DT-Web

DB01536 - 4-Androstenedione


Identification
Name 4-Androstenedione
Accession Number DB01536 (DB07386, EXPT00569)
Type small molecule
Description A delta-4 C19 steroid that is produced not only in the testis, but also in the ovary and the adrenal cortex. Depending on the tissue type, androstenedione can serve as a precursor to testosterone as well as estrone and estradiol. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 286.4085
Groups illicit
Monoisotopic Weight 286.193280076
Pharmacology
Indication Not Available
Mechanism of action 4-androstenedione is a 19-carbon steroid hormone produced in the adrenal glands and the gonads as an intermediate step in the biochemical pathway that produces the androgen testosterone and the estrogens estrone and estradiol.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Estradiol 17-beta-dehydrogenase 1
Name Estradiol 17-beta-dehydrogenase 1
Gene Name HSD17B1
Pharmacological action yes
Actions inducer
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8174
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
Name 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
Gene Name HSD3B1
Pharmacological action yes
Actions positive allosteric modulator
References
  • Ishii-Ohba H, Inano H, Tamaoki B: Purification and properties of testicular 3 beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase. J Steroid Biochem. 1986 Oct;25(4):555-60. - Pubmed
DTHybrid score 0.4426
6-deoxyerythronolide B hydroxylase
Name 6-deoxyerythronolide B hydroxylase
Gene Name eryF
Pharmacological action unknown
Actions inducer
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2349
Aldo-keto reductase family 1 member C3
Name Aldo-keto reductase family 1 member C3
Gene Name AKR1C3
Pharmacological action unknown
Actions inducer
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7156

Predictions


Id Partner name Gene Name Score
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.1347
869 Estrogen receptor beta ESR2 0.0563
136 Estrogen receptor ESR1 0.0502
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0386
672 Prostaglandin F2-alpha receptor PTGFR 0.0371
146 Androgen receptor AR 0.034
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0335
2268 Cholesterol oxidase choB 0.0331
2822 Cholesterol oxidase choA 0.0331
2283 Steroid Delta-isomerase ksi 0.0305
2920 Steroid Delta-isomerase ksi 0.0305
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0286
380 Cytochrome P450 17A1 CYP17A1 0.0259
1050 Bile salt sulfotransferase SULT2A1 0.0252
4512 Cytochrome P450 3A4 CYP3A4 0.0225
756 Sex hormone-binding globulin SHBG 0.0203
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0185
373 Transthyretin TTR 0.0181
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.017
290 Prostaglandin G/H synthase 2 PTGS2 0.0157
4924 Cytochrome P450 2C8 CYP2C8 0.0149
20 Prostaglandin G/H synthase 1 PTGS1 0.0148
4119 Cytochrome P450 2D6 CYP2D6 0.0145
3811 Cytochrome P450 19A1 CYP19A1 0.0144
646 Malate dehydrogenase, cytoplasmic MDH1 0.0143
4757 Cytochrome P450 2C9 CYP2C9 0.0136
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0127
666 NADP-dependent malic enzyme ME1 0.0127
1729 Solute carrier family 22 member 6 SLC22A6 0.0124
11 NAD(P) transhydrogenase, mitochondrial NNT 0.012
1588 Multidrug resistance protein 1 ABCB1 0.0119
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0117
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0116
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0116
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0116
76 Nitric-oxide synthase, brain NOS1 0.0114
6107 Cytochrome P450 3A7 CYP3A7 0.0109
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0103
444 Alcohol dehydrogenase 1B ADH1B 0.0102
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0102
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.01
654 Flavin reductase BLVRB 0.0098
4120 NADPH--cytochrome P450 reductase POR 0.0091
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0089
4403 Protein iolS iolS 0.0089
5330 General stress protein 69 yhdN 0.0089
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0089
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0089
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0089
5322 Oxidoreductase ydhF ydhF 0.0089
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0089
5332 MtdA bifunctional protein mtdA 0.0089
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0089
3778 NAD(P) transhydrogenase subunit beta pntB 0.0089
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0088
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0084
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0083
816 Biliverdin reductase A BLVRA 0.0081
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0081
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0081
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0081
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.008
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0077
