DT-Web

DB00667 - Histamine Phosphate


Identification
Name Histamine Phosphate
Accession Number DB00667 (APRD01015)
Type small molecule
Description Histamine stimulates gastric gland secretion, causing an increased secretion of gastric juice of high acidity. This action is probably due mainly to a direct action on parietal and chief gland cells.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 307.1354
Groups approved
Monoisotopic Weight 307.033437495
Pharmacology
Indication Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.
Mechanism of action Histamine acts directly on the blood vessels to dilate arteries and capillaries; this action is mediated by both H 1- and H 2-receptors. Capillary dilatation may produce flushing of the face, a decrease in systemic blood pressure, and gastric gland secretion, causing an increased secretion of gastric juice of high acidity. Increased capillary permeability accompanies capillary dilatation, producing an outward passage of plasma protein and fluid into the extracellular spaces, an increase in lymph flow and protein content, and the formation of edema. In addition, histamine has a direct stimulant action on smooth muscle, producing contraction if H 1-receptors are activated, or mostly relaxation if H 2-receptors are activated. Also in humans, the stimulant effect of histamine may cause contraction of the intestinal muscle. However, little effect is noticed on the uterus, bladder, or gallbladder. Histamine has some stimulant effect on duodenal, salivary, pancreatic, bronchial, and lacrimal glands. Histamine also can bind to H3 and H4 receptors which are involved in the CNS/PNS neurotransmitter release and immune system chemotaxis, respectively.
Absorption Readily absorbed after parenteral administration
Protein binding Not Available
Biotransformation Primarily hepatic. Histamine is rapidly metabolized by methylation and oxidation. Methylation involves ring methylation and catalyzation by the enzyme histamine-N-methyltransferase, producing N-methylhistamine, which is mostly converted to N-methyl imidazole acetic acid. 2 to 3% excreted as free histamine, 4 to 8% as N-methylhistamine, 42 to 47% as N-methyl imidazole acetic acid, 9 to 11% as imidazole acetic acid, and 16 to 23% as imidazole acetic acid riboside
Route of elimination Not Available
Toxicity LD50=807 mg/kg (mouse, oral). Side effects can lead to hypertension, hypotension, headache, dizziness, nervousness and tachycardia. Large overdoses can lead to seizures.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action yes
Actions agonist
References
  • Miyoshi K, Das AK, Fujimoto K, Horio S, Fukui H: Recent advances in molecular pharmacology of the histamine systems: regulation of histamine H1 receptor signaling by changing its expression level. J Pharmacol Sci. 2006 May;101(1):3-6. Epub 2006 Apr 28. - Pubmed
  • Han SK, Mancino V, Simon MI: Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons. Neuron. 2006 Nov 22;52(4):691-703. - Pubmed
  • Spahr L, Coeytaux A, Giostra E, Hadengue A, Annoni JM: Histamine H1 blocker hydroxyzine improves sleep in patients with cirrhosis and minimal hepatic encephalopathy: a randomized controlled pilot trial. Am J Gastroenterol. 2007 Apr;102(4):744-53. Epub 2007 Jan 11. - Pubmed
  • Suzuki K, Morokata T, Morihira K, Sato I, Takizawa S, Kaneko M, Takahashi K, Shimizu Y: A dual antagonist for chemokine CCR3 receptor and histamine H1 receptor. Eur J Pharmacol. 2007 Jun 1;563(1-3):224-32. Epub 2007 Feb 8. - Pubmed
  • Tanimoto A, Wang KY, Murata Y, Kimura S, Nomaguchi M, Nakata S, Tsutsui M, Sasaguri Y: Histamine upregulates the expression of inducible nitric oxide synthase in human intimal smooth muscle cells via histamine H1 receptor and NF-kappaB signaling pathway. Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1556-61. Epub 2007 May 3. - Pubmed
DTHybrid score 0.7616
Histamine H2 receptor
Name Histamine H2 receptor
Gene Name HRH2
Pharmacological action yes
Actions agonist
References
  • Francis H, Franchitto A, Ueno Y, Glaser S, DeMorrow S, Venter J, Gaudio E, Alvaro D, Fava G, Marzioni M, Vaculin B, Alpini G: H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway. Lab Invest. 2007 May;87(5):473-87. Epub 2007 Mar 5. - Pubmed
  • Soga F, Katoh N, Kishimoto S: Histamine prevents apoptosis in human monocytes. Clin Exp Allergy. 2007 Mar;37(3):323-30. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.667
Histamine H3 receptor
Name Histamine H3 receptor
Gene Name HRH3
Pharmacological action yes
Actions agonist
References
  • Petroianu G, Arafat K, Sasse BC, Stark H: Multiple enzyme inhibitions by histamine H3 receptor antagonists as potential procognitive agents. Pharmazie. 2006 Mar;61(3):179-82. - Pubmed
  • Garduno-Torres B, Arias-Montano JA: Homologous down-regulation of histamine H3 receptors in rat striatal slices. Synapse. 2006 Aug;60(2):165-71. - Pubmed
