DT-Web

DB02854 - Aetiocholanolone


Identification
Name Aetiocholanolone
Accession Number DB02854 (EXPT00443)
Type small molecule
Description The 5-beta-reduced isomer of androsterone. Etiocholanolone is a major metabolite of testosterone and androstenedione in many mammalian species including humans. It is excreted in the urine. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 290.4403
Groups experimental
Monoisotopic Weight 290.224580204
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Bile salt sulfotransferase
Name Bile salt sulfotransferase
Gene Name SULT2A1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9886
Dehydrogenase/reductase SDR family member 8
Name Dehydrogenase/reductase SDR family member 8
Gene Name HSD17B11
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9073
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
Name 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
Gene Name fabG3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.006
Ig gamma-2 chain C region
Name Ig gamma-2 chain C region
Gene Name IGHG2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.7866

Predictions


Id Partner name Gene Name Score
4785 Ig gamma-1 chain C region IGHG1 0.1218
6338 Ig kappa chain C region IGKC 0.1199
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0678
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0485
2268 Cholesterol oxidase choB 0.0472
2822 Cholesterol oxidase choA 0.0472
2283 Steroid Delta-isomerase ksi 0.0437
2920 Steroid Delta-isomerase ksi 0.0437
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0365
1192 Sulfotransferase 1A1 SULT1A1 0.0352
1275 Estrogen sulfotransferase SULT1E1 0.0347
4382 Sulfotransferase family cytosolic 1B member 1 SULT1B1 0.0345
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0344
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0344
4380 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 0.0344
2390 Nonsecretory ribonuclease RNASE2 0.0283
380 Cytochrome P450 17A1 CYP17A1 0.0252
4512 Cytochrome P450 3A4 CYP3A4 0.025
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0249
1353 DNA topoisomerase 1 TOP1 0.0248
3552 DNA topoisomerase 1 topA 0.0248
5682 Ribonuclease pancreatic RNASE1 0.0173
4924 Cytochrome P450 2C8 CYP2C8 0.0169
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0167
862 Multidrug resistance-associated protein 1 ABCC1 0.0155
4119 Cytochrome P450 2D6 CYP2D6 0.0152
6107 Cytochrome P450 3A7 CYP3A7 0.0142
587 Serum albumin ALB 0.0134
6102 Arylamine N-acetyltransferase 2 NAT2 0.0102
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0092
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0077
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0072
20 Prostaglandin G/H synthase 1 PTGS1 0.0072
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0069
4472 Glucose 1-dehydrogenase Not Available 0.0069
4423 Levodione reductase lvr 0.0069
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0069
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0069
4428 Redox-sensing transcriptional repressor rex rex 0.0069
4449 ADP-ribosyltransferase Not Available 0.0069
2350 3-isopropylmalate dehydrogenase leuB 0.0069
3092 3-isopropylmalate dehydrogenase leuB 0.0069
4418 AGR_L_3209p AGR_L_3209 0.0069
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0069
4455 Glycerol dehydrogenase gldA 0.0069
4443 Quinate/shikimate dehydrogenase ydiB 0.0069
4435 L-aspartate dehydrogenase nadX 0.0069
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0069
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0069
4447 Hypothetical protein yhfP yhfP 0.0069
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0069
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0069
3381 Alcohol dehydrogenase Not Available 0.0069
4508 Alcohol dehydrogenase adhA 0.0069
4414 Dehydrogenase TT_P0035 0.0069
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0069
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0069
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0069
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0069
4502 Formate dehydrogenase Not Available 0.0069
4487 Transcriptional regulator nadR nadR 0.0069
3729 Citrate synthase gltA 0.0069
4575 Citrate synthase cit 0.0069
4580 Citrate synthase gltA 0.0069
4451 Vip2Ac vip2Ac 0.0069
4500 L-lactate dehydrogenase 2 ldh2 0.0069
4507 Alanine dehydrogenase ald 0.0069
4497 Benzyl alcohol dehydrogenase xylB 0.0069
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0069
3726 D-3-phosphoglycerate dehydrogenase serA 0.0069
4291 D-3-phosphoglycerate dehydrogenase serA 0.0069
4467 Alpha-glucosidase, putative TM_0752 0.0069
290 Prostaglandin G/H synthase 2 PTGS2 0.0063
5718 Cytochrome P450 2A6 CYP2A6 0.0061
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.006
4509 Acetoin(diacetyl) reductase budC 0.006
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.006
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.006
4427 TDP-glucose-4,6-dehydratase desIV 0.006
4503 NADPH-flavin oxidoreductase frp 0.006
3615 Dihydrodipicolinate reductase dapB 0.006
3618 Dihydrodipicolinate reductase dapB 0.006
4462 Dihydrodipicolinate reductase dapB 0.006
