DT-Web

DB02937 - Gamma-Arsono-Beta, Gamma-Methyleneadenosine-5'-Diphosphate


Identification
Name Gamma-Arsono-Beta, Gamma-Methyleneadenosine-5'-Diphosphate
Accession Number DB02937 (EXPT00589)
Type small molecule
Description Adenylic acid. Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 550.164
Groups experimental
Monoisotopic Weight 549.972140538
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


NH(3)-dependent NAD(+) synthetase
Name NH(3)-dependent NAD(+) synthetase
Gene Name nadE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6882
Glycerol kinase
Name Glycerol kinase
Gene Name glpK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7874

Predictions


Id Partner name Gene Name Score
2910 NH(3)-dependent NAD(+) synthetase nadE 0.6882
3217 NH(3)-dependent NAD(+) synthetase nadE 0.6882
52 Pyruvate kinase isozymes R/L PKLR 0.1719
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.1216
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0937
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0937
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0784
2756 Geranyltranstransferase ispA 0.0752
2632 Adenylosuccinate synthetase purA 0.0752
3323 Adenylosuccinate synthetase purA 0.0752
3975 Adenylosuccinate synthetase ADSS 0.0752
4598 Adenylosuccinate synthetase Adss 0.0752
6817 Adenylosuccinate synthetase purA 0.0752
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.074
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0679
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0679
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0679
2251 Thymidylate kinase tmk 0.0615
2254 Thymidylate kinase DTYMK 0.0615
3522 Thymidylate kinase tmk 0.0615
2427 Ferrichrome-iron receptor fhuA 0.0525
2683 Mono-ADP-ribosyltransferase C3 C3 0.0085
5304 UPF0166 protein TM_0021 TM_0021 0.0067
5287 Signaling protein Not Available 0.0067
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0067
5283 D-alanine--D-alanine ligase B ddlB 0.0067
5292 Putative partitioning protein TT_C1605 0.0067
3199 Phosphopantetheine adenylyltransferase coaD 0.0067
3543 Phosphopantetheine adenylyltransferase coaD 0.0067
3567 Phosphopantetheine adenylyltransferase coaD 0.0067
5289 Phosphopantetheine adenylyltransferase coaD 0.0067
5266 Activator of hgdC 0.0067
5288 Shikimate kinase aroK 0.0067
2874 Nitrogenase iron protein 1 nifH1 0.0067
4346 Polynucleotide kinase pseT 0.0067
5291 Glycogen synthase 1 glgA1 0.0067
5293 Shikimate kinase 2 aroL 0.0067
5281 Plasmid segregation protein parM parM 0.0067
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0067
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0067
5299 D-alanine--D-alanine ligase ddl 0.0067
6598 D-alanine--D-alanine ligase ddl 0.0067
5276 Chromosomal replication initiator protein dnaA dnaA 0.0067
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0067
5259 Transcriptional regulator ntrC1 0.0067
6699 Transcriptional regulator Cgl2612 0.0067
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0067
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0067
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0067
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0067
5264 DNA replication protein REP 0.0067
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0067
5308 Preprotein translocase secA 1 subunit secA1 0.0067
5315 Chaperone protein htpG htpG 0.0067
5277 Preprotein translocase subunit secA secA 0.0067
5284 Large T antigen Not Available 0.0067
5285 Kinesin heavy chain KIF5B 0.0067
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0067
5261 Phosphoribosylformylglycinamidine synthase purL 0.0067
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0065
2270 Dephospho-CoA kinase coaE 0.0058
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0058
2284 Adenylate kinase adk 0.0058
2296 Adenylate kinase adk 0.0058
2311 Adenylate kinase adk 0.0058
2312 Adenylate kinase Not Available 0.0058
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0058
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0058
3470 Hypothetical protein MG245 homolog MPN_348 0.0058
413 Amidophosphoribosyltransferase PPAT 0.0058
2515 Amidophosphoribosyltransferase purF 0.0058
3714 Amidophosphoribosyltransferase purF 0.0058
5302 TrwB trwB 0.0058
4837 Cag-alfa cag-alfa 0.0058
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0058
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0058
4106 Guanylate kinase GUK1 0.0058
4516 Guanylate kinase gmk 0.0058
5646 Galactokinase GALK1 0.0058
3426 Glutamine synthetase glnA 0.0058
3987 Glutamine synthetase GLUL 0.0058
3175 Glutamate--cysteine ligase gshA 0.0058
4774 NTPase P4 Not Available 0.0058
5265 FtsH ftsH 0.0058
4839 DNA polymerase III subunit tau dnaX 0.0058
6277 Heat shock cognate 71 kDa protein HSPA8 0.0058
4838 PMS1 protein homolog 2 PMS2 0.0058
5189 Trimethylamine dehydrogenase tmd 0.0058
340 Apoptotic protease-activating factor 1 APAF1 0.0054
2390 Nonsecretory ribonuclease RNASE2 0.0054
