DT-Web: DB00437

Identification

Name

Allopurinol

Accession Number

DB00437 (APRD00435, DB03027)

Type

small molecule

Description

A xanthine oxidase inhibitor that decreases uric acid production. It also acts as an antimetabolite on some simpler organisms. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

136.1115

Groups

approved

Monoisotopic Weight

136.03851077

Pharmacology

Indication

For the treatment of hyperuricemia associated with primary or secondary gout. Also indicated for the treatment of primary or secondary uric acid nephropathy, with or without the symptoms of gout, as well as chemotherapy-induced hyperuricemia and recurrent renal calculi.

Mechanism of action

Allopurinol and its active metabolite, oxypurinol, inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypoxanthine and xanthine to uric acid. Elevated concentrations of oxypurine and oxypurine inhibition of xanthine oxidase through negative feedback results in a decrease in the concentrations of uric acid in the serum and urine. Allopurinol also facilitates the incorporation of hypoxanthine and xanthine into DNA and RNA, leading to a feedback inhibition of de novo purin synthesis and a decrease in serum uric acid concentrations as a result of an increase in nucleotide concentration.

Absorption

Approximately 80-90% absorbed from the gastrointestinal tract.

Protein binding

Allopurinol and oxypurinol are not bound to plasma proteins

Biotransformation

Hepatic

Route of elimination

Approximately 20% of the ingested allopurinol is excreted in the feces.

Toxicity

LD₅₀=214 mg/kg (in mice)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	Allopurinol may increase the anticoagulant effect of acenocoumarol.
Anisindione	Allopurinol may increase the anticoagulant effect of anisindione.
Azathioprine	Allopurinol may increase the effect of thiopurine, azathioprine.
Cyclosporine	Allopurinol increases the effect and toxicity of cyclosporine
Dicumarol	Allopurinol may increase the anticoagulant effect of dicumarol.
Mercaptopurine	Allopurinol may increase the effect of thiopurine, mercaptopurine.
Trandolapril	The ACE inhibitor, Trandolapril, may increase the risk of hypersensitivity reactions to Allopurinol.
Warfarin	Allopurinol may increase the anticoagulant effect of warfarin. Monitor for changes in prothrombin times and therapeutic effects of warfarin if allopurinol is initiated, discontinued or dose changed.

Food Interactions

Take with food.
Avoid alcohol.
Take with a full glass of water.

Xanthine dehydrogenase/oxidase
Name	Xanthine dehydrogenase/oxidase
Gene Name	XDH
Pharmacological action	yes
Actions	inhibitor
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Suzuki I, Yamauchi T, Onuma M, Nozaki S: Allopurinol, an inhibitor of uric acid synthesis--can it be used for the treatment of metabolic syndrome and related disorders? Drugs Today (Barc). 2009 May;45(5):363-78. - Pubmed Carro MD, Falkenstein E, Radke WJ, Klandorf H: Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens. Comp Biochem Physiol C Toxicol Pharmacol. 2010 Jan;151(1):12-7. Epub 2009 Aug 3. - Pubmed George J, Struthers AD: Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress. Vasc Health Risk Manag. 2009;5(1):265-72. Epub 2009 Apr 8. - Pubmed Higgins P, Dawson J, Walters M: The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease. Cardiovasc Psychiatry Neurol. 2009;2009:282059. Epub 2009 Nov 4. - Pubmed Dincer HE, Dincer AP, Levinson DJ: Asymptomatic hyperuricemia: to treat or not to treat. Cleve Clin J Med. 2002 Aug;69(8):594, 597, 600-2 passim. - Pubmed Kelley WN, Wyngaarden JB: Effects of allopurinol and oxipurinol on purine synthesis in cultured human cells. J Clin Invest. 1970 Mar;49(3):602-9. - Pubmed Okamoto K: [Inhibitors of xanthine oxidoreductase] Nippon Rinsho. 2008 Apr;66(4):748-53. - Pubmed Taha MO, Simoes MJ, Noguerol EC, Mendonca FP, Pascoalick HM, Alves RA, Vivian ME, Morales FP, Campos AC, Magalhaes KG, Venerando PS, Tersariol IL, Monteiro HP, Oliveira-Junior IS, Jurkiewicz A, Caricati-Neto A: Effects of allopurinol on ischemia and reperfusion in rabbit livers. Transplant Proc. 2009 Apr;41(3):820-3. - Pubmed Terkeltaub R: Update on gout: new therapeutic strategies and options. Nat Rev Rheumatol. 2010 Jan;6(1):30-8. - Pubmed Pacher P, Nivorozhkin A, Szabo C: Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114. - Pubmed
DTHybrid score	0.461