  • Minick DJ, Copley RC, Szewczyk JR, Rutkowske RD, Miller LA: An investigation of the absolute configuration of the potent histamine H3 receptor antagonist GT-2331 using vibrational circular dichroism. Chirality. 2007 Sep;19(9):731-40. - Pubmed
  • Arrang JM: [The histamine H3 receptor: a new target for the treatment of arousal and cognitive disorders] Ann Pharm Fr. 2007 Jul;65(4):275-84. - Pubmed
DTHybrid score 0.6292
Histamine H4 receptor
Name Histamine H4 receptor
Gene Name HRH4
Pharmacological action unknown
Actions agonist
References
  • Blaya B, Nicolau-Galmes F, Jangi SM, Ortega-Martinez I, Alonso-Tejerina E, Burgos-Bretones J, Perez-Yarza G, Asumendi A, Boyano MD: Histamine and histamine receptor antagonists in cancer biology. Inflamm Allergy Drug Targets. 2010 Jul 1;9(3):146-57. - Pubmed
  • Yu B, Shao Y, Li P, Zhang J, Zhong Q, Yang H, Hu X, Chen B, Peng X, Wu Q, Chen Y, Guan M, Wan J, Zhang W: Copy number variations of human histamine H4 receptor gene are associated with systemic lupus erythematosus. Br J Dermatol. 2010 Jul 2. - Pubmed
  • Cowden JM, Riley JP, Ma JY, Thurmond RL, Dunford PJ: Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines. Respir Res. 2010 Jun 24;11:86. - Pubmed
DTHybrid score 0.1911

Enzymes


Histamine N-methyltransferase
Name Histamine N-methyltransferase
Gene Name HNMT
Actions substrate
References
  • -
  • Garcia-Martin E, Ayuso P, Martinez C, Blanca M, Agundez JA: Histamine pharmacogenomics. Pharmacogenomics. 2009 May;10(5):867-83. - Pubmed
  • Okinaga S, Ohrui T, Nakazawa H, Yamauchi K, Sakurai E, Watanabe T, Sekizawa K, Sasaki H: The role of HMT (histamine N-methyltransferase) in airways: a review. Methods Find Exp Clin Pharmacol. 1995 Nov;17 Suppl C:16-20. - Pubmed
DTHybrid score 0.7447
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4076
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.551
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5681

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions substrate,inhibitor
References
  • Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed
  • Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed
  • Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed
  • Busch AE, Karbach U, Miska D, Gorboulev V, Akhoundova A, Volk C, Arndt P, Ulzheimer JC, Sonders MS, Baumann C, Waldegger S, Lang F, Koepsell H: Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52. - Pubmed
  • Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed
DTHybrid score 0.3893
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate,inhibitor
References
  • Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed
  • Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed
  • Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed
  • Busch AE, Quester S, Ulzheimer JC, Gorboulev V, Akhoundova A, Waldegger S, Lang F, Koepsell H: Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1. FEBS Lett. 1996 Oct 21;395(2-3):153-6. - Pubmed
  • Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed
DTHybrid score 0.4272
Solute carrier family 22 member 3
Name Solute carrier family 22 member 3
Gene Name SLC22A3
Actions inhibitor
References
  • Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. - Pubmed
DTHybrid score 0.2963
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. - Pubmed
DTHybrid score 0.3539

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.2572
6016 Cytochrome P450 2C19 CYP2C19 0.2465
4200 Cytochrome P450 1A2 CYP1A2 0.2299
4924 Cytochrome P450 2C8 CYP2C8 0.1811
4118 Cytochrome P450 3A5 CYP3A5 0.1752
6030 Cytochrome P450 2B6 CYP2B6 0.1306
833 Organic cation/carnitine transporter 1 SLC22A4 0.1291
6107 Cytochrome P450 3A7 CYP3A7 0.1216
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1165
6013 Cytochrome P450 2E1 CYP2E1 0.1163
6024 Cytochrome P450 1A1 CYP1A1 0.1057
6142 Solute carrier family 22 member 8 SLC22A8 0.1047
556 Alpha-1A adrenergic receptor ADRA1A 0.1026
2417 Chloramphenicol acetyltransferase cat 0.1017
3278 Chloramphenicol acetyltransferase cat 0.1017
502 5-hydroxytryptamine 2A receptor HTR2A 0.0889
318 Alpha-2A adrenergic receptor ADRA2A 0.0861
5718 Cytochrome P450 2A6 CYP2A6 0.0837
1729 Solute carrier family 22 member 6 SLC22A6 0.0814
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0768
831 D(2) dopamine receptor DRD2 0.0761
587 Serum albumin ALB 0.073
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0719
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0703
378 Alpha-2C adrenergic receptor ADRA2C 0.0699
824 Sodium-dependent serotonin transporter SLC6A4 0.0697
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0682
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0669
629 Alpha-2B adrenergic receptor ADRA2B 0.0655
713 Sodium-dependent dopamine transporter SLC6A3 0.0645
766 Beta-2 adrenergic receptor ADRB2 0.0643
