DT-Web

DB01414 - Cefacetrile


Identification
Name Cefacetrile
Accession Number DB01414
Type small molecule
Description A derivative of 7-aminocephalosporanic acid.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 339.324
Groups approved
Monoisotopic Weight 339.052505853
Pharmacology
Indication Cefacetrile is a broad-spectrum first generation cephalosporin antibiotic effective in Gram-positive and Gram-negative bacterial infections.
Mechanism of action In vitro tests demonstrate that the bactericidal action of cephalosporins results from inhibition of cell wall synthesis. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
Absorption Not Available
Protein binding 23 to 38%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Penicillin-binding protein 1A
Name Penicillin-binding protein 1A
Gene Name mrcA
Pharmacological action yes
Actions inhibitor
References
  • Yotsuji A, Mitsuyama J, Hori R, Yasuda T, Saikawa I, Inoue M, Mitsuhashi S: Mechanism of action of cephalosporins and resistance caused by decreased affinity for penicillin-binding proteins in Bacteroides fragilis. Antimicrob Agents Chemother. 1988 Dec;32(12):1848-53. - Pubmed
  • Truesdell SE, Zurenko GE, Laborde AL: Interaction of cephalosporins with penicillin-binding proteins of methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 1989 Apr;23 Suppl D:13-9. - Pubmed
DTHybrid score 0.449
Penicillin-binding protein 1B
Name Penicillin-binding protein 1B
Gene Name mrcB
Pharmacological action yes
Actions inhibitor
References
  • Truesdell SE, Zurenko GE, Laborde AL: Interaction of cephalosporins with penicillin-binding proteins of methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 1989 Apr;23 Suppl D:13-9. - Pubmed
  • Yotsuji A, Mitsuyama J, Hori R, Yasuda T, Saikawa I, Inoue M, Mitsuhashi S: Mechanism of action of cephalosporins and resistance caused by decreased affinity for penicillin-binding proteins in Bacteroides fragilis. Antimicrob Agents Chemother. 1988 Dec;32(12):1848-53. - Pubmed
DTHybrid score 0.4366

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions substrate,inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
  • Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. - Pubmed
  • Uwai Y, Saito H, Inui K: Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone. Drug Metab Pharmacokinet. 2002;17(2):125-9. - Pubmed
DTHybrid score 0.363
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions substrate,inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
  • Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. - Pubmed
  • Uwai Y, Saito H, Inui K: Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone. Drug Metab Pharmacokinet. 2002;17(2):125-9. - Pubmed
DTHybrid score 0.2673

