DT-Web

DB00336 - Nitrofurazone


Identification
Name Nitrofurazone
Accession Number DB00336 (APRD00050)
Type small molecule
Description A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Nitrofurazone has also been administered orally in the treatment of trypanosomiasis. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 198.1362
Groups approved
Monoisotopic Weight 198.0389047
Pharmacology
Indication For the treatement of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms.
Mechanism of action The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase.
Absorption Well absorbed.
Protein binding Not Available
Biotransformation Nitrofurans, including nitrofural, undergo metabolic reduction at the nitro group to generate reactive species which can covalently bind to cellular macromolecules (Polnaszek et al., 1984; Kutcher & McCalla, 1984; McCalla 1979; McCalla et al., 1975).
Route of elimination Not Available
Toxicity Rat LD50 = 590 mg/kg; Allergic contact dermatitis is the most frequently reported adverse effect, occurring in approximately 1 % of patients treated.
Affected organisms
  • Gram negative and gram positive bacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Pyruvate dehydrogenase [cytochrome]
Name Pyruvate dehydrogenase [cytochrome]
Gene Name poxB
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8992
Glutathione reductase
Name Glutathione reductase
Gene Name gor
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Vega-Teijido M, Caracelli I, Zukerman-Schpector J: Conformational analyses and docking studies of a series of 5-nitrofuran- and 5-nitrothiophen-semicarbazone derivatives in three possible binding sites of trypanothione and glutathione reductases. J Mol Graph Model. 2006 Mar;24(5):349-55. Epub 2005 Nov 7. - Pubmed
DTHybrid score 0.6556
Malate dehydrogenase
Name Malate dehydrogenase
Gene Name mdh
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7865
[Citrate [pro-3S]-lyase] ligase
Name [Citrate [pro-3S]-lyase] ligase
Gene Name citC
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8993

Enzymes


Xanthine dehydrogenase/oxidase
Name Xanthine dehydrogenase/oxidase
Gene Name XDH
Actions substrate
References
  • Tatsumi K, Kitamura S, Yoshimura H: Reduction of nitrofuran derivatives by xanthine oxidase and microsomes. Isolation and identification of reduction products. Arch Biochem Biophys. 1976 Jul;175(1):131-7. - Pubmed
  • Kutcher WW, McCalla DR: Aerobic reduction of 5-nitro-2-furaldehyde semicarbazone by rat liver xanthine dehydrogenase. Biochem Pharmacol. 1984 Mar 1;33(5):799-805. - Pubmed
DTHybrid score 0.7194
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4065

Predictions


Id Partner name Gene Name Score
2329 Malate dehydrogenase mdh 0.7865
3445 Malate dehydrogenase mdh 0.7865
4420 Malate dehydrogenase mdh 0.7865
4438 Malate dehydrogenase mdh 0.7865
5110 Glutathione reductase GR2 0.6556
4512 Cytochrome P450 3A4 CYP3A4 0.0965
4200 Cytochrome P450 1A2 CYP1A2 0.0575
4757 Cytochrome P450 2C9 CYP2C9 0.0495
1588 Multidrug resistance protein 1 ABCB1 0.0444
6016 Cytochrome P450 2C19 CYP2C19 0.0435
6020 Aldehyde oxidase AOX1 0.0337
1898 Cytochrome P450 1B1 CYP1B1 0.032
4118 Cytochrome P450 3A5 CYP3A5 0.031
4924 Cytochrome P450 2C8 CYP2C8 0.0309
6013 Cytochrome P450 2E1 CYP2E1 0.0307
6030 Cytochrome P450 2B6 CYP2B6 0.0293
492 Histamine H1 receptor HRH1 0.0261
6024 Cytochrome P450 1A1 CYP1A1 0.0241
6107 Cytochrome P450 3A7 CYP3A7 0.0241
824 Sodium-dependent serotonin transporter SLC6A4 0.0229
556 Alpha-1A adrenergic receptor ADRA1A 0.0229
831 D(2) dopamine receptor DRD2 0.0228
766 Beta-2 adrenergic receptor ADRB2 0.0203
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0199
193 Beta-1 adrenergic receptor ADRB1 0.0192
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.018
4486 Phenol 2-hydroxylase component B pheA2 0.0179
4439 Ferredoxin reductase bphA4 0.0179
4477 Dihydrolipoyl dehydrogenase lpdV 0.0179
5077 Dihydrolipoyl dehydrogenase Not Available 0.0179
5117 Dihydrolipoyl dehydrogenase lpd 0.0179
6142 Solute carrier family 22 member 8 SLC22A8 0.0179
5718 Cytochrome P450 2A6 CYP2A6 0.0175
502 5-hydroxytryptamine 2A receptor HTR2A 0.0173
1405 Thiopurine S-methyltransferase TPMT 0.0172
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0171
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0164
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0164
896 Glutathione S-transferase Mu 1 GSTM1 0.0163
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0162
4440 NADH peroxidase npr 0.016
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0159
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0156
6145 Solute carrier family 22 member 1 SLC22A1 0.0156
290 Prostaglandin G/H synthase 2 PTGS2 0.0151
3823 Cytokine receptor common gamma chain IL2RG 0.0151
833 Organic cation/carnitine transporter 1 SLC22A4 0.0148
713 Sodium-dependent dopamine transporter SLC6A3 0.014