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0635
862 Multidrug resistance-associated protein 1 ABCC1 0.0603
632 Alpha-1B adrenergic receptor ADRA1B 0.0593
20 Prostaglandin G/H synthase 1 PTGS1 0.059
1898 Cytochrome P450 1B1 CYP1B1 0.0586
23 D(1A) dopamine receptor DRD1 0.0576
3923 Cholinesterase BCHE 0.0568
320 5-hydroxytryptamine 1A receptor HTR1A 0.0564
590 5-hydroxytryptamine 2C receptor HTR2C 0.0534
193 Beta-1 adrenergic receptor ADRB1 0.0531
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0496
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0493
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0488
341 5-hydroxytryptamine 3 receptor HTR3A 0.0482
450 Muscarinic acetylcholine receptor M4 CHRM4 0.048
220 Sodium channel protein type 5 subunit alpha SCN5A 0.047
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0467
6106 Cytochrome P450 2C18 CYP2C18 0.0442
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0439
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.042
776 Bile salt export pump ABCB11 0.042
638 D(3) dopamine receptor DRD3 0.0414
789 Alpha-1D adrenergic receptor ADRA1D 0.0405
432 D(4) dopamine receptor DRD4 0.0405
1024 Solute carrier family 22 member 11 SLC22A11 0.0378
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0376
1770 Phospholipase C PLCL1 0.0376
2841 Phospholipase C plc 0.0376
716 5-hydroxytryptamine 7 receptor HTR7 0.0365
6143 Solute carrier family 22 member 7 SLC22A7 0.0353
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0342
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0327
474 Acetylcholinesterase ACHE 0.0312
885 5-hydroxytryptamine 1B receptor HTR1B 0.0306
131 Synaptic vesicular amine transporter SLC18A2 0.029
3939 Amine oxidase [flavin-containing] B MAOB 0.0289
3941 Amine oxidase [flavin-containing] A MAOA 0.0288
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0285
2164 Multidrug resistance-associated protein 4 ABCC4 0.0281
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0279
290 Prostaglandin G/H synthase 2 PTGS2 0.0277
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0277
817 DNA topoisomerase 2-alpha TOP2A 0.0267
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0264
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0264
723 Cytosolic phospholipase A2 PLA2G4A 0.0261
1256 5-hydroxytryptamine 6 receptor HTR6 0.0256
136 Estrogen receptor ESR1 0.0256
477 DNA topoisomerase 4 subunit A parC 0.0253
886 DNA topoisomerase 4 subunit A parC 0.0253
6226 DNA topoisomerase 4 subunit A parC 0.0253
3811 Cytochrome P450 19A1 CYP19A1 0.025
725 5-hydroxytryptamine 1D receptor HTR1D 0.0249
404 DNA gyrase subunit A gyrA 0.0249
6224 DNA gyrase subunit A gyrA 0.0249
6010 Thiamine transporter 1 SLC19A2 0.0248
847 Mu-type opioid receptor OPRM1 0.0248
731 HIV-1 protease HIV-1 protease 0.0238
624 Guanidinoacetate N-methyltransferase GAMT 0.0234
465 Calmodulin CALM1 0.023
1636 Trace amine-associated receptor 1 TAAR1 0.0227
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0224
175 Thiamin pyrophosphokinase 1 TPK1 0.0222
436 5-hydroxytryptamine 2B receptor HTR2B 0.022
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0219
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0219
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0218
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0217
467 Delta-type opioid receptor OPRD1 0.0212
696 Kappa-type opioid receptor OPRK1 0.0211
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0206
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0204
2472 Voltage-gated potassium channel kcsA 0.0203
6366 Voltage-gated potassium channel kcsA 0.0203
6148 Multidrug resistance-associated protein 7 ABCC10 0.0203
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0202
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.02
528 5-hydroxytryptamine 1E receptor HTR1E 0.0195
163 D(1B) dopamine receptor DRD5 0.0195
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0193
6137 Multidrug resistance-associated protein 6 ABCC6 0.0186
871 Glucocorticoid receptor NR3C1 0.0184
738 Monocarboxylate transporter 1 SLC16A1 0.0184
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0182
4773 Deoxycytidine kinase DCK 0.0177
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0177
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0177
159 Penicillin-binding protein 2B penA 0.0175
6121 Penicillin-binding protein 2B penA 0.0175
6136 Multidrug resistance-associated protein 5 ABCC5 0.0174
161 Tubulin beta chain TUBB 0.0172
312 Tubulin beta chain TUB2 0.0172
6070 Nischarin NISCH 0.0172
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0171
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.017
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0169
516 Neurotensin receptor type 2 NTSR2 0.0168
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0162
1757 Myeloperoxidase MPO 0.0161
