Identification
Name N-1,2,3,4-Tetrahydronaphth-1-Yl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine
Accession Number DB04477 (EXPT03076)
Type small molecule
Description Not Available
Structure
Categories (*)
Molecular Weight 560.601
Groups experimental
Monoisotopic Weight 560.238332786
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Name Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Gene Name GAPDHS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9373
Id Partner name Gene Name Score
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.1841
816 Biliverdin reductase A BLVRA 0.0051
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0051
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0051
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0051
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0048
646 Malate dehydrogenase, cytoplasmic MDH1 0.0048
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0048
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0048
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0048
328 Sorbitol dehydrogenase SORD 0.0047
597 Dihydropteridine reductase QDPR 0.0047
396 Alcohol dehydrogenase 4 ADH4 0.0047
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0047
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0046
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0046
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0046
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0046
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0046
77 L-lactate dehydrogenase B chain LDHB 0.0045
12 Alcohol dehydrogenase class 3 ADH5 0.0045
473 L-lactate dehydrogenase A chain LDHA 0.0043
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0043
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0041
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0041
569 Retinal dehydrogenase 2 ALDH1A2 0.0039
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0039
611 Retinal dehydrogenase 1 ALDH1A1 0.0038
251 Alcohol dehydrogenase 1A ADH1A 0.0038
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0038
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0036
444 Alcohol dehydrogenase 1B ADH1B 0.0036
714 Glutathione reductase, mitochondrial GSR 0.0034
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0033
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0033
4472 Glucose 1-dehydrogenase Not Available 0.0033
4428 Redox-sensing transcriptional repressor rex rex 0.0033
4449 ADP-ribosyltransferase Not Available 0.0033
4418 AGR_L_3209p AGR_L_3209 0.0033
4507 Alanine dehydrogenase ald 0.0033
4497 Benzyl alcohol dehydrogenase xylB 0.0033
4435 L-aspartate dehydrogenase nadX 0.0033
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0033
2350 3-isopropylmalate dehydrogenase leuB 0.0033
3092 3-isopropylmalate dehydrogenase leuB 0.0033
4423 Levodione reductase lvr 0.0033
3729 Citrate synthase gltA 0.0033
4575 Citrate synthase cit 0.0033
4580 Citrate synthase gltA 0.0033
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0033
4443 Quinate/shikimate dehydrogenase ydiB 0.0033
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0033
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0033
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0033
4500 L-lactate dehydrogenase 2 ldh2 0.0033
4447 Hypothetical protein yhfP yhfP 0.0033
3381 Alcohol dehydrogenase Not Available 0.0033
4508 Alcohol dehydrogenase adhA 0.0033
4414 Dehydrogenase TT_P0035 0.0033
4451 Vip2Ac vip2Ac 0.0033
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0033
4455 Glycerol dehydrogenase gldA 0.0033
4502 Formate dehydrogenase Not Available 0.0033
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0033
4487 Transcriptional regulator nadR nadR 0.0033
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0033
4467 Alpha-glucosidase, putative TM_0752 0.0033
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0033
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0033
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0032
517 Alcohol dehydrogenase 1C ADH1C 0.0032
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0028
4486 Phenol 2-hydroxylase component B pheA2 0.0028
4477 Dihydrolipoyl dehydrogenase lpdV 0.0028
5077 Dihydrolipoyl dehydrogenase Not Available 0.0028
5117 Dihydrolipoyl dehydrogenase lpd 0.0028
4439 Ferredoxin reductase bphA4 0.0028
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0028
4427 TDP-glucose-4,6-dehydratase desIV 0.0028
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0028
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0028
2967 CDP-paratose 2-epimerase rfbE 0.0028
4482 UDP-galactose 4-epimerase galE 0.0028
4503 NADPH-flavin oxidoreductase frp 0.0028
2507 Diphtheria toxin Not Available 0.0028
2393 Maltose-6'-phosphate glucosidase glvA 0.0028
2538 6-phospho-beta-glucosidase bglT bglT 0.0028
4509 Acetoin(diacetyl) reductase budC 0.0028
3081 3-dehydroquinate synthase aroB 0.0028
2591 Urocanate hydratase hutU 0.0028
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0028
3615 Dihydrodipicolinate reductase dapB 0.0028
3618 Dihydrodipicolinate reductase dapB 0.0028
4462 Dihydrodipicolinate reductase dapB 0.0028
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0028
4450 Iota toxin component Ia Not Available 0.0028
126 D-lactate dehydrogenase dld 0.0028
3545 D-lactate dehydrogenase Not Available 0.0028
4510 D-lactate dehydrogenase ldhA 0.0028
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0028
2424 L-lactate dehydrogenase ldh 0.0028
2641 L-lactate dehydrogenase Not Available 0.0028
4437 L-lactate dehydrogenase ldh 0.0028
4442 L-lactate dehydrogenase ldh 0.0028
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0028
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0028
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0028
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0028
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0028
4498 Ornithine cyclodeaminase PP3533 0.0028
2018 Deoxyhypusine synthase DHPS 0.0028
4496 C-terminal-binding protein 1 CTBP1 0.0028
2336 2,3-diketo-L-gulonate reductase dlgD 0.0028
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0028
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0026
4504 WbpP Not Available 0.0026
2683 Mono-ADP-ribosyltransferase C3 C3 0.0026
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0026
3367 GDP-mannose 6-dehydrogenase algD 0.0026
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0026
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0026
4440 NADH peroxidase npr 0.0026
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0025
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0025
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0025
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0025
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0025
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0025
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0025
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0025
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0025
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0025
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0025
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0025
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0025
