DT-Web

DB01326 - Cefamandole


Identification
Name Cefamandole
Accession Number DB01326
Type small molecule
Description Cefamandole (INN, also known as cephamandole) is a broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. Cefamandole is no longer available in the United States.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 462.503
Groups approved
Monoisotopic Weight 462.078009096
Pharmacology
Indication For the treatment of serious infections caused by susceptible strains of microorganisms.
Mechanism of action Like all beta-lactam antibiotics, cefamandole binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefamandole interferes with an autolysin inhibitor.
Absorption Not Available
Protein binding 75%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin Increased risk of nephrotoxicity
Gentamicin Increased risk of nephrotoxicity
Netilmicin Increased risk of nephrotoxicity
Probenecid Probenecid may increase the serum level of cefamandole.
Tobramycin Increased risk of nephrotoxicity
Food Interactions Not Available

Targets


Penicillin-binding protein 2
Name Penicillin-binding protein 2
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Yotsuji A, Mitsuyama J, Hori R, Yasuda T, Saikawa I, Inoue M, Mitsuhashi S: Mechanism of action of cephalosporins and resistance caused by decreased affinity for penicillin-binding proteins in Bacteroides fragilis. Antimicrob Agents Chemother. 1988 Dec;32(12):1848-53. - Pubmed
DTHybrid score 0.0166

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
  • Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. - Pubmed
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
DTHybrid score 0.4877
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
  • Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, Sekine T, Endou H: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002 Mar 8;70(16):1861-74. - Pubmed
DTHybrid score 0.4248
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Takeda M, Babu E, Narikawa S, Endou H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol. 2002 Mar 8;438(3):137-42. - Pubmed
DTHybrid score 0.3463
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions inhibitor
References
  • Khamdang S, Takeda M, Babu E, Noshiro R, Onozato ML, Tojo A, Enomoto A, Huang XL, Narikawa S, Anzai N, Piyachaturawat P, Endou H: Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol. 2003 Mar 28;465(1-2):1-7. - Pubmed
DTHybrid score 0.3011