Aldehyde oxidase
Name	Aldehyde oxidase
Gene Name	AOX1
Actions	substrate
References	Moriwaki Y, Yamamoto T, Nasako Y, Takahashi S, Suda M, Hiroishi K, Hada T, Higashino K: In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochem Pharmacol. 1993 Sep 14;46(6):975-81. - Pubmed
DTHybrid score	0.2787
Xanthine dehydrogenase/oxidase
Name	Xanthine dehydrogenase/oxidase
Gene Name	XDH
Actions	substrate
References	Moriwaki Y, Yamamoto T, Nasako Y, Takahashi S, Suda M, Hiroishi K, Hada T, Higashino K: In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochem Pharmacol. 1993 Sep 14;46(6):975-81. - Pubmed
DTHybrid score	0.461

Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate
References	Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. - Pubmed
DTHybrid score	0.2655
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	substrate
References	Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. - Pubmed
DTHybrid score	0.1914

Id	Partner name	Gene Name	Score
1729	Solute carrier family 22 member 6	SLC22A6	0.1282
1024	Solute carrier family 22 member 11	SLC22A11	0.1093
4512	Cytochrome P450 3A4	CYP3A4	0.0811
2164	Multidrug resistance-associated protein 4	ABCC4	0.0474
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0471
4200	Cytochrome P450 1A2	CYP1A2	0.0453
1588	Multidrug resistance protein 1	ABCB1	0.0443
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0428
338	DNA polymerase	UL30	0.0415
379	DNA polymerase	UL54	0.0415
697	DNA polymerase	ORF28	0.0415
2482	DNA polymerase	43	0.0415
4104	DNA polymerase	BALF5	0.0415
587	Serum albumin	ALB	0.0403
1757	Myeloperoxidase	MPO	0.0379
723	Cytosolic phospholipase A2	PLA2G4A	0.0378
6136	Multidrug resistance-associated protein 5	ABCC5	0.0375
290	Prostaglandin G/H synthase 2	PTGS2	0.0364
2353	Apolipoprotein(a)	LPA	0.0343
1898	Cytochrome P450 1B1	CYP1B1	0.0337
4757	Cytochrome P450 2C9	CYP2C9	0.0328
1405	Thiopurine S-methyltransferase	TPMT	0.0327
234	Plasminogen	PLG	0.0306
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0303
4924	Cytochrome P450 2C8	CYP2C8	0.0292
4118	Cytochrome P450 3A5	CYP3A5	0.0291
6145	Solute carrier family 22 member 1	SLC22A1	0.0289
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0289
1792	Tissue-type plasminogen activator	PLAT	0.0279
118	Organic cation/carnitine transporter 2	SLC22A5	0.0279
6144	Solute carrier family 22 member 2	SLC22A2	0.0271
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0268
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0265
862	Multidrug resistance-associated protein 1	ABCC1	0.0261
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0252
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0241
833	Organic cation/carnitine transporter 1	SLC22A4	0.0236
3811	Cytochrome P450 19A1	CYP19A1	0.0234
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0231
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0223
6107	Cytochrome P450 3A7	CYP3A7	0.0223
6016	Cytochrome P450 2C19	CYP2C19	0.0221
20	Prostaglandin G/H synthase 1	PTGS1	0.0218
22	30S ribosomal protein S4	rpsD	0.0206
6714	30S ribosomal protein S4	rpsD	0.0206
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0204
6171	Solute carrier family 28 member 3	SLC28A3	0.0202
738	Monocarboxylate transporter 1	SLC16A1	0.02
140	30S ribosomal protein S9	rpsI	0.0194
6719	30S ribosomal protein S9	rpsI	0.0194
6725	30S ribosomal protein S9	rpsI	0.0194
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0187
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0183
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0182
