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DB03804 - 5-Bromothienyldeoxyuridine


Identification
Name 5-Bromothienyldeoxyuridine
Accession Number DB03804 (EXPT00766)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 389.222
Groups experimental
Monoisotopic Weight 387.972854873
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Thymidine kinase
Name Thymidine kinase
Gene Name TK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2077

Predictions


Id Partner name Gene Name Score
509 Thymidine kinase TK 1.2077
570 Thymidine kinase TK 1.2077
3430 Thymidine kinase tdk 1.2077
3518 Thymidine kinase TK 1.2077
5301 Thymidine kinase tdk 1.2077
5771 Thymidine kinase ORF36 1.2077
7009 Thymidine kinase ORF36 1.2077
2251 Thymidylate kinase tmk 0.0534
2254 Thymidylate kinase DTYMK 0.0534
3522 Thymidylate kinase tmk 0.0534
338 DNA polymerase UL30 0.0289
379 DNA polymerase UL54 0.0289
697 DNA polymerase ORF28 0.0289
2482 DNA polymerase 43 0.0289
4104 DNA polymerase BALF5 0.0289
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0288
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0288
6145 Solute carrier family 22 member 1 SLC22A1 0.024
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0204
4275 PCZA361.16 Not Available 0.0175
4276 DNA polymerase III subunit epsilon dnaQ 0.0174
6142 Solute carrier family 22 member 8 SLC22A8 0.0168
1353 DNA topoisomerase 1 TOP1 0.0157
3552 DNA topoisomerase 1 topA 0.0157
1729 Solute carrier family 22 member 6 SLC22A6 0.0153
2257 Uridine phosphorylase udp 0.0146
5132 Uridine phosphorylase udp 0.0146
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.013
6171 Solute carrier family 28 member 3 SLC28A3 0.0129
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0112
6143 Solute carrier family 22 member 7 SLC22A7 0.0108
24 Thymidylate synthase TMP1 0.0097
359 Thymidylate synthase TYMS 0.0097
2626 Thymidylate synthase thyA 0.0097
2729 Thymidylate synthase thyA 0.0097
5352 Thymidylate synthase THYA 0.0097
5287 Signaling protein Not Available 0.0018
2874 Nitrogenase iron protein 1 nifH1 0.0018
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0018
5292 Putative partitioning protein TT_C1605 0.0018
5293 Shikimate kinase 2 aroL 0.0018
5288 Shikimate kinase aroK 0.0018
5304 UPF0166 protein TM_0021 TM_0021 0.0018
5266 Activator of hgdC 0.0018
3199 Phosphopantetheine adenylyltransferase coaD 0.0018
3543 Phosphopantetheine adenylyltransferase coaD 0.0018
3567 Phosphopantetheine adenylyltransferase coaD 0.0018
5289 Phosphopantetheine adenylyltransferase coaD 0.0018
4346 Polynucleotide kinase pseT 0.0018
5283 D-alanine--D-alanine ligase B ddlB 0.0018
5291 Glycogen synthase 1 glgA1 0.0018
5281 Plasmid segregation protein parM parM 0.0018
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0018
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0018
5299 D-alanine--D-alanine ligase ddl 0.0018
6598 D-alanine--D-alanine ligase ddl 0.0018
5276 Chromosomal replication initiator protein dnaA dnaA 0.0018
5259 Transcriptional regulator ntrC1 0.0018
6699 Transcriptional regulator Cgl2612 0.0018
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0018
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0018
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0018
5264 DNA replication protein REP 0.0018
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0018
5315 Chaperone protein htpG htpG 0.0018
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0018
5284 Large T antigen Not Available 0.0018
5308 Preprotein translocase secA 1 subunit secA1 0.0018
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0018
5285 Kinesin heavy chain KIF5B 0.0018
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0018
5261 Phosphoribosylformylglycinamidine synthase purL 0.0018
5277 Preprotein translocase subunit secA secA 0.0018
4106 Guanylate kinase GUK1 0.0016
4516 Guanylate kinase gmk 0.0016
413 Amidophosphoribosyltransferase PPAT 0.0016
2515 Amidophosphoribosyltransferase purF 0.0016
3714 Amidophosphoribosyltransferase purF 0.0016
4837 Cag-alfa cag-alfa 0.0016
5646 Galactokinase GALK1 0.0016
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0016
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0016
5302 TrwB trwB 0.0016
4774 NTPase P4 Not Available 0.0016
5265 FtsH ftsH 0.0016
4839 DNA polymerase III subunit tau dnaX 0.0016
4838 PMS1 protein homolog 2 PMS2 0.0016
2270 Dephospho-CoA kinase coaE 0.0016
5189 Trimethylamine dehydrogenase tmd 0.0016
6277 Heat shock cognate 71 kDa protein HSPA8 0.0016
2284 Adenylate kinase adk 0.0016
2296 Adenylate kinase adk 0.0016
2311 Adenylate kinase adk 0.0016
2312 Adenylate kinase Not Available 0.0016
3470 Hypothetical protein MG245 homolog MPN_348 0.0015
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0015
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0015
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0015
3175 Glutamate--cysteine ligase gshA 0.0015
3426 Glutamine synthetase glnA 0.0015
3987 Glutamine synthetase GLUL 0.0015
2683 Mono-ADP-ribosyltransferase C3 C3 0.0014
2390 Nonsecretory ribonuclease RNASE2 0.0014
5312 Kinesin-like protein KIF1A KIF1A 0.0014
2922 Glycerol kinase glpK 0.0014
5271 Focal adhesion kinase 1 PTK2 0.0014
340 Apoptotic protease-activating factor 1 APAF1 0.0014
2615 Chemotaxis protein cheA cheA 0.0013
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
2282 Protein recA recA 0.0013
2315 Protein recA recA 0.0013
2332 Protein recA recA 0.0013
5263 Protein recA recA 0.0013
2371 Pantothenate kinase coaA 0.0013
1881 Hexokinase-1 HK1 0.0013
3669 Ribokinase rbsK 0.0013
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0013
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0013
2892 Acetylglutamate kinase argB 0.0013
3550 Acetylglutamate kinase argB 0.0013
5300 Antigen peptide transporter 1 TAP1 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0013
408 Riboflavin kinase RFK 0.0013
2727 S-adenosylmethionine synthetase metK 0.0013
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0013
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0013
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0012
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0012
2697 Uridine-cytidine kinase 2 UCK2 0.0012
788 Creatine kinase M-type CKM 0.0012
2334 Dethiobiotin synthetase bioD 0.0012
6555 Dethiobiotin synthetase bioD 0.0012
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0012
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0012
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0012
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0011
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0011
702 UMP-CMP kinase CMPK1 0.0011
48 Pyridoxal kinase PDXK 0.0011
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0011
6395 Myosin-14 MYH14 0.0011
2091 Endoplasmin HSP90B1 0.0011
1422 Serine/threonine-protein kinase 6 AURKA 0.0011
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0011
3379 Kinesin-like protein KIF11 KIF11 0.001
3456 Heat shock protein HSP 90-beta HSP90AB1 0.001
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.001
207 Glutathione synthetase GSS 0.001
5269 Glutathione synthetase gshB 0.001
3822 Actin, alpha skeletal muscle ACTA1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
504 Mast/stem cell growth factor receptor KIT 0.001
1721 Glycogen synthase kinase-3 beta GSK3B 0.0009
4773 Deoxycytidine kinase DCK 0.0009
5682 Ribonuclease pancreatic RNASE1 0.0009
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0008
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0008
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