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0136
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0134
724 Interleukin-2 receptor alpha chain IL2RA 0.0131
717 Interleukin-2 receptor subunit beta IL2RB 0.0131
1656 CYP2B protein CYP2B 0.0128
3923 Cholinesterase BCHE 0.0125
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0125
118 Organic cation/carnitine transporter 2 SLC22A5 0.0125
6143 Solute carrier family 22 member 7 SLC22A7 0.0121
6144 Solute carrier family 22 member 2 SLC22A2 0.012
4435 L-aspartate dehydrogenase nadX 0.0119
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0119
4414 Dehydrogenase TT_P0035 0.0119
2350 3-isopropylmalate dehydrogenase leuB 0.0119
3092 3-isopropylmalate dehydrogenase leuB 0.0119
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0119
4423 Levodione reductase lvr 0.0119
4449 ADP-ribosyltransferase Not Available 0.0119
4502 Formate dehydrogenase Not Available 0.0119
4500 L-lactate dehydrogenase 2 ldh2 0.0119
4472 Glucose 1-dehydrogenase Not Available 0.0119
4455 Glycerol dehydrogenase gldA 0.0119
4428 Redox-sensing transcriptional repressor rex rex 0.0119
4447 Hypothetical protein yhfP yhfP 0.0119
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0119
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0119
4497 Benzyl alcohol dehydrogenase xylB 0.0119
4418 AGR_L_3209p AGR_L_3209 0.0119
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0119
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0119
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0119
3381 Alcohol dehydrogenase Not Available 0.0119
4508 Alcohol dehydrogenase adhA 0.0119
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0119
4507 Alanine dehydrogenase ald 0.0119
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0119
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0119
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0119
4443 Quinate/shikimate dehydrogenase ydiB 0.0119
4487 Transcriptional regulator nadR nadR 0.0119
3729 Citrate synthase gltA 0.0119
4575 Citrate synthase cit 0.0119
4580 Citrate synthase gltA 0.0119
4451 Vip2Ac vip2Ac 0.0119
4467 Alpha-glucosidase, putative TM_0752 0.0119
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0119
4120 NADPH--cytochrome P450 reductase POR 0.0119
320 5-hydroxytryptamine 1A receptor HTR1A 0.0118
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0118
714 Glutathione reductase, mitochondrial GSR 0.0116
465 Calmodulin CALM1 0.0115
847 Mu-type opioid receptor OPRM1 0.0113
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0109
303 Diamine acetyltransferase 2 SAT2 0.0109
623 Spermine oxidase SMOX 0.0109
1317 Spermine synthase SMS 0.0109
3932 Glutathione S-transferase A2 GSTA2 0.0109
590 5-hydroxytryptamine 2C receptor HTR2C 0.0108
3941 Amine oxidase [flavin-containing] A MAOA 0.0107
1757 Myeloperoxidase MPO 0.0102
318 Alpha-2A adrenergic receptor ADRA2A 0.0102
23 D(1A) dopamine receptor DRD1 0.0102
4031 Glutathione S-transferase A1 GSTA1 0.01
816 Biliverdin reductase A BLVRA 0.01
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.01
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.01
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.01
123 Diamine acetyltransferase 1 SAT1 0.01
862 Multidrug resistance-associated protein 1 ABCC1 0.0099
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0098
3811 Cytochrome P450 19A1 CYP19A1 0.0097
3615 Dihydrodipicolinate reductase dapB 0.0095
3618 Dihydrodipicolinate reductase dapB 0.0095
4462 Dihydrodipicolinate reductase dapB 0.0095
2424 L-lactate dehydrogenase ldh 0.0095
2641 L-lactate dehydrogenase Not Available 0.0095
4437 L-lactate dehydrogenase ldh 0.0095
4442 L-lactate dehydrogenase ldh 0.0095
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0095
2591 Urocanate hydratase hutU 0.0095
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0095
4503 NADPH-flavin oxidoreductase frp 0.0095
4482 UDP-galactose 4-epimerase galE 0.0095
2967 CDP-paratose 2-epimerase rfbE 0.0095
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0095
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0095
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0095
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0095
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0095
4427 TDP-glucose-4,6-dehydratase desIV 0.0094
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0094
2507 Diphtheria toxin Not Available 0.0094
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0094
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0094
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0094
4509 Acetoin(diacetyl) reductase budC 0.0094
2336 2,3-diketo-L-gulonate reductase dlgD 0.0094
3081 3-dehydroquinate synthase aroB 0.0094
2018 Deoxyhypusine synthase DHPS 0.0094
2393 Maltose-6'-phosphate glucosidase glvA 0.0094
2538 6-phospho-beta-glucosidase bglT bglT 0.0094
