DT-Web

DB01160 - Dinoprost Tromethamine


Identification
Name Dinoprost Tromethamine
Accession Number DB01160 (APRD00926)
Type small molecule
Description The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or prostaglandin F2 alpha tromethamine.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 475.616
Groups approved
Monoisotopic Weight 475.314517421
Pharmacology
Indication Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities incompatible with life. Also used at low-doses for medically indicated induction of labor at term. Also injected intra-arterially for use as a vasodilator to assist in angiography.
Mechanism of action Dinoprost tromethamine appears to act directly on the myometrium, but this has not been completely established. Dinoprost stimulates myometrial contractions (via its interaction with the prostaglandin receptors) in the gravid uterus that are similar to the contractions that occur in the term uterus during labor. These contractions are usually sufficient to cause abortion. Uterine response to prostaglandins increases gradually throughout pregnancy. Dinoprost also facilitates cervical dilatation and softening.
Absorption Slowly absorbed from the amniotic fluid into systemic circulation.
Protein binding Not Available
Biotransformation Enzymatic dehydrogenation primarily in the maternal lungs and also in the liver.
Route of elimination Not Available
Toxicity Although overdose by intra-amniotic administration of dinoprost has not been reported, exaggeration of the nausea, vomiting, and diarrhea that occur with normal doses would be expected.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Prostaglandin F2-alpha receptor
Name Prostaglandin F2-alpha receptor
Gene Name PTGFR
Pharmacological action yes
Actions agonist
References
  • Sakamoto K, Kamimura M, Kurozumi S, Ito S: Prostaglandin F2 alpha receptor. J Lipid Mediat Cell Signal. 1995 Oct;12(2-3):405-11. - Pubmed
DTHybrid score 0.817
Prostacyclin receptor
Name Prostacyclin receptor
Gene Name PTGIR
Pharmacological action unknown
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3986

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions Not Available
References
  • Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed
DTHybrid score 0.2393
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions Not Available
References
  • Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed
DTHybrid score 0.5212
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions Not Available
References
  • Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed
DTHybrid score 0.3161
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions Not Available
References
  • Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed
DTHybrid score 0.4666
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions Not Available
References
  • Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed
DTHybrid score 0.3794
Solute carrier organic anion transporter family member 2A1
Name Solute carrier organic anion transporter family member 2A1
Gene Name SLCO2A1
Actions Not Available
References
  • Lu R, Kanai N, Bao Y, Schuster VL: Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest. 1996 Sep 1;98(5):1142-9. - Pubmed
DTHybrid score 0.3691
Solute carrier organic anion transporter family member 3A1
Name Solute carrier organic anion transporter family member 3A1
Gene Name SLCO3A1
Actions Not Available
References
  • Adachi H, Suzuki T, Abe M, Asano N, Mizutamari H, Tanemoto M, Nishio T, Onogawa T, Toyohara T, Kasai S, Satoh F, Suzuki M, Tokui T, Unno M, Shimosegawa T, Matsuno S, Ito S, Abe T: Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. - Pubmed
DTHybrid score 0.2705

Predictions


Id Partner name Gene Name Score
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.1879
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.1646
6145 Solute carrier family 22 member 1 SLC22A1 0.1642
4757 Cytochrome P450 2C9 CYP2C9 0.1395
290 Prostaglandin G/H synthase 2 PTGS2 0.1323
122 P2Y purinoceptor 12 P2RY12 0.1321
587 Serum albumin ALB 0.1103
2164 Multidrug resistance-associated protein 4 ABCC4 0.1046
118 Organic cation/carnitine transporter 2 SLC22A5 0.1029
1588 Multidrug resistance protein 1 ABCB1 0.0956
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0926
130 Prostacyclin synthase PTGIS 0.0924
4512 Cytochrome P450 3A4 CYP3A4 0.0898
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0895
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0774
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0721
6136 Multidrug resistance-associated protein 5 ABCC5 0.0696
20 Prostaglandin G/H synthase 1 PTGS1 0.0693
738 Monocarboxylate transporter 1 SLC16A1 0.0676
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.066
862 Multidrug resistance-associated protein 1 ABCC1 0.064
833 Organic cation/carnitine transporter 1 SLC22A4 0.0609
4200 Cytochrome P450 1A2 CYP1A2 0.0606
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0598
1502 Peroxisome proliferator-activated receptor delta PPARD 0.059
