DT-Web

DB00520 - Caspofungin


Identification
Name Caspofungin
Accession Number DB00520 (APRD00199)
Type small molecule
Description Caspofungin (brand name Cancidas worldwide) is an antifungal drug, the first of a new class termed the echinocandins from Merck & Co., Inc. It shows activity against infections with Aspergillus and Candida, and works by inhibiting ?(1,3)-D-Glucan of the fungal cell wall. Caspofungin is administered intravenously.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 1093.3131
Groups approved
Monoisotopic Weight 1092.643062196
Pharmacology
Indication For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
Mechanism of action Caspofungin inhibits the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species. beta-(1,3)-D-glucan is not present in mammalian cells. The primary target is beta-(1,3)-glucan synthase.
Absorption 92% tissue distribution within 36-48 hours after intravenous infusion
Protein binding 97%
Biotransformation Metabolized slowly by hydrolysis and N-acetylation
Route of elimination After single intravenous administration of [3H] caspofungin acetate, excretion of caspofungin and its metabolites in humans was 35% of dose in feces and 41% of dose in urine.
Toxicity Side effects include rash, swelling, and nausea (rare)
Affected organisms
  • Aspergillis, Candida and other fungi
Interactions
Drug Interactions
Drug Mechanism of interaction
Cyclosporine Cyclosporine increases the effect and toxicity of caspofungin
Rifampin Decreased levels/effects of caspofungin
Tacrolimus Caspofungin may decrease the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Caspofungin therapy is initiated, discontinued or altered.
Food Interactions Not Available

Targets


1,3-beta-glucan synthase component FKS1
Name 1,3-beta-glucan synthase component FKS1
Gene Name fksA
Pharmacological action yes
Actions inhibitor
References
  • Sucher AJ, Chahine EB, Balcer HE: Echinocandins: the newest class of antifungals. Ann Pharmacother. 2009 Oct;43(10):1647-57. Epub 2009 Sep 1. - Pubmed
  • Morrison VA: Caspofungin: an overview. Expert Rev Anti Infect Ther. 2005 Oct;3(5):697-705. - Pubmed
  • McCormack PL, Perry CM: Caspofungin: a review of its use in the treatment of fungal infections. Drugs. 2005;65(14):2049-68. - Pubmed
  • Morris MI, Villmann M: Echinocandins in the management of invasive fungal infections, part 1. Am J Health Syst Pharm. 2006 Sep 15;63(18):1693-703. - Pubmed
  • Morris MI, Villmann M: Echinocandins in the management of invasive fungal infections, Part 2. Am J Health Syst Pharm. 2006 Oct 1;63(19):1813-20. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4125

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos. 2005 May;33(5):676-82. Epub 2005 Feb 16. - Pubmed
DTHybrid score 0.2253
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos. 2005 May;33(5):676-82. Epub 2005 Feb 16. - Pubmed
DTHybrid score 0.3609
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos. 2005 May;33(5):676-82. Epub 2005 Feb 16. - Pubmed
DTHybrid score 0.2871
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions inhibitor
References
  • Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos. 2005 May;33(5):676-82. Epub 2005 Feb 16. - Pubmed
DTHybrid score 0.3065
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions substrate
References
  • Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos. 2005 May;33(5):676-82. Epub 2005 Feb 16. - Pubmed
DTHybrid score 0.221

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.1525
4757 Cytochrome P450 2C9 CYP2C9 0.1437
4118 Cytochrome P450 3A5 CYP3A5 0.1399
4924 Cytochrome P450 2C8 CYP2C8 0.1328
6016 Cytochrome P450 2C19 CYP2C19 0.1284
4200 Cytochrome P450 1A2 CYP1A2 0.1235
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1218
6142 Solute carrier family 22 member 8 SLC22A8 0.1186
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1103
587 Serum albumin ALB 0.1083
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1069
6107 Cytochrome P450 3A7 CYP3A7 0.0929
6144 Solute carrier family 22 member 2 SLC22A2 0.0862
6030 Cytochrome P450 2B6 CYP2B6 0.0727
862 Multidrug resistance-associated protein 1 ABCC1 0.0676
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0672
1024 Solute carrier family 22 member 11 SLC22A11 0.0646
6024 Cytochrome P450 1A1 CYP1A1 0.0595
118 Organic cation/carnitine transporter 2 SLC22A5 0.0577
6143 Solute carrier family 22 member 7 SLC22A7 0.0577
20 Prostaglandin G/H synthase 1 PTGS1 0.054
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0535
6013 Cytochrome P450 2E1 CYP2E1 0.0524
2164 Multidrug resistance-associated protein 4 ABCC4 0.0521
776 Bile salt export pump ABCB11 0.0509
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0477
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0438
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0435
6147 Solute carrier family 22 member 3 SLC22A3 0.0418
833 Organic cation/carnitine transporter 1 SLC22A4 0.0412
