DT-Web

DB04076 - Hypoxanthine


Identification
Name Hypoxanthine
Accession Number DB04076 (EXPT01767)
Type small molecule
Description A purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 135.1035
Groups experimental
Monoisotopic Weight 135.030685738
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Purine nucleoside phosphorylase
Name Purine nucleoside phosphorylase
Gene Name PNP
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4522

Predictions


Id Partner name Gene Name Score
2870 Purine nucleoside phosphorylase punA 1.4522
2945 Purine nucleoside phosphorylase punA 1.4522
4659 Purine nucleoside phosphorylase TM_1596 1.4522
4825 Purine nucleoside phosphorylase TTHA1435 1.4522
5421 Uridine phosphorylase, putative PFE0660c 0.0777
2257 Uridine phosphorylase udp 0.0489
5132 Uridine phosphorylase udp 0.0489
338 DNA polymerase UL30 0.0424
379 DNA polymerase UL54 0.0424
697 DNA polymerase ORF28 0.0424
2482 DNA polymerase 43 0.0424
4104 DNA polymerase BALF5 0.0424
1673 GTP cyclohydrolase I GCH1 0.0311
3302 GTP cyclohydrolase I folE 0.0311
2837 Xanthosine phosphorylase xapA 0.0273
3300 Xanthine phosphoribosyltransferase xpt 0.0238
3681 Xanthine phosphoribosyltransferase gpt 0.0238
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0238
1729 Solute carrier family 22 member 6 SLC22A6 0.0139
6111 DNA polymerase epsilon subunit 4 POLE4 0.0087
6112 DNA polymerase epsilon subunit 3 POLE3 0.0087
6110 DNA polymerase epsilon subunit 2 POLE2 0.0087
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0087
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0087
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0086
603 DNA polymerase alpha catalytic subunit POLA1 0.0065
6171 Solute carrier family 28 member 3 SLC28A3 0.0059
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0059
4773 Deoxycytidine kinase DCK 0.0052
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0033
6144 Solute carrier family 22 member 2 SLC22A2 0.0033
6145 Solute carrier family 22 member 1 SLC22A1 0.0033
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