5271 Focal adhesion kinase 1 PTK2 0.0054
5312 Kinesin-like protein KIF1A KIF1A 0.0054
2282 Protein recA recA 0.0051
2315 Protein recA recA 0.0051
2332 Protein recA recA 0.0051
5263 Protein recA recA 0.0051
2892 Acetylglutamate kinase argB 0.0051
3550 Acetylglutamate kinase argB 0.0051
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0051
3669 Ribokinase rbsK 0.0051
2371 Pantothenate kinase coaA 0.0051
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0051
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0051
825 Arsenical pump-driving ATPase ASNA1 0.0051
3435 Arsenical pump-driving ATPase arsA 0.0051
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0051
2615 Chemotaxis protein cheA cheA 0.0051
1881 Hexokinase-1 HK1 0.0051
5300 Antigen peptide transporter 1 TAP1 0.005
408 Riboflavin kinase RFK 0.005
2727 S-adenosylmethionine synthetase metK 0.0048
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0048
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0048
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0047
788 Creatine kinase M-type CKM 0.0047
2334 Dethiobiotin synthetase bioD 0.0047
6555 Dethiobiotin synthetase bioD 0.0047
2697 Uridine-cytidine kinase 2 UCK2 0.0047
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0047
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0045
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0045
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0045
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0044
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0044
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0043
6395 Myosin-14 MYH14 0.0043
48 Pyridoxal kinase PDXK 0.0043
702 UMP-CMP kinase CMPK1 0.0043
2091 Endoplasmin HSP90B1 0.0043
1422 Serine/threonine-protein kinase 6 AURKA 0.0041
3379 Kinesin-like protein KIF11 KIF11 0.0041
207 Glutathione synthetase GSS 0.004
5269 Glutathione synthetase gshB 0.004
3456 Heat shock protein HSP 90-beta HSP90AB1 0.004
4428 Redox-sensing transcriptional repressor rex rex 0.004
4449 ADP-ribosyltransferase Not Available 0.004
4418 AGR_L_3209p AGR_L_3209 0.004
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.004
4455 Glycerol dehydrogenase gldA 0.004
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.004
4472 Glucose 1-dehydrogenase Not Available 0.004
4423 Levodione reductase lvr 0.004
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.004
4443 Quinate/shikimate dehydrogenase ydiB 0.004
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.004
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.004
4500 L-lactate dehydrogenase 2 ldh2 0.004
4447 Hypothetical protein yhfP yhfP 0.004
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.004
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.004
3381 Alcohol dehydrogenase Not Available 0.004
4508 Alcohol dehydrogenase adhA 0.004
4414 Dehydrogenase TT_P0035 0.004
4507 Alanine dehydrogenase ald 0.004
4497 Benzyl alcohol dehydrogenase xylB 0.004
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.004
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.004
4502 Formate dehydrogenase Not Available 0.004
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.004
3726 D-3-phosphoglycerate dehydrogenase serA 0.004
4291 D-3-phosphoglycerate dehydrogenase serA 0.004
4487 Transcriptional regulator nadR nadR 0.004
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.004
4435 L-aspartate dehydrogenase nadX 0.004
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.004
4451 Vip2Ac vip2Ac 0.004
4467 Alpha-glucosidase, putative TM_0752 0.004
2350 3-isopropylmalate dehydrogenase leuB 0.004
3092 3-isopropylmalate dehydrogenase leuB 0.004
4471 CDP-D-glucose-4,6-dehydratase ascB 0.004
3729 Citrate synthase gltA 0.004
4575 Citrate synthase cit 0.004
4580 Citrate synthase gltA 0.004
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.004
3822 Actin, alpha skeletal muscle ACTA1 0.0039
504 Mast/stem cell growth factor receptor KIT 0.0038
509 Thymidine kinase TK 0.0037
570 Thymidine kinase TK 0.0037
2559 Thymidine kinase TK 0.0037
3430 Thymidine kinase tdk 0.0037
3518 Thymidine kinase TK 0.0037
5301 Thymidine kinase tdk 0.0037
5771 Thymidine kinase ORF36 0.0037
7009 Thymidine kinase ORF36 0.0037
5294 Nucleoside diphosphate kinase A NME1 0.0037
1721 Glycogen synthase kinase-3 beta GSK3B 0.0036
4503 NADPH-flavin oxidoreductase frp 0.0034
3615 Dihydrodipicolinate reductase dapB 0.0034
3618 Dihydrodipicolinate reductase dapB 0.0034
4462 Dihydrodipicolinate reductase dapB 0.0034
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0034
4496 C-terminal-binding protein 1 CTBP1 0.0034
4486 Phenol 2-hydroxylase component B pheA2 0.0034
2424 L-lactate dehydrogenase ldh 0.0034
2641 L-lactate dehydrogenase Not Available 0.0034
4437 L-lactate dehydrogenase ldh 0.0034
4442 L-lactate dehydrogenase ldh 0.0034
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0034
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0034
126 D-lactate dehydrogenase dld 0.0034
