DT-Web: DB01147

Identification

Name

Cloxacillin

Accession Number

DB01147 (APRD00882, EXPT01068)

Type

small molecule

Description

A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

435.881

Groups

approved

Monoisotopic Weight

435.065569098

Pharmacology

Indication

Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.

Mechanism of action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor.

Absorption

Well absorbed from the gastrointestinal tract.

Protein binding

95%

Biotransformation

Not Available

Route of elimination

Not Available

Toxicity

Oral LD₅₀ in rat and mouse is 5000 mg/kg. Intravenous LD₅₀ in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.

Affected organisms

Enteric bacteria and other eubacteria

Interactions

Drug Interactions

Drug	Mechanism of interaction
Demeclocycline	Possible antagonism of action
Doxycycline	Possible antagonism of action
Ethinyl Estradiol	This anti-infectious agent could decrease the effect of the oral contraceptive
Mestranol	This anti-infectious agent could decrease the effect of the oral contraceptive
Methacycline	Possible antagonism of action
Methotrexate	The penicillin increases the effect and toxicity of methotrexate
Minocycline	Possible antagonism of action
Oxytetracycline	Possible antagonism of action
Rolitetracycline	Possible antagonism of action
Tetracycline	Possible antagonism of action

Food Interactions

Take on an empty stomach.

Penicillin-binding proteins 1A/1B
Name	Penicillin-binding proteins 1A/1B
Gene Name	pbpA
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Kleppe G, Yu W, Strominger JL: Penicillin-binding proteins in Bacillus subtilis mutants. Antimicrob Agents Chemother. 1982 Jun;21(6):979-83. - Pubmed
DTHybrid score	0.962
Beta-lactamase
Name	Beta-lactamase
Gene Name	ampC
Pharmacological action	unknown
Actions	inducer
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Mirelis B, Rivera A, Miro E, Mesa RJ, Navarro F, Coll P: A simple phenotypic method for differentiation between acquired and chromosomal AmpC beta-lactamases in Escherichia coli. Enferm Infecc Microbiol Clin. 2006 Jun-Jul;24(6):370-2. - Pubmed Ruppe E, Bidet P, Verdet C, Arlet G, Bingen E: First detection of the Ambler class C 1 AmpC beta-lactamase in Citrobacter freundii by a new, simple double-disk synergy test. J Clin Microbiol. 2006 Nov;44(11):4204-7. Epub 2006 Sep 13. - Pubmed Guan XZ, Liu YN, Luo YP, She DY, Zhou G, Chen LA, Xu YP: [A new member of CMY type cephalosporinase prevailing in Escherichia coli.] Zhonghua Yi Xue Za Zhi. 2004 Nov 17;84(22):1872-5. - Pubmed
DTHybrid score	0.0166
Penicillin-binding protein 2a
Name	Penicillin-binding protein 2a
Gene Name	pbp2a
Pharmacological action	yes
Actions	inhibitor
References	Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score	Not Available
Penicillin-binding protein 2B
Name	Penicillin-binding protein 2B
Gene Name	penA
Pharmacological action	yes
Actions	inhibitor
References	Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score	0.5081
Penicillin-binding protein 3
Name	Penicillin-binding protein 3
Gene Name	pbpB
Pharmacological action	yes
Actions	inhibitor
References	Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37. - Pubmed
DTHybrid score	0.0102
Penicillin-binding protein 5
Name	Penicillin-binding protein 5
Gene Name	dacA
Pharmacological action	unknown
Actions	inhibitor
References	Nicola G, Tomberg J, Pratt RF, Nicholas RA, Davies C: Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity. Biochemistry. 2010 Sep 21;49(37):8094-104. - Pubmed
DTHybrid score	0.6382

Oligopeptide transporter, small intestine isoform
Name	Oligopeptide transporter, small intestine isoform
Gene Name	SLC15A1
Actions	inhibitor
References	Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score	0.6777
Oligopeptide transporter, kidney isoform
Name	Oligopeptide transporter, kidney isoform
Gene Name	SLC15A2
Actions	inhibitor
References	Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score	0.6711
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
DTHybrid score	0.4328

