DT-Web

DB01053 - Penicillin G


Identification
Name Penicillin G
Accession Number DB01053 (APRD00646)
Type small molecule
Description Penicillin G is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 334.39
Groups approved
Monoisotopic Weight 334.098727764
Pharmacology
Indication For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia.
Mechanism of action By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, penicillin G inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that penicillin G interferes with an autolysin inhibitor.
Absorption Rapidly absorbed following both intramuscular and subcutaneous injection. Initial blood levels following parenteral administration are high but transient. Oral absorption in fasting, healthy humans is only about 15-30% as it is very susceptible to acid-catalyzed hydrolysis.
Protein binding Bind to serum proteins (45-68%), mainly albumin.
Biotransformation About 16-30% of an intramuscular dose is metabolized to penicilloic acid, an inactive metabolite. Small amounts of 6-aminopenicillanic acid have been recovered in the urine of patients on penicillin G. A small percentage of the drug appears to be hydroxylated into one or more active metabolites, which are also excreted via urine.
Route of elimination Penicillin G is eliminated by the kidneys. Nonrenal clearance includes hepatic metabolism and, to a lesser extent, biliary excretion.
Toxicity Oral LD50 in rat is 8900 mk/kg. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams. Neutropenia can occur if high doses are administered consistently for over 2 weeks.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Demeclocycline Possible antagonism of action
Doxycycline Possible antagonism of action
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Mestranol This anti-infectious agent could decreases the effect of the oral contraceptive
Methacycline Possible antagonism of action
Methotrexate The penicillin increases the effect and toxicity of methotrexate
Minocycline Possible antagonism of action
Oxytetracycline Possible antagonism of action
Rolitetracycline Possible antagonism of action
Tetracycline Possible antagonism of action
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Food Interactions Not Available

Targets


Penicillin-binding protein 3
Name Penicillin-binding protein 3
Gene Name pbp3
Pharmacological action unknown
Actions inhibitor
References
  • Beise F, Labischinski H, Bradaczek H: On the relationships between molecular conformation, affinity towards penicillin-binding proteins, and biological activity of penicillin G-sulfoxide. Z Naturforsch C. 1988 Sep-Oct;43(9-10):656-64. - Pubmed
DTHybrid score 0.0177

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
DTHybrid score 0.4085
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions substrate,inhibitor
References
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
  • Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. - Pubmed
DTHybrid score 0.6004
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions inhibitor
References
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score 0.5831
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
  • Hosoyamada M, Sekine T, Kanai Y, Endou H: Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol. 1999 Jan;276(1 Pt 2):F122-8. - Pubmed
  • Lu R, Chan BS, Schuster VL: Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol. 1999 Feb;276(2 Pt 2):F295-303. - Pubmed
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
  • Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, Endou H, Sugiyama Y: Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther. 2002 Mar;300(3):746-53. - Pubmed
DTHybrid score 0.5692
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions substrate,inhibitor
References
  • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
  • Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. - Pubmed
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
  • Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T: Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003 Apr;23(4):432-40. - Pubmed
  • Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
  • Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, Endou H, Sugiyama Y: Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther. 2002 Mar;300(3):746-53. - Pubmed
  • Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. - Pubmed
  • Nagata Y, Kusuhara H, Endou H, Sugiyama Y: Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol. 2002 May;61(5):982-8. - Pubmed
DTHybrid score 0.4941
Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions inhibitor
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score 0.238
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Enomoto A, Tojo A, Cha SH, Sekine T, Sakthisekaran D, Endou H: Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta. 2002 Jun 12;1590(1-3):64-75. - Pubmed
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
DTHybrid score 0.3464
Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions substrate
References
  • Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. - Pubmed
DTHybrid score 0.3219
Solute carrier organic anion transporter family member 4A1
Name Solute carrier organic anion transporter family member 4A1
Gene Name SLCO4A1
Actions substrate
References
  • Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. - Pubmed
DTHybrid score 0.1825
Solute carrier organic anion transporter family member 3A1
Name Solute carrier organic anion transporter family member 3A1
Gene Name SLCO3A1
Actions substrate
References
  • Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. - Pubmed
DTHybrid score 0.2124
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions substrate
References
  • Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. - Pubmed
DTHybrid score 0.3228

Predictions


Id Partner name Gene Name Score
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1861
1588 Multidrug resistance protein 1 ABCB1 0.1855
6143 Solute carrier family 22 member 7 SLC22A7 0.1837
244 Angiotensin-converting enzyme ACE 0.1808
4512 Cytochrome P450 3A4 CYP3A4 0.1624
587 Serum albumin ALB 0.1579
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1548
6145 Solute carrier family 22 member 1 SLC22A1 0.1434
633 Penicillin-binding proteins 1A/1B pbpA 0.1388
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.1251
6144 Solute carrier family 22 member 2 SLC22A2 0.1177
2164 Multidrug resistance-associated protein 4 ABCC4 0.117
4757 Cytochrome P450 2C9 CYP2C9 0.1167
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1149
738 Monocarboxylate transporter 1 SLC16A1 0.1099
4924 Cytochrome P450 2C8 CYP2C8 0.1033
4119 Cytochrome P450 2D6 CYP2D6 0.1018
862 Multidrug resistance-associated protein 1 ABCC1 0.0976
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0961
4200 Cytochrome P450 1A2 CYP1A2 0.0929
6016 Cytochrome P450 2C19 CYP2C19 0.0913
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0911
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0799
20 Prostaglandin G/H synthase 1 PTGS1 0.0745
645 Penicillin-binding protein 1A mrcA 0.0727
5805 Penicillin-binding protein 1A ponA 0.0727
6185 Penicillin-binding protein 1A mrcA 0.0727
6799 Penicillin-binding protein 1A pbpA 0.0727
6167 Organic solute transporter subunit beta OSTB 0.0708
6166 Organic solute transporter subunit alpha OSTA 0.0708
6141 Sodium/bile acid cotransporter SLC10A1 0.0666
6147 Solute carrier family 22 member 3 SLC22A3 0.066
1 Peptidoglycan synthetase ftsI ftsI 0.0654
4155 Peptidoglycan synthetase ftsI ftsI 0.0654
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0637
776 Bile salt export pump ABCB11 0.0629
4118 Cytochrome P450 3A5 CYP3A5 0.0619
290 Prostaglandin G/H synthase 2 PTGS2 0.0584
758 Thyroid hormone receptor alpha THRA 0.0577
6136 Multidrug resistance-associated protein 5 ABCC5 0.0574
543 Penicillin-binding protein 1B mrcB 0.0557
6186 Penicillin-binding protein 1B ponB 0.0557
6822 Penicillin-binding protein 1b pbp1b 0.0557
6844 Penicillin-binding protein 1b pbp1b 0.0557
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0535
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0519
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0518
346 Thyroid hormone receptor beta-1 THRB 0.0487
527 Prostacyclin receptor PTGIR 0.0479
6024 Cytochrome P450 1A1 CYP1A1 0.0437
672 Prostaglandin F2-alpha receptor PTGFR 0.0434
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0433
6107 Cytochrome P450 3A7 CYP3A7 0.0431
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.042
404 DNA gyrase subunit A gyrA 0.0418
6224 DNA gyrase subunit A gyrA 0.0418
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0418
1757 Myeloperoxidase MPO 0.0405
594 Thyroxine-binding globulin SERPINA7 0.0391
6149 Solute carrier family 22 member 10 SLC22A10 0.0366
6030 Cytochrome P450 2B6 CYP2B6 0.0365
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0363
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0358
22 30S ribosomal protein S4 rpsD 0.0357
6714 30S ribosomal protein S4 rpsD 0.0357
1385 Angiotensin-converting enzyme 2 ACE2 0.035
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.035
477 DNA topoisomerase 4 subunit A parC 0.0347
886 DNA topoisomerase 4 subunit A parC 0.0347
6226 DNA topoisomerase 4 subunit A parC 0.0347
4604 Liver carboxylesterase 1 CES1 0.0345
6148 Multidrug resistance-associated protein 7 ABCC10 0.0342
140 30S ribosomal protein S9 rpsI 0.0336
6719 30S ribosomal protein S9 rpsI 0.0336
6725 30S ribosomal protein S9 rpsI 0.0336
115 Penicillin-binding protein 2 mrdA 0.0335
6069 Penicillin-binding protein 2 mrdA 0.0335
6118 Penicillin-binding protein 2 penA 0.0335
6187 Penicillin-binding protein 2 pbpA 0.0335
6686 Penicillin-binding protein 2 pbp2 0.0335
6939 Penicillin-binding protein 2 mrdA 0.0335
7163 Penicillin-binding protein 2 pbpA 0.0335
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0327
6151 Monocarboxylate transporter 10 SLC16A10 0.0324
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0315
