DT-Web

DB04279 - 3-Isopropylmalic Acid


Identification
Name 3-Isopropylmalic Acid
Accession Number DB04279 (EXPT01919)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 176.1672
Groups experimental
Monoisotopic Weight 176.068473494
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


3-isopropylmalate dehydrogenase
Name 3-isopropylmalate dehydrogenase
Gene Name leuB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0029
Isocitrate dehydrogenase [NADP]
Name Isocitrate dehydrogenase [NADP]
Gene Name icd
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0945

Predictions


Id Partner name Gene Name Score
2319 Methylisocitrate lyase prpB 0.1016
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0945
2286 Isocitrate dehydrogenase [NADP] icd 0.0945
2771 Isocitrate dehydrogenase [NADP] icd 0.0945
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0086
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0075
646 Malate dehydrogenase, cytoplasmic MDH1 0.0071
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.007
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.007
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.007
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.007
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.007
5332 MtdA bifunctional protein mtdA 0.007
5322 Oxidoreductase ydhF ydhF 0.007
4403 Protein iolS iolS 0.007
5330 General stress protein 69 yhdN 0.007
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.007
3778 NAD(P) transhydrogenase subunit beta pntB 0.007
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0062
3446 NADP-dependent alcohol dehydrogenase adh 0.0061
729 GDP-L-fucose synthetase TSTA3 0.0061
3463 GDP-L-fucose synthetase fcl 0.0061
5328 Prostaglandin F synthase Tb11.02.2310 0.0061
4582 Putative pteridine reductase 2 ptr2 0.0061
5073 Ferredoxin--NADP reductase petH 0.0061
5076 Ferredoxin--NADP reductase fpr 0.0061
5119 Ferredoxin--NADP reductase petH 0.0061
5121 Ferredoxin--NADP reductase fpr 0.0061
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0061
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0061
989 L-xylulose reductase DCXR 0.0061
2636 Shikimate dehydrogenase aroE 0.0061
3515 Shikimate dehydrogenase aroE 0.0061
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0061
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0061
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0061
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0057
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0056
6297 Prostaglandin reductase 1 PTGR1 0.0056
3062 Aspartate-semialdehyde dehydrogenase asd 0.0056
4531 Putative ketoacyl reductase actIII 0.0056
444 Alcohol dehydrogenase 1B ADH1B 0.0056
1124 Sepiapterin reductase SPR 0.0053
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0053
2675 Pteridine reductase 1 PTR1 0.0053
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0052
666 NADP-dependent malic enzyme ME1 0.0052
2159 Quinone oxidoreductase CRYZ 0.0051
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0051
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0045
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0045
654 Flavin reductase BLVRB 0.0043
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0041
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0039
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0038
76 Nitric-oxide synthase, brain NOS1 0.0036
822 Aldose reductase AKR1B1 0.0035
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0034
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0034
4120 NADPH--cytochrome P450 reductase POR 0.0033
365 Dihydrofolate reductase DHFR 0.0033
2381 Dihydrofolate reductase DFR1 0.0033
2833 Dihydrofolate reductase Not Available 0.0033
2931 Dihydrofolate reductase folA 0.0033
3544 Dihydrofolate reductase folA 0.0033
3682 Dihydrofolate reductase folA 0.0033
6642 Dihydrofolate reductase folA 0.0033
6756 Dihydrofolate reductase dfrA 0.0033
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0029
4423 Levodione reductase lvr 0.0029
2350 3-isopropylmalate dehydrogenase leuB 0.0029
4428 Redox-sensing transcriptional repressor rex rex 0.0029
4507 Alanine dehydrogenase ald 0.0029
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0029
4435 L-aspartate dehydrogenase nadX 0.0029
4472 Glucose 1-dehydrogenase Not Available 0.0029
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0029
3726 D-3-phosphoglycerate dehydrogenase serA 0.0029
4291 D-3-phosphoglycerate dehydrogenase serA 0.0029
4443 Quinate/shikimate dehydrogenase ydiB 0.0029
4451 Vip2Ac vip2Ac 0.0029
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0029
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0029
4500 L-lactate dehydrogenase 2 ldh2 0.0029
4447 Hypothetical protein yhfP yhfP 0.0029
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0029
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0029
4414 Dehydrogenase TT_P0035 0.0029
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0029
4418 AGR_L_3209p AGR_L_3209 0.0029
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0029
4455 Glycerol dehydrogenase gldA 0.0029
4497 Benzyl alcohol dehydrogenase xylB 0.0029
4449 ADP-ribosyltransferase Not Available 0.0029
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0029
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0029
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0029
4487 Transcriptional regulator nadR nadR 0.0029
3729 Citrate synthase gltA 0.0029