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0182
378	Alpha-2C adrenergic receptor	ADRA2C	0.0176
776	Bile salt export pump	ABCB11	0.0175
629	Alpha-2B adrenergic receptor	ADRA2B	0.0173
6030	Cytochrome P450 2B6	CYP2B6	0.0166
63	Malate dehydrogenase	mdh	0.0165
2329	Malate dehydrogenase	mdh	0.0165
3445	Malate dehydrogenase	mdh	0.0165
4420	Malate dehydrogenase	mdh	0.0165
4438	Malate dehydrogenase	mdh	0.0165
6141	Sodium/bile acid cotransporter	SLC10A1	0.0165
896	Glutathione S-transferase Mu 1	GSTM1	0.0163
159	Penicillin-binding protein 2B	penA	0.016
6121	Penicillin-binding protein 2B	penA	0.016
4119	Cytochrome P450 2D6	CYP2D6	0.0158
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0158
6024	Cytochrome P450 1A1	CYP1A1	0.0158
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0157
327	Glutathione reductase	gor	0.0156
5110	Glutathione reductase	GR2	0.0156
6148	Multidrug resistance-associated protein 7	ABCC10	0.0155
318	Alpha-2A adrenergic receptor	ADRA2A	0.0154
6013	Cytochrome P450 2E1	CYP2E1	0.0152
3823	Cytokine receptor common gamma chain	IL2RG	0.0151
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0149
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0149
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0146
5353	Glutamate decarboxylase alpha	gadA	0.0141
811	Translocator protein	TSPO	0.0137
724	Interleukin-2 receptor alpha chain	IL2RA	0.0131
717	Interleukin-2 receptor subunit beta	IL2RB	0.0131
400	Coagulation factor IX	F9	0.0129
5461	Coagulation factor IX	F9	0.0129
6137	Multidrug resistance-associated protein 6	ABCC6	0.0121
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0119
604	Vitamin K-dependent protein Z	PROZ	0.0119
2016	Dipeptidase 1	DPEP1	0.0115
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0112
543	Penicillin-binding protein 1B	mrcB	0.0111
6186	Penicillin-binding protein 1B	ponB	0.0111
6822	Penicillin-binding protein 1b	pbp1b	0.0111
6844	Penicillin-binding protein 1b	pbp1b	0.0111
4604	Liver carboxylesterase 1	CES1	0.0111
5718	Cytochrome P450 2A6	CYP2A6	0.011
645	Penicillin-binding protein 1A	mrcA	0.0109
5805	Penicillin-binding protein 1A	ponA	0.0109
6185	Penicillin-binding protein 1A	mrcA	0.0109
6799	Penicillin-binding protein 1A	pbpA	0.0109
869	Estrogen receptor beta	ESR2	0.0109
303	Diamine acetyltransferase 2	SAT2	0.0109
623	Spermine oxidase	SMOX	0.0109
1317	Spermine synthase	SMS	0.0109
136	Estrogen receptor	ESR1	0.0109
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0109
422	Vitamin K-dependent protein C	PROC	0.0108
1245	Vitamin K-dependent protein S	PROS1	0.0108
1656	CYP2B protein	CYP2B	0.0108
1867	Major prion protein	PRNP	0.0108
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0107
6168	Solute carrier family 22 member 16	SLC22A16	0.0106
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0104
6147	Solute carrier family 22 member 3	SLC22A3	0.0103
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0101
3685	Catabolite gene activator	crp	0.0101
4655	Adenylate cyclase	cyaC	0.0101
4759	Adenylate cyclase	cyaB2	0.0101
3932	Glutathione S-transferase A2	GSTA2	0.01
4031	Glutathione S-transferase A1	GSTA1	0.01
124	Histamine H2 receptor	HRH2	0.01
123	Diamine acetyltransferase 1	SAT1	0.01
6149	Solute carrier family 22 member 10	SLC22A10	0.0099
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0098
183	Vascular endothelial growth factor A	VEGFA	0.0096
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0096
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
6207	30S ribosomal protein S14	rpsN	0.0093