Predictions


Id Partner name Gene Name Score
587 Serum albumin ALB 0.092
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0663
4512 Cytochrome P450 3A4 CYP3A4 0.0656
290 Prostaglandin G/H synthase 2 PTGS2 0.0648
4757 Cytochrome P450 2C9 CYP2C9 0.0629
2164 Multidrug resistance-associated protein 4 ABCC4 0.0616
1588 Multidrug resistance protein 1 ABCB1 0.0597
20 Prostaglandin G/H synthase 1 PTGS1 0.0586
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0582
118 Organic cation/carnitine transporter 2 SLC22A5 0.0571
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0495
22 30S ribosomal protein S4 rpsD 0.0462
6714 30S ribosomal protein S4 rpsD 0.0462
4924 Cytochrome P450 2C8 CYP2C8 0.0451
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.045
140 30S ribosomal protein S9 rpsI 0.0435
6719 30S ribosomal protein S9 rpsI 0.0435
6725 30S ribosomal protein S9 rpsI 0.0435
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0417
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0415
6144 Solute carrier family 22 member 2 SLC22A2 0.0406
6016 Cytochrome P450 2C19 CYP2C19 0.0388
862 Multidrug resistance-associated protein 1 ABCC1 0.0383
6145 Solute carrier family 22 member 1 SLC22A1 0.0379
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0378
4200 Cytochrome P450 1A2 CYP1A2 0.0362
738 Monocarboxylate transporter 1 SLC16A1 0.0355
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0337
6136 Multidrug resistance-associated protein 5 ABCC5 0.0306
633 Penicillin-binding proteins 1A/1B pbpA 0.0301
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0289
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0286
338 DNA polymerase UL30 0.0285
379 DNA polymerase UL54 0.0285
697 DNA polymerase ORF28 0.0285
2482 DNA polymerase 43 0.0285
4104 DNA polymerase BALF5 0.0285
776 Bile salt export pump ABCB11 0.0283
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0282
6141 Sodium/bile acid cotransporter SLC10A1 0.0276
5353 Glutamate decarboxylase alpha gadA 0.027
4118 Cytochrome P450 3A5 CYP3A5 0.027
645 Penicillin-binding protein 1A mrcA 0.0267
5805 Penicillin-binding protein 1A ponA 0.0267
6185 Penicillin-binding protein 1A mrcA 0.0267
6799 Penicillin-binding protein 1A pbpA 0.0267
833 Organic cation/carnitine transporter 1 SLC22A4 0.0262
438 Taste receptor type 1 member 2 TAS1R2 0.0248
543 Penicillin-binding protein 1B mrcB 0.0246
6186 Penicillin-binding protein 1B ponB 0.0246
6822 Penicillin-binding protein 1b pbp1b 0.0246
6844 Penicillin-binding protein 1b pbp1b 0.0246
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0241
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0226
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0224
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
6149 Solute carrier family 22 member 10 SLC22A10 0.021
1867 Major prion protein PRNP 0.0208
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0205
6107 Cytochrome P450 3A7 CYP3A7 0.0203
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0202
887 DNA gyrase subunit B gyrB 0.0201
4150 DNA gyrase subunit B gyrB 0.0201
6225 DNA gyrase subunit B gyrB 0.0201
6020 Aldehyde oxidase AOX1 0.02
2016 Dipeptidase 1 DPEP1 0.0197
558 Solute carrier family 12 member 1 SLC12A1 0.0196
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0193
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0182
6207 30S ribosomal protein S14 rpsN 0.0179
6209 30S ribosomal protein S19 rpsS 0.0179
6712 30S ribosomal protein S19 rpsS 0.0179
6726 30S ribosomal protein S19 rpsS 0.0179
4119 Cytochrome P450 2D6 CYP2D6 0.0177
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0173
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
357 Carbonic anhydrase 2 CA2 0.017
2249 Aspartate aminotransferase aspC 0.0167
2671 Aspartate aminotransferase aspC 0.0167
5490 Aspartate aminotransferase Not Available 0.0167
115 Penicillin-binding protein 2 mrdA 0.0166
6069 Penicillin-binding protein 2 mrdA 0.0166
6118 Penicillin-binding protein 2 penA 0.0166
6686 Penicillin-binding protein 2 pbp2 0.0166
6939 Penicillin-binding protein 2 mrdA 0.0166
7163 Penicillin-binding protein 2 pbpA 0.0166
6024 Cytochrome P450 1A1 CYP1A1 0.0163
3947 Xanthine dehydrogenase/oxidase XDH 0.0163
332 Beta-lactamase blaZ 0.0159
2478 Beta-lactamase ampC 0.0159
2613 Beta-lactamase ampC 0.0159
2635 Beta-lactamase ampC 0.0159
2700 Beta-lactamase penP 0.0159
5445 Beta-lactamase blaB 0.0159
6019 Beta-lactamase SHV-7 0.0159
6701 Beta-lactamase cphA 0.0159
592 Carbonic anhydrase 4 CA4 0.0159
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0158
6147 Solute carrier family 22 member 3 SLC22A3 0.0155
1 Peptidoglycan synthetase ftsI ftsI 0.0155
4155 Peptidoglycan synthetase ftsI ftsI 0.0155
6033 High affinity interleukin-8 receptor A CXCR1 0.0154
527 Prostacyclin receptor PTGIR 0.0152
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.015
295 Carbonic anhydrase 1 CA1 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
672 Prostaglandin F2-alpha receptor PTGFR 0.0148
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0146
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0146
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0143