Predictions


Id Partner name Gene Name Score
5805 Penicillin-binding protein 1A ponA 0.449
6185 Penicillin-binding protein 1A mrcA 0.449
6799 Penicillin-binding protein 1A pbpA 0.449
6186 Penicillin-binding protein 1B ponB 0.4366
6822 Penicillin-binding protein 1b pbp1b 0.4366
6844 Penicillin-binding protein 1b pbp1b 0.4366
819 Penicillin-binding protein 4 dacB 0.1539
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.127
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.1244
1024 Solute carrier family 22 member 11 SLC22A11 0.121
867 Penicillin-binding protein 3 pbpC 0.1107
6119 Penicillin-binding protein 3 pbp3 0.1107
7154 Penicillin-binding protein 3 pbp3 0.1107
7157 Penicillin-binding protein 3 LMHCC_2184 0.1107
7162 Penicillin-binding protein 3 pbpB 0.1107
7172 Penicillin-binding protein 3 pbp3 0.1107
587 Serum albumin ALB 0.1038
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0952
6143 Solute carrier family 22 member 7 SLC22A7 0.0788
3760 Penicillin-binding protein 5 precursor dacA 0.0707
118 Organic cation/carnitine transporter 2 SLC22A5 0.0566
6067 Penicillin binding protein 2a mecA 0.0551
332 Beta-lactamase blaZ 0.0527
2478 Beta-lactamase ampC 0.0527
2613 Beta-lactamase ampC 0.0527
2635 Beta-lactamase ampC 0.0527
2700 Beta-lactamase penP 0.0527
5445 Beta-lactamase blaB 0.0527
6019 Beta-lactamase SHV-7 0.0527
6701 Beta-lactamase cphA 0.0527
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0476
2164 Multidrug resistance-associated protein 4 ABCC4 0.0442
4512 Cytochrome P450 3A4 CYP3A4 0.0419
290 Prostaglandin G/H synthase 2 PTGS2 0.0382
20 Prostaglandin G/H synthase 1 PTGS1 0.0372
1 Peptidoglycan synthetase ftsI ftsI 0.037
4155 Peptidoglycan synthetase ftsI ftsI 0.037
115 Penicillin-binding protein 2 mrdA 0.0334
6069 Penicillin-binding protein 2 mrdA 0.0334
6118 Penicillin-binding protein 2 penA 0.0334
6187 Penicillin-binding protein 2 pbpA 0.0334
6686 Penicillin-binding protein 2 pbp2 0.0334
6939 Penicillin-binding protein 2 mrdA 0.0334
7163 Penicillin-binding protein 2 pbpA 0.0334
1198 Serum paraoxonase/arylesterase 1 PON1 0.032
6223 Penicillin-binding protein 1C pbpC 0.032
4757 Cytochrome P450 2C9 CYP2C9 0.0313
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.03
1588 Multidrug resistance protein 1 ABCB1 0.0283
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0281
6145 Solute carrier family 22 member 1 SLC22A1 0.0222
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0221
1405 Thiopurine S-methyltransferase TPMT 0.0218
338 DNA polymerase UL30 0.0216
379 DNA polymerase UL54 0.0216
697 DNA polymerase ORF28 0.0216
2482 DNA polymerase 43 0.0216
4104 DNA polymerase BALF5 0.0216
4924 Cytochrome P450 2C8 CYP2C8 0.0215
6016 Cytochrome P450 2C19 CYP2C19 0.0215
6144 Solute carrier family 22 member 2 SLC22A2 0.0207
2016 Dipeptidase 1 DPEP1 0.0197
633 Penicillin-binding proteins 1A/1B pbpA 0.0195
4200 Cytochrome P450 1A2 CYP1A2 0.0194
862 Multidrug resistance-associated protein 1 ABCC1 0.0183
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0183
22 30S ribosomal protein S4 rpsD 0.0173
6714 30S ribosomal protein S4 rpsD 0.0173
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0171
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.017
738 Monocarboxylate transporter 1 SLC16A1 0.0167
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0164
140 30S ribosomal protein S9 rpsI 0.0163
6719 30S ribosomal protein S9 rpsI 0.0163
6725 30S ribosomal protein S9 rpsI 0.0163
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.016
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0156
833 Organic cation/carnitine transporter 1 SLC22A4 0.0155
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
776 Bile salt export pump ABCB11 0.0146
6136 Multidrug resistance-associated protein 5 ABCC5 0.0146
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
592 Carbonic anhydrase 4 CA4 0.0141
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0133
295 Carbonic anhydrase 1 CA1 0.0133
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0131
357 Carbonic anhydrase 2 CA2 0.0131
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.013
6141 Sodium/bile acid cotransporter SLC10A1 0.0128
5626 Nucleoside diphosphate kinase B NME2 0.0127
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
438 Taste receptor type 1 member 2 TAS1R2 0.0122
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
4118 Cytochrome P450 3A5 CYP3A5 0.0113
4119 Cytochrome P450 2D6 CYP2D6 0.0112
3686 Acyl-CoA thioesterase I precursor tesA 0.0111
6024 Cytochrome P450 1A1 CYP1A1 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0109
6147 Solute carrier family 22 member 3 SLC22A3 0.0108
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
5294 Nucleoside diphosphate kinase A NME1 0.0103
887 DNA gyrase subunit B gyrB 0.0099
4150 DNA gyrase subunit B gyrB 0.0099
6225 DNA gyrase subunit B gyrB 0.0099
558 Solute carrier family 12 member 1 SLC12A1 0.0098
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0095
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0093
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0092
124 Histamine H2 receptor HRH2 0.0092
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0091
5353 Glutamate decarboxylase alpha gadA 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
6020 Aldehyde oxidase AOX1 0.0087
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0084
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
3947 Xanthine dehydrogenase/oxidase XDH 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
6148 Multidrug resistance-associated protein 7 ABCC10 0.0081
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0079
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0077
6149 Solute carrier family 22 member 10 SLC22A10 0.0076
2320 Thymidine kinase, cytosolic TK1 0.0074
373 Transthyretin TTR 0.0073
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
6167 Organic solute transporter subunit beta OSTB 0.0073
6166 Organic solute transporter subunit alpha OSTA 0.0073
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
6107 Cytochrome P450 3A7 CYP3A7 0.0071
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0069
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0069
1867 Major prion protein PRNP 0.0067
6013 Cytochrome P450 2E1 CYP2E1 0.0067
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0066
3685 Catabolite gene activator crp 0.0065
4655 Adenylate cyclase cyaC 0.0064
4759 Adenylate cyclase cyaB2 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
275 Arachidonate 5-lipoxygenase ALOX5 0.0064
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0061
130 Prostacyclin synthase PTGIS 0.0061
244 Angiotensin-converting enzyme ACE 0.0061
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
4604 Liver carboxylesterase 1 CES1 0.0059
6106 Cytochrome P450 2C18 CYP2C18 0.0058
6207 30S ribosomal protein S14 rpsN 0.0058
6209 30S ribosomal protein S19 rpsS 0.0058
6712 30S ribosomal protein S19 rpsS 0.0058
6726 30S ribosomal protein S19 rpsS 0.0058
5718 Cytochrome P450 2A6 CYP2A6 0.0058
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