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.04
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0396
70 Type-1 angiotensin II receptor AGTR1 0.0386
492 Histamine H1 receptor HRH1 0.0372
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0368
3587 Gastrotropin FABP6 0.036
290 Prostaglandin G/H synthase 2 PTGS2 0.0354
6141 Sodium/bile acid cotransporter SLC10A1 0.0351
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0349
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0338
5718 Cytochrome P450 2A6 CYP2A6 0.0332
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0316
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0316
556 Alpha-1A adrenergic receptor ADRA1A 0.0307
831 D(2) dopamine receptor DRD2 0.029
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0287
6148 Multidrug resistance-associated protein 7 ABCC10 0.0282
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0267
136 Estrogen receptor ESR1 0.0265
871 Glucocorticoid receptor NR3C1 0.0262
502 5-hydroxytryptamine 2A receptor HTR2A 0.0259
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0257
731 HIV-1 protease HIV-1 protease 0.0252
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0247
738 Monocarboxylate transporter 1 SLC16A1 0.0243
3811 Cytochrome P450 19A1 CYP19A1 0.0243
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0233
1898 Cytochrome P450 1B1 CYP1B1 0.0232
540 Sodium-dependent noradrenaline transporter SLC6A2 0.023
320 5-hydroxytryptamine 1A receptor HTR1A 0.023
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0222
23 D(1A) dopamine receptor DRD1 0.022
758 Thyroid hormone receptor alpha THRA 0.022
824 Sodium-dependent serotonin transporter SLC6A4 0.0219
29 Tubulin beta-1 chain TUBB1 0.0216
3923 Cholinesterase BCHE 0.0212
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.021
6167 Organic solute transporter subunit beta OSTB 0.0208
6166 Organic solute transporter subunit alpha OSTA 0.0208
632 Alpha-1B adrenergic receptor ADRA1B 0.0207
6106 Cytochrome P450 2C18 CYP2C18 0.0207
338 DNA polymerase UL30 0.0201
379 DNA polymerase UL54 0.0201
697 DNA polymerase ORF28 0.0201
2482 DNA polymerase 43 0.0201
4104 DNA polymerase BALF5 0.0201
766 Beta-2 adrenergic receptor ADRB2 0.02
373 Transthyretin TTR 0.0199
346 Thyroid hormone receptor beta-1 THRB 0.0197
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0197
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0196
594 Thyroxine-binding globulin SERPINA7 0.0194
404 DNA gyrase subunit A gyrA 0.0193
6224 DNA gyrase subunit A gyrA 0.0193
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0192
193 Beta-1 adrenergic receptor ADRB1 0.0192
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.019
318 Alpha-2A adrenergic receptor ADRA2A 0.0187
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0176
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0175
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0175
6136 Multidrug resistance-associated protein 5 ABCC5 0.0174
592 Carbonic anhydrase 4 CA4 0.0173
4604 Liver carboxylesterase 1 CES1 0.0171
633 Penicillin-binding proteins 1A/1B pbpA 0.0169
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0167
295 Carbonic anhydrase 1 CA1 0.0163
474 Acetylcholinesterase ACHE 0.0159
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0151
847 Mu-type opioid receptor OPRM1 0.0149
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0149
817 DNA topoisomerase 2-alpha TOP2A 0.0145
789 Alpha-1D adrenergic receptor ADRA1D 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
378 Alpha-2C adrenergic receptor ADRA2C 0.0143
629 Alpha-2B adrenergic receptor ADRA2B 0.0143
341 5-hydroxytryptamine 3 receptor HTR3A 0.0141
220 Sodium channel protein type 5 subunit alpha SCN5A 0.014
357 Carbonic anhydrase 2 CA2 0.014
2539 Tubulin alpha-1 chain TUBA4A 0.0136
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0135
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0132
467 Delta-type opioid receptor OPRD1 0.0132
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0128
756 Sex hormone-binding globulin SHBG 0.0128
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
3941 Amine oxidase [flavin-containing] A MAOA 0.0122
124 Histamine H2 receptor HRH2 0.0121
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0121
723 Cytosolic phospholipase A2 PLA2G4A 0.012
4148 Serine/threonine-protein kinase mTOR MTOR 0.0118
477 DNA topoisomerase 4 subunit A parC 0.0118
886 DNA topoisomerase 4 subunit A parC 0.0118
6226 DNA topoisomerase 4 subunit A parC 0.0118
869 Estrogen receptor beta ESR2 0.0117
885 5-hydroxytryptamine 1B receptor HTR1B 0.0116
725 5-hydroxytryptamine 1D receptor HTR1D 0.0114
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0114
696 Kappa-type opioid receptor OPRK1 0.0113
614 Progesterone receptor PGR 0.0112
260 Cytochrome P450 51 ERG11 0.0112
761 Cytochrome P450 51 ERG11 0.0112
3163 Cytochrome P450 51 cyp51 0.0112