867 Penicillin-binding protein 3 pbpC 0.014
6119 Penicillin-binding protein 3 pbp3 0.014
7154 Penicillin-binding protein 3 pbp3 0.014
7157 Penicillin-binding protein 3 LMHCC_2184 0.014
7162 Penicillin-binding protein 3 pbpB 0.014
7172 Penicillin-binding protein 3 pbp3 0.014
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
6148 Multidrug resistance-associated protein 7 ABCC10 0.0138
1654 Interleukin-1 beta IL1B 0.0137
275 Arachidonate 5-lipoxygenase ALOX5 0.0135
6167 Organic solute transporter subunit beta OSTB 0.013
6166 Organic solute transporter subunit alpha OSTA 0.013
3685 Catabolite gene activator crp 0.0127
53 Solute carrier family 12 member 5 SLC12A5 0.0127
663 Solute carrier family 12 member 4 SLC12A4 0.0127
4655 Adenylate cyclase cyaC 0.0127
4759 Adenylate cyclase cyaB2 0.0127
6013 Cytochrome P450 2E1 CYP2E1 0.0127
5626 Nucleoside diphosphate kinase B NME2 0.0127
3639 Thymidine phosphorylase deoA 0.0127
3936 Thymidine phosphorylase TYMP 0.0127
2320 Thymidine kinase, cytosolic TK1 0.0126
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0125
130 Prostacyclin synthase PTGIS 0.0124
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
124 Histamine H2 receptor HRH2 0.0121
5718 Cytochrome P450 2A6 CYP2A6 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
310 Solute carrier family 12 member 2 SLC12A2 0.0119
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0115
65 Matrix metalloproteinase-9 Not Available 0.0112
494 Caspase-1 CASP1 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
183 Vascular endothelial growth factor A VEGFA 0.011
4760 Mll3241 protein mll3241 0.0109
1507 Cytochrome c CYCS 0.0105
3426 Glutamine synthetase glnA 0.0104
3987 Glutamine synthetase GLUL 0.0104
244 Angiotensin-converting enzyme ACE 0.0103
6126 Carbonic anhydrase 7 CA7 0.0103
5294 Nucleoside diphosphate kinase A NME1 0.0103
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
4217 Telomerase reverse transcriptase TERT 0.0101
3917 Methylenetetrahydrofolate reductase MTHFR 0.0101
3760 Penicillin-binding protein 5 precursor dacA 0.01
1405 Thiopurine S-methyltransferase TPMT 0.0097
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0095
4604 Liver carboxylesterase 1 CES1 0.0093
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
2077 Caspase-3 CASP3 0.0093
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
819 Penicillin-binding protein 4 dacB 0.009
6031 Cytochrome P450 3A43 CYP3A43 0.0089
24 Thymidylate synthase TMP1 0.0089
359 Thymidylate synthase TYMS 0.0089
2626 Thymidylate synthase thyA 0.0089
2729 Thymidylate synthase thyA 0.0089
5352 Thymidylate synthase THYA 0.0089
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0087
4122 Histone deacetylase 2 HDAC2 0.0087
6030 Cytochrome P450 2B6 CYP2B6 0.0087
3811 Cytochrome P450 19A1 CYP19A1 0.0085
373 Transthyretin TTR 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
6137 Multidrug resistance-associated protein 6 ABCC6 0.0083
6106 Cytochrome P450 2C18 CYP2C18 0.0082
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0081
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0081
16 Adenosine A1 receptor ADORA1 0.008
1898 Cytochrome P450 1B1 CYP1B1 0.008
1178 Adenosine A2a receptor ADORA2A 0.0078
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0078
6043 Putative G-protein coupled receptor 44 GPR44 0.0076
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0074
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
293 Gamma-glutamyl hydrolase GGH 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
2981 Phospholipase A2, membrane associated PLA2G2A 0.0071
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0071
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.007
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0069
756 Sex hormone-binding globulin SHBG 0.0068
6218 Pannexin-1 PANX1 0.0068
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0066
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0066
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0065
273 Apoptosis regulator Bcl-2 BCL2 0.0065
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0065
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
4773 Deoxycytidine kinase DCK 0.0064
1650 Heme carrier protein 1 SLC46A1 0.0063
6131 Carbonic anhydrase 14 CA14 0.0062
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0062
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0061
5818 Folate receptor alpha FOLR1 0.0061
6042 Prostaglandin reductase 2 PTGR2 0.006
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.006
146 Androgen receptor AR 0.006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0058
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0058
6085 Fatty acid-binding protein, intestinal FABP2 0.0058
6122 Carbonic anhydrase 3 CA3 0.0058
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0055
2021 Thrombomodulin THBD 0.0055
3007 Carbonic anhydrase 12 CA12 0.0055
4205 Carbonic anhydrase 9 CA9 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
1757 Myeloperoxidase MPO 0.0053
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0053
818 50S ribosomal protein L10 rplJ 0.0053
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