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0025
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0025
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0025
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0025
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0025
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0025
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0025
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0025
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0025
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0025
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0025
4318 Siroheme synthase cysG 0.0025
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0025
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0025
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0025
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0025
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0025
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0025
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0025
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0025
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0025
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0025
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0025
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0025
644 Heme oxygenase 2 HMOX2 0.0025
4982 Heme oxygenase 2 pbsA2 0.0025
711 UDP-glucose 6-dehydrogenase UGDH 0.0025
3672 UDP-glucose 6-dehydrogenase hasB 0.0025
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0025
729 GDP-L-fucose synthetase TSTA3 0.0025
3463 GDP-L-fucose synthetase fcl 0.0025
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0025
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0025
3726 D-3-phosphoglycerate dehydrogenase serA 0.0025
4291 D-3-phosphoglycerate dehydrogenase serA 0.0025
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0025
167 L-lactate dehydrogenase C chain LDHC 0.0025
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0025
206 3-keto-steroid reductase HSD17B7 0.0025
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0025
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0025
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0025
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0025
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0025
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0025
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0025
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0025
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0025
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0025
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0025
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0025
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0025
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0025
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0025
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0025
107 C-4 methylsterol oxidase SC4MOL 0.0025
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0025
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0025
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0025
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0025
643 Peroxisomal bifunctional enzyme EHHADH 0.0025
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0025
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0025
34 7-dehydrocholesterol reductase DHCR7 0.0025
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0025
4343 Alpha-glucosidase aglA 0.0025
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0024
666 NADP-dependent malic enzyme ME1 0.0024
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0024
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0024
63 Malate dehydrogenase mdh 0.0024
2329 Malate dehydrogenase mdh 0.0024
3445 Malate dehydrogenase mdh 0.0024
4420 Malate dehydrogenase mdh 0.0024
4438 Malate dehydrogenase mdh 0.0024
4476 Mannitol dehydrogenase mtlD 0.0024
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0024
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0024
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0024
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0024
2617 Nitric oxide synthase oxygenase nos 0.0024
2701 Nitric oxide synthase oxygenase nos 0.0024
2826 Glucose--fructose oxidoreductase gfo 0.0024
3070 Adenosylhomocysteinase AHCY 0.0024
4424 Adenosylhomocysteinase PFE1050w 0.0024
6278 Adenosylhomocysteinase ahcY 0.0024
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0024
857 Malate dehydrogenase, mitochondrial MDH2 0.0024
3191 Histidinol dehydrogenase hisD 0.0024
327 Glutathione reductase gor 0.0023
5110 Glutathione reductase GR2 0.0023
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0023
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0023
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0023
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0022
4491 DNA ligase, NAD-dependent ligA 0.0022
2286 Isocitrate dehydrogenase [NADP] icd 0.0022
2302 Isocitrate dehydrogenase [NADP] icd 0.0022
2771 Isocitrate dehydrogenase [NADP] icd 0.0022
2762 UDP-glucose 4-epimerase GALE 0.0022
3461 UDP-glucose 4-epimerase galE 0.0022
6026 Alcohol dehydrogenase 6 ADH6 0.0021
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0021
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0021
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0021
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0021
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0021
13 Aminomethyltransferase, mitochondrial AMT 0.0021
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0021
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0021
627 11-cis retinol dehydrogenase RDH5 0.002
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.002
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.002
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.002
626 Cysteine dioxygenase type 1 CDO1 0.002
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.002
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.002
654 Flavin reductase BLVRB 0.0019
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0019
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0018
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0018
810 Heme oxygenase 1 HMOX1 0.0018
3391 Heme oxygenase 1 pbsA1 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0017
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0017
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0017
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0017
279 Tyrosinase TYR 0.0017
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0015
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0015
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0015
822 Aldose reductase AKR1B1 0.0015
365 Dihydrofolate reductase DHFR 0.0014
2381 Dihydrofolate reductase DFR1 0.0014
2833 Dihydrofolate reductase Not Available 0.0014
2931 Dihydrofolate reductase folA 0.0014
3544 Dihydrofolate reductase folA 0.0014
3682 Dihydrofolate reductase folA 0.0014
6642 Dihydrofolate reductase folA 0.0014
6756 Dihydrofolate reductase dfrA 0.0014
468 Cytochrome P450 4A11 CYP4A11 0.0014
6020 Aldehyde oxidase AOX1 0.0014
3947 Xanthine dehydrogenase/oxidase XDH 0.0013