5126 Arginase rocF 0.0161
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0158
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0156
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0155
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0154
380 Cytochrome P450 17A1 CYP17A1 0.0153
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0152
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0147
828 Phenylalanine-4-hydroxylase PAH 0.0145
3109 Phenylalanine-4-hydroxylase phhA 0.0145
7 Nitric oxide synthase, inducible NOS2 0.0145
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0144
5626 Nucleoside diphosphate kinase B NME2 0.0143
6182 Cytochrome P450 2J2 CYP2J2 0.0142
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0141
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0141
891 Dihydropteroate synthase folP 0.014
5359 Dihydropteroate synthase folP 0.014
7175 Dihydropteroate synthase sulI 0.014
1656 CYP2B protein CYP2B 0.014
6141 Sodium/bile acid cotransporter SLC10A1 0.014
6014 Cytochrome P450 2A13 CYP2A13 0.0134
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0134
6031 Cytochrome P450 3A43 CYP3A43 0.013
756 Sex hormone-binding globulin SHBG 0.0129
6432 Transporter snf 0.0129
1275 Estrogen sulfotransferase SULT1E1 0.0128
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0127
614 Progesterone receptor PGR 0.0126
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0124
1517 Beta-3 adrenergic receptor ADRB3 0.0123
633 Penicillin-binding proteins 1A/1B pbpA 0.0123
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0119
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0119
737 Mineralocorticoid receptor NR3C2 0.0118
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0118
122 P2Y purinoceptor 12 P2RY12 0.0117
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0117
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0116
3810 Catechol O-methyltransferase COMT 0.0116
260 Cytochrome P450 51 ERG11 0.0116
761 Cytochrome P450 51 ERG11 0.0116
3163 Cytochrome P450 51 cyp51 0.0116
5294 Nucleoside diphosphate kinase A NME1 0.0115
3947 Xanthine dehydrogenase/oxidase XDH 0.0114
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0113
153 Dopamine beta-hydroxylase DBH 0.0112
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0111
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0105
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0105
4604 Liver carboxylesterase 1 CES1 0.0104
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0104
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0103
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0103
2300 Lysozyme E 0.0101
3633 Lysozyme R 0.0101
5597 Lysozyme 17 0.0101
146 Androgen receptor AR 0.0101
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.01
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
29 Tubulin beta-1 chain TUBB1 0.0098
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
70 Type-1 angiotensin II receptor AGTR1 0.0097
6146 High affinity copper uptake protein 1 SLC31A1 0.0097
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0096
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0096
869 Estrogen receptor beta ESR2 0.0095
232 Corticosteroid-binding globulin SERPINA6 0.0093
468 Cytochrome P450 4A11 CYP4A11 0.0092
342 P protein [Includes: DNA-directed DNA polymerase P 0.0091
612 P protein [Includes: DNA-directed DNA polymerase P 0.0091
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.009
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.009
3927 Choline transporter-like protein 3 SLC44A3 0.009
3933 Choline/ethanolaminephosphotransferase CEPT1 0.009
769 High-affinity choline transporter 1 SLC5A7 0.009
3926 Choline transporter-like protein 2 SLC44A2 0.009
861 Choline kinase alpha CHKA 0.009
1686 Choline transporter-like protein 1 SLC44A1 0.009
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.009
700 Choline dehydrogenase, mitochondrial CHDH 0.009
3925 Choline transporter-like protein 4 SLC44A4 0.009
576 Choline O-acetyltransferase CHAT 0.009
3922 Phospholipase D2 PLD2 0.009
3924 Phospholipase D1 PLD1 0.009
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.009
5682 Ribonuclease pancreatic RNASE1 0.0089
1360 Sphingomyelin phosphodiesterase SMPD1 0.0089
976 Platelet glycoprotein IX GP9 0.0089
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0088
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0088
1998 Protein-L-isoaspartate(D-aspartate) O-methyltransferase PCMT1 0.0088
4330 Hypothetical protein TTHA0667 TTHA0667 0.0088
2551 Cobalt-precorrin-4 C(11)-methyltransferase cbiF 0.0088
3724 Protein methyltransferase hemK hemK 0.0088
4313 Probable tRNA/rRNA methyltransferase HI0766 trmL 0.0088
4316 Mycolic acid synthase pcaA 0.0088
4309 S-adenosyl-L-methionine-dependent methyltransferase mraW rsmH 0.0088
4333 Protein-L-isoaspartate O-methyltransferase pcm 0.0088