1792 Tissue-type plasminogen activator PLAT 0.0585
6016 Cytochrome P450 2C19 CYP2C19 0.0577
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0575
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0556
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0539
4924 Cytochrome P450 2C8 CYP2C8 0.0531
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0521
52 Pyruvate kinase isozymes R/L PKLR 0.0518
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0513
2922 Glycerol kinase glpK 0.0504
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0493
6147 Solute carrier family 22 member 3 SLC22A3 0.0473
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0471
22 30S ribosomal protein S4 rpsD 0.0462
6714 30S ribosomal protein S4 rpsD 0.0462
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.044
140 30S ribosomal protein S9 rpsI 0.0435
6719 30S ribosomal protein S9 rpsI 0.0435
6725 30S ribosomal protein S9 rpsI 0.0435
776 Bile salt export pump ABCB11 0.0426
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0425
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
4118 Cytochrome P450 3A5 CYP3A5 0.0409
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0403
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0401
4119 Cytochrome P450 2D6 CYP2D6 0.0399
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0388
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0387
6141 Sodium/bile acid cotransporter SLC10A1 0.0383
2206 Glucose-6-phosphate isomerase GPI 0.0381
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.038
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0376
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0375
6167 Organic solute transporter subunit beta OSTB 0.037
6166 Organic solute transporter subunit alpha OSTA 0.0369
6107 Cytochrome P450 3A7 CYP3A7 0.0308
633 Penicillin-binding proteins 1A/1B pbpA 0.0301
338 DNA polymerase UL30 0.0285
379 DNA polymerase UL54 0.0285
697 DNA polymerase ORF28 0.0285
2482 DNA polymerase 43 0.0285
4104 DNA polymerase BALF5 0.0285
6149 Solute carrier family 22 member 10 SLC22A10 0.0284
558 Solute carrier family 12 member 1 SLC12A1 0.028
5353 Glutamate decarboxylase alpha gadA 0.027
645 Penicillin-binding protein 1A mrcA 0.0267
5805 Penicillin-binding protein 1A ponA 0.0267
6185 Penicillin-binding protein 1A mrcA 0.0267
6799 Penicillin-binding protein 1A pbpA 0.0267
6148 Multidrug resistance-associated protein 7 ABCC10 0.0266
6024 Cytochrome P450 1A1 CYP1A1 0.0265
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0265
438 Taste receptor type 1 member 2 TAS1R2 0.0248
489 Monocarboxylate transporter 2 SLC16A7 0.0248
543 Penicillin-binding protein 1B mrcB 0.0246
6186 Penicillin-binding protein 1B ponB 0.0246
6822 Penicillin-binding protein 1b pbp1b 0.0246
6844 Penicillin-binding protein 1b pbp1b 0.0246
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0246
6020 Aldehyde oxidase AOX1 0.0237
357 Carbonic anhydrase 2 CA2 0.0236
6085 Fatty acid-binding protein, intestinal FABP2 0.0225
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
124 Histamine H2 receptor HRH2 0.022
2853 14 kDa fatty acid-binding protein Not Available 0.0219
5650 NimA-related protein DR_0842 0.0218
3676 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive aroG 0.0216
3134 Phospho-2-dehydro-3-deoxyheptonate aldolase aroF 0.0215
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0215
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0208
1867 Major prion protein PRNP 0.0208
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0205
6013 Cytochrome P450 2E1 CYP2E1 0.0201
887 DNA gyrase subunit B gyrB 0.0201
4150 DNA gyrase subunit B gyrB 0.0201
6225 DNA gyrase subunit B gyrB 0.0201
5718 Cytochrome P450 2A6 CYP2A6 0.0199
4384 Capsule biosynthesis protein synC 0.0199
2016 Dipeptidase 1 DPEP1 0.0197
404 DNA gyrase subunit A gyrA 0.0195
6224 DNA gyrase subunit A gyrA 0.0195
500 Monocarboxylate transporter 4 SLC16A3 0.0193
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0191
1116 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] PCK1 0.0188
3947 Xanthine dehydrogenase/oxidase XDH 0.0187
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0186
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0182
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.018
6207 30S ribosomal protein S14 rpsN 0.0179
6209 30S ribosomal protein S19 rpsS 0.0179
6712 30S ribosomal protein S19 rpsS 0.0179
6726 30S ribosomal protein S19 rpsS 0.0179
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0175
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0173
6030 Cytochrome P450 2B6 CYP2B6 0.017
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0167
2249 Aspartate aminotransferase aspC 0.0167
2671 Aspartate aminotransferase aspC 0.0167
5490 Aspartate aminotransferase Not Available 0.0167
115 Penicillin-binding protein 2 mrdA 0.0166
6069 Penicillin-binding protein 2 mrdA 0.0166
6118 Penicillin-binding protein 2 penA 0.0166
6187 Penicillin-binding protein 2 pbpA 0.0166
6686 Penicillin-binding protein 2 pbp2 0.0166
