Identification
Name 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid
Accession Number DB02401 (EXPT02463)
Type small molecule
Description Not Available
Structure
Categories (*)
Molecular Weight 130.059
Groups experimental
Monoisotopic Weight 130.001456562
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
L-lactate dehydrogenase
Name L-lactate dehydrogenase
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.1169
L-lactate dehydrogenase B chain
Name L-lactate dehydrogenase B chain
Gene Name LDHB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4632
Id Partner name Gene Name Score
6394 Bacterioferritin comigratory protein XCC1738 0.1796
2424 L-lactate dehydrogenase ldh 0.1169
4437 L-lactate dehydrogenase ldh 0.1169
4442 L-lactate dehydrogenase ldh 0.1169
126 D-lactate dehydrogenase dld 0.1166
3545 D-lactate dehydrogenase Not Available 0.1166
4510 D-lactate dehydrogenase ldhA 0.1166
3178 Formate acetyltransferase 1 pflB 0.1001
473 L-lactate dehydrogenase A chain LDHA 0.0996
500 Monocarboxylate transporter 4 SLC16A3 0.072
816 Biliverdin reductase A BLVRA 0.0079
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0079
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0079
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0079
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0075
646 Malate dehydrogenase, cytoplasmic MDH1 0.0075
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0075
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0075
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0075
328 Sorbitol dehydrogenase SORD 0.0074
597 Dihydropteridine reductase QDPR 0.0074
396 Alcohol dehydrogenase 4 ADH4 0.0074
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0074
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0072
12 Alcohol dehydrogenase class 3 ADH5 0.007
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0069
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0069
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0069
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0069
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0068
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0068
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0065
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0065
4500 L-lactate dehydrogenase 2 ldh2 0.0065
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0065
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0065
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0065
4472 Glucose 1-dehydrogenase Not Available 0.0065
4435 L-aspartate dehydrogenase nadX 0.0065
4423 Levodione reductase lvr 0.0065
4447 Hypothetical protein yhfP yhfP 0.0065
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0065
4443 Quinate/shikimate dehydrogenase ydiB 0.0065
4428 Redox-sensing transcriptional repressor rex rex 0.0065
4449 ADP-ribosyltransferase Not Available 0.0065
4455 Glycerol dehydrogenase gldA 0.0065
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0065
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0065
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0065
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0065
4414 Dehydrogenase TT_P0035 0.0065
2350 3-isopropylmalate dehydrogenase leuB 0.0065
3092 3-isopropylmalate dehydrogenase leuB 0.0065
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0065
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0065
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0065
4467 Alpha-glucosidase, putative TM_0752 0.0065
3381 Alcohol dehydrogenase Not Available 0.0065
4508 Alcohol dehydrogenase adhA 0.0065
4497 Benzyl alcohol dehydrogenase xylB 0.0065
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0065
4418 AGR_L_3209p AGR_L_3209 0.0065
4502 Formate dehydrogenase Not Available 0.0065
4451 Vip2Ac vip2Ac 0.0065
4507 Alanine dehydrogenase ald 0.0065
4487 Transcriptional regulator nadR nadR 0.0065
3729 Citrate synthase gltA 0.0065
4575 Citrate synthase cit 0.0065
4580 Citrate synthase gltA 0.0065
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0062
569 Retinal dehydrogenase 2 ALDH1A2 0.0061
611 Retinal dehydrogenase 1 ALDH1A1 0.0061
251 Alcohol dehydrogenase 1A ADH1A 0.006
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0059
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0058
444 Alcohol dehydrogenase 1B ADH1B 0.0057
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0056
4486 Phenol 2-hydroxylase component B pheA2 0.0056
4439 Ferredoxin reductase bphA4 0.0056
4477 Dihydrolipoyl dehydrogenase lpdV 0.0056
5077 Dihydrolipoyl dehydrogenase Not Available 0.0056
5117 Dihydrolipoyl dehydrogenase lpd 0.0056
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0056
4427 TDP-glucose-4,6-dehydratase desIV 0.0056
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0056
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0056
2967 CDP-paratose 2-epimerase rfbE 0.0055
4482 UDP-galactose 4-epimerase galE 0.0055
4503 NADPH-flavin oxidoreductase frp 0.0055
2507 Diphtheria toxin Not Available 0.0055
2393 Maltose-6'-phosphate glucosidase glvA 0.0055
2538 6-phospho-beta-glucosidase bglT bglT 0.0055
4509 Acetoin(diacetyl) reductase budC 0.0055
3081 3-dehydroquinate synthase aroB 0.0055
2591 Urocanate hydratase hutU 0.0055
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0055
3615 Dihydrodipicolinate reductase dapB 0.0055
3618 Dihydrodipicolinate reductase dapB 0.0055
4462 Dihydrodipicolinate reductase dapB 0.0055
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0055
4450 Iota toxin component Ia Not Available 0.0055
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0055
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0055
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0055
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0055
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0055
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0055
4498 Ornithine cyclodeaminase PP3533 0.0055
4496 C-terminal-binding protein 1 CTBP1 0.0055
2018 Deoxyhypusine synthase DHPS 0.0055
2336 2,3-diketo-L-gulonate reductase dlgD 0.0055
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0055
714 Glutathione reductase, mitochondrial GSR 0.0054
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0052
2683 Mono-ADP-ribosyltransferase C3 C3 0.0051
4504 WbpP Not Available 0.0051
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0051
517 Alcohol dehydrogenase 1C ADH1C 0.0051
3367 GDP-mannose 6-dehydrogenase algD 0.0051
4440 NADH peroxidase npr 0.005
4318 Siroheme synthase cysG 0.005
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.005
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.005
4343 Alpha-glucosidase aglA 0.005
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0048
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0048
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0048
63 Malate dehydrogenase mdh 0.0048
2329 Malate dehydrogenase mdh 0.0048
3445 Malate dehydrogenase mdh 0.0048
4420 Malate dehydrogenase mdh 0.0048
4438 Malate dehydrogenase mdh 0.0048
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0048
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0048
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0048
2617 Nitric oxide synthase oxygenase nos 0.0048
2701 Nitric oxide synthase oxygenase nos 0.0048
2826 Glucose--fructose oxidoreductase gfo 0.0048
3070 Adenosylhomocysteinase AHCY 0.0048
4424 Adenosylhomocysteinase PFE1050w 0.0048
6278 Adenosylhomocysteinase ahcY 0.0048