4323 Modification methylase HhaI hhaIM 0.0088
4324 Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 SETD7 0.0088
4315 DNA adenine methylase DAM 0.0088
4329 Uroporphyrinogen-III C-methyltransferase cobA 0.0088
4331 Chemotaxis protein methyltransferase cheR 0.0088
4314 Modification methylase PvuII pvuIIM 0.0088
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0087
6138 Multidrug resistance protein 3 ABCB4 0.0086
694 Matrix protein 2 M 0.0086
504 Mast/stem cell growth factor receptor KIT 0.0086
338 DNA polymerase UL30 0.0086
379 DNA polymerase UL54 0.0086
697 DNA polymerase ORF28 0.0086
2482 DNA polymerase 43 0.0086
4104 DNA polymerase BALF5 0.0086
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0085
3611 Cytidine deaminase cdd 0.0085
3707 Cytidine deaminase cdd 0.0085
4211 Cytidine deaminase CDA 0.0085
6165 Copper-transporting ATPase 1 ATP7A 0.0084
6163 Copper-transporting ATPase 2 ATP7B 0.0084
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0084
1830 5'-nucleotidase NT5E 0.0084
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0084
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
4311 tRNA TRDMT1 0.0082
4325 tRNA trmD 0.0082
4328 tRNA trmD 0.0082
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0082
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0082
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0082
527 Prostacyclin receptor PTGIR 0.0082
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0081
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0081
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0081
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0081
125 DNA polymerase beta POLB 0.0081
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
908 Glutathione S-transferase theta-1 GSTT1 0.008
645 Penicillin-binding protein 1A mrcA 0.0079
5805 Penicillin-binding protein 1A ponA 0.0079
6185 Penicillin-binding protein 1A mrcA 0.0079
6799 Penicillin-binding protein 1A pbpA 0.0079
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0078
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0078
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0078
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0078
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0078
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0077
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
904 Glutathione S-transferase P GSTP1 0.0077
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0077
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0077
4318 Siroheme synthase cysG 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
4332 Modification methylase TaqI taqIM 0.0077
4310 rRNA adenine N-6-methyltransferase ermC' 0.0077
3117 Carminomycin 4-O-methyltransferase dnrK 0.0077
4302 METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 mmaA2 0.0076
2242 Cyclopropane-fatty-acyl-phospholipid synthase 2 cmaA2 0.0076
4306 HemK protein TM_0488 0.0076
2297 Genome polyprotein Not Available 0.0076
2322 Genome polyprotein Not Available 0.0076
2694 Genome polyprotein Not Available 0.0076
2719 Genome polyprotein Not Available 0.0076
2860 Genome polyprotein Not Available 0.0076
2928 Genome polyprotein Not Available 0.0076
3160 Genome polyprotein Not Available 0.0076
3260 Genome polyprotein Not Available 0.0076
4783 Genome polyprotein Not Available 0.0076
5726 Genome polyprotein Not Available 0.0076
5779 Genome polyprotein Not Available 0.0076
5867 Genome polyprotein Not Available 0.0076
6253 Genome polyprotein Not Available 0.0076
6301 Genome polyprotein Not Available 0.0076
6380 Genome polyprotein Not Available 0.0076
6381 Genome polyprotein Not Available 0.0076
6437 Genome polyprotein Not Available 0.0076
6520 Genome polyprotein Not Available 0.0076
6521 Genome polyprotein Not Available 0.0076
6652 Genome polyprotein Not Available 0.0076
6734 Genome polyprotein Not Available 0.0076
6735 Genome polyprotein Not Available 0.0076
6736 Genome polyprotein Not Available 0.0076
6737 Genome polyprotein Not Available 0.0076
6738 Genome polyprotein Not Available 0.0076
6739 Genome polyprotein Not Available 0.0076
6744 Genome polyprotein Not Available 0.0076
6748 Genome polyprotein Not Available 0.0076
6894 Genome polyprotein Not Available 0.0076
6898 Genome polyprotein Not Available 0.0076
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0076
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0075
896 Glutathione S-transferase Mu 1 GSTM1 0.0075
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0075
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0074
844 Epidermal growth factor receptor EGFR 0.0074
357 Carbonic anhydrase 2 CA2 0.0074
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0074
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0073
592 Carbonic anhydrase 4 CA4 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