Oligopeptide transporter, small intestine isoform
Name	Oligopeptide transporter, small intestine isoform
Gene Name	SLC15A1
Actions
References	Not Available
DTHybrid score	0.6777
Oligopeptide transporter, kidney isoform
Name	Oligopeptide transporter, kidney isoform
Gene Name	SLC15A2
Actions
References	Not Available
DTHybrid score	0.6711
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions
References	Not Available
DTHybrid score	0.4328

Id	Partner name	Gene Name	Score
6121	Penicillin-binding protein 2B	penA	0.5081
3760	Penicillin-binding protein 5 precursor	dacA	0.3329
3403	Penicillin-binding protein 2X	pbpX	0.2718
4154	Penicillin-binding protein 2x	pbpX	0.2718
244	Angiotensin-converting enzyme	ACE	0.1799
118	Organic cation/carnitine transporter 2	SLC22A5	0.122
6142	Solute carrier family 22 member 8	SLC22A8	0.1188
4512	Cytochrome P450 3A4	CYP3A4	0.0889
1	Peptidoglycan synthetase ftsI	ftsI	0.0882
4155	Peptidoglycan synthetase ftsI	ftsI	0.0882
1024	Solute carrier family 22 member 11	SLC22A11	0.0877
4629	Beta-lactamase CTX-M-9a	blaCTX-M-9a	0.0803
1588	Multidrug resistance protein 1	ABCB1	0.0692
4757	Cytochrome P450 2C9	CYP2C9	0.06
645	Penicillin-binding protein 1A	mrcA	0.0584
5805	Penicillin-binding protein 1A	ponA	0.0584
6185	Penicillin-binding protein 1A	mrcA	0.0584
6799	Penicillin-binding protein 1A	pbpA	0.0584
6016	Cytochrome P450 2C19	CYP2C19	0.058
6143	Solute carrier family 22 member 7	SLC22A7	0.0561
20	Prostaglandin G/H synthase 1	PTGS1	0.0538
543	Penicillin-binding protein 1B	mrcB	0.0458
6186	Penicillin-binding protein 1B	ponB	0.0458
6822	Penicillin-binding protein 1b	pbp1b	0.0458
6844	Penicillin-binding protein 1b	pbp1b	0.0458
290	Prostaglandin G/H synthase 2	PTGS2	0.043
6067	Penicillin binding protein 2a	mecA	0.0414
1757	Myeloperoxidase	MPO	0.041
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0401
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0384
2858	Beta-lactamase TEM	bla	0.0383
6396	Beta-lactamase TEM	bla	0.0383
4924	Cytochrome P450 2C8	CYP2C8	0.0375
3010	Regulatory protein blaR1	blaR1	0.0365
1385	Angiotensin-converting enzyme 2	ACE2	0.035
4119	Cytochrome P450 2D6	CYP2D6	0.0343
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0321
4200	Cytochrome P450 1A2	CYP1A2	0.0321
4812	Extended-spectrum beta-lactamase CTX-M-14	blaCTX-M-14	0.0316
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0315
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0293
2164	Multidrug resistance-associated protein 4	ABCC4	0.0288
6113	MecA PBP2' (penicillin binding protein 2')	mecA	0.0264
234	Plasminogen	PLG	0.0246
3195	Beta-lactamase Toho-1	bla	0.0244
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.024
115	Penicillin-binding protein 2	mrdA	0.0235
6069	Penicillin-binding protein 2	mrdA	0.0235
6118	Penicillin-binding protein 2	penA	0.0235
6187	Penicillin-binding protein 2	pbpA	0.0235
6686	Penicillin-binding protein 2	pbp2	0.0235
6939	Penicillin-binding protein 2	mrdA	0.0235
7163	Penicillin-binding protein 2	pbpA	0.0235
738	Monocarboxylate transporter 1	SLC16A1	0.0235
56	Delta-aminolevulinic acid dehydratase	ALAD	0.023
2356	Delta-aminolevulinic acid dehydratase	hemB	0.023
3613	Delta-aminolevulinic acid dehydratase	hemB	0.023
3674	Delta-aminolevulinic acid dehydratase	hemB	0.023
3923	Cholinesterase	BCHE	0.0227
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0223
4604	Liver carboxylesterase 1	CES1	0.0219
4118	Cytochrome P450 3A5	CYP3A5	0.0217
891	Dihydropteroate synthase	folP	0.0207
5359	Dihydropteroate synthase	folP	0.0207
7175	Dihydropteroate synthase	sulI	0.0207
338	DNA polymerase	UL30	0.0203
379	DNA polymerase	UL54	0.0203
697	DNA polymerase	ORF28	0.0203
2482	DNA polymerase	43	0.0203
4104	DNA polymerase	BALF5	0.0203
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0202
2544	Bacterial leucyl aminopeptidase	Not Available	0.0198
819	Penicillin-binding protein 4	dacB	0.0196
862	Multidrug resistance-associated protein 1	ABCC1	0.0196
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0178
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0175
