DT-Web

DB03589 - Alpha-Ketomalonic Acid


Identification
Name Alpha-Ketomalonic Acid
Accession Number DB03589 (EXPT02110)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 118.045
Groups experimental
Monoisotopic Weight 117.990223174
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


NAD-dependent malic enzyme, mitochondrial
Name NAD-dependent malic enzyme, mitochondrial
Gene Name ME2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6039

Predictions


Id Partner name Gene Name Score
363 NADP-dependent malic enzyme, mitochondrial ME3 0.1506
605 Fumarate reductase flavoprotein subunit frdA 0.0685
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0685
3673 Fumarate reductase flavoprotein subunit fccA 0.0685
4912 Fumarate reductase flavoprotein subunit ifcA 0.0685
6549 Fumarate reductase flavoprotein subunit frdA 0.0685
2891 Circadian clock protein kaiB kaiB 0.0659
2248 Malate synthase G glcB 0.0614
3190 Malate synthase G glcB 0.0614
4384 Capsule biosynthesis protein synC 0.0608
3486 Fumarate hydratase class II fumC 0.0574
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0042
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0042
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0042
816 Biliverdin reductase A BLVRA 0.0042
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.004
646 Malate dehydrogenase, cytoplasmic MDH1 0.004
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.004
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.004
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.004
328 Sorbitol dehydrogenase SORD 0.004
597 Dihydropteridine reductase QDPR 0.004
396 Alcohol dehydrogenase 4 ADH4 0.004
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0039
77 L-lactate dehydrogenase B chain LDHB 0.0038
12 Alcohol dehydrogenase class 3 ADH5 0.0038
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0038
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0038
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0038
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0038
473 L-lactate dehydrogenase A chain LDHA 0.0037
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0037
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0037
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0035
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0033
569 Retinal dehydrogenase 2 ALDH1A2 0.0033
611 Retinal dehydrogenase 1 ALDH1A1 0.0033
251 Alcohol dehydrogenase 1A ADH1A 0.0032
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0032
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
444 Alcohol dehydrogenase 1B ADH1B 0.0031
714 Glutathione reductase, mitochondrial GSR 0.0029
4500 L-lactate dehydrogenase 2 ldh2 0.0029
4428 Redox-sensing transcriptional repressor rex rex 0.0029
4449 ADP-ribosyltransferase Not Available 0.0029
3381 Alcohol dehydrogenase Not Available 0.0029
4508 Alcohol dehydrogenase adhA 0.0029
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0029
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0029
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0029
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0029
4502 Formate dehydrogenase Not Available 0.0029
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0029
4472 Glucose 1-dehydrogenase Not Available 0.0029
4423 Levodione reductase lvr 0.0029
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0029
4455 Glycerol dehydrogenase gldA 0.0029
4443 Quinate/shikimate dehydrogenase ydiB 0.0029
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0029
3729 Citrate synthase gltA 0.0029
4575 Citrate synthase cit 0.0029
4580 Citrate synthase gltA 0.0029
4447 Hypothetical protein yhfP yhfP 0.0029
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0029
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0029
4414 Dehydrogenase TT_P0035 0.0029
2350 3-isopropylmalate dehydrogenase leuB 0.0029
3092 3-isopropylmalate dehydrogenase leuB 0.0029
4418 AGR_L_3209p AGR_L_3209 0.0029
4507 Alanine dehydrogenase ald 0.0029
4497 Benzyl alcohol dehydrogenase xylB 0.0029
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0029
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0029
4487 Transcriptional regulator nadR nadR 0.0029
4435 L-aspartate dehydrogenase nadX 0.0029
4451 Vip2Ac vip2Ac 0.0029
4467 Alpha-glucosidase, putative TM_0752 0.0029
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0029
517 Alcohol dehydrogenase 1C ADH1C 0.0028
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0028
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0025
4486 Phenol 2-hydroxylase component B pheA2 0.0025
4439 Ferredoxin reductase bphA4 0.0024
4477 Dihydrolipoyl dehydrogenase lpdV 0.0024
5077 Dihydrolipoyl dehydrogenase Not Available 0.0024
5117 Dihydrolipoyl dehydrogenase lpd 0.0024
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0024
4427 TDP-glucose-4,6-dehydratase desIV 0.0024
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0024
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0024
2967 CDP-paratose 2-epimerase rfbE 0.0024
4482 UDP-galactose 4-epimerase galE 0.0024
4503 NADPH-flavin oxidoreductase frp 0.0024
2507 Diphtheria toxin Not Available 0.0024
2538 6-phospho-beta-glucosidase bglT bglT 0.0024
2393 Maltose-6'-phosphate glucosidase glvA 0.0024
4509 Acetoin(diacetyl) reductase budC 0.0024
3081 3-dehydroquinate synthase aroB 0.0024
2591 Urocanate hydratase hutU 0.0024
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0024
3615 Dihydrodipicolinate reductase dapB 0.0024
3618 Dihydrodipicolinate reductase dapB 0.0024
4462 Dihydrodipicolinate reductase dapB 0.0024
4450 Iota toxin component Ia Not Available 0.0024
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0024
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0024
2424 L-lactate dehydrogenase ldh 0.0024
2641 L-lactate dehydrogenase Not Available 0.0024
4437 L-lactate dehydrogenase ldh 0.0024
4442 L-lactate dehydrogenase ldh 0.0024
126 D-lactate dehydrogenase dld 0.0024
3545 D-lactate dehydrogenase Not Available 0.0024
4510 D-lactate dehydrogenase ldhA 0.0024
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0024
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0024
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0024
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0024
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0024
2336 2,3-diketo-L-gulonate reductase dlgD 0.0024
4498 Ornithine cyclodeaminase PP3533 0.0024
2018 Deoxyhypusine synthase DHPS 0.0024
4496 C-terminal-binding protein 1 CTBP1 0.0024
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0024
4504 WbpP Not Available 0.0022
2683 Mono-ADP-ribosyltransferase C3 C3 0.0022
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0022
3367 GDP-mannose 6-dehydrogenase algD 0.0022
4440 NADH peroxidase npr 0.0022
4318 Siroheme synthase cysG 0.0022
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0022
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0022
4343 Alpha-glucosidase aglA 0.0022
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0021
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0021
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0021
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0021
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0021
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0021
2617 Nitric oxide synthase oxygenase nos 0.0021
2701 Nitric oxide synthase oxygenase nos 0.0021
2826 Glucose--fructose oxidoreductase gfo 0.0021