6209	30S ribosomal protein S19	rpsS	0.0093
6712	30S ribosomal protein S19	rpsS	0.0093
6726	30S ribosomal protein S19	rpsS	0.0093
6859	Protein S100-A4	S100A4	0.0091
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0091
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0091
798	Osteocalcin	BGLAP	0.0088
2249	Aspartate aminotransferase	aspC	0.0087
2671	Aspartate aminotransferase	aspC	0.0087
5490	Aspartate aminotransferase	Not Available	0.0087
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0087
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0087
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0087
4122	Histone deacetylase 2	HDAC2	0.0087
4760	Mll3241 protein	mll3241	0.0086
3923	Cholinesterase	BCHE	0.0084
6163	Copper-transporting ATPase 2	ATP7B	0.0083
6165	Copper-transporting ATPase 1	ATP7A	0.0083
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0081
5818	Folate receptor alpha	FOLR1	0.0081
6033	High affinity interleukin-8 receptor A	CXCR1	0.008
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.008
16	Adenosine A1 receptor	ADORA1	0.008
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.008
527	Prostacyclin receptor	PTGIR	0.0079
6146	High affinity copper uptake protein 1	SLC31A1	0.0079
369	Coagulation factor VII	F7	0.0079
1178	Adenosine A2a receptor	ADORA2A	0.0078
449	Ornithine decarboxylase	ODC1	0.0078
672	Prostaglandin F2-alpha receptor	PTGFR	0.0077
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0077
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0077
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0076
908	Glutathione S-transferase theta-1	GSTT1	0.0076
551	Carnitine O-acetyltransferase	CRAT	0.0075
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0075
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0075
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0074
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0074
6031	Cytochrome P450 3A43	CYP3A43	0.0074
867	Penicillin-binding protein 3	pbpC	0.0073
6119	Penicillin-binding protein 3	pbp3	0.0073
7154	Penicillin-binding protein 3	pbp3	0.0073
7157	Penicillin-binding protein 3	LMHCC_2184	0.0073
7162	Penicillin-binding protein 3	pbpB	0.0073
7172	Penicillin-binding protein 3	pbp3	0.0073
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0072
1654	Interleukin-1 beta	IL1B	0.0072
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0071
438	Taste receptor type 1 member 2	TAS1R2	0.0071
293	Gamma-glutamyl hydrolase	GGH	0.007
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.007
633	Penicillin-binding proteins 1A/1B	pbpA	0.0069
6167	Organic solute transporter subunit beta	OSTB	0.0069
6166	Organic solute transporter subunit alpha	OSTA	0.0069
558	Solute carrier family 12 member 1	SLC12A1	0.0069
244	Angiotensin-converting enzyme	ACE	0.0067
5626	Nucleoside diphosphate kinase B	NME2	0.0067
663	Solute carrier family 12 member 4	SLC12A4	0.0066
53	Solute carrier family 12 member 5	SLC12A5	0.0066
3686	Acyl-CoA thioesterase I precursor	tesA	0.0065
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0064
24	Thymidylate synthase	TMP1	0.0063
359	Thymidylate synthase	TYMS	0.0063
2626	Thymidylate synthase	thyA	0.0063
2729	Thymidylate synthase	thyA	0.0063
5352	Thymidylate synthase	THYA	0.0063
115	Penicillin-binding protein 2	mrdA	0.0062
6069	Penicillin-binding protein 2	mrdA	0.0062
6118	Penicillin-binding protein 2	penA	0.0062
6187	Penicillin-binding protein 2	pbpA	0.0062
6686	Penicillin-binding protein 2	pbp2	0.0062
6939	Penicillin-binding protein 2	mrdA	0.0062