199 Monocarboxylate transporter 8 SLC16A2 0.0111
672 Prostaglandin F2-alpha receptor PTGFR 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
1852 Microtubule-associated protein 2 MAP2 0.011
275 Arachidonate 5-lipoxygenase ALOX5 0.0108
6031 Cytochrome P450 3A43 CYP3A43 0.0108
645 Penicillin-binding protein 1A mrcA 0.0107
5805 Penicillin-binding protein 1A ponA 0.0107
6185 Penicillin-binding protein 1A mrcA 0.0107
6799 Penicillin-binding protein 1A pbpA 0.0107
33 Cystine/glutamate transporter SLC7A11 0.0107
4773 Deoxycytidine kinase DCK 0.0104
244 Angiotensin-converting enzyme ACE 0.0104
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0103
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
26 Vascular endothelial growth factor receptor 3 FLT4 0.0103
952 Dipeptidyl peptidase 4 DPP4 0.0103
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0101
140 30S ribosomal protein S9 rpsI 0.01
6719 30S ribosomal protein S9 rpsI 0.01
6725 30S ribosomal protein S9 rpsI 0.01
6149 Solute carrier family 22 member 10 SLC22A10 0.0099
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0099
32 Vascular endothelial growth factor receptor 1 FLT1 0.0098
713 Sodium-dependent dopamine transporter SLC6A3 0.0098
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0097
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0097
468 Cytochrome P450 4A11 CYP4A11 0.0097
407 Vascular endothelial growth factor receptor 2 KDR 0.0094
590 5-hydroxytryptamine 2C receptor HTR2C 0.0094
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0094
6126 Carbonic anhydrase 7 CA7 0.0094
638 D(3) dopamine receptor DRD3 0.0094
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
5923 Microtubule-associated protein tau MAPT 0.0092
5924 Microtubule-associated protein 4 MAP4 0.0092
232 Corticosteroid-binding globulin SERPINA6 0.0091
273 Apoptosis regulator Bcl-2 BCL2 0.0091
24 Thymidylate synthase TMP1 0.009
359 Thymidylate synthase TYMS 0.009
2626 Thymidylate synthase thyA 0.009
2729 Thymidylate synthase thyA 0.009
5352 Thymidylate synthase THYA 0.009
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
6182 Cytochrome P450 2J2 CYP2J2 0.0088
465 Calmodulin CALM1 0.0086
3939 Amine oxidase [flavin-containing] B MAOB 0.0086
504 Mast/stem cell growth factor receptor KIT 0.0086
6137 Multidrug resistance-associated protein 6 ABCC6 0.0086
3947 Xanthine dehydrogenase/oxidase XDH 0.0085
818 50S ribosomal protein L10 rplJ 0.0085
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0083
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
146 Androgen receptor AR 0.0083
5626 Nucleoside diphosphate kinase B NME2 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0082
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0081
5880 Thrombopoietin receptor MPL 0.0081
1353 DNA topoisomerase 1 TOP1 0.0081
3552 DNA topoisomerase 1 topA 0.0081
22 30S ribosomal protein S4 rpsD 0.0081
6714 30S ribosomal protein S4 rpsD 0.0081
436 5-hydroxytryptamine 2B receptor HTR2B 0.008
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0079
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0078
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0078
6151 Monocarboxylate transporter 10 SLC16A10 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
543 Penicillin-binding protein 1B mrcB 0.0077
6186 Penicillin-binding protein 1B ponB 0.0077
6822 Penicillin-binding protein 1b pbp1b 0.0077
6844 Penicillin-binding protein 1b pbp1b 0.0077
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0076
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0074
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0074
844 Epidermal growth factor receptor EGFR 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
161 Tubulin beta chain TUBB 0.0073
312 Tubulin beta chain TUB2 0.0073
3917 Methylenetetrahydrofolate reductase MTHFR 0.0073
228 Beta platelet-derived growth factor receptor PDGFRB 0.0072
380 Cytochrome P450 17A1 CYP17A1 0.0072
122 P2Y purinoceptor 12 P2RY12 0.0072
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0071
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0071
1192 Sulfotransferase 1A1 SULT1A1 0.0071
768 FK506-binding protein 1A FKBP1A 0.007
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0069
6085 Fatty acid-binding protein, intestinal FABP2 0.0069
2320 Thymidine kinase, cytosolic TK1 0.0067
5294 Nucleoside diphosphate kinase A NME1 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0066
1757 Myeloperoxidase MPO 0.0066
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
432 D(4) dopamine receptor DRD4 0.0066
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0066
284 DNA-directed RNA polymerase beta chain rpoB 0.0066
5773 DNA-directed RNA polymerase beta chain rpoB 0.0066
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0065
277 Purine nucleoside phosphorylase PNP 0.0064
2870 Purine nucleoside phosphorylase punA 0.0064
2945 Purine nucleoside phosphorylase punA 0.0064