4439 Ferredoxin reductase bphA4 0.006
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.006
4486 Phenol 2-hydroxylase component B pheA2 0.006
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.006
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.006
2336 2,3-diketo-L-gulonate reductase dlgD 0.006
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.006
126 D-lactate dehydrogenase dld 0.006
3545 D-lactate dehydrogenase Not Available 0.006
4510 D-lactate dehydrogenase ldhA 0.006
4498 Ornithine cyclodeaminase PP3533 0.006
3081 3-dehydroquinate synthase aroB 0.006
3177 dTDP-glucose 4,6-dehydratase rfbB 0.006
4499 dTDP-glucose 4,6-dehydratase rmlB 0.006
2018 Deoxyhypusine synthase DHPS 0.006
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.006
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.006
2967 CDP-paratose 2-epimerase rfbE 0.006
2393 Maltose-6'-phosphate glucosidase glvA 0.006
4450 Iota toxin component Ia Not Available 0.006
4477 Dihydrolipoyl dehydrogenase lpdV 0.006
5077 Dihydrolipoyl dehydrogenase Not Available 0.006
5117 Dihydrolipoyl dehydrogenase lpd 0.006
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.006
4482 UDP-galactose 4-epimerase galE 0.006
2591 Urocanate hydratase hutU 0.006
4496 C-terminal-binding protein 1 CTBP1 0.006
2507 Diphtheria toxin Not Available 0.006
2424 L-lactate dehydrogenase ldh 0.006
2641 L-lactate dehydrogenase Not Available 0.006
4437 L-lactate dehydrogenase ldh 0.006
4442 L-lactate dehydrogenase ldh 0.006
2538 6-phospho-beta-glucosidase bglT bglT 0.006
6024 Cytochrome P450 1A1 CYP1A1 0.0056
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0055
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0055
4504 WbpP Not Available 0.0055
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0055
711 UDP-glucose 6-dehydrogenase UGDH 0.0055
3672 UDP-glucose 6-dehydrogenase hasB 0.0055
3367 GDP-mannose 6-dehydrogenase algD 0.0055
2683 Mono-ADP-ribosyltransferase C3 C3 0.0055
4440 NADH peroxidase npr 0.0055
4318 Siroheme synthase cysG 0.0055
4343 Alpha-glucosidase aglA 0.0055
1729 Solute carrier family 22 member 6 SLC22A6 0.0054
816 Biliverdin reductase A BLVRA 0.0054
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0054
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0054
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0054
6013 Cytochrome P450 2E1 CYP2E1 0.0054
63 Malate dehydrogenase mdh 0.0054
2329 Malate dehydrogenase mdh 0.0054
3445 Malate dehydrogenase mdh 0.0054
4420 Malate dehydrogenase mdh 0.0054
4438 Malate dehydrogenase mdh 0.0054
4476 Mannitol dehydrogenase mtlD 0.0054
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0052
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0052
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0052
2826 Glucose--fructose oxidoreductase gfo 0.0052
3191 Histidinol dehydrogenase hisD 0.0052
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0052
3070 Adenosylhomocysteinase AHCY 0.0052
4424 Adenosylhomocysteinase PFE1050w 0.0052
6278 Adenosylhomocysteinase ahcY 0.0052
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0052
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0052
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0052
2617 Nitric oxide synthase oxygenase nos 0.0052
2701 Nitric oxide synthase oxygenase nos 0.0052
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0052
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0052
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0052
328 Sorbitol dehydrogenase SORD 0.0052
396 Alcohol dehydrogenase 4 ADH4 0.0052
597 Dihydropteridine reductase QDPR 0.0052
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0052
646 Malate dehydrogenase, cytoplasmic MDH1 0.0052
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0052
327 Glutathione reductase gor 0.0052
5110 Glutathione reductase GR2 0.0052
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.005
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.005
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.005
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.005
12 Alcohol dehydrogenase class 3 ADH5 0.005
77 L-lactate dehydrogenase B chain LDHB 0.005
2286 Isocitrate dehydrogenase [NADP] icd 0.0048
2302 Isocitrate dehydrogenase [NADP] icd 0.0048
2771 Isocitrate dehydrogenase [NADP] icd 0.0048
4491 DNA ligase, NAD-dependent ligA 0.0048
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0048
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0048
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0048
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0048
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0048
473 L-lactate dehydrogenase A chain LDHA 0.0048
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0048
1588 Multidrug resistance protein 1 ABCB1 0.0047
4200 Cytochrome P450 1A2 CYP1A2 0.0047
2762 UDP-glucose 4-epimerase GALE 0.0047
3461 UDP-glucose 4-epimerase galE 0.0047
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0047
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0046
4757 Cytochrome P450 2C9 CYP2C9 0.0046
569 Retinal dehydrogenase 2 ALDH1A2 0.0045
611 Retinal dehydrogenase 1 ALDH1A1 0.0044