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0172
1389	Transforming growth factor beta-1	TGFB1	0.0169
2385	Penicillin acylase	Not Available	0.0166
332	Beta-lactamase	blaZ	0.0166
2613	Beta-lactamase	ampC	0.0166
2635	Beta-lactamase	ampC	0.0166
2700	Beta-lactamase	penP	0.0166
5445	Beta-lactamase	blaB	0.0166
6019	Beta-lactamase	SHV-7	0.0166
6701	Beta-lactamase	cphA	0.0166
6145	Solute carrier family 22 member 1	SLC22A1	0.0163
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0161
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0151
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0151
3060	Leukotriene A-4 hydrolase	LTA4H	0.0149
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0149
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
592	Carbonic anhydrase 4	CA4	0.0141
6107	Cytochrome P450 3A7	CYP3A7	0.014
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0139
404	DNA gyrase subunit A	gyrA	0.0139
6224	DNA gyrase subunit A	gyrA	0.0139
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0137
6030	Cytochrome P450 2B6	CYP2B6	0.0136
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0133
295	Carbonic anhydrase 1	CA1	0.0133
3426	Glutamine synthetase	glnA	0.0129
3987	Glutamine synthetase	GLUL	0.0129
6024	Cytochrome P450 1A1	CYP1A1	0.0127
6106	Cytochrome P450 2C18	CYP2C18	0.0127
509	Thymidine kinase	TK	0.0126
570	Thymidine kinase	TK	0.0126
2559	Thymidine kinase	TK	0.0126
3430	Thymidine kinase	tdk	0.0126
3518	Thymidine kinase	TK	0.0126
5301	Thymidine kinase	tdk	0.0126
5771	Thymidine kinase	ORF36	0.0126
7009	Thymidine kinase	ORF36	0.0126
357	Carbonic anhydrase 2	CA2	0.0125
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0123
6013	Cytochrome P450 2E1	CYP2E1	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0117
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0114
776	Bile salt export pump	ABCB11	0.0112
3639	Thymidine phosphorylase	deoA	0.0111
3936	Thymidine phosphorylase	TYMP	0.0111
4790	Glycosyltransferase GtfA	gtfA	0.011
833	Organic cation/carnitine transporter 1	SLC22A4	0.0106
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0106
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0104
867	Penicillin-binding protein 3	pbpC	0.0102
6119	Penicillin-binding protein 3	pbp3	0.0102
7154	Penicillin-binding protein 3	pbp3	0.0102
7157	Penicillin-binding protein 3	LMHCC_2184	0.0102
7172	Penicillin-binding protein 3	pbp3	0.0102
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0101
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0101
558	Solute carrier family 12 member 1	SLC12A1	0.0099
2211	Fatty acid-binding protein, heart	FABP3	0.0098
3810	Catechol O-methyltransferase	COMT	0.0097
632	Alpha-1B adrenergic receptor	ADRA1B	0.0097
707	72 kDa type IV collagenase	MMP2	0.0095
566	Serotransferrin	TF	0.0094
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0094
556	Alpha-1A adrenergic receptor	ADRA1A	0.0093
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0092
65	Matrix metalloproteinase-9	Not Available	0.009
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
373	Transthyretin	TTR	0.009
6144	Solute carrier family 22 member 2	SLC22A2	0.0086
723	Cytosolic phospholipase A2	PLA2G4A	0.0083
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0083
2016	Dipeptidase 1	DPEP1	0.0082
6126	Carbonic anhydrase 7	CA7	0.0082
318	Alpha-2A adrenergic receptor	ADRA2A	0.0081
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.008
6141	Sodium/bile acid cotransporter	SLC10A1	0.008
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
23	D(1A) dopamine receptor	DRD1	0.008
5718	Cytochrome P450 2A6	CYP2A6	0.0079
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0078
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0075
831	D(2) dopamine receptor	DRD2	0.0074
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0074
22	30S ribosomal protein S4	rpsD	0.0072
6714	30S ribosomal protein S4	rpsD	0.0072
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0071
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0071
6136	Multidrug resistance-associated protein 5	ABCC5	0.007