6939 Penicillin-binding protein 2 mrdA 0.0166
7163 Penicillin-binding protein 2 pbpA 0.0166
2310 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.0163
2542 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.0163
3811 Cytochrome P450 19A1 CYP19A1 0.016
332 Beta-lactamase blaZ 0.0159
2478 Beta-lactamase ampC 0.0159
2613 Beta-lactamase ampC 0.0159
2635 Beta-lactamase ampC 0.0159
2700 Beta-lactamase penP 0.0159
5445 Beta-lactamase blaB 0.0159
6019 Beta-lactamase SHV-7 0.0159
6701 Beta-lactamase cphA 0.0159
6151 Monocarboxylate transporter 10 SLC16A10 0.0159
592 Carbonic anhydrase 4 CA4 0.0159
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0158
766 Beta-2 adrenergic receptor ADRB2 0.0155
1 Peptidoglycan synthetase ftsI ftsI 0.0155
4155 Peptidoglycan synthetase ftsI ftsI 0.0155
6033 High affinity interleukin-8 receptor A CXCR1 0.0154
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0153
295 Carbonic anhydrase 1 CA1 0.015
2183 Fatty acid-binding protein, adipocyte FABP4 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
5626 Nucleoside diphosphate kinase B NME2 0.0147
1898 Cytochrome P450 1B1 CYP1B1 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
2320 Thymidine kinase, cytosolic TK1 0.0144
6106 Cytochrome P450 2C18 CYP2C18 0.0142
3917 Methylenetetrahydrofolate reductase MTHFR 0.0141
6137 Multidrug resistance-associated protein 6 ABCC6 0.014
867 Penicillin-binding protein 3 pbpC 0.014
6119 Penicillin-binding protein 3 pbp3 0.014
7154 Penicillin-binding protein 3 pbp3 0.014
7157 Penicillin-binding protein 3 LMHCC_2184 0.014
7162 Penicillin-binding protein 3 pbpB 0.014
7172 Penicillin-binding protein 3 pbp3 0.014
193 Beta-1 adrenergic receptor ADRB1 0.0137
1654 Interleukin-1 beta IL1B 0.0137
275 Arachidonate 5-lipoxygenase ALOX5 0.0135
4773 Deoxycytidine kinase DCK 0.0131
293 Gamma-glutamyl hydrolase GGH 0.013
5818 Folate receptor alpha FOLR1 0.0128
3685 Catabolite gene activator crp 0.0127
53 Solute carrier family 12 member 5 SLC12A5 0.0127
663 Solute carrier family 12 member 4 SLC12A4 0.0127
4655 Adenylate cyclase cyaC 0.0127
4759 Adenylate cyclase cyaB2 0.0127
3639 Thymidine phosphorylase deoA 0.0127
3936 Thymidine phosphorylase TYMP 0.0127
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0125
4217 Telomerase reverse transcriptase TERT 0.0125
24 Thymidylate synthase TMP1 0.0125
359 Thymidylate synthase TYMS 0.0125
2626 Thymidylate synthase thyA 0.0125
2729 Thymidylate synthase thyA 0.0125
5352 Thymidylate synthase THYA 0.0125
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
477 DNA topoisomerase 4 subunit A parC 0.012
886 DNA topoisomerase 4 subunit A parC 0.012
6226 DNA topoisomerase 4 subunit A parC 0.012
723 Cytosolic phospholipase A2 PLA2G4A 0.0119
5294 Nucleoside diphosphate kinase A NME1 0.0119
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
310 Solute carrier family 12 member 2 SLC12A2 0.0119
1650 Heme carrier protein 1 SLC46A1 0.0113
65 Matrix metalloproteinase-9 Not Available 0.0112
494 Caspase-1 CASP1 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
183 Vascular endothelial growth factor A VEGFA 0.011
7 Nitric oxide synthase, inducible NOS2 0.0109
4760 Mll3241 protein mll3241 0.0109
1507 Cytochrome c CYCS 0.0105
3587 Gastrotropin FABP6 0.0104
3426 Glutamine synthetase glnA 0.0104
3987 Glutamine synthetase GLUL 0.0104
244 Angiotensin-converting enzyme ACE 0.0103
6126 Carbonic anhydrase 7 CA7 0.0103
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
3760 Penicillin-binding protein 5 precursor dacA 0.01
492 Histamine H1 receptor HRH1 0.0099
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0097
1405 Thiopurine S-methyltransferase TPMT 0.0097
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0096
136 Estrogen receptor ESR1 0.0095
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0095
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0094
4604 Liver carboxylesterase 1 CES1 0.0093
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
2077 Caspase-3 CASP3 0.0093
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0092
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
819 Penicillin-binding protein 4 dacB 0.009
6031 Cytochrome P450 3A43 CYP3A43 0.0089
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0089
218 Monocarboxylate transporter 5 SLC16A4 0.0088
195 Monocarboxylate transporter 7 SLC16A6 0.0088
397 Monocarboxylate transporter 3 SLC16A8 0.0088
429 Monocarboxylate transporter 6 SLC16A5 0.0088
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0087
4122 Histone deacetylase 2 HDAC2 0.0087
6010 Thiamine transporter 1 SLC19A2 0.0086
3810 Catechol O-methyltransferase COMT 0.0086
6218 Pannexin-1 PANX1 0.0085
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0084
373 Transthyretin TTR 0.0084
817 DNA topoisomerase 2-alpha TOP2A 0.0083
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0081
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0081
2472 Voltage-gated potassium channel kcsA 0.008
6366 Voltage-gated potassium channel kcsA 0.008