5073 Ferredoxin--NADP reductase petH 0.0077
5076 Ferredoxin--NADP reductase fpr 0.0077
5119 Ferredoxin--NADP reductase petH 0.0077
5121 Ferredoxin--NADP reductase fpr 0.0077
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0077
4582 Putative pteridine reductase 2 ptr2 0.0076
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0076
989 L-xylulose reductase DCXR 0.0076
5328 Prostaglandin F synthase Tb11.02.2310 0.0076
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0076
2636 Shikimate dehydrogenase aroE 0.0076
3515 Shikimate dehydrogenase aroE 0.0076
3446 NADP-dependent alcohol dehydrogenase adh 0.0076
2286 Isocitrate dehydrogenase [NADP] icd 0.0076
2302 Isocitrate dehydrogenase [NADP] icd 0.0076
2771 Isocitrate dehydrogenase [NADP] icd 0.0076
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0076
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0076
822 Aldose reductase AKR1B1 0.0075
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0073
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0073
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0073
365 Dihydrofolate reductase DHFR 0.0073
2381 Dihydrofolate reductase DFR1 0.0073
2833 Dihydrofolate reductase Not Available 0.0073
2931 Dihydrofolate reductase folA 0.0073
3544 Dihydrofolate reductase folA 0.0073
3682 Dihydrofolate reductase folA 0.0073
6642 Dihydrofolate reductase folA 0.0073
6756 Dihydrofolate reductase dfrA 0.0073
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0072
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0072
396 Alcohol dehydrogenase 4 ADH4 0.0072
328 Sorbitol dehydrogenase SORD 0.0071
597 Dihydropteridine reductase QDPR 0.0071
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0071
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.007
6297 Prostaglandin reductase 1 PTGR1 0.007
3947 Xanthine dehydrogenase/oxidase XDH 0.007
4531 Putative ketoacyl reductase actIII 0.007
3062 Aspartate-semialdehyde dehydrogenase asd 0.0069
810 Heme oxygenase 1 HMOX1 0.0068
3391 Heme oxygenase 1 pbsA1 0.0068
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0068
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0067
2675 Pteridine reductase 1 PTR1 0.0067
2159 Quinone oxidoreductase CRYZ 0.0066
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0066
77 L-lactate dehydrogenase B chain LDHB 0.0066
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0066
12 Alcohol dehydrogenase class 3 ADH5 0.0066
1124 Sepiapterin reductase SPR 0.0066
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0064
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0064
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0064
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0064
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0064
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0064
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0064
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0064
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0064
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0064
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0064
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0064
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0064
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0064
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0064
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0064
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0064
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0063
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0063
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0063
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0063
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0063
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0063
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0063
206 3-keto-steroid reductase HSD17B7 0.0063
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0063
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0063
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0063
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0063
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0063
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0063
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0063
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0063
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0063
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0063
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0063
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0063
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0063
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0063
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0063
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0063
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0063
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0063
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0063