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0094
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0094
4498 Ornithine cyclodeaminase PP3533 0.0094
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0094
4496 C-terminal-binding protein 1 CTBP1 0.0094
4450 Iota toxin component Ia Not Available 0.0094
632 Alpha-1B adrenergic receptor ADRA1B 0.0093
20 Prostaglandin G/H synthase 1 PTGS1 0.0092
4476 Mannitol dehydrogenase mtlD 0.0092
6859 Protein S100-A4 S100A4 0.0091
473 L-lactate dehydrogenase A chain LDHA 0.0091
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0091
2683 Mono-ADP-ribosyltransferase C3 C3 0.009
328 Sorbitol dehydrogenase SORD 0.009
646 Malate dehydrogenase, cytoplasmic MDH1 0.009
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0089
3939 Amine oxidase [flavin-containing] B MAOB 0.0089
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0089
597 Dihydropteridine reductase QDPR 0.0089
396 Alcohol dehydrogenase 4 ADH4 0.0089
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0089
5122 Mersacidin decarboxylase mrsD 0.0089
5095 Putidaredoxin reductase camA 0.0089
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0089
3763 5,10-methylenetetrahydrofolate reductase metF 0.0089
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0089
5094 5,10-methylenetetrahydrofolate reductase metF 0.0089
5078 Amine oxidase, flavin-containing PSPTO1126 0.0089
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0089
526 Thioredoxin reductase trxB 0.0089
3767 Thioredoxin reductase trxB 0.0089
5111 Phenylacetone monooxygenase pamO 0.0089
5115 FkbI fkbI 0.0089
3133 UDP-galactopyranose mutase glf 0.0089
5099 UDP-galactopyranose mutase glf 0.0089
1410 Oxidoreductase HSD17B6 0.0089
4725 Oxidoreductase Not Available 0.0089
5124 Oxidoreductase Not Available 0.0089
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0089
5109 Outer membrane protein p64k or PM-6 m-6 0.0089
5083 Cryptochrome DASH cry 0.0089
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0089
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0089
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0089
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0089
5081 L-aspartate oxidase nadB 0.0089
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0089
6168 Solute carrier family 22 member 16 SLC22A16 0.0088
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0087
467 Delta-type opioid receptor OPRD1 0.0087
6136 Multidrug resistance-associated protein 5 ABCC5 0.0087
587 Serum albumin ALB 0.0086
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0086
6137 Multidrug resistance-associated protein 6 ABCC6 0.0085
6146 High affinity copper uptake protein 1 SLC31A1 0.0085
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0085
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0085
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0085
4504 WbpP Not Available 0.0085
3367 GDP-mannose 6-dehydrogenase algD 0.0084
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0084
4318 Siroheme synthase cysG 0.0084
4343 Alpha-glucosidase aglA 0.0084
696 Kappa-type opioid receptor OPRK1 0.0083
77 L-lactate dehydrogenase B chain LDHB 0.0083
6163 Copper-transporting ATPase 2 ATP7B 0.0083
6165 Copper-transporting ATPase 1 ATP7A 0.0083
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0083
12 Alcohol dehydrogenase class 3 ADH5 0.0083
2617 Nitric oxide synthase oxygenase nos 0.0082
2701 Nitric oxide synthase oxygenase nos 0.0082
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0081
569 Retinal dehydrogenase 2 ALDH1A2 0.008
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0079
817 DNA topoisomerase 2-alpha TOP2A 0.0079
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0079
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0079
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0079
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0079
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0079
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0079
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0078
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0078
638 D(3) dopamine receptor DRD3 0.0078
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0078
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0078
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0078
3191 Histidinol dehydrogenase hisD 0.0078
2826 Glucose--fructose oxidoreductase gfo 0.0078
449 Ornithine decarboxylase ODC1 0.0078
3070 Adenosylhomocysteinase AHCY 0.0078
4424 Adenosylhomocysteinase PFE1050w 0.0078
6278 Adenosylhomocysteinase ahcY 0.0078
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0078
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0078
3594 Deoxyribodipyrimidine photo-lyase phr 0.0078
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0078
5080 Deoxyribodipyrimidine photo-lyase phr 0.0078
5072 N,N-dimethylglycine oxidase dmg 0.0078