16 Adenosine A1 receptor ADORA1 0.008
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0079
1178 Adenosine A2a receptor ADORA2A 0.0078
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0078
1757 Myeloperoxidase MPO 0.0078
378 Alpha-2C adrenergic receptor ADRA2C 0.0077
756 Sex hormone-binding globulin SHBG 0.0077
175 Thiamin pyrophosphokinase 1 TPK1 0.0077
341 5-hydroxytryptamine 3 receptor HTR3A 0.0076
6043 Putative G-protein coupled receptor 44 GPR44 0.0076
771 Pyruvate carboxylase, mitochondrial PC 0.0076
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0075
199 Monocarboxylate transporter 8 SLC16A2 0.0075
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0074
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0074
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0074
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0074
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
2981 Phospholipase A2, membrane associated PLA2G2A 0.0071
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0071
3923 Cholinesterase BCHE 0.0071
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.007
556 Alpha-1A adrenergic receptor ADRA1A 0.007
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0069
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0069
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0069
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0066
277 Purine nucleoside phosphorylase PNP 0.0066
2870 Purine nucleoside phosphorylase punA 0.0066
2945 Purine nucleoside phosphorylase punA 0.0066
4659 Purine nucleoside phosphorylase TM_1596 0.0066
4825 Purine nucleoside phosphorylase TTHA1435 0.0066
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0066
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0066
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0066
365 Dihydrofolate reductase DHFR 0.0065
2381 Dihydrofolate reductase DFR1 0.0065
2833 Dihydrofolate reductase Not Available 0.0065
2931 Dihydrofolate reductase folA 0.0065
3544 Dihydrofolate reductase folA 0.0065
3682 Dihydrofolate reductase folA 0.0065
6642 Dihydrofolate reductase folA 0.0065
6756 Dihydrofolate reductase dfrA 0.0065
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0065
273 Apoptosis regulator Bcl-2 BCL2 0.0065
33 Cystine/glutamate transporter SLC7A11 0.0065
629 Alpha-2B adrenergic receptor ADRA2B 0.0065
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0063
5126 Arginase rocF 0.0062
6131 Carbonic anhydrase 14 CA14 0.0062
4203 Histamine N-methyltransferase HNMT 0.0062
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0062
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0061
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0061
6042 Prostaglandin reductase 2 PTGR2 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
146 Androgen receptor AR 0.006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0058
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0058
3941 Amine oxidase [flavin-containing] A MAOA 0.0058
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0058
6122 Carbonic anhydrase 3 CA3 0.0058
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0058
318 Alpha-2A adrenergic receptor ADRA2A 0.0057
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
6014 Cytochrome P450 2A13 CYP2A13 0.0057
740 Argininosuccinate synthase ASS1 0.0056
865 Argininosuccinate synthase ASS1 0.0056
2680 Argininosuccinate synthase argG 0.0056
3194 Argininosuccinate synthase argG 0.0056
789 Alpha-1D adrenergic receptor ADRA1D 0.0056
2021 Thrombomodulin THBD 0.0055
3007 Carbonic anhydrase 12 CA12 0.0055
4205 Carbonic anhydrase 9 CA9 0.0055
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0055
1770 Phospholipase C PLCL1 0.0055
2841 Phospholipase C plc 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
468 Cytochrome P450 4A11 CYP4A11 0.0054
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0054
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0053
818 50S ribosomal protein L10 rplJ 0.0053
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
4238 50S ribosomal protein L4 rplD 0.0052
5578 50S ribosomal protein L4 rplD 0.0052
6173 50S ribosomal protein L4 rplD 0.0052
6219 50S ribosomal protein L4 rplD 0.0052
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
624 Guanidinoacetate N-methyltransferase GAMT 0.005
474 Acetylcholinesterase ACHE 0.0049
824 Sodium-dependent serotonin transporter SLC6A4 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
713 Sodium-dependent dopamine transporter SLC6A3 0.0049
6070 Nischarin NISCH 0.0048
6171 Solute carrier family 28 member 3 SLC28A3 0.0047
4237 50S ribosomal protein L22 rplV 0.0047
694 Matrix protein 2 M 0.0047
1313 Lactoylglutathione lyase GLO1 0.0046
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0046
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0046
3939 Amine oxidase [flavin-containing] B MAOB 0.0046
1039 Histone deacetylase 9 HDAC9 0.0045
831 D(2) dopamine receptor DRD2 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0044
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0044