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0311
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0311
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0304
338 DNA polymerase UL30 0.0303
379 DNA polymerase UL54 0.0303
697 DNA polymerase ORF28 0.0303
2482 DNA polymerase 43 0.0303
4104 DNA polymerase BALF5 0.0303
3923 Cholinesterase BCHE 0.0299
492 Histamine H1 receptor HRH1 0.0294
6067 Penicillin binding protein 2a mecA 0.0291
3587 Gastrotropin FABP6 0.0288
373 Transthyretin TTR 0.0283
3917 Methylenetetrahydrofolate reductase MTHFR 0.028
817 DNA topoisomerase 2-alpha TOP2A 0.0267
1792 Tissue-type plasminogen activator PLAT 0.0264
6013 Cytochrome P450 2E1 CYP2E1 0.0262
6106 Cytochrome P450 2C18 CYP2C18 0.0254
438 Taste receptor type 1 member 2 TAS1R2 0.0248
234 Plasminogen PLG 0.0246
3810 Catechol O-methyltransferase COMT 0.0245
5718 Cytochrome P450 2A6 CYP2A6 0.024
56 Delta-aminolevulinic acid dehydratase ALAD 0.023
2356 Delta-aminolevulinic acid dehydratase hemB 0.023
3613 Delta-aminolevulinic acid dehydratase hemB 0.023
3674 Delta-aminolevulinic acid dehydratase hemB 0.023
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.022
238 Peroxisome proliferator-activated receptor gamma PPARG 0.022
332 Beta-lactamase blaZ 0.0219
2478 Beta-lactamase ampC 0.0219
2613 Beta-lactamase ampC 0.0219
2635 Beta-lactamase ampC 0.0219
2700 Beta-lactamase penP 0.0219
5445 Beta-lactamase blaB 0.0219
6019 Beta-lactamase SHV-7 0.0219
6701 Beta-lactamase cphA 0.0219
318 Alpha-2A adrenergic receptor ADRA2A 0.0217
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0212
275 Arachidonate 5-lipoxygenase ALOX5 0.0211
136 Estrogen receptor ESR1 0.021
2429 Putrescine-binding periplasmic protein potF 0.0206
199 Monocarboxylate transporter 8 SLC16A2 0.0205
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0203
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0203
563 Thyroid peroxidase TPO 0.0202
449 Ornithine decarboxylase ODC1 0.0202
887 DNA gyrase subunit B gyrB 0.0201
4150 DNA gyrase subunit B gyrB 0.0201
6225 DNA gyrase subunit B gyrB 0.0201
2544 Bacterial leucyl aminopeptidase Not Available 0.0198
3947 Xanthine dehydrogenase/oxidase XDH 0.0198
2016 Dipeptidase 1 DPEP1 0.0197
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0195
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0194
558 Solute carrier family 12 member 1 SLC12A1 0.0194
3426 Glutamine synthetase glnA 0.0193
3987 Glutamine synthetase GLUL 0.0193
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
33 Cystine/glutamate transporter SLC7A11 0.0191
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.019
51 Muscarinic acetylcholine receptor M3 CHRM3 0.019
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0189
357 Carbonic anhydrase 2 CA2 0.0189
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0186
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0184
5353 Glutamate decarboxylase alpha gadA 0.0183
3811 Cytochrome P450 19A1 CYP19A1 0.018
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0179
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0179
867 Penicillin-binding protein 3 pbpC 0.0177
6119 Penicillin-binding protein 3 pbp3 0.0177
7154 Penicillin-binding protein 3 pbp3 0.0177
7157 Penicillin-binding protein 3 LMHCC_2184 0.0177
7162 Penicillin-binding protein 3 pbpB 0.0177
150 Cationic amino acid transporter 3 SLC7A3 0.0173
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0173
58 Cationic amino acid transporter 4 SLC7A4 0.0173
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0171
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0166
2472 Voltage-gated potassium channel kcsA 0.0165
6366 Voltage-gated potassium channel kcsA 0.0165
6599 HTH-type transcriptional regulator ttgR ttgR 0.0163
556 Alpha-1A adrenergic receptor ADRA1A 0.0162
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0161
509 Thymidine kinase TK 0.0161
570 Thymidine kinase TK 0.0161
2559 Thymidine kinase TK 0.0161
3430 Thymidine kinase tdk 0.0161
3518 Thymidine kinase TK 0.0161
5301 Thymidine kinase tdk 0.0161
5771 Thymidine kinase ORF36 0.0161
7009 Thymidine kinase ORF36 0.0161
124 Histamine H2 receptor HRH2 0.016
3760 Penicillin-binding protein 5 precursor dacA 0.0159
592 Carbonic anhydrase 4 CA4 0.0159
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0152
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0151
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0151
159 Penicillin-binding protein 2B penA 0.0151
6121 Penicillin-binding protein 2B penA 0.0151
624 Guanidinoacetate N-methyltransferase GAMT 0.015
295 Carbonic anhydrase 1 CA1 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
3060 Leukotriene A-4 hydrolase LTA4H 0.0149
6085 Fatty acid-binding protein, intestinal FABP2 0.0148
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0148
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0147
4252 Penicillin-binding protein 5 dacA 0.0146
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6020 Aldehyde oxidase AOX1 0.0144
