DT-Web

DB01051 - Novobiocin


Identification
Name Novobiocin
Accession Number DB01051 (APRD00694)
Type small molecule
Description An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 612.6243
Groups approved
Monoisotopic Weight 612.231910004
Pharmacology
Indication For the treatment of infections due to staphylococci and other susceptible organisms
Mechanism of action Novobiocin is an aminocoumarin. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by inhibiting the GyrB subunit of the enzyme involved in energy tranduction. Novobiocin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB.
Absorption Oral bioavailability is negligible.
Protein binding 95%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


DNA gyrase subunit B
Name DNA gyrase subunit B
Gene Name gyrB
Pharmacological action yes
Actions inhibitor
References
  • Maxwell A: The interaction between coumarin drugs and DNA gyrase. Mol Microbiol. 1993 Aug;9(4):681-6. - Pubmed
  • Gormley NA, Orphanides G, Meyer A, Cullis PM, Maxwell A: The interaction of coumarin antibiotics with fragments of DNA gyrase B protein. Biochemistry. 1996 Apr 16;35(15):5083-92. - Pubmed
DTHybrid score 0.3691

Transporters


Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions inhibitor
References
  • Saito H, Osumi M, Hirano H, Shin W, Nakamura R, Ishikawa T: Technical pitfalls and improvements for high-speed screening and QSAR analysis to predict inhibitors of the human bile salt export pump (ABCB11/BSEP). AAPS J. 2009 Sep;11(3):581-9. Epub 2009 Aug 18. - Pubmed
DTHybrid score 0.2444
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Duan P, You G: Novobiocin is a potent inhibitor for human organic anion transporters. Drug Metab Dispos. 2009 Jun;37(6):1203-10. Epub 2009 Mar 12. - Pubmed
DTHybrid score 0.4753
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Duan P, You G: Novobiocin is a potent inhibitor for human organic anion transporters. Drug Metab Dispos. 2009 Jun;37(6):1203-10. Epub 2009 Mar 12. - Pubmed
DTHybrid score 0.4032
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Duan P, You G: Novobiocin is a potent inhibitor for human organic anion transporters. Drug Metab Dispos. 2009 Jun;37(6):1203-10. Epub 2009 Mar 12. - Pubmed
DTHybrid score 0.3351
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Gedeon C, Behravan J, Koren G, Piquette-Miller M: Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102. Epub 2006 Feb 3. - Pubmed
  • Shiozawa K, Oka M, Soda H, Yoshikawa M, Ikegami Y, Tsurutani J, Nakatomi K, Nakamura Y, Doi S, Kitazaki T, Mizuta Y, Murase K, Yoshida H, Ross DD, Kohno S: Reversal of breast cancer resistance protein (BCRP/ABCG2)-mediated drug resistance by novobiocin, a coumermycin antibiotic. Int J Cancer. 2004 Jan 1;108(1):146-51. - Pubmed
  • Elahian F, Kalalinia F, Behravan J: Evaluation of indomethacin and dexamethasone effects on BCRP-mediated drug resistance in MCF-7 parental and resistant cell lines. Drug Chem Toxicol. 2010 Apr;33(2):113-9. - Pubmed
DTHybrid score 0.2733

Predictions


Id Partner name Gene Name Score
887 DNA gyrase subunit B gyrB 0.3691
6225 DNA gyrase subunit B gyrB 0.3691
1588 Multidrug resistance protein 1 ABCB1 0.1312
6143 Solute carrier family 22 member 7 SLC22A7 0.1305
4512 Cytochrome P450 3A4 CYP3A4 0.1162
587 Serum albumin ALB 0.0917
4757 Cytochrome P450 2C9 CYP2C9 0.091
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0892
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0887
862 Multidrug resistance-associated protein 1 ABCC1 0.0779
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0723
4924 Cytochrome P450 2C8 CYP2C8 0.072
2164 Multidrug resistance-associated protein 4 ABCC4 0.065
6016 Cytochrome P450 2C19 CYP2C19 0.0627
4200 Cytochrome P450 1A2 CYP1A2 0.0581
4118 Cytochrome P450 3A5 CYP3A5 0.0579
290 Prostaglandin G/H synthase 2 PTGS2 0.0573
118 Organic cation/carnitine transporter 2 SLC22A5 0.0563
6141 Sodium/bile acid cotransporter SLC10A1 0.0563
20 Prostaglandin G/H synthase 1 PTGS1 0.0554
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0542
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0508
6144 Solute carrier family 22 member 2 SLC22A2 0.0492
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0466
6145 Solute carrier family 22 member 1 SLC22A1 0.0462
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0453
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0448
6024 Cytochrome P450 1A1 CYP1A1 0.0432
4119 Cytochrome P450 2D6 CYP2D6 0.0411
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0385
22 30S ribosomal protein S4 rpsD 0.0357