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0047
4476 Mannitol dehydrogenase mtlD 0.0047
3191 Histidinol dehydrogenase hisD 0.0047
327 Glutathione reductase gor 0.0046
5110 Glutathione reductase GR2 0.0046
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0046
2286 Isocitrate dehydrogenase [NADP] icd 0.0043
2302 Isocitrate dehydrogenase [NADP] icd 0.0043
2771 Isocitrate dehydrogenase [NADP] icd 0.0043
4491 DNA ligase, NAD-dependent ligA 0.0043
2762 UDP-glucose 4-epimerase GALE 0.0043
3461 UDP-glucose 4-epimerase galE 0.0043
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0035
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
167 L-lactate dehydrogenase C chain LDHC 0.0033
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0032
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0032
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0031
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0031
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0031
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0031
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0031
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0031
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0031
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0031
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0031
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0031
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0031
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0031
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0031
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0031
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0031
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0031
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0031
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0031
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0031
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0031
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0031
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0031
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0031
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0031
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0031
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0031
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0031
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0031
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0031
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0031
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0031
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0031
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0031
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0031
107 C-4 methylsterol oxidase SC4MOL 0.0031
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0031
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0031
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0031
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0031
206 3-keto-steroid reductase HSD17B7 0.0031
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0031
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0031
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0031
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0031
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0031
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0031
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0031
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0031
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0031
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0031
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0031
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0031
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0031
34 7-dehydrocholesterol reductase DHCR7 0.0031
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0031
711 UDP-glucose 6-dehydrogenase UGDH 0.0031
3672 UDP-glucose 6-dehydrogenase hasB 0.0031
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0031
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0031
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0031
3726 D-3-phosphoglycerate dehydrogenase serA 0.0031
4291 D-3-phosphoglycerate dehydrogenase serA 0.0031
644 Heme oxygenase 2 HMOX2 0.0031
4982 Heme oxygenase 2 pbsA2 0.0031
729 GDP-L-fucose synthetase TSTA3 0.0031
3463 GDP-L-fucose synthetase fcl 0.0031
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0031
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0031
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0031
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0031
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0031
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0031
643 Peroxisomal bifunctional enzyme EHHADH 0.0031
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0031
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0031
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0031
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0029
666 NADP-dependent malic enzyme ME1 0.0029
857 Malate dehydrogenase, mitochondrial MDH2 0.0028
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0028
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0027
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0026
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0026
626 Cysteine dioxygenase type 1 CDO1 0.0025
6026 Alcohol dehydrogenase 6 ADH6 0.0025
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0025
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0025
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0025
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0025
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0025
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0025
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0025
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0025
627 11-cis retinol dehydrogenase RDH5 0.0025
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0025
13 Aminomethyltransferase, mitochondrial AMT 0.0025
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0025
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0024
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0024
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0023
654 Flavin reductase BLVRB 0.0023
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0022
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0022
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0021
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0021
279 Tyrosinase TYR 0.0021
810 Heme oxygenase 1 HMOX1 0.0021
3391 Heme oxygenase 1 pbsA1 0.0021
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.002
380 Cytochrome P450 17A1 CYP17A1 0.002
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0018
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0018
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0018
822 Aldose reductase AKR1B1 0.0017
468 Cytochrome P450 4A11 CYP4A11 0.0017
6020 Aldehyde oxidase AOX1 0.0017
365 Dihydrofolate reductase DHFR 0.0017
2381 Dihydrofolate reductase DFR1 0.0017
2833 Dihydrofolate reductase Not Available 0.0017
2931 Dihydrofolate reductase folA 0.0017
3544 Dihydrofolate reductase folA 0.0017
3682 Dihydrofolate reductase folA 0.0017
6642 Dihydrofolate reductase folA 0.0017
6756 Dihydrofolate reductase dfrA 0.0017
3947 Xanthine dehydrogenase/oxidase XDH 0.0015