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.007
2320	Thymidine kinase, cytosolic	TK1	0.0069
140	30S ribosomal protein S9	rpsI	0.0068
6719	30S ribosomal protein S9	rpsI	0.0068
6725	30S ribosomal protein S9	rpsI	0.0068
1141	Sialidase-1	NEU1	0.0068
64	Neuraminidase	NA	0.0068
641	Neuraminidase	NA	0.0068
2676	Neuraminidase	NA	0.0068
3026	Neuraminidase	NA	0.0068
3519	Neuraminidase	NA	0.0068
6007	Neuraminidase	NA	0.0068
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0067
183	Vascular endothelial growth factor A	VEGFA	0.0067
36	Insulin receptor	INSR	0.0066
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0066
477	DNA topoisomerase 4 subunit A	parC	0.0064
886	DNA topoisomerase 4 subunit A	parC	0.0064
6226	DNA topoisomerase 4 subunit A	parC	0.0064
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0063
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
3932	Glutathione S-transferase A2	GSTA2	0.0063
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0061
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0061
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0061
705	Glutamate receptor 1	GRIA1	0.0061
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0061
4810	Beta-glucosidase	bgl3	0.0061
4816	Orange carotenoid-binding protein	Not Available	0.0061
4748	Levansucrase	sacB	0.0061
4817	Sucrose porin	scrY	0.0061
4818	Beta-lactamase CTX-M-27	blaCTX-M-27	0.0061
482	Glycine receptor subunit alpha-1	GLRA1	0.006
756	Sex hormone-binding globulin	SHBG	0.006
5626	Nucleoside diphosphate kinase B	NME2	0.006
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0059
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0059
6085	Fatty acid-binding protein, intestinal	FABP2	0.0056
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0056
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0056
4813	Heme oxygenase	hmuO	0.0056
5769	Heme oxygenase	Not Available	0.0056
466	Solute carrier family 12 member 3	SLC12A3	0.0055
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0054
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0054
6043	Putative G-protein coupled receptor 44	GPR44	0.0054
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
4814	Copper transport protein ATOX1	ATOX1	0.0053
2780	Septum formation protein Maf	maf	0.0053
6149	Solute carrier family 22 member 10	SLC22A10	0.0052
1867	Major prion protein	PRNP	0.0052
5482	Sialidase-2	NEU2	0.0052
24	Thymidylate synthase	TMP1	0.0052
359	Thymidylate synthase	TYMS	0.0052
2626	Thymidylate synthase	thyA	0.0052
2729	Thymidylate synthase	thyA	0.0052
5352	Thymidylate synthase	THYA	0.0052
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0051
438	Taste receptor type 1 member 2	TAS1R2	0.0051
492	Histamine H1 receptor	HRH1	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
146	Androgen receptor	AR	0.0049
3367	GDP-mannose 6-dehydrogenase	algD	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
4811	Amylosucrase	ams	0.0049
5294	Nucleoside diphosphate kinase A	NME1	0.0048
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0048
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0047
70	Type-1 angiotensin II receptor	AGTR1	0.0047
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
459	Retinoic acid receptor RXR-alpha	RXRA	0.0046
275	Arachidonate 5-lipoxygenase	ALOX5	0.0046
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
6207	30S ribosomal protein S14	rpsN	0.0045
6209	30S ribosomal protein S19	rpsS	0.0045
6712	30S ribosomal protein S19	rpsS	0.0045
6726	30S ribosomal protein S19	rpsS	0.0045
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0044
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0044
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0044
6147	Solute carrier family 22 member 3	SLC22A3	0.0044
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0044
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
6148	Multidrug resistance-associated protein 7	ABCC10	0.0043
817	DNA topoisomerase 2-alpha	TOP2A	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0042