4659 Purine nucleoside phosphorylase TM_1596 0.0064
4825 Purine nucleoside phosphorylase TTHA1435 0.0064
6220 Aryl hydrocarbon receptor AHR 0.0064
6020 Aldehyde oxidase AOX1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0063
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
293 Gamma-glutamyl hydrolase GGH 0.0062
4237 50S ribosomal protein L22 rplV 0.0062
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0062
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0062
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0062
6014 Cytochrome P450 2A13 CYP2A13 0.0062
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0062
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0062
4120 NADPH--cytochrome P450 reductase POR 0.0062
6043 Putative G-protein coupled receptor 44 GPR44 0.0062
3932 Glutathione S-transferase A2 GSTA2 0.0062
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.006
737 Mineralocorticoid receptor NR3C2 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0059
558 Solute carrier family 12 member 1 SLC12A1 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
3810 Catechol O-methyltransferase COMT 0.0058
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0058
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0058
6171 Solute carrier family 28 member 3 SLC28A3 0.0058
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0057
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0057
2449 Tubulin alpha-3 chain TUBA1A 0.0056
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0056
1650 Heme carrier protein 1 SLC46A1 0.0056
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0055
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0054
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0054
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0054
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0054
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0054
3809 Estrogen-related receptor gamma ESRRG 0.0053
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0053
511 5-hydroxytryptamine 1F receptor HTR1F 0.0053
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0053
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0053
163 D(1B) dopamine receptor DRD5 0.0052
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0052
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0051
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0051
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0051
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0051
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0051
694 Matrix protein 2 M 0.0051
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0051
716 5-hydroxytryptamine 7 receptor HTR7 0.0051
131 Synaptic vesicular amine transporter SLC18A2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0051
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0051
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
5818 Folate receptor alpha FOLR1 0.005
365 Dihydrofolate reductase DHFR 0.005
2381 Dihydrofolate reductase DFR1 0.005
2833 Dihydrofolate reductase Not Available 0.005
2931 Dihydrofolate reductase folA 0.005
3544 Dihydrofolate reductase folA 0.005
3682 Dihydrofolate reductase folA 0.005
6642 Dihydrofolate reductase folA 0.005
6756 Dihydrofolate reductase dfrA 0.005
777 Tumor necrosis factor TNF 0.005
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.005
1525 Heparin-binding growth factor 2 FGF2 0.0048
4238 50S ribosomal protein L4 rplD 0.0047
5578 50S ribosomal protein L4 rplD 0.0047
6173 50S ribosomal protein L4 rplD 0.0047
6219 50S ribosomal protein L4 rplD 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0047
683 Potassium transporter GK0582 0.0047
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0046
1760 Aminopeptidase N ANPEP 0.0046
6843 Aminopeptidase N pepN 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
68 Cannabinoid receptor 1 CNR1 0.0045
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0045
3611 Cytidine deaminase cdd 0.0045
3707 Cytidine deaminase cdd 0.0045
4211 Cytidine deaminase CDA 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
3856 Fibroblast growth factor receptor 3 FGFR3 0.0045
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0045
811 Translocator protein TSPO 0.0044
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0044
563 Thyroid peroxidase TPO 0.0044
6131 Carbonic anhydrase 14 CA14 0.0044
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
702 UMP-CMP kinase CMPK1 0.0044
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0044
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
65 Matrix metalloproteinase-9 Not Available 0.0043
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0043
6138 Multidrug resistance protein 3 ABCB4 0.0043
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
2391 Ferrochelatase hemH 0.0042
6502 Ferrochelatase DKFZp686P18130 0.0042
1591 Ferrochelatase, mitochondrial FECH 0.0042
