DT-Web

DB04289 - Genz-10850


Identification
Name Genz-10850
Accession Number DB04289 (EXPT01584)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 393.4803
Groups experimental
Monoisotopic Weight 393.184112373
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Enoyl-[acyl-carrier-protein] reductase [NADH]
Name Enoyl-[acyl-carrier-protein] reductase [NADH]
Gene Name inhA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4302

Predictions


Id Partner name Gene Name Score
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 1.4302
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 1.4302
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 1.4302
518 Peroxidase/catalase T katG 0.0785
6855 Enoyl-(Acyl-carrier-protein) reductase fabI 0.0328
6877 Enoyl-(Acyl-carrier-protein) reductase fabK 0.0328
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0261
6102 Arylamine N-acetyltransferase 2 NAT2 0.0096
5718 Cytochrome P450 2A6 CYP2A6 0.0056
6013 Cytochrome P450 2E1 CYP2E1 0.005
4924 Cytochrome P450 2C8 CYP2C8 0.0047
6016 Cytochrome P450 2C19 CYP2C19 0.0045
4200 Cytochrome P450 1A2 CYP1A2 0.0044
4757 Cytochrome P450 2C9 CYP2C9 0.0043
4119 Cytochrome P450 2D6 CYP2D6 0.0042
4512 Cytochrome P450 3A4 CYP3A4 0.0038
4428 Redox-sensing transcriptional repressor rex rex 0.0015
4449 ADP-ribosyltransferase Not Available 0.0015
3381 Alcohol dehydrogenase Not Available 0.0015
4508 Alcohol dehydrogenase adhA 0.0015
2350 3-isopropylmalate dehydrogenase leuB 0.0015
3092 3-isopropylmalate dehydrogenase leuB 0.0015
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0015
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0015
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0015
4472 Glucose 1-dehydrogenase Not Available 0.0015
4423 Levodione reductase lvr 0.0015
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0015
4443 Quinate/shikimate dehydrogenase ydiB 0.0015
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0015
4500 L-lactate dehydrogenase 2 ldh2 0.0015
4447 Hypothetical protein yhfP yhfP 0.0015
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0015
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0015
4414 Dehydrogenase TT_P0035 0.0015
4418 AGR_L_3209p AGR_L_3209 0.0015
4507 Alanine dehydrogenase ald 0.0015
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0015
4497 Benzyl alcohol dehydrogenase xylB 0.0015
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0015
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0015
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0015
4502 Formate dehydrogenase Not Available 0.0015
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0015
3726 D-3-phosphoglycerate dehydrogenase serA 0.0015
4291 D-3-phosphoglycerate dehydrogenase serA 0.0015
4487 Transcriptional regulator nadR nadR 0.0015
3729 Citrate synthase gltA 0.0015
4575 Citrate synthase cit 0.0015
4580 Citrate synthase gltA 0.0015
4435 L-aspartate dehydrogenase nadX 0.0015
4467 Alpha-glucosidase, putative TM_0752 0.0015
4455 Glycerol dehydrogenase gldA 0.0015
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0015
4451 Vip2Ac vip2Ac 0.0015
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0012
3615 Dihydrodipicolinate reductase dapB 0.0012
3618 Dihydrodipicolinate reductase dapB 0.0012
4462 Dihydrodipicolinate reductase dapB 0.0012
4503 NADPH-flavin oxidoreductase frp 0.0012
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0012
2591 Urocanate hydratase hutU 0.0012
2967 CDP-paratose 2-epimerase rfbE 0.0012
4482 UDP-galactose 4-epimerase galE 0.0012
2424 L-lactate dehydrogenase ldh 0.0012
2641 L-lactate dehydrogenase Not Available 0.0012
4437 L-lactate dehydrogenase ldh 0.0012
4442 L-lactate dehydrogenase ldh 0.0012
126 D-lactate dehydrogenase dld 0.0012
3545 D-lactate dehydrogenase Not Available 0.0012
4510 D-lactate dehydrogenase ldhA 0.0012
4486 Phenol 2-hydroxylase component B pheA2 0.0012
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0012
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0012
4427 TDP-glucose-4,6-dehydratase desIV 0.0012
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0012
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0012
2507 Diphtheria toxin Not Available 0.0012
4439 Ferredoxin reductase bphA4 0.0012