7163	Penicillin-binding protein 2	pbpA	0.0062
310	Solute carrier family 12 member 2	SLC12A2	0.0062
1650	Heme carrier protein 1	SLC46A1	0.0061
4120	NADPH--cytochrome P450 reductase	POR	0.0061
904	Glutathione S-transferase P	GSTP1	0.0061
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.006
465	Calmodulin	CALM1	0.006
239	Coagulation factor X	F10	0.0059
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0059
556	Alpha-1A adrenergic receptor	ADRA1A	0.0059
1	Peptidoglycan synthetase ftsI	ftsI	0.0058
4155	Peptidoglycan synthetase ftsI	ftsI	0.0058
494	Caspase-1	CASP1	0.0058
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0058
887	DNA gyrase subunit B	gyrB	0.0057
4150	DNA gyrase subunit B	gyrB	0.0057
6225	DNA gyrase subunit B	gyrB	0.0057
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0057
756	Sex hormone-binding globulin	SHBG	0.0056
1507	Cytochrome c	CYCS	0.0055
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0055
5294	Nucleoside diphosphate kinase A	NME1	0.0055
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0054
4217	Telomerase reverse transcriptase	TERT	0.0053
818	50S ribosomal protein L10	rplJ	0.0053
275	Arachidonate 5-lipoxygenase	ALOX5	0.0052
3760	Penicillin-binding protein 5 precursor	dacA	0.0052
4238	50S ribosomal protein L4	rplD	0.0052
5578	50S ribosomal protein L4	rplD	0.0052
6173	50S ribosomal protein L4	rplD	0.0052
6219	50S ribosomal protein L4	rplD	0.0052
1374	Natriuretic peptides B	NPPB	0.0051
1827	Gap junction alpha-1 protein	GJA1	0.0051
1908	Vascular cell adhesion protein 1	VCAM1	0.0051
365	Dihydrofolate reductase	DHFR	0.005
2381	Dihydrofolate reductase	DFR1	0.005
2833	Dihydrofolate reductase	Not Available	0.005
2931	Dihydrofolate reductase	folA	0.005
3544	Dihydrofolate reductase	folA	0.005
3682	Dihydrofolate reductase	folA	0.005
6642	Dihydrofolate reductase	folA	0.005
6756	Dihydrofolate reductase	dfrA	0.005
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.005
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.005
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0049
54	Prothrombin	F2	0.0049
1141	Sialidase-1	NEU1	0.0049
64	Neuraminidase	NA	0.0049
641	Neuraminidase	NA	0.0049
2676	Neuraminidase	NA	0.0049
3026	Neuraminidase	NA	0.0049
3519	Neuraminidase	NA	0.0049
6007	Neuraminidase	NA	0.0049
2077	Caspase-3	CASP3	0.0048
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0048
65	Matrix metalloproteinase-9	Not Available	0.0048
468	Cytochrome P450 4A11	CYP4A11	0.0048
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0047
4237	50S ribosomal protein L22	rplV	0.0047
817	DNA topoisomerase 2-alpha	TOP2A	0.0047
819	Penicillin-binding protein 4	dacB	0.0046
332	Beta-lactamase	blaZ	0.0046
2478	Beta-lactamase	ampC	0.0046
2613	Beta-lactamase	ampC	0.0046
2635	Beta-lactamase	ampC	0.0046
2700	Beta-lactamase	penP	0.0046
5445	Beta-lactamase	blaB	0.0046
6019	Beta-lactamase	SHV-7	0.0046
6701	Beta-lactamase	cphA	0.0046
3941	Amine oxidase [flavin-containing] A	MAOA	0.0045
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0045
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0044
6128	Carbonic anhydrase-related protein 10	CA10	0.0044
6133	Sodium channel subunit beta-2	SCN2B	0.0044
6134	Sodium channel subunit beta-3	SCN3B	0.0044
6132	Sodium channel subunit beta-1	SCN1B	0.0044
6135	Sodium channel subunit beta-4	SCN4B	0.0044
6129	Carbonic anhydrase-related protein 11	CA11	0.0044
6127	Carbonic anhydrase-related protein	CA8	0.0044
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0043
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0043