6714 30S ribosomal protein S4 rpsD 0.0357
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0357
6107 Cytochrome P450 3A7 CYP3A7 0.0345
140 30S ribosomal protein S9 rpsI 0.0336
6719 30S ribosomal protein S9 rpsI 0.0336
6725 30S ribosomal protein S9 rpsI 0.0336
6148 Multidrug resistance-associated protein 7 ABCC10 0.0319
738 Monocarboxylate transporter 1 SLC16A1 0.0318
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0315
1898 Cytochrome P450 1B1 CYP1B1 0.0285
6013 Cytochrome P450 2E1 CYP2E1 0.0282
633 Penicillin-binding proteins 1A/1B pbpA 0.0277
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0274
833 Organic cation/carnitine transporter 1 SLC22A4 0.0262
6030 Cytochrome P450 2B6 CYP2B6 0.0257
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0255
438 Taste receptor type 1 member 2 TAS1R2 0.0248
6147 Solute carrier family 22 member 3 SLC22A3 0.0246
645 Penicillin-binding protein 1A mrcA 0.0242
5805 Penicillin-binding protein 1A ponA 0.0242
6185 Penicillin-binding protein 1A mrcA 0.0242
6799 Penicillin-binding protein 1A pbpA 0.0242
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0241
6136 Multidrug resistance-associated protein 5 ABCC5 0.0233
6137 Multidrug resistance-associated protein 6 ABCC6 0.0224
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
543 Penicillin-binding protein 1B mrcB 0.0221
6186 Penicillin-binding protein 1B ponB 0.0221
6822 Penicillin-binding protein 1b pbp1b 0.0221
6844 Penicillin-binding protein 1b pbp1b 0.0221
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0219
338 DNA polymerase UL30 0.0216
379 DNA polymerase UL54 0.0216
697 DNA polymerase ORF28 0.0216
2482 DNA polymerase 43 0.0216
4104 DNA polymerase BALF5 0.0216
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0199
2016 Dipeptidase 1 DPEP1 0.0197
5718 Cytochrome P450 2A6 CYP2A6 0.0194
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0194
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
5353 Glutamate decarboxylase alpha gadA 0.0183
6167 Organic solute transporter subunit beta OSTB 0.0181
6166 Organic solute transporter subunit alpha OSTA 0.0181
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
357 Carbonic anhydrase 2 CA2 0.017
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0167
558 Solute carrier family 12 member 1 SLC12A1 0.0166
6149 Solute carrier family 22 member 10 SLC22A10 0.0165
817 DNA topoisomerase 2-alpha TOP2A 0.0163
332 Beta-lactamase blaZ 0.0159
2478 Beta-lactamase ampC 0.0159
2613 Beta-lactamase ampC 0.0159
2635 Beta-lactamase ampC 0.0159
2700 Beta-lactamase penP 0.0159
5445 Beta-lactamase blaB 0.0159
6019 Beta-lactamase SHV-7 0.0159
6701 Beta-lactamase cphA 0.0159
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0159
592 Carbonic anhydrase 4 CA4 0.0159
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0158
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0158
136 Estrogen receptor ESR1 0.0158
683 Potassium transporter GK0582 0.0156
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0156
3811 Cytochrome P450 19A1 CYP19A1 0.0151
3947 Xanthine dehydrogenase/oxidase XDH 0.0151
295 Carbonic anhydrase 1 CA1 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0146
33 Cystine/glutamate transporter SLC7A11 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0143
5626 Nucleoside diphosphate kinase B NME2 0.0141
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0141
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
1867 Major prion protein PRNP 0.0139
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0139
115 Penicillin-binding protein 2 mrdA 0.0138
6069 Penicillin-binding protein 2 mrdA 0.0138
6118 Penicillin-binding protein 2 penA 0.0138
6187 Penicillin-binding protein 2 pbpA 0.0138
6686 Penicillin-binding protein 2 pbp2 0.0138
6939 Penicillin-binding protein 2 mrdA 0.0138
7163 Penicillin-binding protein 2 pbpA 0.0138
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0138
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0138
1353 DNA topoisomerase 1 TOP1 0.0135
3552 DNA topoisomerase 1 topA 0.0135
844 Epidermal growth factor receptor EGFR 0.0134
2808 Chloramphenicol acetyltransferase 3 cat3 0.0132
1 Peptidoglycan synthetase ftsI ftsI 0.0129
4155 Peptidoglycan synthetase ftsI ftsI 0.0129
6106 Cytochrome P450 2C18 CYP2C18 0.0127
275 Arachidonate 5-lipoxygenase ALOX5 0.0124
130 Prostacyclin synthase PTGIS 0.0124
4604 Liver carboxylesterase 1 CES1 0.0123
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0122
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
124 Histamine H2 receptor HRH2 0.0122
6207 30S ribosomal protein S14 rpsN 0.012