3545 D-lactate dehydrogenase Not Available 0.0034
4510 D-lactate dehydrogenase ldhA 0.0034
4427 TDP-glucose-4,6-dehydratase desIV 0.0034
4498 Ornithine cyclodeaminase PP3533 0.0034
3081 3-dehydroquinate synthase aroB 0.0034
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0034
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0034
4482 UDP-galactose 4-epimerase galE 0.0034
4439 Ferredoxin reductase bphA4 0.0034
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0034
2591 Urocanate hydratase hutU 0.0034
2393 Maltose-6'-phosphate glucosidase glvA 0.0034
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0034
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0034
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0034
4450 Iota toxin component Ia Not Available 0.0034
4509 Acetoin(diacetyl) reductase budC 0.0034
4477 Dihydrolipoyl dehydrogenase lpdV 0.0034
5077 Dihydrolipoyl dehydrogenase Not Available 0.0034
5117 Dihydrolipoyl dehydrogenase lpd 0.0034
2018 Deoxyhypusine synthase DHPS 0.0034
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0034
2538 6-phospho-beta-glucosidase bglT bglT 0.0034
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0034
2507 Diphtheria toxin Not Available 0.0034
2336 2,3-diketo-L-gulonate reductase dlgD 0.0034
2967 CDP-paratose 2-epimerase rfbE 0.0034
5682 Ribonuclease pancreatic RNASE1 0.0034
4773 Deoxycytidine kinase DCK 0.0033
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0033
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0033
711 UDP-glucose 6-dehydrogenase UGDH 0.0032
3672 UDP-glucose 6-dehydrogenase hasB 0.0032
4440 NADH peroxidase npr 0.0032
4504 WbpP Not Available 0.0032
3367 GDP-mannose 6-dehydrogenase algD 0.0032
4318 Siroheme synthase cysG 0.0032
4343 Alpha-glucosidase aglA 0.0032
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0032
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0032
816 Biliverdin reductase A BLVRA 0.0032
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0031
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0031
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0031
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0031
3070 Adenosylhomocysteinase AHCY 0.003
4424 Adenosylhomocysteinase PFE1050w 0.003
6278 Adenosylhomocysteinase ahcY 0.003
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.003
2617 Nitric oxide synthase oxygenase nos 0.003
2701 Nitric oxide synthase oxygenase nos 0.003
3191 Histidinol dehydrogenase hisD 0.003
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.003
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.003
2826 Glucose--fructose oxidoreductase gfo 0.003
396 Alcohol dehydrogenase 4 ADH4 0.003
597 Dihydropteridine reductase QDPR 0.003
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.003
646 Malate dehydrogenase, cytoplasmic MDH1 0.003
328 Sorbitol dehydrogenase SORD 0.003
363 NADP-dependent malic enzyme, mitochondrial ME3 0.003
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.003
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.003
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.003
63 Malate dehydrogenase mdh 0.0029
2329 Malate dehydrogenase mdh 0.0029
3445 Malate dehydrogenase mdh 0.0029
4420 Malate dehydrogenase mdh 0.0029
4438 Malate dehydrogenase mdh 0.0029
4476 Mannitol dehydrogenase mtlD 0.0029
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0029
77 L-lactate dehydrogenase B chain LDHB 0.0029
12 Alcohol dehydrogenase class 3 ADH5 0.0029
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0029
327 Glutathione reductase gor 0.0029
5110 Glutathione reductase GR2 0.0029
473 L-lactate dehydrogenase A chain LDHA 0.0028
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0028
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0028
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0028
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0028
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0028
2286 Isocitrate dehydrogenase [NADP] icd 0.0028
2302 Isocitrate dehydrogenase [NADP] icd 0.0028
2771 Isocitrate dehydrogenase [NADP] icd 0.0028
4491 DNA ligase, NAD-dependent ligA 0.0028
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0027
2762 UDP-glucose 4-epimerase GALE 0.0027
3461 UDP-glucose 4-epimerase galE 0.0027
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0027
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0026
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
251 Alcohol dehydrogenase 1A ADH1A 0.0024
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0024
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0023
444 Alcohol dehydrogenase 1B ADH1B 0.0023
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0022
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
714 Glutathione reductase, mitochondrial GSR 0.0022
517 Alcohol dehydrogenase 1C ADH1C 0.0021
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0021
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