1830 5'-nucleotidase NT5E 0.0042
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0042
4203 Histamine N-methyltransferase HNMT 0.0042
115 Penicillin-binding protein 2 mrdA 0.0041
6069 Penicillin-binding protein 2 mrdA 0.0041
6118 Penicillin-binding protein 2 penA 0.0041
6187 Penicillin-binding protein 2 pbpA 0.0041
6686 Penicillin-binding protein 2 pbp2 0.0041
6939 Penicillin-binding protein 2 mrdA 0.0041
7163 Penicillin-binding protein 2 pbpA 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
6122 Carbonic anhydrase 3 CA3 0.0041
6070 Nischarin NISCH 0.0041
408 Riboflavin kinase RFK 0.0041
125 DNA polymerase beta POLB 0.0041
1656 CYP2B protein CYP2B 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.004
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.004
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.004
6432 Transporter snf 0.0039
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0039
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0039
1517 Beta-3 adrenergic receptor ADRB3 0.0039
814 Ryanodine receptor 1 RYR1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0039
1 Peptidoglycan synthetase ftsI ftsI 0.0038
4155 Peptidoglycan synthetase ftsI ftsI 0.0038
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0038
2472 Voltage-gated potassium channel kcsA 0.0038
6366 Voltage-gated potassium channel kcsA 0.0038
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0038
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0038
904 Glutathione S-transferase P GSTP1 0.0037
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0037
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0037
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0037
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0037
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0037
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0037
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0037
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0037
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0037
6493 Cytochrome c oxidase subunit 6C COX6C 0.0037
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0037
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0037
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0037
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0037
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0037
6559 Cytochrome c oxidase subunit 2 ctaC 0.0037
6669 Cytochrome c oxidase subunit 2 ctaC 0.0037
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0037
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0037
6558 Cytochrome c oxidase subunit 1 ctaD 0.0037
707 72 kDa type IV collagenase MMP2 0.0036
1867 Major prion protein PRNP 0.0036
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0036
751 Potassium channel subfamily K member 6 KCNK6 0.0036
164 Histamine H4 receptor HRH4 0.0036
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0036
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0036
856 Vitamin D3 receptor VDR 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
1630 Integrin beta-2 ITGB2 0.0035
828 Phenylalanine-4-hydroxylase PAH 0.0035
3109 Phenylalanine-4-hydroxylase phhA 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
1025 Aquaporin-1 AQP1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
4122 Histone deacetylase 2 HDAC2 0.0035
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0034
3007 Carbonic anhydrase 12 CA12 0.0034
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0034
4205 Carbonic anhydrase 9 CA9 0.0034
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0034
2540 Choloylglycine hydrolase cbh 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1341 Histamine H3 receptor HRH3 0.0033
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0033
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0033
172 Potassium channel subfamily K member 1 KCNK1 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
130 Prostacyclin synthase PTGIS 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
6102 Arylamine N-acetyltransferase 2 NAT2 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
1714 Mitogen-activated protein kinase 3 MAPK3 0.0032
6168 Solute carrier family 22 member 16 SLC22A16 0.0031
6501 Fatty acid-binding protein, liver FABP1 0.0031
976 Platelet glycoprotein IX GP9 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
6207 30S ribosomal protein S14 rpsN 0.0031
6209 30S ribosomal protein S19 rpsS 0.0031
6712 30S ribosomal protein S19 rpsS 0.0031
6726 30S ribosomal protein S19 rpsS 0.0031
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0031
1050 Bile salt sulfotransferase SULT2A1 0.0031
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6218 Pannexin-1 PANX1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.003
239 Coagulation factor X F10 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