844	Epidermal growth factor receptor	EGFR	0.0041
887	DNA gyrase subunit B	gyrB	0.0041
4150	DNA gyrase subunit B	gyrB	0.0041
6225	DNA gyrase subunit B	gyrB	0.0041
408	Riboflavin kinase	RFK	0.0041
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.004
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.004
6033	High affinity interleukin-8 receptor A	CXCR1	0.004
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.004
1198	Serum paraoxonase/arylesterase 1	PON1	0.0039
6223	Penicillin-binding protein 1C	pbpC	0.0039
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0038
5353	Glutamate decarboxylase alpha	gadA	0.0037
1714	Mitogen-activated protein kinase 3	MAPK3	0.0037
136	Estrogen receptor	ESR1	0.0037
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0036
3822	Actin, alpha skeletal muscle	ACTA1	0.0036
6131	Carbonic anhydrase 14	CA14	0.0035
380	Cytochrome P450 17A1	CYP17A1	0.0035
6151	Monocarboxylate transporter 10	SLC16A10	0.0035
2178	Metabotropic glutamate receptor 5	GRM5	0.0033
6122	Carbonic anhydrase 3	CA3	0.0033
3007	Carbonic anhydrase 12	CA12	0.0033
4205	Carbonic anhydrase 9	CA9	0.0033
594	Thyroxine-binding globulin	SERPINA7	0.0032
6677	Myelin P2 protein	PMP2	0.0032
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0032
293	Gamma-glutamyl hydrolase	GGH	0.0032
6102	Arylamine N-acetyltransferase 2	NAT2	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0031
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0031
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
1050	Bile salt sulfotransferase	SULT2A1	0.003
758	Thyroid hormone receptor alpha	THRA	0.003
654	Flavin reductase	BLVRB	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0029
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0028
1650	Heme carrier protein 1	SLC46A1	0.0028
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0028
1898	Cytochrome P450 1B1	CYP1B1	0.0028
163	D(1B) dopamine receptor	DRD5	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0028
1025	Aquaporin-1	AQP1	0.0027
1405	Thiopurine S-methyltransferase	TPMT	0.0027
346	Thyroid hormone receptor beta-1	THRB	0.0027
3685	Catabolite gene activator	crp	0.0027
4655	Adenylate cyclase	cyaC	0.0027
4759	Adenylate cyclase	cyaB2	0.0027
122	P2Y purinoceptor 12	P2RY12	0.0026
432	D(4) dopamine receptor	DRD4	0.0026
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0026
822	Aldose reductase	AKR1B1	0.0026
4217	Telomerase reverse transcriptase	TERT	0.0026
4773	Deoxycytidine kinase	DCK	0.0026
638	D(3) dopamine receptor	DRD3	0.0025
3941	Amine oxidase [flavin-containing] A	MAOA	0.0025
130	Prostacyclin synthase	PTGIS	0.0025
824	Sodium-dependent serotonin transporter	SLC6A4	0.0025
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0025
847	Mu-type opioid receptor	OPRM1	0.0025
811	Translocator protein	TSPO	0.0024
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0024
6014	Cytochrome P450 2A13	CYP2A13	0.0024
6231	Pepsin A	PGA3	0.0024
2249	Aspartate aminotransferase	aspC	0.0023
2671	Aspartate aminotransferase	aspC	0.0023
5490	Aspartate aminotransferase	Not Available	0.0023
696	Kappa-type opioid receptor	OPRK1	0.0023
6167	Organic solute transporter subunit beta	OSTB	0.0023
4760	Mll3241 protein	mll3241	0.0023
6166	Organic solute transporter subunit alpha	OSTA	0.0023
3811	Cytochrome P450 19A1	CYP19A1	0.0023
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0022
1525	Heparin-binding growth factor 2	FGF2	0.0022
6103	Arylamine N-acetyltransferase 1	NAT1	0.0022
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0022
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0022
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0022
6137	Multidrug resistance-associated protein 6	ABCC6	0.0021
1196	Complement decay-accelerating factor	CD55	0.0021
2021	Thrombomodulin	THBD	0.0021
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0021
718	Folate receptor gamma	FOLR3	0.0021
299	Folate receptor beta	FOLR2	0.0021
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0021
4210	Toll-like receptor 4	TLR4	0.0021