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0063
729 GDP-L-fucose synthetase TSTA3 0.0063
3463 GDP-L-fucose synthetase fcl 0.0063
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0063
107 C-4 methylsterol oxidase SC4MOL 0.0063
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0063
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0063
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0063
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0063
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0063
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0063
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0063
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0063
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0063
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0063
3726 D-3-phosphoglycerate dehydrogenase serA 0.0063
4291 D-3-phosphoglycerate dehydrogenase serA 0.0063
644 Heme oxygenase 2 HMOX2 0.0063
4982 Heme oxygenase 2 pbsA2 0.0063
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0063
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0063
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0063
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0063
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0063
711 UDP-glucose 6-dehydrogenase UGDH 0.0063
3672 UDP-glucose 6-dehydrogenase hasB 0.0063
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0063
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0063
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0063
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0063
643 Peroxisomal bifunctional enzyme EHHADH 0.0063
167 L-lactate dehydrogenase C chain LDHC 0.0063
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0063
34 7-dehydrocholesterol reductase DHCR7 0.0063
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0063
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0063
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0063
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0063
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0063
7 Nitric oxide synthase, inducible NOS2 0.0063
473 L-lactate dehydrogenase A chain LDHA 0.0063
291 Nitric-oxide synthase, endothelial NOS3 0.0062
569 Retinal dehydrogenase 2 ALDH1A2 0.0062
6168 Solute carrier family 22 member 16 SLC22A16 0.006
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.006
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0059
611 Retinal dehydrogenase 1 ALDH1A1 0.0059
251 Alcohol dehydrogenase 1A ADH1A 0.0056
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0055
857 Malate dehydrogenase, mitochondrial MDH2 0.0054
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0053
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0052
6026 Alcohol dehydrogenase 6 ADH6 0.0052
627 11-cis retinol dehydrogenase RDH5 0.0052
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0052
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0051
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0051
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0051
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0051
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0051
626 Cysteine dioxygenase type 1 CDO1 0.0051
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0051
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.005
4943 Cytochrome c6 petJ 0.0049
4934 Cytochrome c-551 nirM 0.0049
5218 Cytochrome c-551 nirM 0.0049
4764 Cytochrome P450 165C4 CYP165C4 0.0049
4960 Putative cytochrome P450-family protein SCO7417 0.0049
4994 Hemoglobin-like protein HbO glbO 0.0049
4925 Cytochrome c-type protein SHP shp 0.0049
4998 Hemoglobin-like protein yjbI yjbI 0.0049
4947 Bacterial hemoglobin vhb 0.0049
4999 Cytochrome P450 165B3 CYP165B3 0.0049
4975 Cytochrome c-556 RPA3973 0.0049
3116 Bacterioferritin bfr 0.0049
4906 Bacterioferritin bfr 0.0049
4965 Bacterioferritin bfr 0.0049
4954 Soluble cytochrome b558 Not Available 0.0049
4961 Hemophore HasA hasA 0.0049
4905 Cytochrome c2 Not Available 0.0049
4939 Cytochrome c2 cycA 0.0049
4964 Cytochrome c2 cycA 0.0049
4979 Cytochrome c2 cycA 0.0049
6673 Cytochrome c2 cycA 0.0049
4910 Cytoglobin CYGB 0.0049
4936 Cytochrome c2 iso-2 Not Available 0.0049
4916 Cyanoglobin glbN 0.0049
4909 CooA protein cooA 0.0049
4915 Cytochrome c-550 psbV 0.0049
4959 Cytochrome c-550 psbV 0.0049
5216 Cytochrome c-550 psbV 0.0049
5000 HemO hemO 0.0049
4935 Cytochrome c-554 cycA1 0.0049
4907 Cytochrome c-L moxG 0.0049
6865 Cytochrome c-L moxG 0.0049
4942 Diheme cytochrome c napB napB 0.0049
4984 Neuroglobin NGB 0.0049
4972 P450cin cinA 0.0049
4937 Cytochrome oxidase subunit II rcoxA 0.0049
4971 Nonaheme cytochrome c hmcA 0.0049
4931 Cytochrome P450 167A1 CYP167A1 0.0049
4989 Cytochrome c551 peroxidase ccp 0.0049
5222 Cytochrome c551 peroxidase ccpA 0.0049
4976 Apocytochrome f petA 0.0049
6407 Apocytochrome f petA 0.0049
4904 Cytochrome c family protein GSU1996 0.0049
4981 Iron-starvation protein PigA pigA 0.0049
