DT-Web

DB03534 - 3-[(Acetyl-Methyl-Amino)-Methyl]-4-Amino-N-Methyl-N-(1-Methyl-1h-Indol-2-Ylmethyl)-Benzamide


Identification
Name 3-[(Acetyl-Methyl-Amino)-Methyl]-4-Amino-N-Methyl-N-(1-Methyl-1h-Indol-2-Ylmethyl)-Benzamide
Accession Number DB03534 (EXPT03283)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 378.4674
Groups experimental
Monoisotopic Weight 378.205576096
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Enoyl-[acyl-carrier-protein] reductase [NADH]
Name Enoyl-[acyl-carrier-protein] reductase [NADH]
Gene Name fabI
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.0265

Predictions


Id Partner name Gene Name Score
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.1381
6855 Enoyl-(Acyl-carrier-protein) reductase fabI 0.0455
6877 Enoyl-(Acyl-carrier-protein) reductase fabK 0.0455
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0265
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0265
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0265
4509 Acetoin(diacetyl) reductase budC 0.0045
2826 Glucose--fructose oxidoreductase gfo 0.0039
3689 Endoglucanase A celA 0.0033
5411 Slt-IIvB stxB2e 0.0033
5563 Galectin-2 LGALS2 0.0033
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0033
5046 Ecotin eco 0.0033
5554 D-galactose-binding periplasmic protein mglB 0.0033
3741 D-galactose-binding periplasmic protein precursor mglB 0.0033
4668 Laminarinase TM_0024 0.0033
1875 Pulmonary surfactant-associated protein D SFTPD 0.0033
3009 Beta-glucanase Not Available 0.0033
5562 Hexokinase Not Available 0.0033
3793 Aspartate ammonia-lyase aspA 0.0033
4670 Cellulase B celB 0.0033
5569 Endo-1,4-beta glucanase EngF engF 0.0033
5553 Endoglucanase E1 Acel_0614 0.0033
5568 Endoglucanase C307 celC307 0.0033
5570 Endoglucanase E-4 celD 0.0033
4667 BH0236 protein BH0236 0.0033
5559 Neopullulanase nplT 0.0033
4671 Endoglucanase C cenC 0.0033
3744 Endoglucanase SS precursor celS 0.0033
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0028
1503 Galectin-7 LGALS7 0.0028
1184 Interferon beta IFNB1 0.0028
5416 Coat protein VP1 Not Available 0.0028
5176 YtnJ moxC 0.0028
5498 Maltoporin lamB 0.0028
5561 Maltoporin lamB 0.0028
4622 Amylase Not Available 0.0028
5247 Endo-1,4-beta-xylanase Not Available 0.0028
5248 Endo-1,4-beta-xylanase xlnA 0.0028
5250 Endo-1,4-beta-xylanase xyl 0.0028
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0028
4669 Endo-1,4-beta-xylanase A xynA 0.0028
4715 Endo-1,4-beta-xylanase A xlnA 0.0028
5560 Endo-1,4-beta-xylanase A xynA 0.0028
2705 Dimethyl sulfoxide reductase dmsA 0.0028
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0028
3547 Enterotoxin type B entB 0.0026
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0026
3747 Cellulase B precursor celB 0.0026
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0026
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0026
4811 Amylosucrase ams 0.0026
2531 Alpha-amylase amyE 0.0026
2948 Alpha-amylase amy 0.0026
3169 Alpha-amylase Not Available 0.0026
2541 Neopullulanase 1 tvaI 0.0026
4819 Hydrolase Not Available 0.0026
5249 Hydrolase Not Available 0.0026
5436 Hydrolase Not Available 0.0026
3091 Maltodextrin phosphorylase malP 0.0026
2606 Neopullulanase 2 tvaII 0.0026
2324 Botulinum neurotoxin type B botB 0.0026
3225 Shiga toxin B-chain stxB 0.0025
4666 Fucose-binding lectin PA-IIL lecB 0.0025
4830 Aldose 1-epimerase galM 0.0025
3365 Beta-amylase spoII 0.0025
1881 Hexokinase-1 HK1 0.0025
2372 Bifunctional tail protein 9 0.0025
3030 Salivary alpha-amylase AMY1A 0.0024
6614 Lactase-like protein LCTL 0.0024
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0024
2508 Cyclomaltodextrin glucanotransferase cgt 0.0024
2523 Cyclomaltodextrin glucanotransferase cgt 0.0024
3207 Cyclomaltodextrin glucanotransferase amyA 0.0024
1675 Glucokinase GCK 0.0024
4662 Glucokinase glk 0.0024
4692 A/G-specific adenine glycosylase mutY 0.0023
3668 Maltose-binding periplasmic protein precursor malE 0.0023
2802 Endoglucanase G celCCG 0.0023
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0023