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0021
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0021
527	Prostacyclin receptor	PTGIR	0.0021
6031	Cytochrome P450 3A43	CYP3A43	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
672	Prostaglandin F2-alpha receptor	PTGFR	0.002
6501	Fatty acid-binding protein, liver	FABP1	0.002
768	FK506-binding protein 1A	FKBP1A	0.002
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.002
1992	Vitamin D-binding protein	GC	0.002
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0019
869	Estrogen receptor beta	ESR2	0.0019
1654	Interleukin-1 beta	IL1B	0.0019
1517	Beta-3 adrenergic receptor	ADRB3	0.0019
2808	Chloramphenicol acetyltransferase 3	cat3	0.0019
5787	Angiopoietin-1 receptor	TEK	0.0019
199	Monocarboxylate transporter 8	SLC16A2	0.0018
5934	Cytochrome P450 26A1	CYP26A1	0.0018
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
6218	Pannexin-1	PANX1	0.0018
53	Solute carrier family 12 member 5	SLC12A5	0.0018
663	Solute carrier family 12 member 4	SLC12A4	0.0018
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
1291	cAMP response element-binding protein	CREB1	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
780	Retinoic acid receptor RXR-gamma	RXRG	0.0017
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0017
33	Cystine/glutamate transporter	SLC7A11	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
310	Solute carrier family 12 member 2	SLC12A2	0.0017
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0016
1507	Cytochrome c	CYCS	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0016
2207	Rhodopsin	RHO	0.0016
6042	Prostaglandin reductase 2	PTGR2	0.0016
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0016
5818	Folate receptor alpha	FOLR1	0.0016
88	Retinoic acid receptor RXR-beta	RXRB	0.0016
162	Retinoic acid receptor gamma-1	RARG	0.0015
494	Caspase-1	CASP1	0.0015
614	Progesterone receptor	PGR	0.0015
1792	Tissue-type plasminogen activator	PLAT	0.0015
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0015
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0015
871	Glucocorticoid receptor	NR3C1	0.0014
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0014
273	Apoptosis regulator Bcl-2	BCL2	0.0014
789	Alpha-1D adrenergic receptor	ADRA1D	0.0014
465	Calmodulin	CALM1	0.0014
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0014
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0014
467	Delta-type opioid receptor	OPRD1	0.0013
1656	CYP2B protein	CYP2B	0.0013
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0013
283	SEC14-like protein 2	SEC14L2	0.0013
1618	High affinity nerve growth factor receptor	NTRK1	0.0013
2077	Caspase-3	CASP3	0.0013
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0013
6459	Glycodelin	PAEP	0.0013
6432	Transporter	snf	0.0013
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0013
1313	Lactoylglutathione lyase	GLO1	0.0012
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0012
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0012
4226	Uridine phosphorylase 2	UPP2	0.0012
702	UMP-CMP kinase	CMPK1	0.0012
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0012
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0012
489	Monocarboxylate transporter 2	SLC16A7	0.0011
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0011
4225	Uridine phosphorylase 1	UPP1	0.0011
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0011
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0011
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0011
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0011
1192	Sulfotransferase 1A1	SULT1A1	0.001
51	Muscarinic acetylcholine receptor M3	CHRM3	0.001
997	Protein kinase C beta type	PRKCB	0.001
413	Amidophosphoribosyltransferase	PPAT	0.001
2515	Amidophosphoribosyltransferase	purF	0.001
3714	Amidophosphoribosyltransferase	purF	0.001
617	Muscarinic acetylcholine receptor M2	CHRM2	0.001
1275	Estrogen sulfotransferase	SULT1E1	0.001
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.001
103	Muscarinic acetylcholine receptor M1	CHRM1	0.001