3560 Gentamicin 3'-acetyltransferase aacC1 0.0143
500 Monocarboxylate transporter 4 SLC16A3 0.0142
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0141
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0141
1867 Major prion protein PRNP 0.0139
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0139
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0137
756 Sex hormone-binding globulin SHBG 0.0131
860 Nicotinamide N-methyltransferase NNMT 0.013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.013
699 Nicotinic acid receptor 1 GPR109A 0.013
928 Nicotinic acid receptor 2 GPR109B 0.013
1898 Cytochrome P450 1B1 CYP1B1 0.0129
70 Type-1 angiotensin II receptor AGTR1 0.0128
5626 Nucleoside diphosphate kinase B NME2 0.0127
5126 Arginase rocF 0.0125
489 Monocarboxylate transporter 2 SLC16A7 0.0125
293 Gamma-glutamyl hydrolase GGH 0.0124
130 Prostacyclin synthase PTGIS 0.0124
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0123
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
6168 Solute carrier family 22 member 16 SLC22A16 0.0122
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0122
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0122
5818 Folate receptor alpha FOLR1 0.0122
6137 Multidrug resistance-associated protein 6 ABCC6 0.0121
65 Matrix metalloproteinase-9 Not Available 0.0121
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0121
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0121
6207 30S ribosomal protein S14 rpsN 0.012
6209 30S ribosomal protein S19 rpsS 0.012
6712 30S ribosomal protein S19 rpsS 0.012
6726 30S ribosomal protein S19 rpsS 0.012
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.012
551 Carnitine O-acetyltransferase CRAT 0.0119
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
3941 Amine oxidase [flavin-containing] A MAOA 0.0117
1141 Sialidase-1 NEU1 0.0117
64 Neuraminidase NA 0.0117
641 Neuraminidase NA 0.0117
2676 Neuraminidase NA 0.0117
3026 Neuraminidase NA 0.0117
3519 Neuraminidase NA 0.0117
6007 Neuraminidase NA 0.0117
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0115
2249 Aspartate aminotransferase aspC 0.0112
2671 Aspartate aminotransferase aspC 0.0112
5490 Aspartate aminotransferase Not Available 0.0112
221 Lysyl-tRNA synthetase KARS 0.0112
4790 Glycosyltransferase GtfA gtfA 0.011
1650 Heme carrier protein 1 SLC46A1 0.0109
6033 High affinity interleukin-8 receptor A CXCR1 0.0104
6126 Carbonic anhydrase 7 CA7 0.0103
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
5294 Nucleoside diphosphate kinase A NME1 0.0103
24 Thymidylate synthase TMP1 0.0102
359 Thymidylate synthase TYMS 0.0102
2626 Thymidylate synthase thyA 0.0102
2729 Thymidylate synthase thyA 0.0102
5352 Thymidylate synthase THYA 0.0102
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0102
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0101
2320 Thymidine kinase, cytosolic TK1 0.01
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
5650 NimA-related protein DR_0842 0.0098
1405 Thiopurine S-methyltransferase TPMT 0.0097
303 Diamine acetyltransferase 2 SAT2 0.0096
1317 Spermine synthase SMS 0.0096
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0096
623 Spermine oxidase SMOX 0.0096
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0095
629 Alpha-2B adrenergic receptor ADRA2B 0.0095
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
1654 Interleukin-1 beta IL1B 0.0092
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0091
5482 Sialidase-2 NEU2 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
499 Arginine decarboxylase ADC 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0087
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0086
123 Diamine acetyltransferase 1 SAT1 0.0086
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0086
320 5-hydroxytryptamine 1A receptor HTR1A 0.0086
2021 Thrombomodulin THBD 0.0086
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0086
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0086
53 Solute carrier family 12 member 5 SLC12A5 0.0085
663 Solute carrier family 12 member 4 SLC12A4 0.0085
577 Argininosuccinate lyase ASL 0.0085
834 Arginase-2, mitochondrial ARG2 0.0084
632 Alpha-1B adrenergic receptor ADRA1B 0.0084
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
6014 Cytochrome P450 2A13 CYP2A13 0.0083
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0082
5880 Thrombopoietin receptor MPL 0.0081
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0081
175 Thiamin pyrophosphokinase 1 TPK1 0.008
378 Alpha-2C adrenergic receptor ADRA2C 0.008
310 Solute carrier family 12 member 2 SLC12A2 0.008
474 Acetylcholinesterase ACHE 0.0079
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0079
5682 Ribonuclease pancreatic RNASE1 0.0078
740 Argininosuccinate synthase ASS1 0.0076
865 Argininosuccinate synthase ASS1 0.0076
2680 Argininosuccinate synthase argG 0.0076
3194 Argininosuccinate synthase argG 0.0076
494 Caspase-1 CASP1 0.0075
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0075