295 Carbonic anhydrase 1 CA1 0.0072
702 UMP-CMP kinase CMPK1 0.0072
2653 Modification methylase RsrI rsrIM 0.0071
4327 RdmB rdmB 0.007
6171 Solute carrier family 28 member 3 SLC28A3 0.007
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.007
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.007
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0069
49 Endothelin B receptor EDNRB 0.0069
6085 Fatty acid-binding protein, intestinal FABP2 0.0068
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0067
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0067
811 Translocator protein TSPO 0.0066
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0066
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0066
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0066
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0066
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0066
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
1629 Transcription factor AP-1 JUN 0.0066
578 Endothelin-1 receptor EDNRA 0.0065
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0065
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0065
94 5-hydroxytryptamine 4 receptor HTR4 0.0064
860 Nicotinamide N-methyltransferase NNMT 0.0064
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0064
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
699 Nicotinic acid receptor 1 GPR109A 0.0064
928 Nicotinic acid receptor 2 GPR109B 0.0064
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0064
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0064
4120 NADPH--cytochrome P450 reductase POR 0.0064
228 Beta platelet-derived growth factor receptor PDGFRB 0.0063
952 Dipeptidyl peptidase 4 DPP4 0.0063
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
365 Dihydrofolate reductase DHFR 0.0063
2381 Dihydrofolate reductase DFR1 0.0063
2833 Dihydrofolate reductase Not Available 0.0063
2931 Dihydrofolate reductase folA 0.0063
3544 Dihydrofolate reductase folA 0.0063
3682 Dihydrofolate reductase folA 0.0063
6642 Dihydrofolate reductase folA 0.0063
6756 Dihydrofolate reductase dfrA 0.0063
133 Dihydropterate synthase sulI 0.0063
2539 Tubulin alpha-1 chain TUBA4A 0.0063
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0061
6097 Protein S100-A2 S100A2 0.006
1810 Protein S100-A1 S100A1 0.006
1618 High affinity nerve growth factor receptor NTRK1 0.006
411 Glycine N-methyltransferase GNMT 0.006
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0059
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0059
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0058
818 50S ribosomal protein L10 rplJ 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0058
2557 Cap-specific mRNA PAPS 0.0058
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0058
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0058
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0058
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6220 Aryl hydrocarbon receptor AHR 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
751 Potassium channel subfamily K member 6 KCNK6 0.0057
6102 Arylamine N-acetyltransferase 2 NAT2 0.0057
407 Vascular endothelial growth factor receptor 2 KDR 0.0057
788 Creatine kinase M-type CKM 0.0057
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0056
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0055
6506 Stathmin-4 STMN4 0.0055
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0055
6218 Pannexin-1 PANX1 0.0055
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0054
6149 Solute carrier family 22 member 10 SLC22A10 0.0054
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0054
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0054
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0054
974 Phenylethanolamine N-methyltransferase PNMT 0.0053
172 Potassium channel subfamily K member 1 KCNK1 0.0053
1048 Protein S100-A13 S100A13 0.0052
2226 Protein S100-A12 S100A12 0.0052
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0052
2112 Toll-like receptor 9 TLR9 0.0051
777 Tumor necrosis factor TNF 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0049
2449 Tubulin alpha-3 chain TUBA1A 0.0049
2132 Protein S100-B S100B 0.0049
173 Toll-like receptor 7 TLR7 0.0049
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0048
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
1864 RET proto-oncogene RET 0.0046
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0046
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0046
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0046
856 Vitamin D3 receptor VDR 0.0046
6126 Carbonic anhydrase 7 CA7 0.0046
68 Cannabinoid receptor 1 CNR1 0.0046
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0046
814 Ryanodine receptor 1 RYR1 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0045
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0044