1618 High affinity nerve growth factor receptor NTRK1 0.003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
654 Flavin reductase BLVRB 0.0029
5126 Arginase rocF 0.0029
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0029
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0029
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0029
183 Vascular endothelial growth factor A VEGFA 0.0029
1629 Transcription factor AP-1 JUN 0.0029
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
319 Opioid receptor, sigma 1 OPRS1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0028
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0028
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0028
2300 Lysozyme E 0.0028
3633 Lysozyme R 0.0028
5597 Lysozyme 17 0.0028
3426 Glutamine synthetase glnA 0.0027
3987 Glutamine synthetase GLUL 0.0027
4103 Proteasome subunit beta type 2 PSMB2 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
1196 Complement decay-accelerating factor CD55 0.0027
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0027
572 Integrin alpha-L ITGAL 0.0027
6111 DNA polymerase epsilon subunit 4 POLE4 0.0027
3685 Catabolite gene activator crp 0.0027
1010 Cytochrome P450 51A1 CYP51A1 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
6112 DNA polymerase epsilon subunit 3 POLE3 0.0027
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0026
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0026
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0026
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0026
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0026
6110 DNA polymerase epsilon subunit 2 POLE2 0.0026
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0026
6500 Phospholipase A2 PLA2G1B 0.0026
6824 Tyrosine-protein kinase Lyn LYN 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
1178 Adenosine A2a receptor ADORA2A 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
49 Endothelin B receptor EDNRB 0.0026
517 Alcohol dehydrogenase 1C ADH1C 0.0026
427 Substance-P receptor TACR1 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
551 Carnitine O-acetyltransferase CRAT 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0025
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0025
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0025
908 Glutathione S-transferase theta-1 GSTT1 0.0025
760 Fibroblast growth factor 1 FGF1 0.0024
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
705 Glutamate receptor 1 GRIA1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
4217 Telomerase reverse transcriptase TERT 0.0024
528 5-hydroxytryptamine 1E receptor HTR1E 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2808 Chloramphenicol acetyltransferase 3 cat3 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
165 FL cytokine receptor FLT3 0.0024
1256 5-hydroxytryptamine 6 receptor HTR6 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
489 Monocarboxylate transporter 2 SLC16A7 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0023
5816 Cadherin-5 CDH5 0.0023
896 Glutathione S-transferase Mu 1 GSTM1 0.0023
153 Dopamine beta-hydroxylase DBH 0.0023
1864 RET proto-oncogene RET 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0023
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0023
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0023
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0023
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0023
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0023
4760 Mll3241 protein mll3241 0.0023
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6146 High affinity copper uptake protein 1 SLC31A1 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
2417 Chloramphenicol acetyltransferase cat 0.0022
3278 Chloramphenicol acetyltransferase cat 0.0022
2810 Dr hemagglutinin structural subunit draA 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0021
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
527 Prostacyclin receptor PTGIR 0.0021
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0021
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0021
267 Plasminogen activator inhibitor 1 SERPINE1 0.002
780 Retinoic acid receptor RXR-gamma RXRG 0.002
603 DNA polymerase alpha catalytic subunit POLA1 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
1360 Sphingomyelin phosphodiesterase SMPD1 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
6165 Copper-transporting ATPase 1 ATP7A 0.0019
6163 Copper-transporting ATPase 2 ATP7B 0.0019
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0019
54 Prothrombin F2 0.0019
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
1654 Interleukin-1 beta IL1B 0.0019
2981 Phospholipase A2, membrane associated PLA2G2A 0.0019
6221 Steroid hormone receptor ERR1 ESRRA 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
88 Retinoic acid receptor RXR-beta RXRB 0.0019
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0018
