DT-Web

DB03501 - Uridine Diphosphate Galactose


Identification
Name Uridine Diphosphate Galactose
Accession Number DB03501 (EXPT01576)
Type small molecule
Description A nucleoside diphosphate sugar which can be epimerized into UDPglucose for entry into the mainstream of carbohydrate metabolism. Serves as a source of galactose in the synthesis of lipopolysaccharides, cerebrosides, and lactose. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 566.3018
Groups experimental
Monoisotopic Weight 566.055020376
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Beta-1,4-galactosyltransferase 1
Name Beta-1,4-galactosyltransferase 1
Gene Name B4GALT1
Pharmacological action unknown
Actions Not Available
References
  • Ramakrishnan B, Balaji PV, Qasba PK: Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site. J Mol Biol. 2002 Apr 26;318(2):491-502. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7597
Histo-blood group ABO system transferase
Name Histo-blood group ABO system transferase
Gene Name ABO
Pharmacological action unknown
Actions Not Available
References
  • Nguyen HP, Seto NO, Cai Y, Leinala EK, Borisova SN, Palcic MM, Evans SV: The influence of an intramolecular hydrogen bond in differential recognition of inhibitory acceptor analogs by human ABO(H) blood group A and B glycosyltransferases. J Biol Chem. 2003 Dec 5;278(49):49191-5. Epub 2003 Sep 11. - Pubmed
DTHybrid score 1.6687
UDP-glucose 4-epimerase
Name UDP-glucose 4-epimerase
Gene Name GALE
Pharmacological action unknown
Actions Not Available
References
  • Thoden JB, Wohlers TM, Fridovich-Keil JL, Holden HM: Molecular basis for severe epimerase deficiency galactosemia. X-ray structure of the human V94m-substituted UDP-galactose 4-epimerase. J Biol Chem. 2001 Jun 8;276(23):20617-23. Epub 2001 Mar 7. - Pubmed
DTHybrid score 0.8301

Predictions


Id Partner name Gene Name Score
3461 UDP-glucose 4-epimerase galE 0.8301
2916 Chitobiase chb 0.1912
2590 Galactose-1-phosphate uridylyltransferase galT 0.1893
2612 UDP-N-acetylhexosamine pyrophosphorylase UAP1 0.136
4504 WbpP Not Available 0.1275
2608 UDP-N-acetylglucosamine 2-epimerase wecB 0.0997
2651 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase murG 0.0963
3524 DNA beta-glucosyltransferase bgt 0.068
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0598
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0598
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0598
5252 Bifunctional protein glmU glmU 0.0598
6789 Bifunctional protein glmU glmU 0.0598
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.0592
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0565
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0521
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0521
3529 Interferon-stimulated gene 20 kDa protein ISG20 0.0379
3056 Orotidine 5'-phosphate decarboxylase pyrF 0.0379
3564 Orotidine 5'-phosphate decarboxylase pyrF 0.0379
3575 Uracil phosphoribosyltransferase upp 0.0378
3600 Uracil phosphoribosyltransferase upp 0.0378
4013 Beta-1,4-galactosyltransferase 2 B4GALT2 0.0357
4011 Beta-1,4-galactosyltransferase 3 B4GALT3 0.035
4012 Beta-1,4-galactosyltransferase 4 B4GALT4 0.0349
4014 N-acetylglucosamine kinase NAGK 0.0345
434 Alpha-N-acetylglucosaminidase NAGLU 0.0345
4015 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase NAGPA 0.0345
121 N-acylglucosamine 2-epimerase RENBP 0.0344
3257 Bifunctional polymyxin resistance protein arnA arnA 0.0331
2344 Ribosomal small subunit pseudouridine synthase A rsuA 0.0329
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.0329
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0306
24 Thymidylate synthase TMP1 0.023
359 Thymidylate synthase TYMS 0.023
2626 Thymidylate synthase thyA 0.023
2729 Thymidylate synthase thyA 0.023
5352 Thymidylate synthase THYA 0.023
3523 Spore coat polysaccharide biosynthesis protein spsA spsA 0.0182
4482 UDP-galactose 4-epimerase galE 0.0181
2291 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 B3GAT1 0.0159
3408 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 B3GAT3 0.0159
6389 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial ETFDH 0.0146
2555 Pol polyprotein pol 0.0127
3242 Pol polyprotein gag-pol 0.0127
3471 Pol polyprotein gag-pro-pol 0.0127
5256 Pol polyprotein pol 0.0127
6469 Pol polyprotein gag-pol 0.0127
6565 Pol polyprotein Not Available 0.0127
4498 Ornithine cyclodeaminase PP3533 0.0117
702 UMP-CMP kinase CMPK1 0.0112
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0107
5449 Hypothetical gliding protein mglB 0.0105
5443 UPF0189 protein ymdB ymdB 0.0105
332 Beta-lactamase blaZ 0.0105
2478 Beta-lactamase ampC 0.0105
2613 Beta-lactamase ampC 0.0105
2635 Beta-lactamase ampC 0.0105
2700 Beta-lactamase penP 0.0105
5445 Beta-lactamase blaB 0.0105
6019 Beta-lactamase SHV-7 0.0105
6701 Beta-lactamase cphA 0.0105
5439 33 kDa chaperonin hslO 0.0105
5448 Ribonuclease Z rnz 0.0105
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0105
5440 UPF0067 protein yebR yebR 0.0105