2570 Tetanus toxin tetX 0.0023
4272 POSSIBLE CELLULASE CELA1 celA1 0.0022
2440 Endoglucanase F celCCF 0.0021
2430 Chondroitinase B cslB 0.0021
2245 Xylose isomerase xylA 0.002
2253 Xylose isomerase xylA 0.002
2260 Xylose isomerase xylA 0.002
2431 Xylose isomerase xylA 0.002
2252 Endoglucanase 5A cel5A 0.0019
2723 Cholera enterotoxin subunit B ctxB 0.0019
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0019
4428 Redox-sensing transcriptional repressor rex rex 0.0019
4435 L-aspartate dehydrogenase nadX 0.0019
4423 Levodione reductase lvr 0.0019
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0019
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0019
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0019
4447 Hypothetical protein yhfP yhfP 0.0019
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0019
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0019
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0019
4418 AGR_L_3209p AGR_L_3209 0.0019
4507 Alanine dehydrogenase ald 0.0019
4455 Glycerol dehydrogenase gldA 0.0019
4497 Benzyl alcohol dehydrogenase xylB 0.0019
4449 ADP-ribosyltransferase Not Available 0.0019
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0019
3726 D-3-phosphoglycerate dehydrogenase serA 0.0019
4291 D-3-phosphoglycerate dehydrogenase serA 0.0019
3729 Citrate synthase gltA 0.0019
4575 Citrate synthase cit 0.0019
4580 Citrate synthase gltA 0.0019
2350 3-isopropylmalate dehydrogenase leuB 0.0019
3092 3-isopropylmalate dehydrogenase leuB 0.0019
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0019
4451 Vip2Ac vip2Ac 0.0019
4472 Glucose 1-dehydrogenase Not Available 0.0019
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0019
4443 Quinate/shikimate dehydrogenase ydiB 0.0019
4500 L-lactate dehydrogenase 2 ldh2 0.0019
3381 Alcohol dehydrogenase Not Available 0.0019
4508 Alcohol dehydrogenase adhA 0.0019
4414 Dehydrogenase TT_P0035 0.0019
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0019
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0019
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0019
4502 Formate dehydrogenase Not Available 0.0019
4487 Transcriptional regulator nadR nadR 0.0019
4467 Alpha-glucosidase, putative TM_0752 0.0019
10 Glycogen phosphorylase, liver form PYGL 0.0018
2427 Ferrichrome-iron receptor fhuA 0.0018
4513 Pancreatic alpha-amylase AMY2A 0.0018
4486 Phenol 2-hydroxylase component B pheA2 0.0017
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0017
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0017
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0017
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0017
2336 2,3-diketo-L-gulonate reductase dlgD 0.0017
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0017
4503 NADPH-flavin oxidoreductase frp 0.0017
3615 Dihydrodipicolinate reductase dapB 0.0017
3618 Dihydrodipicolinate reductase dapB 0.0017
4462 Dihydrodipicolinate reductase dapB 0.0017
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0017
2424 L-lactate dehydrogenase ldh 0.0017
2641 L-lactate dehydrogenase Not Available 0.0017
4437 L-lactate dehydrogenase ldh 0.0017
4442 L-lactate dehydrogenase ldh 0.0017
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0017
4427 TDP-glucose-4,6-dehydratase desIV 0.0017
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0017
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0017
4482 UDP-galactose 4-epimerase galE 0.0017
4439 Ferredoxin reductase bphA4 0.0017
2538 6-phospho-beta-glucosidase bglT bglT 0.0017
2393 Maltose-6'-phosphate glucosidase glvA 0.0017
4450 Iota toxin component Ia Not Available 0.0017
4477 Dihydrolipoyl dehydrogenase lpdV 0.0017
5077 Dihydrolipoyl dehydrogenase Not Available 0.0017
5117 Dihydrolipoyl dehydrogenase lpd 0.0017
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0017
2507 Diphtheria toxin Not Available 0.0017
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0017
4498 Ornithine cyclodeaminase PP3533 0.0017