5073 Ferredoxin--NADP reductase petH 0.0078
5076 Ferredoxin--NADP reductase fpr 0.0078
5119 Ferredoxin--NADP reductase petH 0.0078
5121 Ferredoxin--NADP reductase fpr 0.0078
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0078
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0077
2526 NADPH-ferredoxin reductase fprA fprA 0.0077
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0077
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0077
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0077
2470 Pyruvate oxidase pox5 0.0077
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0077
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0077
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0077
2268 Cholesterol oxidase choB 0.0077
2822 Cholesterol oxidase choA 0.0077
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0077
611 Retinal dehydrogenase 1 ALDH1A1 0.0076
3102 Flavohemoprotein hmp 0.0076
4969 Flavohemoprotein hmp 0.0076
341 5-hydroxytryptamine 3 receptor HTR3A 0.0076
908 Glutathione S-transferase theta-1 GSTT1 0.0076
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0075
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0075
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0075
776 Bile salt export pump ABCB11 0.0075
723 Cytosolic phospholipase A2 PLA2G4A 0.0075
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0074
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0074
251 Alcohol dehydrogenase 1A ADH1A 0.0074
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0072
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0072
126 D-lactate dehydrogenase dld 0.0072
3545 D-lactate dehydrogenase Not Available 0.0072
4510 D-lactate dehydrogenase ldhA 0.0072
4491 DNA ligase, NAD-dependent ligA 0.0072
2893 Glycine oxidase thiO 0.0071
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0071
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0071
2286 Isocitrate dehydrogenase [NADP] icd 0.0071
2302 Isocitrate dehydrogenase [NADP] icd 0.0071
2771 Isocitrate dehydrogenase [NADP] icd 0.0071
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0069
2762 UDP-glucose 4-epimerase GALE 0.0069
3461 UDP-glucose 4-epimerase galE 0.0069
6171 Solute carrier family 28 member 3 SLC28A3 0.0068
605 Fumarate reductase flavoprotein subunit frdA 0.0068
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0068
3673 Fumarate reductase flavoprotein subunit fccA 0.0068
4912 Fumarate reductase flavoprotein subunit ifcA 0.0068
6549 Fumarate reductase flavoprotein subunit frdA 0.0068
76 Nitric-oxide synthase, brain NOS1 0.0068
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0068
2823 Trypanothione reductase TPR 0.0068
2567 Thymidylate synthase thyX thyX 0.0068
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0067
6106 Cytochrome P450 2C18 CYP2C18 0.0067
444 Alcohol dehydrogenase 1B ADH1B 0.0067
2164 Multidrug resistance-associated protein 4 ABCC4 0.0067
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0066
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0066
904 Glutathione S-transferase P GSTP1 0.0066
2769 P-hydroxybenzoate hydroxylase pobA 0.0065
2809 P-hydroxybenzoate hydroxylase pobA 0.0065
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0065
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0065
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0064
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0063
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0062
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0062
2380 Monomeric sarcosine oxidase soxA 0.0062
6148 Multidrug resistance-associated protein 7 ABCC10 0.0061
432 D(4) dopamine receptor DRD4 0.0061
6645 D-amino-acid oxidase DAO 0.0059
629 Alpha-2B adrenergic receptor ADRA2B 0.0058
517 Alcohol dehydrogenase 1C ADH1C 0.0058
885 5-hydroxytryptamine 1B receptor HTR1B 0.0058
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0057
1374 Natriuretic peptides B NPPB 0.0057
1827 Gap junction alpha-1 protein GJA1 0.0057
1908 Vascular cell adhesion protein 1 VCAM1 0.0057
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0056
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0055
436 5-hydroxytryptamine 2B receptor HTR2B 0.0054
551 Carnitine O-acetyltransferase CRAT 0.0054
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0054
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0053
378 Alpha-2C adrenergic receptor ADRA2C 0.0053
474 Acetylcholinesterase ACHE 0.0053
131 Synaptic vesicular amine transporter SLC18A2 0.0053
731 HIV-1 protease HIV-1 protease 0.0052
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.005
400 Coagulation factor IX F9 0.005
5461 Coagulation factor IX F9 0.005
4604 Liver carboxylesterase 1 CES1 0.005
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0049
163 D(1B) dopamine receptor DRD5 0.0047
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0046