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0044
632 Alpha-1B adrenergic receptor ADRA1B 0.0043
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0043
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0043
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
1830 5'-nucleotidase NT5E 0.0042
408 Riboflavin kinase RFK 0.0041
125 DNA polymerase beta POLB 0.004
131 Synaptic vesicular amine transporter SLC18A2 0.004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0039
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0039
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0039
5482 Sialidase-2 NEU2 0.0039
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0037
1517 Beta-3 adrenergic receptor ADRB3 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
828 Phenylalanine-4-hydroxylase PAH 0.0037
3109 Phenylalanine-4-hydroxylase phhA 0.0037
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0037
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0036
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0036
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0036
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0036
2300 Lysozyme E 0.0036
3633 Lysozyme R 0.0036
5597 Lysozyme 17 0.0036
5682 Ribonuclease pancreatic RNASE1 0.0035
997 Protein kinase C beta type PRKCB 0.0035
3611 Cytidine deaminase cdd 0.0035
3707 Cytidine deaminase cdd 0.0035
4211 Cytidine deaminase CDA 0.0035
465 Calmodulin CALM1 0.0034
594 Thyroxine-binding globulin SERPINA7 0.0034
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
4226 Uridine phosphorylase 2 UPP2 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0033
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
6163 Copper-transporting ATPase 2 ATP7B 0.0033
6165 Copper-transporting ATPase 1 ATP7A 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0033
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0033
1341 Histamine H3 receptor HRH3 0.0032
5924 Microtubule-associated protein 4 MAP4 0.0032
5923 Microtubule-associated protein tau MAPT 0.0032
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
2408 Tyrosine-protein kinase SYK SYK 0.0032
702 UMP-CMP kinase CMPK1 0.0032
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
6146 High affinity copper uptake protein 1 SLC31A1 0.0032
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0031
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0031
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0031
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0031
758 Thyroid hormone receptor alpha THRA 0.0031
6111 DNA polymerase epsilon subunit 4 POLE4 0.0031
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0031
6112 DNA polymerase epsilon subunit 3 POLE3 0.0031
164 Histamine H4 receptor HRH4 0.0031
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0031
6110 DNA polymerase epsilon subunit 2 POLE2 0.0031
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0031
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0031
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0031
6212 Tubulin gamma-1 chain TUBG1 0.0031
6210 Tubulin delta chain TUBD1 0.0031
6211 Tubulin epsilon chain TUBE1 0.0031
4152 Superoxide dismutase [Cu-Zn] SOD1 0.003
4225 Uridine phosphorylase 1 UPP1 0.003
908 Glutathione S-transferase theta-1 GSTT1 0.003
1852 Microtubule-associated protein 2 MAP2 0.003
380 Cytochrome P450 17A1 CYP17A1 0.003
654 Flavin reductase BLVRB 0.0029
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0029
885 5-hydroxytryptamine 1B receptor HTR1B 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0029
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0029
2391 Ferrochelatase hemH 0.0029
6502 Ferrochelatase DKFZp686P18130 0.0029
1591 Ferrochelatase, mitochondrial FECH 0.0029
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0029
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
413 Amidophosphoribosyltransferase PPAT 0.0029
2515 Amidophosphoribosyltransferase purF 0.0029
3714 Amidophosphoribosyltransferase purF 0.0029
751 Potassium channel subfamily K member 6 KCNK6 0.0029
163 D(1B) dopamine receptor DRD5 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0027
1025 Aquaporin-1 AQP1 0.0027
432 D(4) dopamine receptor DRD4 0.0027
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0027
320 5-hydroxytryptamine 1A receptor HTR1A 0.0026
172 Potassium channel subfamily K member 1 KCNK1 0.0026
896 Glutathione S-transferase Mu 1 GSTM1 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
638 D(3) dopamine receptor DRD3 0.0026
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0026
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0026
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0026
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0026
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0026
6493 Cytochrome c oxidase subunit 6C COX6C 0.0025
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0025
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0025