3070 Adenosylhomocysteinase AHCY 0.0021
4424 Adenosylhomocysteinase PFE1050w 0.0021
6278 Adenosylhomocysteinase ahcY 0.0021
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0021
4476 Mannitol dehydrogenase mtlD 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
666 NADP-dependent malic enzyme ME1 0.0021
3191 Histidinol dehydrogenase hisD 0.0021
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.002
327 Glutathione reductase gor 0.002
5110 Glutathione reductase GR2 0.002
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.002
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.002
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.002
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.002
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.002
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.002
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.002
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.002
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.002
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.002
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.002
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.002
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.002
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.002
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.002
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.002
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.002
602 Acyl carrier protein, mitochondrial NDUFAB1 0.002
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.002
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.002
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.002
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.002
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.002
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.002
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.002
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.002
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.002
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.002
107 C-4 methylsterol oxidase SC4MOL 0.002
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.002
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.002
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.002
644 Heme oxygenase 2 HMOX2 0.002
4982 Heme oxygenase 2 pbsA2 0.002
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.002
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.002
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.002
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.002
3726 D-3-phosphoglycerate dehydrogenase serA 0.002
4291 D-3-phosphoglycerate dehydrogenase serA 0.002
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.002
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.002
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.002
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.002
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.002
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.002
729 GDP-L-fucose synthetase TSTA3 0.002
3463 GDP-L-fucose synthetase fcl 0.002
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.002
167 L-lactate dehydrogenase C chain LDHC 0.002
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.002
206 3-keto-steroid reductase HSD17B7 0.002
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.002
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.002
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.002
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.002
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.002
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.002
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.002
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.002
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.002
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.002
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.002
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.002
34 7-dehydrocholesterol reductase DHCR7 0.002
662 Fatty aldehyde dehydrogenase ALDH3A2 0.002
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.002
711 UDP-glucose 6-dehydrogenase UGDH 0.002
3672 UDP-glucose 6-dehydrogenase hasB 0.002
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.002
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.002
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.002
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.002
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.002
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.002
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.002
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.002
643 Peroxisomal bifunctional enzyme EHHADH 0.002
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.002
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.002
857 Malate dehydrogenase, mitochondrial MDH2 0.002
11 NAD(P) transhydrogenase, mitochondrial NNT 0.002
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.002
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0019
4491 DNA ligase, NAD-dependent ligA 0.0019
2286 Isocitrate dehydrogenase [NADP] icd 0.0019
2302 Isocitrate dehydrogenase [NADP] icd 0.0019
2771 Isocitrate dehydrogenase [NADP] icd 0.0019
2762 UDP-glucose 4-epimerase GALE 0.0019
3461 UDP-glucose 4-epimerase galE 0.0019
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0017
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0017
626 Cysteine dioxygenase type 1 CDO1 0.0017
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0017
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0017
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0017
13 Aminomethyltransferase, mitochondrial AMT 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0017
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0017
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0017
6026 Alcohol dehydrogenase 6 ADH6 0.0017
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
627 11-cis retinol dehydrogenase RDH5 0.0017
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0017
654 Flavin reductase BLVRB 0.0016
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0016
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0016
810 Heme oxygenase 1 HMOX1 0.0015
3391 Heme oxygenase 1 pbsA1 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0015
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0015
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0015
279 Tyrosinase TYR 0.0015
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0014
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0014
380 Cytochrome P450 17A1 CYP17A1 0.0014
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0013
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0013
822 Aldose reductase AKR1B1 0.0013
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0013
365 Dihydrofolate reductase DHFR 0.0012
2381 Dihydrofolate reductase DFR1 0.0012
2833 Dihydrofolate reductase Not Available 0.0012
2931 Dihydrofolate reductase folA 0.0012
3544 Dihydrofolate reductase folA 0.0012
3682 Dihydrofolate reductase folA 0.0012
6642 Dihydrofolate reductase folA 0.0012
6756 Dihydrofolate reductase dfrA 0.0012
468 Cytochrome P450 4A11 CYP4A11 0.0012
6020 Aldehyde oxidase AOX1 0.0011
3947 Xanthine dehydrogenase/oxidase XDH 0.0011
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