2249 Aspartate aminotransferase aspC 0.0056
2671 Aspartate aminotransferase aspC 0.0056
5490 Aspartate aminotransferase Not Available 0.0056
4760 Mll3241 protein mll3241 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0055
1757 Myeloperoxidase MPO 0.0053
3917 Methylenetetrahydrofolate reductase MTHFR 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
6030 Cytochrome P450 2B6 CYP2B6 0.0052
3426 Glutamine synthetase glnA 0.0051
3987 Glutamine synthetase GLUL 0.0051
65 Matrix metalloproteinase-9 Not Available 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0051
6033 High affinity interleukin-8 receptor A CXCR1 0.0051
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
527 Prostacyclin receptor PTGIR 0.005
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0049
3811 Cytochrome P450 19A1 CYP19A1 0.0049
1141 Sialidase-1 NEU1 0.0049
672 Prostaglandin F2-alpha receptor PTGFR 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
146 Androgen receptor AR 0.0048
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0048
24 Thymidylate synthase TMP1 0.0047
359 Thymidylate synthase TYMS 0.0047
2626 Thymidylate synthase thyA 0.0047
2729 Thymidylate synthase thyA 0.0047
5352 Thymidylate synthase THYA 0.0047
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0045
1654 Interleukin-1 beta IL1B 0.0045
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
756 Sex hormone-binding globulin SHBG 0.0042
53 Solute carrier family 12 member 5 SLC12A5 0.0042
663 Solute carrier family 12 member 4 SLC12A4 0.0042
408 Riboflavin kinase RFK 0.0041
310 Solute carrier family 12 member 2 SLC12A2 0.0039
6043 Putative G-protein coupled receptor 44 GPR44 0.0039
5482 Sialidase-2 NEU2 0.0039
494 Caspase-1 CASP1 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
183 Vascular endothelial growth factor A VEGFA 0.0036
293 Gamma-glutamyl hydrolase GGH 0.0036
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0035
6131 Carbonic anhydrase 14 CA14 0.0035
492 Histamine H1 receptor HRH1 0.0035
1507 Cytochrome c CYCS 0.0035
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0035
594 Thyroxine-binding globulin SERPINA7 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
4217 Telomerase reverse transcriptase TERT 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
1650 Heme carrier protein 1 SLC46A1 0.0032
758 Thyroid hormone receptor alpha THRA 0.0031
2077 Caspase-3 CASP3 0.0031
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0031
654 Flavin reductase BLVRB 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
3587 Gastrotropin FABP6 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
2981 Phospholipase A2, membrane associated PLA2G2A 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
6014 Cytochrome P450 2A13 CYP2A13 0.0028
3941 Amine oxidase [flavin-containing] A MAOA 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0027
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0027
6137 Multidrug resistance-associated protein 6 ABCC6 0.0027
5126 Arginase rocF 0.0027
2021 Thrombomodulin THBD 0.0027
1025 Aquaporin-1 AQP1 0.0027
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0027
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
6085 Fatty acid-binding protein, intestinal FABP2 0.0026
4773 Deoxycytidine kinase DCK 0.0026
136 Estrogen receptor ESR1 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
6031 Cytochrome P450 3A43 CYP3A43 0.0024
1039 Histone deacetylase 9 HDAC9 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
6218 Pannexin-1 PANX1 0.0022
1898 Cytochrome P450 1B1 CYP1B1 0.0022
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6168 Solute carrier family 22 member 16 SLC22A16 0.0021
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
5818 Folate receptor alpha FOLR1 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
6042 Prostaglandin reductase 2 PTGR2 0.002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.002
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.002
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.002
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0019
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0019
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
1792 Tissue-type plasminogen activator PLAT 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0018
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
273 Apoptosis regulator Bcl-2 BCL2 0.0018
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
33 Cystine/glutamate transporter SLC7A11 0.0016
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0015
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0015
1313 Lactoylglutathione lyase GLO1 0.0015
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0015
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0015
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0015
489 Monocarboxylate transporter 2 SLC16A7 0.0015
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
3810 Catechol O-methyltransferase COMT 0.0014
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0014
6645 D-amino-acid oxidase DAO 0.0014
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0014
822 Aldose reductase AKR1B1 0.0014
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
702 UMP-CMP kinase CMPK1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
365 Dihydrofolate reductase DHFR 0.0011
2381 Dihydrofolate reductase DFR1 0.0011
2833 Dihydrofolate reductase Not Available 0.0011
2931 Dihydrofolate reductase folA 0.0011
3544 Dihydrofolate reductase folA 0.0011
3682 Dihydrofolate reductase folA 0.0011
6642 Dihydrofolate reductase folA 0.0011
6756 Dihydrofolate reductase dfrA 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
465 Calmodulin CALM1 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
997 Protein kinase C beta type PRKCB 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.001
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.001
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.001
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.001
6493 Cytochrome c oxidase subunit 6C COX6C 0.001
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.001
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.001
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.001
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.001
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.001
6559 Cytochrome c oxidase subunit 2 ctaC 0.001
6669 Cytochrome c oxidase subunit 2 ctaC 0.001
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.001
371 Cytochrome c oxidase subunit 1 MT-CO1 0.001
6558 Cytochrome c oxidase subunit 1 ctaD 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0009
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
2540 Choloylglycine hydrolase cbh 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0007
3809 Estrogen-related receptor gamma ESRRG 0.0007
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0007
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
869 Estrogen receptor beta ESR2 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0006
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