DT-Web

DB02377 - Guanine


Identification
Name Guanine
Accession Number DB02377 (EXPT01672)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 150.1182
Groups experimental
Monoisotopic Weight 150.041584775
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Purine nucleoside phosphorylase
Name Purine nucleoside phosphorylase
Gene Name TM_1596
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.9838
Purine nucleoside phosphorylase
Name Purine nucleoside phosphorylase
Gene Name PNP
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.9838
Xanthosine phosphorylase
Name Xanthosine phosphorylase
Gene Name xapA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6649
Xanthine phosphoribosyltransferase
Name Xanthine phosphoribosyltransferase
Gene Name gpt
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6156
GTP cyclohydrolase I
Name GTP cyclohydrolase I
Gene Name GCH1
Pharmacological action unknown
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.0804

Predictions


Id Partner name Gene Name Score
2870 Purine nucleoside phosphorylase punA 1.9838
2945 Purine nucleoside phosphorylase punA 1.9838
4825 Purine nucleoside phosphorylase TTHA1435 1.9838
3300 Xanthine phosphoribosyltransferase xpt 1.6156
3302 GTP cyclohydrolase I folE 1.0804
3015 Pur operon repressor purR 0.1876
5421 Uridine phosphorylase, putative PFE0660c 0.0777
338 DNA polymerase UL30 0.0771
379 DNA polymerase UL54 0.0771
697 DNA polymerase ORF28 0.0771
2482 DNA polymerase 43 0.0771
4104 DNA polymerase BALF5 0.0771
2257 Uridine phosphorylase udp 0.0489
5132 Uridine phosphorylase udp 0.0489
2361 Response regulator pleD pleD 0.0433
2516 GMP reductase 1 GMPR 0.0432
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0377
4106 Guanylate kinase GUK1 0.0377
4516 Guanylate kinase gmk 0.0377
413 Amidophosphoribosyltransferase PPAT 0.0376
2515 Amidophosphoribosyltransferase purF 0.0376
3714 Amidophosphoribosyltransferase purF 0.0376
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0348
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0298
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0287
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0247
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0238
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0217
1729 Solute carrier family 22 member 6 SLC22A6 0.0139
6111 DNA polymerase epsilon subunit 4 POLE4 0.0087
6112 DNA polymerase epsilon subunit 3 POLE3 0.0087
6110 DNA polymerase epsilon subunit 2 POLE2 0.0087
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0087
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0087
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0086
603 DNA polymerase alpha catalytic subunit POLA1 0.0065
6171 Solute carrier family 28 member 3 SLC28A3 0.0059
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0059
4773 Deoxycytidine kinase DCK 0.0052
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0033
6144 Solute carrier family 22 member 2 SLC22A2 0.0033
6145 Solute carrier family 22 member 1 SLC22A1 0.0033
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