251 Alcohol dehydrogenase 1A ADH1A 0.0043
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0043
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0042
4878 Glycoprotein hormones alpha chain CGA 0.0041
4889 Ig epsilon chain C region IGHE 0.0041
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0041
1072 Granzyme B GZMB 0.0041
4880 Membrane cofactor protein CD46 0.0041
4856 CD209 antigen CD209 0.0041
4189 Alpha-galactosidase A GLA 0.0041
4852 Reticulon-4 receptor RTN4R 0.0041
4877 Beta-mannanase man 0.0041
757 Fusion glycoprotein F0 F 0.0041
4875 Fusion glycoprotein F0 F 0.0041
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0041
4850 Beta-2-glycoprotein 1 APOH 0.0041
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0041
1354 Beta-glucuronidase GUSB 0.0041
442 Envelope glycoprotein gp41 0.0041
4859 Envelope glycoprotein env 0.0041
4869 Major capsid protein A430L 0.0041
3352 Structural polyprotein Not Available 0.0041
3628 Structural polyprotein Not Available 0.0041
4892 Structural polyprotein Not Available 0.0041
4845 ADAM 33 ADAM33 0.0041
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0041
4721 Beta-1,4-mannanase manA 0.0041
444 Alcohol dehydrogenase 1B ADH1B 0.0041
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0039
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0039
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0039
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0039
714 Glutathione reductase, mitochondrial GSR 0.0039
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0038
517 Alcohol dehydrogenase 1C ADH1C 0.0037
1184 Interferon beta IFNB1 0.0036
6858 Inactive carboxylesterase 4 CES1P1 0.0036
793 T-cell surface antigen CD2 CD2 0.0036
4861 Interleukin-6 receptor alpha chain IL6R 0.0036
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0036
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0036
4890 Hemagglutinin HA 0.0036
6566 Hemagglutinin Not Available 0.0036
1379 Interleukin-12 subunit beta IL12B 0.0036
3837 Cytokine receptor common beta chain CSF2RB 0.0036
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0036
3444 Cyanovirin-N Not Available 0.0033
1859 Prostatic acid phosphatase ACPP 0.0033
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0033
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0033
3140 Hemagglutinin-neuraminidase HN 0.0033
3609 Hemagglutinin-neuraminidase HN 0.0033
2297 Genome polyprotein Not Available 0.0033
2322 Genome polyprotein Not Available 0.0033
2694 Genome polyprotein Not Available 0.0033
2719 Genome polyprotein Not Available 0.0033
2860 Genome polyprotein Not Available 0.0033
2928 Genome polyprotein Not Available 0.0033
3160 Genome polyprotein Not Available 0.0033
3260 Genome polyprotein Not Available 0.0033
4783 Genome polyprotein Not Available 0.0033
5726 Genome polyprotein Not Available 0.0033
5779 Genome polyprotein Not Available 0.0033
5867 Genome polyprotein Not Available 0.0033
6253 Genome polyprotein Not Available 0.0033
6301 Genome polyprotein Not Available 0.0033
6380 Genome polyprotein Not Available 0.0033
6381 Genome polyprotein Not Available 0.0033
6437 Genome polyprotein Not Available 0.0033
6520 Genome polyprotein Not Available 0.0033
6521 Genome polyprotein Not Available 0.0033
6652 Genome polyprotein Not Available 0.0033
6734 Genome polyprotein Not Available 0.0033
6735 Genome polyprotein Not Available 0.0033
6736 Genome polyprotein Not Available 0.0033
6737 Genome polyprotein Not Available 0.0033
6738 Genome polyprotein Not Available 0.0033
6739 Genome polyprotein Not Available 0.0033
6744 Genome polyprotein Not Available 0.0033
6748 Genome polyprotein Not Available 0.0033
6894 Genome polyprotein Not Available 0.0033
6898 Genome polyprotein Not Available 0.0033
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0033
4666 Fucose-binding lectin PA-IIL lecB 0.0031
2372 Bifunctional tail protein 9 0.0031
4787 Envelope glycoprotein gp160 env 0.0031
4820 Envelope glycoprotein gp160 env 0.0031
5727 Envelope glycoprotein gp160 env 0.0031
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.003
554 Low-density lipoprotein receptor LDLR 0.0029
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0029
852 Heparin cofactor 2 SERPIND1 0.0029
3480 Mannan endo-1,4-beta-mannosidase manA 0.0029
64 Neuraminidase NA 0.0029
641 Neuraminidase NA 0.0029
2676 Neuraminidase NA 0.0029
3026 Neuraminidase NA 0.0029
3519 Neuraminidase NA 0.0029
6007 Neuraminidase NA 0.0029
1439 Lactotransferrin LTF 0.0028
1243 Cathepsin D CTSD 0.0027
595 Fibrinogen alpha chain FGA 0.0027
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0027
2430 Chondroitinase B cslB 0.0026
958 Insulin-like growth factor 1 receptor IGF1R 0.0026
2581 Chondroitinase AC cslA 0.0026
6500 Phospholipase A2 PLA2G1B 0.0025
6847 Lactase-phlorizin hydrolase LCT 0.0025
2207 Rhodopsin RHO 0.0023
3814 Complement C1r subcomponent C1R 0.0023
309 Antithrombin-III SERPINC1 0.0022
76 Nitric-oxide synthase, brain NOS1 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0018
4604 Liver carboxylesterase 1 CES1 0.0018
3923 Cholinesterase BCHE 0.0013
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