604 Vitamin K-dependent protein Z PROZ 0.0046
789 Alpha-1D adrenergic receptor ADRA1D 0.0044
468 Cytochrome P450 4A11 CYP4A11 0.0044
2112 Toll-like receptor 9 TLR9 0.0044
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0044
183 Vascular endothelial growth factor A VEGFA 0.0044
422 Vitamin K-dependent protein C PROC 0.0042
1245 Vitamin K-dependent protein S PROS1 0.0042
725 5-hydroxytryptamine 1D receptor HTR1D 0.0042
6147 Solute carrier family 22 member 3 SLC22A3 0.0041
1729 Solute carrier family 22 member 6 SLC22A6 0.0041
4192 DNA topoisomerase 2-beta TOP2B 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0038
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0038
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0038
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0038
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0038
380 Cytochrome P450 17A1 CYP17A1 0.0038
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0037
798 Osteocalcin BGLAP 0.0035
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0034
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0034
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0033
6506 Stathmin-4 STMN4 0.0033
94 5-hydroxytryptamine 4 receptor HTR4 0.0033
6182 Cytochrome P450 2J2 CYP2J2 0.0033
173 Toll-like receptor 7 TLR7 0.0033
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0033
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0032
369 Coagulation factor VII F7 0.0032
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0031
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
716 5-hydroxytryptamine 7 receptor HTR7 0.0029
3917 Methylenetetrahydrofolate reductase MTHFR 0.0029
124 Histamine H2 receptor HRH2 0.0028
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0028
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
6031 Cytochrome P450 3A43 CYP3A43 0.0028
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0027
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0027
1256 5-hydroxytryptamine 6 receptor HTR6 0.0027
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0027
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0026
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0025
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0025
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
161 Tubulin beta chain TUBB 0.0024
312 Tubulin beta chain TUB2 0.0024
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0024
7 Nitric oxide synthase, inducible NOS2 0.0024
239 Coagulation factor X F10 0.0024
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0024
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0023
365 Dihydrofolate reductase DHFR 0.0023
2381 Dihydrofolate reductase DFR1 0.0023
2833 Dihydrofolate reductase Not Available 0.0023
2931 Dihydrofolate reductase folA 0.0023
3544 Dihydrofolate reductase folA 0.0023
3682 Dihydrofolate reductase folA 0.0023
6642 Dihydrofolate reductase folA 0.0023
6756 Dihydrofolate reductase dfrA 0.0023
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0022
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
291 Nitric-oxide synthase, endothelial NOS3 0.0021
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
174 Sigma 1-type opioid receptor SIGMAR1 0.002
54 Prothrombin F2 0.002
4203 Histamine N-methyltransferase HNMT 0.0019
871 Glucocorticoid receptor NR3C1 0.0019
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0018
844 Epidermal growth factor receptor EGFR 0.0018
1178 Adenosine A2a receptor ADORA2A 0.0018
528 5-hydroxytryptamine 1E receptor HTR1E 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0017
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0017
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0016
146 Androgen receptor AR 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0016
6220 Aryl hydrocarbon receptor AHR 0.0016
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
1629 Transcription factor AP-1 JUN 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0015
1050 Bile salt sulfotransferase SULT2A1 0.0014
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0014
3086 Plasmepsin-2 Not Available 0.0014
373 Transthyretin TTR 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
738 Monocarboxylate transporter 1 SLC16A1 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0013
3404 Exotoxin A eta 0.0013
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0013
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0013
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0012
1010 Cytochrome P450 51A1 CYP51A1 0.0012
6432 Transporter snf 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0011
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0011
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0011
6014 Cytochrome P450 2A13 CYP2A13 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0011
164 Histamine H4 receptor HRH4 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.001