482 Glycine receptor subunit alpha-1 GLRA1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6211 Tubulin epsilon chain TUBE1 0.0044
6212 Tubulin gamma-1 chain TUBG1 0.0044
6210 Tubulin delta chain TUBD1 0.0044
1353 DNA topoisomerase 1 TOP1 0.0044
3552 DNA topoisomerase 1 topA 0.0044
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0043
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0043
558 Solute carrier family 12 member 1 SLC12A1 0.0042
6167 Organic solute transporter subunit beta OSTB 0.0042
6166 Organic solute transporter subunit alpha OSTA 0.0042
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0041
1010 Cytochrome P450 51A1 CYP51A1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
427 Substance-P receptor TACR1 0.004
123 Diamine acetyltransferase 1 SAT1 0.004
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.004
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.004
275 Arachidonate 5-lipoxygenase ALOX5 0.004
373 Transthyretin TTR 0.004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.004
500 Monocarboxylate transporter 4 SLC16A3 0.004
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0039
1541 Metalloproteinase mmp20 0.0039
1178 Adenosine A2a receptor ADORA2A 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0038
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0038
183 Vascular endothelial growth factor A VEGFA 0.0038
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0037
208 DNA-directed RNA polymerase beta' chain rpoC 0.0037
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0037
54 Prothrombin F2 0.0037
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0037
1050 Bile salt sulfotransferase SULT2A1 0.0036
705 Glutamate receptor 1 GRIA1 0.0036
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
26 Vascular endothelial growth factor receptor 3 FLT4 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
4217 Telomerase reverse transcriptase TERT 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
489 Monocarboxylate transporter 2 SLC16A7 0.0034
32 Vascular endothelial growth factor receptor 1 FLT1 0.0034
24 Thymidylate synthase TMP1 0.0034
359 Thymidylate synthase TYMS 0.0034
2626 Thymidylate synthase thyA 0.0034
2729 Thymidylate synthase thyA 0.0034
5352 Thymidylate synthase THYA 0.0034
6020 Aldehyde oxidase AOX1 0.0033
780 Retinoic acid receptor RXR-gamma RXRG 0.0033
6168 Solute carrier family 22 member 16 SLC22A16 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
277 Purine nucleoside phosphorylase PNP 0.0033
2870 Purine nucleoside phosphorylase punA 0.0033
2945 Purine nucleoside phosphorylase punA 0.0033
4659 Purine nucleoside phosphorylase TM_1596 0.0033
4825 Purine nucleoside phosphorylase TTHA1435 0.0033
499 Arginine decarboxylase ADC 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
284 DNA-directed RNA polymerase beta chain rpoB 0.0032
5773 DNA-directed RNA polymerase beta chain rpoB 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
4122 Histone deacetylase 2 HDAC2 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0031
16 Adenosine A1 receptor ADORA1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0031
577 Argininosuccinate lyase ASL 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
88 Retinoic acid receptor RXR-beta RXRB 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
581 Cytochrome P450 2R1 CYP2R1 0.003
174 Sigma 1-type opioid receptor SIGMAR1 0.003
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.003
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
291 Nitric-oxide synthase, endothelial NOS3 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0028
518 Peroxidase/catalase T katG 0.0028
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
3932 Glutathione S-transferase A2 GSTA2 0.0028
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0027
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
2320 Thymidine kinase, cytosolic TK1 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
537 ATP synthase delta chain, mitochondrial ATP5D 0.0027
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0026
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0026
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0025
921 Glutamate receptor 2 GRIA2 0.0025
563 Thyroid peroxidase TPO 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
1648 Elastin ELN 0.0024
4192 DNA topoisomerase 2-beta TOP2B 0.0024
1039 Histone deacetylase 9 HDAC9 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6151 Monocarboxylate transporter 10 SLC16A10 0.0024
634 Squalene monooxygenase SQLE 0.0024
7196 Squalene monooxygenase ERG1 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0023
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0023
1192 Sulfotransferase 1A1 SULT1A1 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
823 Fibroblast growth factor receptor 2 FGFR2 0.0022
