0019
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0019
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0019
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0019
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0019
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
124	Histamine H2 receptor	HRH2	0.0019
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0019
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0019
284	DNA-directed RNA polymerase beta chain	rpoB	0.0019
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0019
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0019
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0018
2823	Trypanothione reductase	TPR	0.0018
2567	Thymidylate synthase thyX	thyX	0.0018
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0018
126	D-lactate dehydrogenase	dld	0.0018
3545	D-lactate dehydrogenase	Not Available	0.0018
4510	D-lactate dehydrogenase	ldhA	0.0018
122	P2Y purinoceptor 12	P2RY12	0.0018
33	Cystine/glutamate transporter	SLC7A11	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0018
504	Mast/stem cell growth factor receptor	KIT	0.0018
2769	P-hydroxybenzoate hydroxylase	pobA	0.0018
2809	P-hydroxybenzoate hydroxylase	pobA	0.0018
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0017
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0017
1648	Elastin	ELN	0.0017
4120	NADPH--cytochrome P450 reductase	POR	0.0017
2380	Monomeric sarcosine oxidase	soxA	0.0017
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0017
569	Retinal dehydrogenase 2	ALDH1A2	0.0017
275	Arachidonate 5-lipoxygenase	ALOX5	0.0017
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0017
611	Retinal dehydrogenase 1	ALDH1A1	0.0017
1656	CYP2B protein	CYP2B	0.0017
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0017
407	Vascular endothelial growth factor receptor 2	KDR	0.0017
1830	5'-nucleotidase	NT5E	0.0016
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0016
1243	Cathepsin D	CTSD	0.0016
6645	D-amino-acid oxidase	DAO	0.0016
1010	Cytochrome P450 51A1	CYP51A1	0.0016
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0016
373	Transthyretin	TTR	0.0016
474	Acetylcholinesterase	ACHE	0.0016
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0016
427	Substance-P receptor	TACR1	0.0016
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0016
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0016
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0016
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0016
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0016
4495	3-oxoacyl-(Acyl carrier protein) reductase	TM_1169	0.0015
4423	Levodione reductase	lvr	0.0015
4456	Inorganic polyphosphate/ATP-NAD kinase	ppnK	0.0015
4428	Redox-sensing transcriptional repressor rex	rex	0.0015
4449	ADP-ribosyltransferase	Not Available	0.0015
4471	CDP-D-glucose-4,6-dehydratase	ascB	0.0015
4455	Glycerol dehydrogenase	gldA	0.0015
4435	L-aspartate dehydrogenase	nadX	0.0015
4466	Glutathione-independent formaldehyde dehydrogenase	fdhA	0.0015
4446	3alpha-hydroxysteroid dehydrogenase/carbonyl reductase	Not Available	0.0015
4472	Glucose 1-dehydrogenase	Not Available	0.0015
4487	Transcriptional regulator nadR	nadR	0.0015
4505	Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	bphB	0.0015
4443	Quinate/shikimate dehydrogenase	ydiB	0.0015
4500	L-lactate dehydrogenase 2	ldh2	0.0015
4447	Hypothetical protein yhfP	yhfP	0.0015
4336	Glyceraldehyde 3-phosphate dehydrogenase	Not Available	0.0015
4436	Glyceraldehyde 3-phosphate dehydrogenase	tthHB8IM	0.0015
3381	Alcohol dehydrogenase	Not Available	0.0015
4508	Alcohol dehydrogenase	adhA	0.0015
4414	Dehydrogenase	TT_P0035	0.0015
2350	3-isopropylmalate dehydrogenase	leuB	0.0015
3092	3-isopropylmalate dehydrogenase	leuB	0.0015
4418	AGR_L_3209p	AGR_L_3209	0.0015
4507	Alanine dehydrogenase	ald	0.0015
4475	Hypothetical protein Rv0046c/MT0052	ino1	0.0015
4497	Benzyl alcohol dehydrogenase	xylB	0.0015
4506	Myo-inositol-1-phosphate synthase-related protein	TM_1419	0.0015
3735	NAD(P) transhydrogenase subunit alpha part 1	pntAA	0.0015
4502	Formate dehydrogenase	Not Available	0.0015
3729	Citrate synthase	gltA	0.0015
4575	Citrate synthase	cit	0.0015
4580	Citrate synthase	gltA	0.0015
4451	Vip2Ac	vip2Ac	0.0015
4467	Alpha-glucosidase, putative	TM_0752	0.0015
4448	L-2-hydroxyisocaproate dehydrogenase	Not Available	0.0015
921	Glutamate receptor 2	GRIA2	0.0015
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0015
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0015
365	Dihydrofolate reductase	DHFR	0.0015
2381	Dihydrofolate reductase	DFR1	0.0015
2833	Dihydrofolate reductase	Not Available	0.0015
2931	Dihydrofolate reductase	folA	0.0015
3544	Dihydrofolate reductase	folA	0.0015
3682	Dihydrofolate reductase	folA	0.0015
6642	Dihydrofolate reductase	folA	0.0015
6756	Dihydrofolate reductase	dfrA	0.0015
6031	Cytochrome P450 3A43	CYP3A43	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0015
70	Type-1 angiotensin II receptor	AGTR1	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
6432	Transporter	snf	0.0015
6102	Arylamine N-acetyltransferase 2	NAT2	0.0014
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0014
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0014
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
822	Aldose reductase	AKR1B1	0.0014
2449	Tubulin alpha-3 chain	TUBA1A	0.0014
847	Mu-type opioid receptor	OPRM1	0.0014
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0013
543	Penicillin-binding protein 1B	mrcB	0.0013
6186	Penicillin-binding protein 1B	ponB	0.0013
6822	Penicillin-binding protein 1b	pbp1b	0.0013
6844	Penicillin-binding protein 1b	pbp1b	0.0013
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0013
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0013
844	Epidermal growth factor receptor	EGFR	0.0013
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0013
3598	dTDP-4-dehydrorhamnose reductase	rfbD	0.0013
4427	TDP-glucose-4,6-dehydratase	desIV	0.0013
3177	dTDP-glucose 4,6-dehydratase	rfbB	0.0013
4499	dTDP-glucose 4,6-dehydratase	rmlB	0.0013
4503	NADPH-flavin oxidoreductase	frp	0.0013