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.001
2290 ADP-ribosyl cyclase 2 BST1 0.001
614 Progesterone receptor PGR 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
407 Vascular endothelial growth factor receptor 2 KDR 0.001
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
260 Cytochrome P450 51 ERG11 0.001
761 Cytochrome P450 51 ERG11 0.001
3163 Cytochrome P450 51 cyp51 0.001
144 Hemoglobin subunit alpha HBA1 0.001
518 Peroxidase/catalase T katG 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
777 Tumor necrosis factor TNF 0.0009
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
563 Thyroid peroxidase TPO 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
26 Vascular endothelial growth factor receptor 3 FLT4 0.0009
295 Carbonic anhydrase 1 CA1 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4122 Histone deacetylase 2 HDAC2 0.0009
16 Adenosine A1 receptor ADORA1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
32 Vascular endothelial growth factor receptor 1 FLT1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
1341 Histamine H3 receptor HRH3 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
1192 Sulfotransferase 1A1 SULT1A1 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
165 FL cytokine receptor FLT3 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0008
482 Glycine receptor subunit alpha-1 GLRA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0008
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
122 P2Y purinoceptor 12 P2RY12 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0007
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
4773 Deoxycytidine kinase DCK 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
1618 High affinity nerve growth factor receptor NTRK1 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
737 Mineralocorticoid receptor NR3C2 0.0006
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0006
592 Carbonic anhydrase 4 CA4 0.0006
976 Platelet glycoprotein IX GP9 0.0006
4103 Proteasome subunit beta type 2 PSMB2 0.0006
4102 Proteasome subunit beta type 5 PSMB5 0.0006
4101 Proteasome subunit beta type 1 PSMB1 0.0006
1630 Integrin beta-2 ITGB2 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0006
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0006
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0006
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0006
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0006
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0006
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0006
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0006
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0006
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0006
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0006
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0006
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0006
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0006
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0006
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0006
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0006
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0006
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0006
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0006
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0006
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0006
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0006
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0006
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0006
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0006
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0006
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0006
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0006
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0006
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0006
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0006
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0006
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0006
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0006
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0006
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0006
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0006
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0006
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0006
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0006
729 GDP-L-fucose synthetase TSTA3 0.0006
3463 GDP-L-fucose synthetase fcl 0.0006
167 L-lactate dehydrogenase C chain LDHC 0.0006
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0006
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0006
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0006