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0022
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0022
3404 Exotoxin A eta 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0021
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0021
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0021
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0021
165 FL cytokine receptor FLT3 0.0021
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0021
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
1992 Vitamin D-binding protein GC 0.0019
2981 Phospholipase A2, membrane associated PLA2G2A 0.0018
33 Cystine/glutamate transporter SLC7A11 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
319 Opioid receptor, sigma 1 OPRS1 0.0018
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0018
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0018
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
84 Nuclear receptor 0B1 NR0B1 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
683 Potassium transporter GK0582 0.0018
239 Coagulation factor X F10 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
4103 Proteasome subunit beta type 2 PSMB2 0.0017
4102 Proteasome subunit beta type 5 PSMB5 0.0017
4101 Proteasome subunit beta type 1 PSMB1 0.0017
1630 Integrin beta-2 ITGB2 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
1374 Natriuretic peptides B NPPB 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
106 Cannabinoid receptor 2 CNR2 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
6174 50S ribosomal protein L32 rpmF 0.0017
1196 Complement decay-accelerating factor CD55 0.0017
3809 Estrogen-related receptor gamma ESRRG 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
511 5-hydroxytryptamine 1F receptor HTR1F 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0015
273 Apoptosis regulator Bcl-2 BCL2 0.0015
3937 Fatty-acid amide hydrolase FAAH 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
2808 Chloramphenicol acetyltransferase 3 cat3 0.0014
6824 Tyrosine-protein kinase Lyn LYN 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
6044 Serum paraoxonase/lactonase 3 PON3 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
469 Annexin A1 ANXA1 0.0014
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
572 Integrin alpha-L ITGAL 0.0013
3808 Dihydropteroate synthase 2 folP2 0.0013
3601 Dihydropteroate synthase 1 folP1 0.0013
3807 Dihydropteroate synthase 1 folP1 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
2810 Dr hemagglutinin structural subunit draA 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0013
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
5924 Microtubule-associated protein 4 MAP4 0.0012
5923 Microtubule-associated protein tau MAPT 0.0012
3587 Gastrotropin FABP6 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1295 Fatty acid synthase FASN 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
5934 Cytochrome P450 26A1 CYP26A1 0.0011
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
605 Fumarate reductase flavoprotein subunit frdA 0.0011
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0011
3673 Fumarate reductase flavoprotein subunit fccA 0.0011
4912 Fumarate reductase flavoprotein subunit ifcA 0.0011
6549 Fumarate reductase flavoprotein subunit frdA 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.001
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.001
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
936 Ephrin type-A receptor 2 EPHA2 0.001
3957 Adenosine deaminase ADA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
444 Alcohol dehydrogenase 1B ADH1B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
2207 Rhodopsin RHO 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
267 Plasminogen activator inhibitor 1 SERPINE1 0.0008
1867 Major prion protein PRNP 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
1025 Aquaporin-1 AQP1 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
2298 Cytochrome P450-cam camC 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0007
6221 Steroid hormone receptor ERR1 ESRRA 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
3221 Cytochrome c4 cc4 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
162 Retinoic acid receptor gamma-1 RARG 0.0006
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1507 Cytochrome c CYCS 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
3917 Methylenetetrahydrofolate reductase MTHFR 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4943 Cytochrome c6 petJ 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
5000 HemO hemO 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4909 CooA protein cooA 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4942 Diheme cytochrome c napB napB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
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