4238 50S ribosomal protein L4 rplD 0.0052
5578 50S ribosomal protein L4 rplD 0.0052
6173 50S ribosomal protein L4 rplD 0.0052
6219 50S ribosomal protein L4 rplD 0.0052
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
4237 50S ribosomal protein L22 rplV 0.0047
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0047
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0047
1313 Lactoylglutathione lyase GLO1 0.0046
136 Estrogen receptor ESR1 0.0046
1039 Histone deacetylase 9 HDAC9 0.0045
6014 Cytochrome P450 2A13 CYP2A13 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0044
489 Monocarboxylate transporter 2 SLC16A7 0.0044
3587 Gastrotropin FABP6 0.0043
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0043
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0041
408 Riboflavin kinase RFK 0.0041
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0039
3941 Amine oxidase [flavin-containing] A MAOA 0.0039
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0039
5482 Sialidase-2 NEU2 0.0039
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0039
1792 Tissue-type plasminogen activator PLAT 0.0038
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0037
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
492 Histamine H1 receptor HRH1 0.0035
997 Protein kinase C beta type PRKCB 0.0035
594 Thyroxine-binding globulin SERPINA7 0.0034
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
4226 Uridine phosphorylase 2 UPP2 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0033
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
365 Dihydrofolate reductase DHFR 0.0032
2381 Dihydrofolate reductase DFR1 0.0032
2833 Dihydrofolate reductase Not Available 0.0032
2931 Dihydrofolate reductase folA 0.0032
3544 Dihydrofolate reductase folA 0.0032
3682 Dihydrofolate reductase folA 0.0032
6642 Dihydrofolate reductase folA 0.0032
6756 Dihydrofolate reductase dfrA 0.0032
5924 Microtubule-associated protein 4 MAP4 0.0032
5923 Microtubule-associated protein tau MAPT 0.0032
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0032
2408 Tyrosine-protein kinase SYK SYK 0.0032
758 Thyroid hormone receptor alpha THRA 0.0031
4225 Uridine phosphorylase 1 UPP1 0.003
1852 Microtubule-associated protein 2 MAP2 0.003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.003
654 Flavin reductase BLVRB 0.0029
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
2391 Ferrochelatase hemH 0.0029
6502 Ferrochelatase DKFZp686P18130 0.0029
1591 Ferrochelatase, mitochondrial FECH 0.0029
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
413 Amidophosphoribosyltransferase PPAT 0.0029
2515 Amidophosphoribosyltransferase purF 0.0029
3714 Amidophosphoribosyltransferase purF 0.0029
3810 Catechol O-methyltransferase COMT 0.0029
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
5126 Arginase rocF 0.0027
1025 Aquaporin-1 AQP1 0.0027
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0026
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0026
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0026
6493 Cytochrome c oxidase subunit 6C COX6C 0.0025
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0025
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0025
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0025
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0025
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0025
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0025
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0025
6559 Cytochrome c oxidase subunit 2 ctaC 0.0025
6669 Cytochrome c oxidase subunit 2 ctaC 0.0025
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0025
6558 Cytochrome c oxidase subunit 1 ctaD 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
2540 Choloylglycine hydrolase cbh 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0022
6501 Fatty acid-binding protein, liver FABP1 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6168 Solute carrier family 22 member 16 SLC22A16 0.0021
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
3809 Estrogen-related receptor gamma ESRRG 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0019
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
3957 Adenosine deaminase ADA 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
6500 Phospholipase A2 PLA2G1B 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0018
284 DNA-directed RNA polymerase beta chain rpoB 0.0017
5773 DNA-directed RNA polymerase beta chain rpoB 0.0017
869 Estrogen receptor beta ESR2 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
33 Cystine/glutamate transporter SLC7A11 0.0016
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0015
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
6645 D-amino-acid oxidase DAO 0.0014
468 Cytochrome P450 4A11 CYP4A11 0.0014
822 Aldose reductase AKR1B1 0.0014
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
702 UMP-CMP kinase CMPK1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
465 Calmodulin CALM1 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0008
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0007
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