DT-Web

DB03227 - Nicotinamide Mononucleotide


Identification
Name Nicotinamide Mononucleotide
Accession Number DB03227 (EXPT02366)
Type small molecule
Description 3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 335.2271
Groups experimental
Monoisotopic Weight 335.06442701
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Nicotinamide mononucleotide adenylyltransferase 1
Name Nicotinamide mononucleotide adenylyltransferase 1
Gene Name NMNAT1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6512
Nicotinamide mononucleotide adenylyltransferase 3
Name Nicotinamide mononucleotide adenylyltransferase 3
Gene Name NMNAT3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6624
ADP-ribosyl cyclase 2
Name ADP-ribosyl cyclase 2
Gene Name BST1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0855
DNA ligase, NAD-dependent
Name DNA ligase, NAD-dependent
Gene Name ligA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.5578

Predictions


Id Partner name Gene Name Score
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.2118
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.2118
6275 DNA ligase ligA 0.2036
473 L-lactate dehydrogenase A chain LDHA 0.2029
2434 NH(3)-dependent NAD(+) synthetase nadE 0.1694
2910 NH(3)-dependent NAD(+) synthetase nadE 0.1694
3217 NH(3)-dependent NAD(+) synthetase nadE 0.1694
2282 Protein recA recA 0.0878
2315 Protein recA recA 0.0878
2332 Protein recA recA 0.0878
5263 Protein recA recA 0.0878
4775 PROBABLE LIGNIN PEROXIDASE LIPJ lipJ 0.0624
4774 NTPase P4 Not Available 0.0544
4776 CarA carA 0.0543
4655 Adenylate cyclase cyaC 0.0501
4759 Adenylate cyclase cyaB2 0.0501
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0493
2532 Pantoate--beta-alanine ligase panC 0.0473
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.0473
3404 Exotoxin A eta 0.0471
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0423
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0423
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0423
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0331
6013 Cytochrome P450 2E1 CYP2E1 0.0149
4119 Cytochrome P450 2D6 CYP2D6 0.0123
4428 Redox-sensing transcriptional repressor rex rex 0.0118
4449 ADP-ribosyltransferase Not Available 0.0118
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0118
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0118
2350 3-isopropylmalate dehydrogenase leuB 0.0118
3092 3-isopropylmalate dehydrogenase leuB 0.0118
4443 Quinate/shikimate dehydrogenase ydiB 0.0118
4435 L-aspartate dehydrogenase nadX 0.0118
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0118
4472 Glucose 1-dehydrogenase Not Available 0.0118
4423 Levodione reductase lvr 0.0118
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0118
4414 Dehydrogenase TT_P0035 0.0118
4500 L-lactate dehydrogenase 2 ldh2 0.0118
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0118
4418 AGR_L_3209p AGR_L_3209 0.0118
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0118
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0118
4497 Benzyl alcohol dehydrogenase xylB 0.0118
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0118
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0118
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0118
4507 Alanine dehydrogenase ald 0.0118
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0118
3726 D-3-phosphoglycerate dehydrogenase serA 0.0118
4291 D-3-phosphoglycerate dehydrogenase serA 0.0118
4451 Vip2Ac vip2Ac 0.0118
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0118
4455 Glycerol dehydrogenase gldA 0.0118
4487 Transcriptional regulator nadR nadR 0.0118
3729 Citrate synthase gltA 0.0118
4575 Citrate synthase cit 0.0118
4580 Citrate synthase gltA 0.0118
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0118
4502 Formate dehydrogenase Not Available 0.0118
4447 Hypothetical protein yhfP yhfP 0.0118
3381 Alcohol dehydrogenase Not Available 0.0118
4508 Alcohol dehydrogenase adhA 0.0118
4467 Alpha-glucosidase, putative TM_0752 0.0118
4512 Cytochrome P450 3A4 CYP3A4 0.0112
4486 Phenol 2-hydroxylase component B pheA2 0.0103
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0103
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0103
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0103
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0103
3615 Dihydrodipicolinate reductase dapB 0.0103
3618 Dihydrodipicolinate reductase dapB 0.0103
4462 Dihydrodipicolinate reductase dapB 0.0103
4503 NADPH-flavin oxidoreductase frp 0.0103
2018 Deoxyhypusine synthase DHPS 0.0103
4509 Acetoin(diacetyl) reductase budC 0.0103
4498 Ornithine cyclodeaminase PP3533 0.0103
126 D-lactate dehydrogenase dld 0.0103
3545 D-lactate dehydrogenase Not Available 0.0103
4510 D-lactate dehydrogenase ldhA 0.0103