4482	UDP-galactose 4-epimerase	galE	0.0013
2967	CDP-paratose 2-epimerase	rfbE	0.0013
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0013
756	Sex hormone-binding globulin	SHBG	0.0013
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
1199	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	ART1	0.0013
2424	L-lactate dehydrogenase	ldh	0.0013
2641	L-lactate dehydrogenase	Not Available	0.0013
4437	L-lactate dehydrogenase	ldh	0.0013
4442	L-lactate dehydrogenase	ldh	0.0013
3401	D-2-hydroxyisocaproate dehydrogenase	Not Available	0.0013
2538	6-phospho-beta-glucosidase bglT	bglT	0.0013
645	Penicillin-binding protein 1A	mrcA	0.0013
5805	Penicillin-binding protein 1A	ponA	0.0013
6185	Penicillin-binding protein 1A	mrcA	0.0013
6799	Penicillin-binding protein 1A	pbpA	0.0013
2336	2,3-diketo-L-gulonate reductase	dlgD	0.0013
2507	Diphtheria toxin	Not Available	0.0013
3081	3-dehydroquinate synthase	aroB	0.0013
3615	Dihydrodipicolinate reductase	dapB	0.0013
3618	Dihydrodipicolinate reductase	dapB	0.0013
4462	Dihydrodipicolinate reductase	dapB	0.0013
2393	Maltose-6'-phosphate glucosidase	glvA	0.0013
4509	Acetoin(diacetyl) reductase	budC	0.0013
6698	Dehydrogenase/reductase SDR family member 4-like 2	DHRS4L2	0.0013
2591	Urocanate hydratase	hutU	0.0013
2831	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	Not Available	0.0013
3059	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	fabG3	0.0013
159	Penicillin-binding protein 2B	penA	0.0013
6121	Penicillin-binding protein 2B	penA	0.0013
2018	Deoxyhypusine synthase	DHPS	0.0013
4496	C-terminal-binding protein 1	CTBP1	0.0013
4498	Ornithine cyclodeaminase	PP3533	0.0013
696	Kappa-type opioid receptor	OPRK1	0.0013
4450	Iota toxin component Ia	Not Available	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
2881	Gamma-aminobutyraldehyde dehydrogenase	prr	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
1024	Solute carrier family 22 member 11	SLC22A11	0.0013
76	Nitric-oxide synthase, brain	NOS1	0.0012
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0012
6146	High affinity copper uptake protein 1	SLC31A1	0.0012
4311	tRNA	TRDMT1	0.0012
4325	tRNA	trmD	0.0012
4328	tRNA	trmD	0.0012
2683	Mono-ADP-ribosyltransferase C3	C3	0.0012
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0012
518	Peroxidase/catalase T	katG	0.0012
1629	Transcription factor AP-1	JUN	0.0012
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0012
3296	Nicotinamide mononucleotide adenylyltransferase 1	NMNAT1	0.0011
4504	WbpP	Not Available	0.0011
4318	Siroheme synthase	cysG	0.0011
482	Glycine receptor subunit alpha-1	GLRA1	0.0011
3367	GDP-mannose 6-dehydrogenase	algD	0.0011
828	Phenylalanine-4-hydroxylase	PAH	0.0011
3109	Phenylalanine-4-hydroxylase	phhA	0.0011
4343	Alpha-glucosidase	aglA	0.0011
2799	Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	Not Available	0.0011
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0011
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0011
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0011
6043	Putative G-protein coupled receptor 44	GPR44	0.0011
563	Thyroid peroxidase	TPO	0.0011
63	Malate dehydrogenase	mdh	0.0011
2329	Malate dehydrogenase	mdh	0.0011
3445	Malate dehydrogenase	mdh	0.0011
4420	Malate dehydrogenase	mdh	0.0011
4438	Malate dehydrogenase	mdh	0.0011
2617	Nitric oxide synthase oxygenase	nos	0.0011
2701	Nitric oxide synthase oxygenase	nos	0.0011
4476	Mannitol dehydrogenase	mtlD	0.0011
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0011
4192	DNA topoisomerase 2-beta	TOP2B	0.0011
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0011
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0011
3333	Nicotinamide mononucleotide adenylyltransferase 3	NMNAT3	0.0011
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.0011
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.0011
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.0011
2826	Glucose--fructose oxidoreductase	gfo	0.0011
3070	Adenosylhomocysteinase	AHCY	0.0011
4424	Adenosylhomocysteinase	PFE1050w	0.0011
6278	Adenosylhomocysteinase	ahcY	0.0011
467	Delta-type opioid receptor	OPRD1	0.0011
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.0011
3191	Histidinol dehydrogenase	hisD	0.0011
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.001
634	Squalene monooxygenase	SQLE	0.001
7196	Squalene monooxygenase	ERG1	0.001
239	Coagulation factor X	F10	0.001
4237	50S ribosomal protein L22	rplV	0.001
1714	Mitogen-activated protein kinase 3	MAPK3	0.001
4604	Liver carboxylesterase 1	CES1	0.001
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.001
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.001
666	NADP-dependent malic enzyme	ME1	0.001
564	Cellular retinoic acid-binding protein 1	CRABP1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
857	Malate dehydrogenase, mitochondrial	MDH2	0.001
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.001
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.001
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.001
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.001
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.001
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.001
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.001
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.001
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.001
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.001
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.001
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.001
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.001
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.001
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.001
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.001
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.001
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.001
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.001
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.001
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.001