6209 30S ribosomal protein S19 rpsS 0.012
6712 30S ribosomal protein S19 rpsS 0.012
6726 30S ribosomal protein S19 rpsS 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
3270 Elongation factor G fusA 0.0119
504 Mast/stem cell growth factor receptor KIT 0.0118
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0118
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0115
5294 Nucleoside diphosphate kinase A NME1 0.0115
3639 Thymidine phosphorylase deoA 0.0115
3936 Thymidine phosphorylase TYMP 0.0115
2320 Thymidine kinase, cytosolic TK1 0.0114
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0113
49 Endothelin B receptor EDNRB 0.0113
2249 Aspartate aminotransferase aspC 0.0112
2671 Aspartate aminotransferase aspC 0.0112
5490 Aspartate aminotransferase Not Available 0.0112
373 Transthyretin TTR 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0109
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0109
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0109
578 Endothelin-1 receptor EDNRA 0.0106
6020 Aldehyde oxidase AOX1 0.0105
3426 Glutamine synthetase glnA 0.0104
3987 Glutamine synthetase GLUL 0.0104
6033 High affinity interleukin-8 receptor A CXCR1 0.0104
6126 Carbonic anhydrase 7 CA7 0.0103
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0103
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
527 Prostacyclin receptor PTGIR 0.0102
3917 Methylenetetrahydrofolate reductase MTHFR 0.01
4773 Deoxycytidine kinase DCK 0.01
672 Prostaglandin F2-alpha receptor PTGFR 0.0099
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0098
183 Vascular endothelial growth factor A VEGFA 0.0098
1650 Heme carrier protein 1 SLC46A1 0.0098
1405 Thiopurine S-methyltransferase TPMT 0.0097
4120 NADPH--cytochrome P450 reductase POR 0.0096
867 Penicillin-binding protein 3 pbpC 0.0094
6119 Penicillin-binding protein 3 pbp3 0.0094
7154 Penicillin-binding protein 3 pbp3 0.0094
7157 Penicillin-binding protein 3 LMHCC_2184 0.0094
7162 Penicillin-binding protein 3 pbpB 0.0094
7172 Penicillin-binding protein 3 pbp3 0.0094
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
1654 Interleukin-1 beta IL1B 0.0092
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0091
117 Sterol O-acyltransferase 1 SOAT1 0.009
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.009
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
273 Apoptosis regulator Bcl-2 BCL2 0.0087
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0087
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0087
468 Cytochrome P450 4A11 CYP4A11 0.0086
53 Solute carrier family 12 member 5 SLC12A5 0.0085
663 Solute carrier family 12 member 4 SLC12A4 0.0085
293 Gamma-glutamyl hydrolase GGH 0.0085
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0085
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0085
756 Sex hormone-binding globulin SHBG 0.0084
1757 Myeloperoxidase MPO 0.0084
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0084
4217 Telomerase reverse transcriptase TERT 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
65 Matrix metalloproteinase-9 Not Available 0.0082
2539 Tubulin alpha-1 chain TUBA4A 0.0082
161 Tubulin beta chain TUBB 0.0081
312 Tubulin beta chain TUB2 0.0081
310 Solute carrier family 12 member 2 SLC12A2 0.008
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0077
3587 Gastrotropin FABP6 0.0077
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0076
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0076
494 Caspase-1 CASP1 0.0075
24 Thymidylate synthase TMP1 0.0075
359 Thymidylate synthase TYMS 0.0075
2626 Thymidylate synthase thyA 0.0075
2729 Thymidylate synthase thyA 0.0075
5352 Thymidylate synthase THYA 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
5787 Angiopoietin-1 receptor TEK 0.0074
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
869 Estrogen receptor beta ESR2 0.0073
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0072
6599 HTH-type transcriptional regulator ttgR ttgR 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
1507 Cytochrome c CYCS 0.0071
29 Tubulin beta-1 chain TUBB1 0.0071
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.007
228 Beta platelet-derived growth factor receptor PDGFRB 0.007
407 Vascular endothelial growth factor receptor 2 KDR 0.007
102 DNA topoisomerase I, mitochondrial TOP1MT 0.007
6031 Cytochrome P450 3A43 CYP3A43 0.0068
3760 Penicillin-binding protein 5 precursor dacA 0.0068
992 Protein tyrosine kinase 2 beta PTK2B 0.0067
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0066
6085 Fatty acid-binding protein, intestinal FABP2 0.0066