4575 Citrate synthase cit 0.0029
4580 Citrate synthase gltA 0.0029
4467 Alpha-glucosidase, putative TM_0752 0.0029
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0029
3381 Alcohol dehydrogenase Not Available 0.0029
4508 Alcohol dehydrogenase adhA 0.0029
4502 Formate dehydrogenase Not Available 0.0029
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0025
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0025
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0025
4486 Phenol 2-hydroxylase component B pheA2 0.0025
4509 Acetoin(diacetyl) reductase budC 0.0025
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0025
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0025
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0025
4503 NADPH-flavin oxidoreductase frp 0.0025
3615 Dihydrodipicolinate reductase dapB 0.0025
3618 Dihydrodipicolinate reductase dapB 0.0025
4462 Dihydrodipicolinate reductase dapB 0.0025
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0025
2424 L-lactate dehydrogenase ldh 0.0025
2641 L-lactate dehydrogenase Not Available 0.0025
4437 L-lactate dehydrogenase ldh 0.0025
4442 L-lactate dehydrogenase ldh 0.0025
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0025
2336 2,3-diketo-L-gulonate reductase dlgD 0.0025
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0025
126 D-lactate dehydrogenase dld 0.0025
3545 D-lactate dehydrogenase Not Available 0.0025
4510 D-lactate dehydrogenase ldhA 0.0025
4427 TDP-glucose-4,6-dehydratase desIV 0.0025
2967 CDP-paratose 2-epimerase rfbE 0.0025
3081 3-dehydroquinate synthase aroB 0.0025
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0025
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0025
2018 Deoxyhypusine synthase DHPS 0.0025
4482 UDP-galactose 4-epimerase galE 0.0025
4439 Ferredoxin reductase bphA4 0.0025
2538 6-phospho-beta-glucosidase bglT bglT 0.0025
4496 C-terminal-binding protein 1 CTBP1 0.0025
2393 Maltose-6'-phosphate glucosidase glvA 0.0025
4477 Dihydrolipoyl dehydrogenase lpdV 0.0025
5077 Dihydrolipoyl dehydrogenase Not Available 0.0025
5117 Dihydrolipoyl dehydrogenase lpd 0.0025
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0025
2591 Urocanate hydratase hutU 0.0025
2507 Diphtheria toxin Not Available 0.0025
4498 Ornithine cyclodeaminase PP3533 0.0025
4450 Iota toxin component Ia Not Available 0.0025
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0023
2683 Mono-ADP-ribosyltransferase C3 C3 0.0023
711 UDP-glucose 6-dehydrogenase UGDH 0.0023
3672 UDP-glucose 6-dehydrogenase hasB 0.0023
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0023
3367 GDP-mannose 6-dehydrogenase algD 0.0023
4318 Siroheme synthase cysG 0.0023
4504 WbpP Not Available 0.0023
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0023
4440 NADH peroxidase npr 0.0023
4343 Alpha-glucosidase aglA 0.0023
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0022
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0022
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0022
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0022
3070 Adenosylhomocysteinase AHCY 0.0022
4424 Adenosylhomocysteinase PFE1050w 0.0022
6278 Adenosylhomocysteinase ahcY 0.0022
2617 Nitric oxide synthase oxygenase nos 0.0022
2701 Nitric oxide synthase oxygenase nos 0.0022
2826 Glucose--fructose oxidoreductase gfo 0.0022
3191 Histidinol dehydrogenase hisD 0.0022
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0021
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0021
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0021
816 Biliverdin reductase A BLVRA 0.0021
4476 Mannitol dehydrogenase mtlD 0.0021
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0021
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0021
328 Sorbitol dehydrogenase SORD 0.0021
396 Alcohol dehydrogenase 4 ADH4 0.0021
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0021
597 Dihydropteridine reductase QDPR 0.0021
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0021
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0021
327 Glutathione reductase gor 0.002
5110 Glutathione reductase GR2 0.002
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.002
77 L-lactate dehydrogenase B chain LDHB 0.002
12 Alcohol dehydrogenase class 3 ADH5 0.002
4491 DNA ligase, NAD-dependent ligA 0.002
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0019
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0019
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0019
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0019
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
2762 UDP-glucose 4-epimerase GALE 0.0019
3461 UDP-glucose 4-epimerase galE 0.0019
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0019
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0019
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0017
251 Alcohol dehydrogenase 1A ADH1A 0.0017
611 Retinal dehydrogenase 1 ALDH1A1 0.0017
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0017
569 Retinal dehydrogenase 2 ALDH1A2 0.0016
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0016
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0016
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0016
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0016
714 Glutathione reductase, mitochondrial GSR 0.0015
517 Alcohol dehydrogenase 1C ADH1C 0.0015
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0014
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