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.001
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.001
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.001
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.001
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.001
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.001
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.001
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.001
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.001
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.001
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.001
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.001
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.001
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.001
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.001
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.001
107	C-4 methylsterol oxidase	SC4MOL	0.001
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.001
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.001
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.001
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.001
729	GDP-L-fucose synthetase	TSTA3	0.001
3463	GDP-L-fucose synthetase	fcl	0.001
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.001
167	L-lactate dehydrogenase C chain	LDHC	0.001
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.001
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.001
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.001
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.001
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.001
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.001
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.001
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.001
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.001
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.001
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.001
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.001
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.001
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.001
644	Heme oxygenase 2	HMOX2	0.001
4982	Heme oxygenase 2	pbsA2	0.001
206	3-keto-steroid reductase	HSD17B7	0.001
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.001
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.001
34	7-dehydrocholesterol reductase	DHCR7	0.001
711	UDP-glucose 6-dehydrogenase	UGDH	0.001
3672	UDP-glucose 6-dehydrogenase	hasB	0.001
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.001
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.001
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.001
3726	D-3-phosphoglycerate dehydrogenase	serA	0.001
4291	D-3-phosphoglycerate dehydrogenase	serA	0.001
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.001
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.001
643	Peroxisomal bifunctional enzyme	EHHADH	0.001
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.001
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.001
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.001
1192	Sulfotransferase 1A1	SULT1A1	0.001
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.001
2286	Isocitrate dehydrogenase [NADP]	icd	0.001
2302	Isocitrate dehydrogenase [NADP]	icd	0.001
2771	Isocitrate dehydrogenase [NADP]	icd	0.001
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.001
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.001
4491	DNA ligase, NAD-dependent	ligA	0.001
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.001
859	Cellular retinoic acid-binding protein 2	CRABP2	0.001
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.001
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.001
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.001
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.001
823	Fibroblast growth factor receptor 2	FGFR2	0.001
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
2762	UDP-glucose 4-epimerase	GALE	0.0009
3461	UDP-glucose 4-epimerase	galE	0.0009
6137	Multidrug resistance-associated protein 6	ABCC6	0.0009
6182	Cytochrome P450 2J2	CYP2J2	0.0009
780	Retinoic acid receptor RXR-gamma	RXRG	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0009
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0009
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0009
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0009
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0009
13	Aminomethyltransferase, mitochondrial	AMT	0.0009
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0009
626	Cysteine dioxygenase type 1	CDO1	0.0009
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0009
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0009
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0009
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0009
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0009
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0009
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0009
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0008
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0008
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0008
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0008
6026	Alcohol dehydrogenase 6	ADH6	0.0008
459	Retinoic acid receptor RXR-alpha	RXRA	0.0008
627	11-cis retinol dehydrogenase	RDH5	0.0008
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0008
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0008
88	Retinoic acid receptor RXR-beta	RXRB	0.0008
2236	Casein kinase II subunit alpha	CSNK2A1	0.0008
654	Flavin reductase	BLVRB	0.0008
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0008
3830	Calreticulin	CALR	0.0008
162	Retinoic acid receptor gamma-1	RARG	0.0008
6167	Organic solute transporter subunit beta	OSTB	0.0008
6166	Organic solute transporter subunit alpha	OSTA	0.0008
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0008
146	Androgen receptor	AR	0.0008
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0008