3685 Catabolite gene activator crp 0.0065
4655 Adenylate cyclase cyaC 0.0064
4759 Adenylate cyclase cyaB2 0.0064
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0064
165 FL cytokine receptor FLT3 0.0064
3856 Fibroblast growth factor receptor 3 FGFR3 0.0063
2077 Caspase-3 CASP3 0.0063
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0063
6131 Carbonic anhydrase 14 CA14 0.0062
277 Purine nucleoside phosphorylase PNP 0.0062
2870 Purine nucleoside phosphorylase punA 0.0062
2945 Purine nucleoside phosphorylase punA 0.0062
4659 Purine nucleoside phosphorylase TM_1596 0.0062
4825 Purine nucleoside phosphorylase TTHA1435 0.0062
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0062
380 Cytochrome P450 17A1 CYP17A1 0.0061
244 Angiotensin-converting enzyme ACE 0.0061
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0061
819 Penicillin-binding protein 4 dacB 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
6043 Putative G-protein coupled receptor 44 GPR44 0.0058
6122 Carbonic anhydrase 3 CA3 0.0058
3809 Estrogen-related receptor gamma ESRRG 0.0057
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
5923 Microtubule-associated protein tau MAPT 0.0057
131 Synaptic vesicular amine transporter SLC18A2 0.0057
5924 Microtubule-associated protein 4 MAP4 0.0057
2981 Phospholipase A2, membrane associated PLA2G2A 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0056
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0056
2021 Thrombomodulin THBD 0.0055
3007 Carbonic anhydrase 12 CA12 0.0055
4205 Carbonic anhydrase 9 CA9 0.0055
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0055
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0055
4760 Mll3241 protein mll3241 0.0055
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
146 Androgen receptor AR 0.0055
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0054
26 Vascular endothelial growth factor receptor 3 FLT4 0.0053
4192 DNA topoisomerase 2-beta TOP2B 0.0053
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0053
1852 Microtubule-associated protein 2 MAP2 0.0053
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0052
492 Histamine H1 receptor HRH1 0.0052
2216 Fibroblast growth factor receptor 4 FGFR4 0.0052
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0052
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0052
3941 Amine oxidase [flavin-containing] A MAOA 0.0051
32 Vascular endothelial growth factor receptor 1 FLT1 0.0051
5818 Folate receptor alpha FOLR1 0.0051
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0051
6168 Solute carrier family 22 member 16 SLC22A16 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0051
3810 Catechol O-methyltransferase COMT 0.005
469 Annexin A1 ANXA1 0.0049
908 Glutathione S-transferase theta-1 GSTT1 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0048
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0048
718 Folate receptor gamma FOLR3 0.0047
804 Mitochondrial folate transporter/carrier SLC25A32 0.0047
299 Folate receptor beta FOLR2 0.0047
823 Fibroblast growth factor receptor 2 FGFR2 0.0046
6218 Pannexin-1 PANX1 0.0046
6212 Tubulin gamma-1 chain TUBG1 0.0045
6210 Tubulin delta chain TUBD1 0.0045
6211 Tubulin epsilon chain TUBE1 0.0045
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
70 Type-1 angiotensin II receptor AGTR1 0.0042
6163 Copper-transporting ATPase 2 ATP7B 0.0041
6165 Copper-transporting ATPase 1 ATP7A 0.0041
6171 Solute carrier family 28 member 3 SLC28A3 0.0041
408 Riboflavin kinase RFK 0.0041
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0041
6042 Prostaglandin reductase 2 PTGR2 0.0041
904 Glutathione S-transferase P GSTP1 0.004
1192 Sulfotransferase 1A1 SULT1A1 0.004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.004
489 Monocarboxylate transporter 2 SLC16A7 0.004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.004
6146 High affinity copper uptake protein 1 SLC31A1 0.004
6824 Tyrosine-protein kinase Lyn LYN 0.0039
6220 Aryl hydrocarbon receptor AHR 0.0039
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0039
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0039
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0039
5482 Sialidase-2 NEU2 0.0039
1792 Tissue-type plasminogen activator PLAT 0.0038
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0037
7 Nitric oxide synthase, inducible NOS2 0.0037
6014 Cytochrome P450 2A13 CYP2A13 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
731 HIV-1 protease HIV-1 protease 0.0036
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
751 Potassium channel subfamily K member 6 KCNK6 0.0035