3726 D-3-phosphoglycerate dehydrogenase serA 0.0006
4291 D-3-phosphoglycerate dehydrogenase serA 0.0006
206 3-keto-steroid reductase HSD17B7 0.0006
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0006
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0006
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0006
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0006
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0006
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0006
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0006
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0006
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0006
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0006
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0006
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0006
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0006
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0006
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0006
34 7-dehydrocholesterol reductase DHCR7 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0006
711 UDP-glucose 6-dehydrogenase UGDH 0.0006
3672 UDP-glucose 6-dehydrogenase hasB 0.0006
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0006
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0006
107 C-4 methylsterol oxidase SC4MOL 0.0006
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0006
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0006
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0006
643 Peroxisomal bifunctional enzyme EHHADH 0.0006
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
511 5-hydroxytryptamine 1F receptor HTR1F 0.0006
6141 Sodium/bile acid cotransporter SLC10A1 0.0006
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0006
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0006
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0006
666 NADP-dependent malic enzyme ME1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
857 Malate dehydrogenase, mitochondrial MDH2 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0005
6026 Alcohol dehydrogenase 6 ADH6 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0005
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0005
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0005
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0005
626 Cysteine dioxygenase type 1 CDO1 0.0005
627 11-cis retinol dehydrogenase RDH5 0.0005
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0005
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0005
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0005
1024 Solute carrier family 22 member 11 SLC22A11 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
856 Vitamin D3 receptor VDR 0.0005
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0005
13 Aminomethyltransferase, mitochondrial AMT 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
357 Carbonic anhydrase 2 CA2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0005
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0005
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0005
1864 RET proto-oncogene RET 0.0005
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
279 Tyrosinase TYR 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0004
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0004
136 Estrogen receptor ESR1 0.0004
654 Flavin reductase BLVRB 0.0004
153 Dopamine beta-hydroxylase DBH 0.0004
760 Fibroblast growth factor 1 FGF1 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0004
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0004
823 Fibroblast growth factor receptor 2 FGFR2 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
3810 Catechol O-methyltransferase COMT 0.0004
3957 Adenosine deaminase ADA 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0003
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0003
822 Aldose reductase AKR1B1 0.0003
469 Annexin A1 ANXA1 0.0003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0003
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0003
2207 Rhodopsin RHO 0.0003
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0003
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0003
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0003
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0003
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0003
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0003
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0003
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0003
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0003
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0003
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0002
869 Estrogen receptor beta ESR2 0.0002
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0002
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