1618	High affinity nerve growth factor receptor	NTRK1	0.0008
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0008
810	Heme oxygenase 1	HMOX1	0.0008
3391	Heme oxygenase 1	pbsA1	0.0008
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0008
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0008
6035	Nuclear receptor ROR-beta	RORB	0.0008
6036	Eosinophil peroxidase	EPX	0.0008
811	Translocator protein	TSPO	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
976	Platelet glycoprotein IX	GP9	0.0008
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0008
1374	Natriuretic peptides B	NPPB	0.0008
1827	Gap junction alpha-1 protein	GJA1	0.0008
1908	Vascular cell adhesion protein 1	VCAM1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0008
4103	Proteasome subunit beta type 2	PSMB2	0.0007
4102	Proteasome subunit beta type 5	PSMB5	0.0007
4101	Proteasome subunit beta type 1	PSMB1	0.0007
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0007
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
279	Tyrosinase	TYR	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
3810	Catechol O-methyltransferase	COMT	0.0007
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0007
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0007
814	Ryanodine receptor 1	RYR1	0.0007
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0007
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0007
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0007
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
705	Glutamate receptor 1	GRIA1	0.0007
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0007
6141	Sodium/bile acid cotransporter	SLC10A1	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
268	Adenosine A2b receptor	ADORA2B	0.0006
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0006
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0006
484	Tyrosine-protein kinase ABL2	ABL2	0.0006
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0006
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0006
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0006
183	Vascular endothelial growth factor A	VEGFA	0.0006
6163	Copper-transporting ATPase 2	ATP7B	0.0006
6165	Copper-transporting ATPase 1	ATP7A	0.0006
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1864	RET proto-oncogene	RET	0.0006
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0006
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0006
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0006
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0006
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0006
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0006
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0006
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0006
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0006
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0006
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0006
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0005
1275	Estrogen sulfotransferase	SULT1E1	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0005
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0005
153	Dopamine beta-hydroxylase	DBH	0.0005
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0005
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0005
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0005
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0005
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
798	Osteocalcin	BGLAP	0.0005
5934	Cytochrome P450 26A1	CYP26A1	0.0005
1050	Bile salt sulfotransferase	SULT2A1	0.0005
751	Potassium channel subfamily K member 6	KCNK6	0.0005
1039	Histone deacetylase 9	HDAC9	0.0005
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
3937	Fatty-acid amide hydrolase	FAAH	0.0005
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0005
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0005
172	Potassium channel subfamily K member 1	KCNK1	0.0005
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0005
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0004
6149	Solute carrier family 22 member 10	SLC22A10	0.0004
165	FL cytokine receptor	FLT3	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0004
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0004
24	Thymidylate synthase	TMP1	0.0004
359	Thymidylate synthase	TYMS	0.0004
2626	Thymidylate synthase	thyA	0.0004
2729	Thymidylate synthase	thyA	0.0004
5352	Thymidylate synthase	THYA	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0004
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0004
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0004
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0004
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0004
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0004
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0004
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0004
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0004
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0004
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0004
737	Mineralocorticoid receptor	NR3C2	0.0004
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0004
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0004
295	Carbonic anhydrase 1	CA1	0.0004
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0004
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0004
614	Progesterone receptor	PGR	0.0003
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0003
6085	Fatty acid-binding protein, intestinal	FABP2	0.0003
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0003
164	Histamine H4 receptor	HRH4	0.0003
54	Prothrombin	F2	0.0003
738	Monocarboxylate transporter 1	SLC16A1	0.0003
7	Nitric oxide synthase, inducible	NOS2	0.0003
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0003
291	Nitric-oxide synthase, endothelial	NOS3	0.0003
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0002
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00262 - Carmustine

Targets

Enzymes

Predictions