997 Protein kinase C beta type PRKCB 0.0035
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0035
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0035
1629 Transcription factor AP-1 JUN 0.0035
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0035
320 5-hydroxytryptamine 1A receptor HTR1A 0.0035
896 Glutathione S-transferase Mu 1 GSTM1 0.0035
594 Thyroxine-binding globulin SERPINA7 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0033
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
172 Potassium channel subfamily K member 1 KCNK1 0.0033
2449 Tubulin alpha-3 chain TUBA1A 0.0033
2408 Tyrosine-protein kinase SYK SYK 0.0032
461 Glycine receptor subunit alpha-3 GLRA3 0.0032
3923 Cholinesterase BCHE 0.0032
2391 Ferrochelatase hemH 0.0032
6502 Ferrochelatase DKFZp686P18130 0.0032
1591 Ferrochelatase, mitochondrial FECH 0.0032
758 Thyroid hormone receptor alpha THRA 0.0031
1313 Lactoylglutathione lyase GLO1 0.0031
84 Nuclear receptor 0B1 NR0B1 0.0031
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0031
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.003
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.003
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.003
632 Alpha-1B adrenergic receptor ADRA1B 0.003
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0029
871 Glucocorticoid receptor NR3C1 0.0029
654 Flavin reductase BLVRB 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
484 Tyrosine-protein kinase ABL2 ABL2 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0029
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
365 Dihydrofolate reductase DHFR 0.0027
2381 Dihydrofolate reductase DFR1 0.0027
2833 Dihydrofolate reductase Not Available 0.0027
2931 Dihydrofolate reductase folA 0.0027
3544 Dihydrofolate reductase folA 0.0027
3682 Dihydrofolate reductase folA 0.0027
6642 Dihydrofolate reductase folA 0.0027
6756 Dihydrofolate reductase dfrA 0.0027
5126 Arginase rocF 0.0027
1025 Aquaporin-1 AQP1 0.0027
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0027
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
6493 Cytochrome c oxidase subunit 6C COX6C 0.0027
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0027
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0027
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0027
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0027
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0027
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0027
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0027
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0027
6559 Cytochrome c oxidase subunit 2 ctaC 0.0027
6669 Cytochrome c oxidase subunit 2 ctaC 0.0027
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0027
6558 Cytochrome c oxidase subunit 1 ctaD 0.0027
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0027
702 UMP-CMP kinase CMPK1 0.0027
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0027
267 Plasminogen activator inhibitor 1 SERPINE1 0.0027
556 Alpha-1A adrenergic receptor ADRA1A 0.0026
824 Sodium-dependent serotonin transporter SLC6A4 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
68 Cannabinoid receptor 1 CNR1 0.0026
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0026
936 Ephrin type-A receptor 2 EPHA2 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
2540 Choloylglycine hydrolase cbh 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0025
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
6221 Steroid hormone receptor ERR1 ESRRA 0.0024
1760 Aminopeptidase N ANPEP 0.0024
6843 Aminopeptidase N pepN 0.0024
5934 Cytochrome P450 26A1 CYP26A1 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
6501 Fatty acid-binding protein, liver FABP1 0.0023
1010 Cytochrome P450 51A1 CYP51A1 0.0023
1039 Histone deacetylase 9 HDAC9 0.0023
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
6182 Cytochrome P450 2J2 CYP2J2 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
1618 High affinity nerve growth factor receptor NTRK1 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0021
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0021
340 Apoptotic protease-activating factor 1 APAF1 0.0021
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
76 Nitric-oxide synthase, brain NOS1 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.002
1058 Cell division protein kinase 5 CDK5 0.002
6500 Phospholipase A2 PLA2G1B 0.0019
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
260 Cytochrome P450 51 ERG11 0.0019
761 Cytochrome P450 51 ERG11 0.0019