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0025
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0025
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0025
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0025
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0025
6559 Cytochrome c oxidase subunit 2 ctaC 0.0025
6669 Cytochrome c oxidase subunit 2 ctaC 0.0025
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0025
6558 Cytochrome c oxidase subunit 1 ctaD 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
502 5-hydroxytryptamine 2A receptor HTR2A 0.0025
921 Glutamate receptor 2 GRIA2 0.0025
976 Platelet glycoprotein IX GP9 0.0025
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0025
869 Estrogen receptor beta ESR2 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0024
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0024
1629 Transcription factor AP-1 JUN 0.0024
603 DNA polymerase alpha catalytic subunit POLA1 0.0024
904 Glutathione S-transferase P GSTP1 0.0023
23 D(1A) dopamine receptor DRD1 0.0023
2540 Choloylglycine hydrolase cbh 0.0023
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0022
6432 Transporter snf 0.0022
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0022
6501 Fatty acid-binding protein, liver FABP1 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6168 Solute carrier family 22 member 16 SLC22A16 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
161 Tubulin beta chain TUBB 0.0021
312 Tubulin beta chain TUB2 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
3809 Estrogen-related receptor gamma ESRRG 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0019
3926 Choline transporter-like protein 2 SLC44A2 0.0019
3925 Choline transporter-like protein 4 SLC44A4 0.0019
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0019
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0019
3927 Choline transporter-like protein 3 SLC44A3 0.0019
1686 Choline transporter-like protein 1 SLC44A1 0.0019
861 Choline kinase alpha CHKA 0.0019
769 High-affinity choline transporter 1 SLC5A7 0.0019
700 Choline dehydrogenase, mitochondrial CHDH 0.0019
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0019
576 Choline O-acetyltransferase CHAT 0.0019
3922 Phospholipase D2 PLD2 0.0019
3924 Phospholipase D1 PLD1 0.0019
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
1074 Urokinase-type plasminogen activator PLAU 0.0019
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
3957 Adenosine deaminase ADA 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
4192 DNA topoisomerase 2-beta TOP2B 0.0019
6500 Phospholipase A2 PLA2G1B 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0018
1864 RET proto-oncogene RET 0.0018
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0018
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0018
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0018
284 DNA-directed RNA polymerase beta chain rpoB 0.0017
5773 DNA-directed RNA polymerase beta chain rpoB 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
153 Dopamine beta-hydroxylase DBH 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
4120 NADPH--cytochrome P450 reductase POR 0.0016
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0016
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0015
1360 Sphingomyelin phosphodiesterase SMPD1 0.0015
436 5-hydroxytryptamine 2B receptor HTR2B 0.0015
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0015
1618 High affinity nerve growth factor receptor NTRK1 0.0015
725 5-hydroxytryptamine 1D receptor HTR1D 0.0014
2693 Heat-labile enterotoxin B chain eltB 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
6645 D-amino-acid oxidase DAO 0.0014
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
822 Aldose reductase AKR1B1 0.0014
590 5-hydroxytryptamine 2C receptor HTR2C 0.0013
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0013
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0013
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0013
228 Beta platelet-derived growth factor receptor PDGFRB 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
504 Mast/stem cell growth factor receptor KIT 0.0012
737 Mineralocorticoid receptor NR3C2 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
614 Progesterone receptor PGR 0.0011
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.001
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.001
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.001
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.001
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.001
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.001
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.001
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.001
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.001
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0009
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0009
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
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