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0074
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0074
183 Vascular endothelial growth factor A VEGFA 0.0074
751 Potassium channel subfamily K member 6 KCNK6 0.0073
707 72 kDa type IV collagenase MMP2 0.0073
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0073
2300 Lysozyme E 0.0073
3633 Lysozyme R 0.0073
5597 Lysozyme 17 0.0073
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
1507 Cytochrome c CYCS 0.0071
824 Sodium-dependent serotonin transporter SLC6A4 0.007
976 Platelet glycoprotein IX GP9 0.007
869 Estrogen receptor beta ESR2 0.0069
731 HIV-1 protease HIV-1 protease 0.0069
468 Cytochrome P450 4A11 CYP4A11 0.0068
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0068
3014 Ribonuclease UK114 HRSP12 0.0068
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0067
5428 Replication protein repA 0.0067
3617 Non-heme chloroperoxidase cpo 0.0067
5426 Non-heme chloroperoxidase cpo 0.0067
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0067
3018 HTH-type transcriptional regulator malT malT 0.0067
6031 Cytochrome P450 3A43 CYP3A43 0.0067
172 Potassium channel subfamily K member 1 KCNK1 0.0067
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0067
4217 Telomerase reverse transcriptase TERT 0.0067
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0066
3685 Catabolite gene activator crp 0.0065
4655 Adenylate cyclase cyaC 0.0064
4759 Adenylate cyclase cyaB2 0.0064
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
146 Androgen receptor AR 0.0063
6218 Pannexin-1 PANX1 0.0063
2077 Caspase-3 CASP3 0.0063
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0063
365 Dihydrofolate reductase DHFR 0.0063
2381 Dihydrofolate reductase DFR1 0.0063
2833 Dihydrofolate reductase Not Available 0.0063
2931 Dihydrofolate reductase folA 0.0063
3544 Dihydrofolate reductase folA 0.0063
3682 Dihydrofolate reductase folA 0.0063
6642 Dihydrofolate reductase folA 0.0063
6756 Dihydrofolate reductase dfrA 0.0063
6131 Carbonic anhydrase 14 CA14 0.0062
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0062
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0062
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0061
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0061
819 Penicillin-binding protein 4 dacB 0.006
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
380 Cytochrome P450 17A1 CYP17A1 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
713 Sodium-dependent dopamine transporter SLC6A3 0.0059
2958 Probable tautomerase ydcE pptA 0.0058
2573 Cocaine esterase cocE 0.0058
7263 Cocaine esterase Not Available 0.0058
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0058
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0058
6043 Putative G-protein coupled receptor 44 GPR44 0.0058
6122 Carbonic anhydrase 3 CA3 0.0058
273 Apoptosis regulator Bcl-2 BCL2 0.0058
3115 Ras-related protein Rab-9 RAB9A 0.0057
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0057
788 Creatine kinase M-type CKM 0.0057
2981 Phospholipase A2, membrane associated PLA2G2A 0.0057
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0057
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0056
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0055
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0055
769 High-affinity choline transporter 1 SLC5A7 0.0055
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0055
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0055
576 Choline O-acetyltransferase CHAT 0.0055
700 Choline dehydrogenase, mitochondrial CHDH 0.0055
861 Choline kinase alpha CHKA 0.0055
3927 Choline transporter-like protein 3 SLC44A3 0.0055
1686 Choline transporter-like protein 1 SLC44A1 0.0055
3922 Phospholipase D2 PLD2 0.0055
3926 Choline transporter-like protein 2 SLC44A2 0.0055
3925 Choline transporter-like protein 4 SLC44A4 0.0055
3924 Phospholipase D1 PLD1 0.0055
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0055
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0055
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0055
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0055
3007 Carbonic anhydrase 12 CA12 0.0055
4205 Carbonic anhydrase 9 CA9 0.0055
26 Vascular endothelial growth factor receptor 3 FLT4 0.0055
4760 Mll3241 protein mll3241 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
952 Dipeptidyl peptidase 4 DPP4 0.0054
32 Vascular endothelial growth factor receptor 1 FLT1 0.0053
7 Nitric oxide synthase, inducible NOS2 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
6432 Transporter snf 0.0052
291 Nitric-oxide synthase, endothelial NOS3 0.0052
3939 Amine oxidase [flavin-containing] B MAOB 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0051
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.005
193 Beta-1 adrenergic receptor ADRB1 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
766 Beta-2 adrenergic receptor ADRB2 0.0048
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
789 Alpha-1D adrenergic receptor ADRA1D 0.0046