4427 TDP-glucose-4,6-dehydratase desIV 0.0103
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0103
4439 Ferredoxin reductase bphA4 0.0103
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0103
2336 2,3-diketo-L-gulonate reductase dlgD 0.0103
3081 3-dehydroquinate synthase aroB 0.0103
4496 C-terminal-binding protein 1 CTBP1 0.0103
2424 L-lactate dehydrogenase ldh 0.0103
2641 L-lactate dehydrogenase Not Available 0.0103
4437 L-lactate dehydrogenase ldh 0.0103
4442 L-lactate dehydrogenase ldh 0.0103
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0103
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0103
4477 Dihydrolipoyl dehydrogenase lpdV 0.0103
5077 Dihydrolipoyl dehydrogenase Not Available 0.0103
5117 Dihydrolipoyl dehydrogenase lpd 0.0103
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0103
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0103
4450 Iota toxin component Ia Not Available 0.0103
2393 Maltose-6'-phosphate glucosidase glvA 0.0103
4482 UDP-galactose 4-epimerase galE 0.0103
2538 6-phospho-beta-glucosidase bglT bglT 0.0103
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0103
2967 CDP-paratose 2-epimerase rfbE 0.0103
2591 Urocanate hydratase hutU 0.0103
2507 Diphtheria toxin Not Available 0.0103
2683 Mono-ADP-ribosyltransferase C3 C3 0.0095
4343 Alpha-glucosidase aglA 0.0095
3367 GDP-mannose 6-dehydrogenase algD 0.0095
711 UDP-glucose 6-dehydrogenase UGDH 0.0095
3672 UDP-glucose 6-dehydrogenase hasB 0.0095
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0095
4440 NADH peroxidase npr 0.0095
4318 Siroheme synthase cysG 0.0095
4504 WbpP Not Available 0.0095
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0095
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0093
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0093
816 Biliverdin reductase A BLVRA 0.0093
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0093
2617 Nitric oxide synthase oxygenase nos 0.0089
2701 Nitric oxide synthase oxygenase nos 0.0089
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0089
2826 Glucose--fructose oxidoreductase gfo 0.0089
3191 Histidinol dehydrogenase hisD 0.0089
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0089
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0089
3070 Adenosylhomocysteinase AHCY 0.0089
4424 Adenosylhomocysteinase PFE1050w 0.0089
6278 Adenosylhomocysteinase ahcY 0.0089
597 Dihydropteridine reductase QDPR 0.0089
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0089
328 Sorbitol dehydrogenase SORD 0.0089
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0089
646 Malate dehydrogenase, cytoplasmic MDH1 0.0089
396 Alcohol dehydrogenase 4 ADH4 0.0089
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0089
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0089
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0089
63 Malate dehydrogenase mdh 0.0088
2329 Malate dehydrogenase mdh 0.0088
3445 Malate dehydrogenase mdh 0.0088
4420 Malate dehydrogenase mdh 0.0088
4438 Malate dehydrogenase mdh 0.0088
4476 Mannitol dehydrogenase mtlD 0.0087
327 Glutathione reductase gor 0.0086
5110 Glutathione reductase GR2 0.0086
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0085
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0085
12 Alcohol dehydrogenase class 3 ADH5 0.0085
77 L-lactate dehydrogenase B chain LDHB 0.0085
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0085
2286 Isocitrate dehydrogenase [NADP] icd 0.0082
2302 Isocitrate dehydrogenase [NADP] icd 0.0082
2771 Isocitrate dehydrogenase [NADP] icd 0.0082
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0082
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0082
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0082
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0082
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0082
2762 UDP-glucose 4-epimerase GALE 0.008
3461 UDP-glucose 4-epimerase galE 0.008
166 NAD-dependent malic enzyme, mitochondrial ME2 0.008
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0079
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0078
611 Retinal dehydrogenase 1 ALDH1A1 0.0072
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0072
251 Alcohol dehydrogenase 1A ADH1A 0.0072
569 Retinal dehydrogenase 2 ALDH1A2 0.0072
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.007
444 Alcohol dehydrogenase 1B ADH1B 0.0069
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0067
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0067
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0067
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0067
714 Glutathione reductase, mitochondrial GSR 0.0065
517 Alcohol dehydrogenase 1C ADH1C 0.0062
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0062
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