4922 Cytochrome c, putative SO_4144 0.0049
4952 Catalase/peroxidase katA 0.0049
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0049
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0049
4993 Hydroxylamine oxidoreductase hao1 0.0049
4903 Methyl-accepting chemotaxis protein Tar4 0.0049
3093 Catalase HPII katE 0.0049
4926 Heme-based aerotactic transducer hemAT hemAT 0.0049
13 Aminomethyltransferase, mitochondrial AMT 0.0048
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0048
714 Glutathione reductase, mitochondrial GSR 0.0048
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0047
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0046
517 Alcohol dehydrogenase 1C ADH1C 0.0045
6137 Multidrug resistance-associated protein 6 ABCC6 0.0043
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0043
279 Tyrosinase TYR 0.0042
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0042
6030 Cytochrome P450 2B6 CYP2B6 0.0041
4990 PpcA ppcA 0.0041
6148 Multidrug resistance-associated protein 7 ABCC10 0.0041
3375 Acidic cytochrome c3 Not Available 0.0041
4813 Heme oxygenase hmuO 0.0041
5769 Heme oxygenase Not Available 0.0041
4385 Cytochrome c' Not Available 0.004
4967 Cytochrome c' cycA 0.004
5038 Cytochrome c' Not Available 0.004
5223 Cytochrome c' cycP 0.004
4948 Cytochrome c-553 Not Available 0.004
4037 Hypothetical protein GPX1 0.004
4297 Hypothetical protein SP_1951 0.004
4521 Hypothetical protein BC_2969 0.004
4540 Hypothetical protein TM_1070 0.004
4555 Hypothetical protein MT1739 0.004
4569 Hypothetical protein mshD 0.004
4578 Hypothetical protein PA3270 0.004
4747 Hypothetical protein PA3967 0.004
5177 Hypothetical protein TM_0096 0.004
5194 Hypothetical protein PA1204 0.004
5240 Hypothetical protein Rv2991 0.004
5370 Hypothetical protein TM_1158 0.004
5710 Hypothetical protein Tb927.5.1360 0.004
2119 Cytochrome b5 CYB5A 0.004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.004
4988 Sulfite oxidase, mitochondrial SUOX 0.004
4923 Cytochrome c3 DvMF_2499 0.004
4945 Cytochrome c3 Not Available 0.004
4949 Cytochrome c3 DVU_3171 0.004
4968 Cytochrome c3 cytc3 0.004
4997 Cytochrome c3 SO_2727 0.004
5219 Cytochrome c3 cyd 0.004
4289 Cytochrome P450 TT_P0059 0.004
6262 Cytochrome P450 staP 0.004
4992 Cytochrome c peroxidase Not Available 0.004
4902 Nine-heme cytochrome c Ddes_2038 0.004
2915 Sensor protein fixL fixL 0.004
4944 Sensor protein fixL fixL 0.004
3189 High-molecular-weight cytochrome c hmcA 0.004
3570 Cytochrome P450 152A1 cypC 0.004
4920 Peroxidase/catalase katG 0.004
817 DNA topoisomerase 2-alpha TOP2A 0.0038
3102 Flavohemoprotein hmp 0.0037
4969 Flavohemoprotein hmp 0.0037
3411 Cytochrome P450 121 cyp121 0.0037
2617 Nitric oxide synthase oxygenase nos 0.0037
2701 Nitric oxide synthase oxygenase nos 0.0037
3291 Cytochrome c-552 cycA 0.0037
4927 Cytochrome c-552 nrfA 0.0037
4938 Cytochrome c-552 cycA 0.0037
4953 Cytochrome c-552 nrfA 0.0037
5217 Cytochrome c-552 cycM 0.0037
4386 Hemoglobin-like protein HbN glbN 0.0037
3670 Soluble cytochrome b562 precursor cybC 0.0037
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0037
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0036
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0036
2230 Catalase CAT 0.0036
3249 Catalase katA 0.0036
3625 Catalase katA 0.0036
4539 Catalase katA 0.0036
4941 Catalase katB 0.0036
468 Cytochrome P450 4A11 CYP4A11 0.0036
776 Bile salt export pump ABCB11 0.0036
1898 Cytochrome P450 1B1 CYP1B1 0.0035
3127 Nitrite reductase nirS 0.0034
3284 Nitrite reductase nirS 0.0034
3221 Cytochrome c4 cc4 0.0034
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0034
6020 Aldehyde oxidase AOX1 0.0033
4608 Putative cytochrome P450 SCO1207 0.0033
4963 Putative cytochrome P450 SCO2884 0.0033
6254 Putative cytochrome P450 SCO6998 0.0033
862 Multidrug resistance-associated protein 1 ABCC1 0.0033
605 Fumarate reductase flavoprotein subunit frdA 0.0032
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0032
3673 Fumarate reductase flavoprotein subunit fccA 0.0032
4912 Fumarate reductase flavoprotein subunit ifcA 0.0032
6549 Fumarate reductase flavoprotein subunit frdA 0.0032
518 Peroxidase/catalase T katG 0.0032
260 Cytochrome P450 51 ERG11 0.003
761 Cytochrome P450 51 ERG11 0.003
3163 Cytochrome P450 51 cyp51 0.003
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.003
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.003
1507 Cytochrome c CYCS 0.0029
693 Hemoglobin subunit beta HBB 0.0028
6268 Hydroxyacid oxidase 1 HAO1 0.0028
358 Cystathionine beta-synthase CBS 0.0027
2298 Cytochrome P450-cam camC 0.0025
275 Arachidonate 5-lipoxygenase ALOX5 0.0022
4423 Levodione reductase lvr 0.0021
4428 Redox-sensing transcriptional repressor rex rex 0.0021
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0021
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0021
4447 Hypothetical protein yhfP yhfP 0.0021
4449 ADP-ribosyltransferase Not Available 0.0021
2350 3-isopropylmalate dehydrogenase leuB 0.0021