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.001
904	Glutathione S-transferase P	GSTP1	0.001
634	Squalene monooxygenase	SQLE	0.001
7196	Squalene monooxygenase	ERG1	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
1039	Histone deacetylase 9	HDAC9	0.0009
1353	DNA topoisomerase 1	TOP1	0.0009
3552	DNA topoisomerase 1	topA	0.0009
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0009
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0009
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0009
6020	Aldehyde oxidase	AOX1	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
233	Potassium channel subfamily K member 2	KCNK2	0.0009
1864	RET proto-oncogene	RET	0.0009
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0009
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0009
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0009
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0009
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0009
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0009
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0009
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0009
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0009
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0009
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0009
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0009
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0009
1268	Neuropeptide S receptor	NPSR1	0.0009
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0009
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0009
365	Dihydrofolate reductase	DHFR	0.0009
2381	Dihydrofolate reductase	DFR1	0.0009
2833	Dihydrofolate reductase	Not Available	0.0009
2931	Dihydrofolate reductase	folA	0.0009
3544	Dihydrofolate reductase	folA	0.0009
3682	Dihydrofolate reductase	folA	0.0009
6642	Dihydrofolate reductase	folA	0.0009
6756	Dihydrofolate reductase	dfrA	0.0009
468	Cytochrome P450 4A11	CYP4A11	0.0008
378	Alpha-2C adrenergic receptor	ADRA2C	0.0008
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0008
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0008
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0008
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0008
629	Alpha-2B adrenergic receptor	ADRA2B	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0008
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0008
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0008
3587	Gastrotropin	FABP6	0.0008
3937	Fatty-acid amide hydrolase	FAAH	0.0008
6073	Potassium channel subfamily K member 9	KCNK9	0.0008
6072	Potassium channel subfamily K member 3	KCNK3	0.0008
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0008
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0008
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0008
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0008
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0008
731	HIV-1 protease	HIV-1 protease	0.0008
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0007
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0007
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0007
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
2236	Casein kinase II subunit alpha	CSNK2A1	0.0007
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0007
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0007
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0007
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0006
504	Mast/stem cell growth factor receptor	KIT	0.0006
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0006
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0006
124	Histamine H2 receptor	HRH2	0.0006
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0006
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0006
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0006
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0006
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0005
193	Beta-1 adrenergic receptor	ADRB1	0.0005