126 D-lactate dehydrogenase dld 0.0017
3545 D-lactate dehydrogenase Not Available 0.0017
4510 D-lactate dehydrogenase ldhA 0.0017
2967 CDP-paratose 2-epimerase rfbE 0.0017
3081 3-dehydroquinate synthase aroB 0.0017
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0017
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0017
2018 Deoxyhypusine synthase DHPS 0.0017
4496 C-terminal-binding protein 1 CTBP1 0.0017
2591 Urocanate hydratase hutU 0.0017
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0015
2683 Mono-ADP-ribosyltransferase C3 C3 0.0015
4504 WbpP Not Available 0.0015
3367 GDP-mannose 6-dehydrogenase algD 0.0015
4440 NADH peroxidase npr 0.0015
4318 Siroheme synthase cysG 0.0015
4343 Alpha-glucosidase aglA 0.0015
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0015
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0015
711 UDP-glucose 6-dehydrogenase UGDH 0.0015
3672 UDP-glucose 6-dehydrogenase hasB 0.0015
1152 Glycogen phosphorylase, muscle form PYGM 0.0015
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0014
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0014
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0014
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0014
3070 Adenosylhomocysteinase AHCY 0.0014
4424 Adenosylhomocysteinase PFE1050w 0.0014
6278 Adenosylhomocysteinase ahcY 0.0014
3191 Histidinol dehydrogenase hisD 0.0014
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0014
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0014
2617 Nitric oxide synthase oxygenase nos 0.0014
2701 Nitric oxide synthase oxygenase nos 0.0014
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0014
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0014
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0014
4476 Mannitol dehydrogenase mtlD 0.0014
63 Malate dehydrogenase mdh 0.0014
2329 Malate dehydrogenase mdh 0.0014
3445 Malate dehydrogenase mdh 0.0014
4420 Malate dehydrogenase mdh 0.0014
4438 Malate dehydrogenase mdh 0.0014
816 Biliverdin reductase A BLVRA 0.0014
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0014
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0014
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0014
327 Glutathione reductase gor 0.0014
5110 Glutathione reductase GR2 0.0014
597 Dihydropteridine reductase QDPR 0.0014
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0014
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0014
646 Malate dehydrogenase, cytoplasmic MDH1 0.0014
328 Sorbitol dehydrogenase SORD 0.0014
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0014
396 Alcohol dehydrogenase 4 ADH4 0.0013
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0013
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0013
2286 Isocitrate dehydrogenase [NADP] icd 0.0013
2302 Isocitrate dehydrogenase [NADP] icd 0.0013
2771 Isocitrate dehydrogenase [NADP] icd 0.0013
4491 DNA ligase, NAD-dependent ligA 0.0013
77 L-lactate dehydrogenase B chain LDHB 0.0013
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0013
12 Alcohol dehydrogenase class 3 ADH5 0.0013
2762 UDP-glucose 4-epimerase GALE 0.0013
3461 UDP-glucose 4-epimerase galE 0.0013
473 L-lactate dehydrogenase A chain LDHA 0.0013
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0013
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0013
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0013
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0012
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0012
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0011
251 Alcohol dehydrogenase 1A ADH1A 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0011
611 Retinal dehydrogenase 1 ALDH1A1 0.0011
444 Alcohol dehydrogenase 1B ADH1B 0.0011
569 Retinal dehydrogenase 2 ALDH1A2 0.0011
714 Glutathione reductase, mitochondrial GSR 0.001
517 Alcohol dehydrogenase 1C ADH1C 0.001
20 Prostaglandin G/H synthase 1 PTGS1 0.001
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
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