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0105
4705 Manganese catalase Not Available 0.0105
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0105
2720 Copper-containing nitrite reductase nirK 0.0105
5454 Internalin-A inlA 0.0105
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0102
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0102
597 Dihydropteridine reductase QDPR 0.0098
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.0097
6359 Cytochrome b-c1 complex subunit 8 UQCRQ 0.0096
6358 Cytochrome b-c1 complex subunit 6, mitochondrial UQCRH 0.0096
6357 Cytochrome b-c1 complex subunit 2, mitochondrial UQCRC2 0.0096
6363 Cytochrome b-c1 complex subunit 9 UQCR10 0.0094
6362 Cytochrome b-c1 complex subunit 7 UQCRB 0.0094
6360 Cytochrome b-c1 complex subunit Rieske, mitochondrial UQCRFS1 0.0094
1495 Ubiquinol-cytochrome-c reductase complex core protein 1, mitochondrial UQCRC1 0.0094
6356 Cytochrome c1, heme protein, mitochondrial CYC1 0.0094
1227 Cytochrome b MT-CYB 0.0094
6386 Cytochrome b petB 0.0094
6937 Cytochrome b MT-CYB 0.0094
3356 Diaminopimelate decarboxylase lysA 0.0092
5450 Prolyl endopeptidase Pep pep 0.0092
3274 Hydroxylamine reductase hcp 0.0092
4804 Hydroxylamine reductase hcp 0.0092
2714 Chorismate mutase aroH 0.0092
4611 Chorismate mutase aroG 0.0092
4771 Dissimilatory copper-containing nitrite reductase nir 0.0091
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.0088
3399 Limonene-1,2-epoxide hydrolase limA 0.0085
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0084
5180 L(+)-mandelate dehydrogenase mdlB 0.008
3500 Putative family 31 glucosidase yicI yicI 0.008
4608 Putative cytochrome P450 SCO1207 0.0077
4963 Putative cytochrome P450 SCO2884 0.0077
6254 Putative cytochrome P450 SCO6998 0.0077
1615 Chymase CMA1 0.0076
3480 Mannan endo-1,4-beta-mannosidase manA 0.0076
577 Argininosuccinate lyase ASL 0.0075
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0074
365 Dihydrofolate reductase DHFR 0.0071
2381 Dihydrofolate reductase DFR1 0.0071
2833 Dihydrofolate reductase Not Available 0.0071
2931 Dihydrofolate reductase folA 0.0071
3544 Dihydrofolate reductase folA 0.0071
3682 Dihydrofolate reductase folA 0.0071
6642 Dihydrofolate reductase folA 0.0071
6756 Dihydrofolate reductase dfrA 0.0071
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0057
904 Glutathione S-transferase P GSTP1 0.0049
474 Acetylcholinesterase ACHE 0.0042
3923 Cholinesterase BCHE 0.0034
4447 Hypothetical protein yhfP yhfP 0.0025
4449 ADP-ribosyltransferase Not Available 0.0025
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0025
3381 Alcohol dehydrogenase Not Available 0.0025
4508 Alcohol dehydrogenase adhA 0.0025
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0025
4435 L-aspartate dehydrogenase nadX 0.0025
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0025
4472 Glucose 1-dehydrogenase Not Available 0.0025
4423 Levodione reductase lvr 0.0025
4428 Redox-sensing transcriptional repressor rex rex 0.0025
4497 Benzyl alcohol dehydrogenase xylB 0.0025
4443 Quinate/shikimate dehydrogenase ydiB 0.0025
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0025
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0025
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0025
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0025
4414 Dehydrogenase TT_P0035 0.0025
2350 3-isopropylmalate dehydrogenase leuB 0.0025
3092 3-isopropylmalate dehydrogenase leuB 0.0025
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0025
4418 AGR_L_3209p AGR_L_3209 0.0025
4507 Alanine dehydrogenase ald 0.0025
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0025
4455 Glycerol dehydrogenase gldA 0.0025
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0025
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0025
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0025
4502 Formate dehydrogenase Not Available 0.0025
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0025
3726 D-3-phosphoglycerate dehydrogenase serA 0.0025
4291 D-3-phosphoglycerate dehydrogenase serA 0.0025
4487 Transcriptional regulator nadR nadR 0.0025
4451 Vip2Ac vip2Ac 0.0025
4467 Alpha-glucosidase, putative TM_0752 0.0025
4500 L-lactate dehydrogenase 2 ldh2 0.0025
3729 Citrate synthase gltA 0.0025
4575 Citrate synthase cit 0.0025
4580 Citrate synthase gltA 0.0025
4427 TDP-glucose-4,6-dehydratase desIV 0.0022
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0022
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0022
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0022
4486 Phenol 2-hydroxylase component B pheA2 0.0022
4509 Acetoin(diacetyl) reductase budC 0.0022
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0022
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0022
3615 Dihydrodipicolinate reductase dapB 0.0022
3618 Dihydrodipicolinate reductase dapB 0.0022
4462 Dihydrodipicolinate reductase dapB 0.0022
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0022