2112 Toll-like receptor 9 TLR9 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
469 Annexin A1 ANXA1 0.0018
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
712 Tubulin alpha chain TUB1 0.0018
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0018
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0018
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0018
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
1275 Estrogen sulfotransferase SULT1E1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
16 Adenosine A1 receptor ADORA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
5682 Ribonuclease pancreatic RNASE1 0.0017
2021 Thrombomodulin THBD 0.0017
1074 Urokinase-type plasminogen activator PLAU 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
106 Cannabinoid receptor 2 CNR2 0.0016
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0016
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0016
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0016
1686 Choline transporter-like protein 1 SLC44A1 0.0016
3926 Choline transporter-like protein 2 SLC44A2 0.0016
861 Choline kinase alpha CHKA 0.0016
3927 Choline transporter-like protein 3 SLC44A3 0.0016
769 High-affinity choline transporter 1 SLC5A7 0.0016
700 Choline dehydrogenase, mitochondrial CHDH 0.0016
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0016
3925 Choline transporter-like protein 4 SLC44A4 0.0016
576 Choline O-acetyltransferase CHAT 0.0016
3922 Phospholipase D2 PLD2 0.0016
3924 Phospholipase D1 PLD1 0.0016
6174 50S ribosomal protein L32 rpmF 0.0016
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0016
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0016
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
2408 Tyrosine-protein kinase SYK SYK 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3233 Bile acid receptor NR1H4 0.0015
4192 DNA topoisomerase 2-beta TOP2B 0.0015
494 Caspase-1 CASP1 0.0015
6755 Poliovirus receptor PVR 0.0015
634 Squalene monooxygenase SQLE 0.0015
7196 Squalene monooxygenase ERG1 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
1507 Cytochrome c CYCS 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
1541 Metalloproteinase mmp20 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0014
822 Aldose reductase AKR1B1 0.0014
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0013
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0013
823 Fibroblast growth factor receptor 2 FGFR2 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
921 Glutamate receptor 2 GRIA2 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0013
2077 Caspase-3 CASP3 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
819 Penicillin-binding protein 4 dacB 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
6042 Prostaglandin reductase 2 PTGR2 0.0012
85 Growth hormone receptor GHR 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
1039 Histone deacetylase 9 HDAC9 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
1295 Fatty acid synthase FASN 0.0012
3957 Adenosine deaminase ADA 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
6859 Protein S100-A4 S100A4 0.0012
2236 Casein kinase II subunit alpha CSNK2A1 0.0012
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
7 Nitric oxide synthase, inducible NOS2 0.0011
1792 Tissue-type plasminogen activator PLAT 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0011
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6459 Glycodelin PAEP 0.0011
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0011
4311 tRNA TRDMT1 0.0011
4325 tRNA trmD 0.0011
4328 tRNA trmD 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
1374 Natriuretic peptides B NPPB 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
997 Protein kinase C beta type PRKCB 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
162 Retinoic acid receptor gamma-1 RARG 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
1313 Lactoylglutathione lyase GLO1 0.0009
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0009
84 Nuclear receptor 0B1 NR0B1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
94 5-hydroxytryptamine 4 receptor HTR4 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
229 Retinoic acid receptor beta RARB 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
291 Nitric-oxide synthase, endothelial NOS3 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
2207 Rhodopsin RHO 0.0007
5934 Cytochrome P450 26A1 CYP26A1 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2298 Cytochrome P450-cam camC 0.0007
518 Peroxidase/catalase T katG 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
3937 Fatty-acid amide hydrolase FAAH 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
1992 Vitamin D-binding protein GC 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
268 Adenosine A2b receptor ADORA2B 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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