3163 Cytochrome P450 51 cyp51 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0019
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0018
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
284 DNA-directed RNA polymerase beta chain rpoB 0.0018
5773 DNA-directed RNA polymerase beta chain rpoB 0.0018
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0018
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0018
825 Arsenical pump-driving ATPase ASNA1 0.0018
3435 Arsenical pump-driving ATPase arsA 0.0018
154 AFG3-like protein 2 AFG3L2 0.0018
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0018
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0018
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0018
733 Activin receptor type 1B ACVR1B 0.0018
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0018
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0018
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0018
395 ALK tyrosine kinase receptor Not Available 0.0018
737 Mineralocorticoid receptor NR3C2 0.0018
725 5-hydroxytryptamine 1D receptor HTR1D 0.0018
23 D(1A) dopamine receptor DRD1 0.0018
885 5-hydroxytryptamine 1B receptor HTR1B 0.0018
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0018
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0018
291 Nitric-oxide synthase, endothelial NOS3 0.0018
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0018
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
517 Alcohol dehydrogenase 1C ADH1C 0.0017
6228 Nuclear receptor coactivator 1 NCOA1 0.0017
502 5-hydroxytryptamine 2A receptor HTR2A 0.0017
1063 Signal transducer and activator of transcription 5B STAT5B 0.0017
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0017
831 D(2) dopamine receptor DRD2 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
6241 Nuclear receptor coactivator 2 NCOA2 0.0017
239 Coagulation factor X F10 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0017
292 Activin receptor type-1 ACVR1 0.0017
849 Activated CDC42 kinase 1 TNK2 0.0017
614 Progesterone receptor PGR 0.0016
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0016
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0016
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0016
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0016
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0016
297 Adenylate cyclase type 1 ADCY1 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0016
713 Sodium-dependent dopamine transporter SLC6A3 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0015
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0015
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0015
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0015
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0015
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0014
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0014
6645 D-amino-acid oxidase DAO 0.0014
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
822 Aldose reductase AKR1B1 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0013
740 Argininosuccinate synthase ASS1 0.0013
865 Argininosuccinate synthase ASS1 0.0013
2680 Argininosuccinate synthase argG 0.0013
3194 Argininosuccinate synthase argG 0.0013
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0013
661 ADP/ATP translocase 1 SLC25A4 0.0013
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0013
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0013
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0013
6021 Adenosine kinase ADK 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
1864 RET proto-oncogene RET 0.0013
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
789 Alpha-1D adrenergic receptor ADRA1D 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0011
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0011
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0011
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
2240 Cell division protein kinase 2 CDK2 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
465 Calmodulin CALM1 0.0011
921 Glutamate receptor 2 GRIA2 0.001
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
467 Delta-type opioid receptor OPRD1 0.001
696 Kappa-type opioid receptor OPRK1 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.001
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0009
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
847 Mu-type opioid receptor OPRM1 0.0009
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0009
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