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0022
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0022
4439 Ferredoxin reductase bphA4 0.0022
4477 Dihydrolipoyl dehydrogenase lpdV 0.0022
5077 Dihydrolipoyl dehydrogenase Not Available 0.0022
5117 Dihydrolipoyl dehydrogenase lpd 0.0022
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0022
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0022
2336 2,3-diketo-L-gulonate reductase dlgD 0.0022
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0022
126 D-lactate dehydrogenase dld 0.0022
3545 D-lactate dehydrogenase Not Available 0.0022
4510 D-lactate dehydrogenase ldhA 0.0022
2967 CDP-paratose 2-epimerase rfbE 0.0022
2018 Deoxyhypusine synthase DHPS 0.0022
2424 L-lactate dehydrogenase ldh 0.0022
2641 L-lactate dehydrogenase Not Available 0.0022
4437 L-lactate dehydrogenase ldh 0.0022
4442 L-lactate dehydrogenase ldh 0.0022
2538 6-phospho-beta-glucosidase bglT bglT 0.0022
4503 NADPH-flavin oxidoreductase frp 0.0022
4496 C-terminal-binding protein 1 CTBP1 0.0022
2393 Maltose-6'-phosphate glucosidase glvA 0.0022
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0022
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0022
2591 Urocanate hydratase hutU 0.0022
2507 Diphtheria toxin Not Available 0.0022
3081 3-dehydroquinate synthase aroB 0.0022
4450 Iota toxin component Ia Not Available 0.0022
2683 Mono-ADP-ribosyltransferase C3 C3 0.002
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.002
4318 Siroheme synthase cysG 0.002
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.002
711 UDP-glucose 6-dehydrogenase UGDH 0.002
3672 UDP-glucose 6-dehydrogenase hasB 0.002
3367 GDP-mannose 6-dehydrogenase algD 0.002
4440 NADH peroxidase npr 0.002
4343 Alpha-glucosidase aglA 0.002
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.002
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.002
816 Biliverdin reductase A BLVRA 0.002
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.002
2826 Glucose--fructose oxidoreductase gfo 0.0019
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0019
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0019
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0019
2617 Nitric oxide synthase oxygenase nos 0.0019
2701 Nitric oxide synthase oxygenase nos 0.0019
3070 Adenosylhomocysteinase AHCY 0.0019
4424 Adenosylhomocysteinase PFE1050w 0.0019
6278 Adenosylhomocysteinase ahcY 0.0019
3191 Histidinol dehydrogenase hisD 0.0019
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0019
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0019
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0019
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0019
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0019
646 Malate dehydrogenase, cytoplasmic MDH1 0.0019
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0019
328 Sorbitol dehydrogenase SORD 0.0019
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0019
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0019
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0019
396 Alcohol dehydrogenase 4 ADH4 0.0019
4476 Mannitol dehydrogenase mtlD 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0018
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0018
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0018
63 Malate dehydrogenase mdh 0.0018
2329 Malate dehydrogenase mdh 0.0018
3445 Malate dehydrogenase mdh 0.0018
4420 Malate dehydrogenase mdh 0.0018
4438 Malate dehydrogenase mdh 0.0018
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0018
77 L-lactate dehydrogenase B chain LDHB 0.0018
12 Alcohol dehydrogenase class 3 ADH5 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
2286 Isocitrate dehydrogenase [NADP] icd 0.0018
2302 Isocitrate dehydrogenase [NADP] icd 0.0018
2771 Isocitrate dehydrogenase [NADP] icd 0.0018
4491 DNA ligase, NAD-dependent ligA 0.0018
473 L-lactate dehydrogenase A chain LDHA 0.0018
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0018
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0018
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0018
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0018
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0018
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0017
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0017
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
251 Alcohol dehydrogenase 1A ADH1A 0.0015
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0015
611 Retinal dehydrogenase 1 ALDH1A1 0.0015
569 Retinal dehydrogenase 2 ALDH1A2 0.0015
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0015
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0015
444 Alcohol dehydrogenase 1B ADH1B 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
714 Glutathione reductase, mitochondrial GSR 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0013
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0013
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