5961	Insulin	INS	0.0005
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
6755	Poliovirus receptor	PVR	0.0005
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0004
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
716	5-hydroxytryptamine 7 receptor	HTR7	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0004
2297	Genome polyprotein	Not Available	0.0004
2322	Genome polyprotein	Not Available	0.0004
2694	Genome polyprotein	Not Available	0.0004
2719	Genome polyprotein	Not Available	0.0004
2860	Genome polyprotein	Not Available	0.0004
2928	Genome polyprotein	Not Available	0.0004
3160	Genome polyprotein	Not Available	0.0004
3260	Genome polyprotein	Not Available	0.0004
4783	Genome polyprotein	Not Available	0.0004
5726	Genome polyprotein	Not Available	0.0004
5779	Genome polyprotein	Not Available	0.0004
5867	Genome polyprotein	Not Available	0.0004
6253	Genome polyprotein	Not Available	0.0004
6301	Genome polyprotein	Not Available	0.0004
6380	Genome polyprotein	Not Available	0.0004
6381	Genome polyprotein	Not Available	0.0004
6437	Genome polyprotein	Not Available	0.0004
6520	Genome polyprotein	Not Available	0.0004
6521	Genome polyprotein	Not Available	0.0004
6652	Genome polyprotein	Not Available	0.0004
6734	Genome polyprotein	Not Available	0.0004
6735	Genome polyprotein	Not Available	0.0004
6736	Genome polyprotein	Not Available	0.0004
6737	Genome polyprotein	Not Available	0.0004
6738	Genome polyprotein	Not Available	0.0004
6739	Genome polyprotein	Not Available	0.0004
6744	Genome polyprotein	Not Available	0.0004
6748	Genome polyprotein	Not Available	0.0004
6894	Genome polyprotein	Not Available	0.0004
6898	Genome polyprotein	Not Available	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0003
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0003
4943	Cytochrome c6	petJ	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
5000	HemO	hemO	0.0003
4916	Cyanoglobin	glbN	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4984	Neuroglobin	NGB	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4961	Hemophore HasA	hasA	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4910	Cytoglobin	CYGB	0.0003
3116	Bacterioferritin	bfr	0.0003
4906	Bacterioferritin	bfr	0.0003
4965	Bacterioferritin	bfr	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4909	CooA protein	cooA	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4952	Catalase/peroxidase	katA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6228	Nuclear receptor coactivator 1	NCOA1	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
4920	Peroxidase/catalase	katG	0.0002
4923	Cytochrome c3	DvMF_2499	0.0002
4945	Cytochrome c3	Not Available	0.0002
4949	Cytochrome c3	DVU_3171	0.0002
4968	Cytochrome c3	cytc3	0.0002
4997	Cytochrome c3	SO_2727	0.0002
5219	Cytochrome c3	cyd	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4948	Cytochrome c-553	Not Available	0.0002
4902	Nine-heme cytochrome c	Ddes_2038	0.0002
3189	High-molecular-weight cytochrome c	hmcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
4990	PpcA	ppcA	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
4386	Hemoglobin-like protein HbN	glbN	0.0002
518	Peroxidase/catalase T	katG	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
3221	Cytochrome c4	cc4	0.0002
605	Fumarate reductase flavoprotein subunit	frdA	0.0002
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0002
3673	Fumarate reductase flavoprotein subunit	fccA	0.0002
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0002
6549	Fumarate reductase flavoprotein subunit	frdA	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
260	Cytochrome P450 51	ERG11	0.0002
761	Cytochrome P450 51	ERG11	0.0002
3163	Cytochrome P450 51	cyp51	0.0002
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001
2298	Cytochrome P450-cam	camC	0.0001
76	Nitric-oxide synthase, brain	NOS1	0.0001
7	Nitric oxide synthase, inducible	NOS2	0.0001
291	Nitric-oxide synthase, endothelial	NOS3	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01147 - Cloxacillin

Targets

Transporters

Carriers

Predictions