2693 Heat-labile enterotoxin B chain eltB 0.0044
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0044
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0044
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
6645 D-amino-acid oxidase DAO 0.0043
1360 Sphingomyelin phosphodiesterase SMPD1 0.0043
407 Vascular endothelial growth factor receptor 2 KDR 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
6837 Serine/threonine-protein kinase 17B STK17B 0.0042
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0042
408 Riboflavin kinase RFK 0.0041
6042 Prostaglandin reductase 2 PTGR2 0.0041
1039 Histone deacetylase 9 HDAC9 0.004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0039
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0039
737 Mineralocorticoid receptor NR3C2 0.0039
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
163 D(1B) dopamine receptor DRD5 0.0038
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0037
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0037
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0037
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0037
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0037
6220 Aryl hydrocarbon receptor AHR 0.0036
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0036
432 D(4) dopamine receptor DRD4 0.0036
2539 Tubulin alpha-1 chain TUBA4A 0.0035
997 Protein kinase C beta type PRKCB 0.0035
1074 Urokinase-type plasminogen activator PLAU 0.0035
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0035
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0035
4148 Serine/threonine-protein kinase mTOR MTOR 0.0035
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0035
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0034
638 D(3) dopamine receptor DRD3 0.0034
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0034
1341 Histamine H3 receptor HRH3 0.0034
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0034
511 5-hydroxytryptamine 1F receptor HTR1F 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0033
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
1525 Heparin-binding growth factor 2 FGF2 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
29 Tubulin beta-1 chain TUBB1 0.0032
164 Histamine H4 receptor HRH4 0.0032
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0032
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
2408 Tyrosine-protein kinase SYK SYK 0.0032
2599 Tyrosine-protein kinase HCK HCK 0.0032
284 DNA-directed RNA polymerase beta chain rpoB 0.0032
5773 DNA-directed RNA polymerase beta chain rpoB 0.0032
1760 Aminopeptidase N ANPEP 0.0032
6843 Aminopeptidase N pepN 0.0032
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0032
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0032
1313 Lactoylglutathione lyase GLO1 0.0031
23 D(1A) dopamine receptor DRD1 0.0031
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0031
502 5-hydroxytryptamine 2A receptor HTR2A 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.003
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.003
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.003
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.003
654 Flavin reductase BLVRB 0.0029
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0029
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0029
3809 Estrogen-related receptor gamma ESRRG 0.0029
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0029
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0029
768 FK506-binding protein 1A FKBP1A 0.0029
831 D(2) dopamine receptor DRD2 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0029
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0028
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
1025 Aquaporin-1 AQP1 0.0027
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0027
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
4203 Histamine N-methyltransferase HNMT 0.0026
4773 Deoxycytidine kinase DCK 0.0026
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0025
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0025
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0025
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0025
3856 Fibroblast growth factor receptor 3 FGFR3 0.0025
2391 Ferrochelatase hemH 0.0025
6502 Ferrochelatase DKFZp686P18130 0.0025
1591 Ferrochelatase, mitochondrial FECH 0.0025
725 5-hydroxytryptamine 1D receptor HTR1D 0.0024
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0024
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
1630 Integrin beta-2 ITGB2 0.0024
885 5-hydroxytryptamine 1B receptor HTR1B 0.0024
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0024
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0023
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0023
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0023
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0023
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0023