3092 3-isopropylmalate dehydrogenase leuB 0.0021
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0021
4507 Alanine dehydrogenase ald 0.0021
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0021
4497 Benzyl alcohol dehydrogenase xylB 0.0021
4435 L-aspartate dehydrogenase nadX 0.0021
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0021
4472 Glucose 1-dehydrogenase Not Available 0.0021
4418 AGR_L_3209p AGR_L_3209 0.0021
4443 Quinate/shikimate dehydrogenase ydiB 0.0021
4500 L-lactate dehydrogenase 2 ldh2 0.0021
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0021
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0021
3381 Alcohol dehydrogenase Not Available 0.0021
4508 Alcohol dehydrogenase adhA 0.0021
4414 Dehydrogenase TT_P0035 0.0021
4455 Glycerol dehydrogenase gldA 0.0021
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0021
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0021
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0021
4502 Formate dehydrogenase Not Available 0.0021
4487 Transcriptional regulator nadR nadR 0.0021
3729 Citrate synthase gltA 0.0021
4575 Citrate synthase cit 0.0021
4580 Citrate synthase gltA 0.0021
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0021
4451 Vip2Ac vip2Ac 0.0021
4467 Alpha-glucosidase, putative TM_0752 0.0021
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0021
6106 Cytochrome P450 2C18 CYP2C18 0.0018
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0017
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0017
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0017
4427 TDP-glucose-4,6-dehydratase desIV 0.0017
4439 Ferredoxin reductase bphA4 0.0017
4486 Phenol 2-hydroxylase component B pheA2 0.0017
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0017
4477 Dihydrolipoyl dehydrogenase lpdV 0.0017
5077 Dihydrolipoyl dehydrogenase Not Available 0.0017
5117 Dihydrolipoyl dehydrogenase lpd 0.0017
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0017
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0017
2967 CDP-paratose 2-epimerase rfbE 0.0017
4482 UDP-galactose 4-epimerase galE 0.0017
2538 6-phospho-beta-glucosidase bglT bglT 0.0017
2393 Maltose-6'-phosphate glucosidase glvA 0.0017
4509 Acetoin(diacetyl) reductase budC 0.0017
3081 3-dehydroquinate synthase aroB 0.0017
2507 Diphtheria toxin Not Available 0.0017
4503 NADPH-flavin oxidoreductase frp 0.0017
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0017
4450 Iota toxin component Ia Not Available 0.0017
3615 Dihydrodipicolinate reductase dapB 0.0017
3618 Dihydrodipicolinate reductase dapB 0.0017
4462 Dihydrodipicolinate reductase dapB 0.0017
2591 Urocanate hydratase hutU 0.0017
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0017
4498 Ornithine cyclodeaminase PP3533 0.0017
2424 L-lactate dehydrogenase ldh 0.0017
2641 L-lactate dehydrogenase Not Available 0.0017
4437 L-lactate dehydrogenase ldh 0.0017
4442 L-lactate dehydrogenase ldh 0.0017
126 D-lactate dehydrogenase dld 0.0017
3545 D-lactate dehydrogenase Not Available 0.0017
4510 D-lactate dehydrogenase ldhA 0.0017
2018 Deoxyhypusine synthase DHPS 0.0017
2336 2,3-diketo-L-gulonate reductase dlgD 0.0017
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0017
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0017
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0017
4496 C-terminal-binding protein 1 CTBP1 0.0017
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0017
2683 Mono-ADP-ribosyltransferase C3 C3 0.0016
4504 WbpP Not Available 0.0015
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0015
3367 GDP-mannose 6-dehydrogenase algD 0.0015
4318 Siroheme synthase cysG 0.0015
4440 NADH peroxidase npr 0.0015
4343 Alpha-glucosidase aglA 0.0015
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0015
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0015
63 Malate dehydrogenase mdh 0.0015
2329 Malate dehydrogenase mdh 0.0015
3445 Malate dehydrogenase mdh 0.0015
4420 Malate dehydrogenase mdh 0.0015
4438 Malate dehydrogenase mdh 0.0015
4476 Mannitol dehydrogenase mtlD 0.0015
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0014
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0014
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0014
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0014
2826 Glucose--fructose oxidoreductase gfo 0.0014
3070 Adenosylhomocysteinase AHCY 0.0014
4424 Adenosylhomocysteinase PFE1050w 0.0014
6278 Adenosylhomocysteinase ahcY 0.0014
3191 Histidinol dehydrogenase hisD 0.0014
587 Serum albumin ALB 0.0014
327 Glutathione reductase gor 0.0014
5110 Glutathione reductase GR2 0.0014
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0014
4491 DNA ligase, NAD-dependent ligA 0.0013
2762 UDP-glucose 4-epimerase GALE 0.0013
3461 UDP-glucose 4-epimerase galE 0.0013
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.001
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
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