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0012
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0012
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0012
4477 Dihydrolipoyl dehydrogenase lpdV 0.0012
5077 Dihydrolipoyl dehydrogenase Not Available 0.0012
5117 Dihydrolipoyl dehydrogenase lpd 0.0012
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0012
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0012
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0012
4450 Iota toxin component Ia Not Available 0.0012
2336 2,3-diketo-L-gulonate reductase dlgD 0.0012
4498 Ornithine cyclodeaminase PP3533 0.0012
2018 Deoxyhypusine synthase DHPS 0.0012
2538 6-phospho-beta-glucosidase bglT bglT 0.0012
4496 C-terminal-binding protein 1 CTBP1 0.0012
2393 Maltose-6'-phosphate glucosidase glvA 0.0012
3081 3-dehydroquinate synthase aroB 0.0012
4509 Acetoin(diacetyl) reductase budC 0.0012
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0012
2683 Mono-ADP-ribosyltransferase C3 C3 0.0011
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0011
4504 WbpP Not Available 0.0011
711 UDP-glucose 6-dehydrogenase UGDH 0.0011
3672 UDP-glucose 6-dehydrogenase hasB 0.0011
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0011
4318 Siroheme synthase cysG 0.0011
3367 GDP-mannose 6-dehydrogenase algD 0.0011
4440 NADH peroxidase npr 0.0011
4343 Alpha-glucosidase aglA 0.0011
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0011
2617 Nitric oxide synthase oxygenase nos 0.0011
2701 Nitric oxide synthase oxygenase nos 0.0011
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0011
3070 Adenosylhomocysteinase AHCY 0.0011
4424 Adenosylhomocysteinase PFE1050w 0.0011
6278 Adenosylhomocysteinase ahcY 0.0011
3191 Histidinol dehydrogenase hisD 0.0011
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0011
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0011
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0011
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0011
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0011
2826 Glucose--fructose oxidoreductase gfo 0.0011
63 Malate dehydrogenase mdh 0.001
2329 Malate dehydrogenase mdh 0.001
3445 Malate dehydrogenase mdh 0.001
4420 Malate dehydrogenase mdh 0.001
4438 Malate dehydrogenase mdh 0.001
816 Biliverdin reductase A BLVRA 0.001
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.001
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.001
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.001
4476 Mannitol dehydrogenase mtlD 0.001
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.001
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.001
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.001
327 Glutathione reductase gor 0.001
5110 Glutathione reductase GR2 0.001
328 Sorbitol dehydrogenase SORD 0.001
646 Malate dehydrogenase, cytoplasmic MDH1 0.001
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.001
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.001
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.001
597 Dihydropteridine reductase QDPR 0.001
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.001
396 Alcohol dehydrogenase 4 ADH4 0.001
363 NADP-dependent malic enzyme, mitochondrial ME3 0.001
4491 DNA ligase, NAD-dependent ligA 0.001
77 L-lactate dehydrogenase B chain LDHB 0.001
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.001
12 Alcohol dehydrogenase class 3 ADH5 0.001
2286 Isocitrate dehydrogenase [NADP] icd 0.001
2302 Isocitrate dehydrogenase [NADP] icd 0.001
2771 Isocitrate dehydrogenase [NADP] icd 0.001
473 L-lactate dehydrogenase A chain LDHA 0.0009
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0009
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0009
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
2762 UDP-glucose 4-epimerase GALE 0.0009
3461 UDP-glucose 4-epimerase galE 0.0009
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
251 Alcohol dehydrogenase 1A ADH1A 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0008
444 Alcohol dehydrogenase 1B ADH1B 0.0008
714 Glutathione reductase, mitochondrial GSR 0.0007
517 Alcohol dehydrogenase 1C ADH1C 0.0007
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0007
↑