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0023
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0022
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0022
3830 Calreticulin CALR 0.0022
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0022
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0022
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0022
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0022
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0022
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0022
6493 Cytochrome c oxidase subunit 6C COX6C 0.0022
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0021
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0021
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0021
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0021
6559 Cytochrome c oxidase subunit 2 ctaC 0.0021
6669 Cytochrome c oxidase subunit 2 ctaC 0.0021
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0021
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0021
6558 Cytochrome c oxidase subunit 1 ctaD 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0021
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0021
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
844 Epidermal growth factor receptor EGFR 0.002
822 Aldose reductase AKR1B1 0.002
6044 Serum paraoxonase/lactonase 3 PON3 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
2540 Choloylglycine hydrolase cbh 0.002
950 Alpha platelet-derived growth factor receptor PDGFRA 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
6501 Fatty acid-binding protein, liver FABP1 0.0019
572 Integrin alpha-L ITGAL 0.0018
228 Beta platelet-derived growth factor receptor PDGFRB 0.0018
1517 Beta-3 adrenergic receptor ADRB3 0.0018
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
1353 DNA topoisomerase 1 TOP1 0.0018
3552 DNA topoisomerase 1 topA 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
267 Plasminogen activator inhibitor 1 SERPINE1 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
504 Mast/stem cell growth factor receptor KIT 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
4122 Histone deacetylase 2 HDAC2 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
6221 Steroid hormone receptor ERR1 ESRRA 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
6500 Phospholipase A2 PLA2G1B 0.0015
517 Alcohol dehydrogenase 1C ADH1C 0.0014
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
5590 N utilization substance protein B homolog nusB 0.0012
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0012
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0012
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0012
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0012
2838 Ribose-5-phosphate isomerase A rpiA 0.0012
2952 Ribose-5-phosphate isomerase A rpiA 0.0012
5595 Ribose-5-phosphate isomerase A rpiA 0.0012
4695 UPF0124 protein yfiH yfiH 0.0012
5060 Intron-associated endonuclease 1 ITEVIR 0.0012
5593 Transferase Not Available 0.0012
5588 Cell division protein FtsY TM_0570 0.0012
5591 Complement component C8 gamma chain C8G 0.0012
5587 Iron(III)-binding periplasmic protein fbpA 0.0012
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0012
5582 Regulator of transcription; stringent starvation protein A sspA 0.0012
4238 50S ribosomal protein L4 rplD 0.0012
5578 50S ribosomal protein L4 rplD 0.0012
6173 50S ribosomal protein L4 rplD 0.0012
6219 50S ribosomal protein L4 rplD 0.0012
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0012
5581 Beta-fructosidase bfrA 0.0012
5600 Pyruvate decarboxylase pdc 0.0012
4375 Glutamine synthetase 1 glnA1 0.0012
5575 Short tail fiber protein 12 0.0012
5580 Hexon protein PII 0.0012
5574 Invasin YPTB1668 0.0012
702 UMP-CMP kinase CMPK1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
5006 RNASE4 protein RNASE4 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
465 Calmodulin CALM1 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
2603 Beta-lactamase II blm 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
2149 Angiogenin ANG 0.001
3583 6-phosphogluconolactonase pgl 0.001
857 Malate dehydrogenase, mitochondrial MDH2 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2942 Sialidase nanH 0.0009
3546 Sialidase nedA 0.0009
3486 Fumarate hydratase class II fumC 0.0009
1123 Eosinophil cationic protein RNASE3 0.0009
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0009
2286 Isocitrate dehydrogenase [NADP] icd 0.0009
2302 Isocitrate dehydrogenase [NADP] icd 0.0009
2771 Isocitrate dehydrogenase [NADP] icd 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
2697 Uridine-cytidine kinase 2 UCK2 0.0009
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
411 Glycine N-methyltransferase GNMT 0.0009
5579 Carboxypeptidase B CPB1 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
128 Adenine phosphoribosyltransferase APRT 0.0008
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0007
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