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0043
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0042
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0042
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0042
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0042
2320	Thymidine kinase, cytosolic	TK1	0.0041
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0041
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.004
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.004
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0039
146	Androgen receptor	AR	0.0039
4192	DNA topoisomerase 2-beta	TOP2B	0.0039
5482	Sialidase-2	NEU2	0.0039
831	D(2) dopamine receptor	DRD2	0.0039
273	Apoptosis regulator Bcl-2	BCL2	0.0039
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0038
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0038
4773	Deoxycytidine kinase	DCK	0.0038
6130	Carbonic anhydrase 13	CA13	0.0038
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0037
6131	Carbonic anhydrase 14	CA14	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
1039	Histone deacetylase 9	HDAC9	0.0036
130	Prostacyclin synthase	PTGIS	0.0036
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0035
6218	Pannexin-1	PANX1	0.0035
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0035
3587	Gastrotropin	FABP6	0.0035
509	Thymidine kinase	TK	0.0035
570	Thymidine kinase	TK	0.0035
2559	Thymidine kinase	TK	0.0035
3430	Thymidine kinase	tdk	0.0035
3518	Thymidine kinase	TK	0.0035
5301	Thymidine kinase	tdk	0.0035
5771	Thymidine kinase	ORF36	0.0035
7009	Thymidine kinase	ORF36	0.0035
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0035
6122	Carbonic anhydrase 3	CA3	0.0034
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0034
594	Thyroxine-binding globulin	SERPINA7	0.0034
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0034
4226	Uridine phosphorylase 2	UPP2	0.0034
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0033
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0033
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0032
357	Carbonic anhydrase 2	CA2	0.0032
5924	Microtubule-associated protein 4	MAP4	0.0032
5923	Microtubule-associated protein tau	MAPT	0.0032
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0031
6042	Prostaglandin reductase 2	PTGR2	0.0031
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0031
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0031
758	Thyroid hormone receptor alpha	THRA	0.0031
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0031
3007	Carbonic anhydrase 12	CA12	0.0031
4205	Carbonic anhydrase 9	CA9	0.0031
2981	Phospholipase A2, membrane associated	PLA2G2A	0.003
4225	Uridine phosphorylase 1	UPP1	0.003
3426	Glutamine synthetase	glnA	0.003
3987	Glutamine synthetase	GLUL	0.003
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.003
1852	Microtubule-associated protein 2	MAP2	0.003
6126	Carbonic anhydrase 7	CA7	0.0029
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0029
268	Adenosine A2b receptor	ADORA2B	0.0029
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0029
2391	Ferrochelatase	hemH	0.0029
6502	Ferrochelatase	DKFZp686P18130	0.0029
1591	Ferrochelatase, mitochondrial	FECH	0.0029
1198	Serum paraoxonase/arylesterase 1	PON1	0.0029
6223	Penicillin-binding protein 1C	pbpC	0.0029
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0029
952	Dipeptidyl peptidase 4	DPP4	0.0029
413	Amidophosphoribosyltransferase	PPAT	0.0029
2515	Amidophosphoribosyltransferase	purF	0.0029
3714	Amidophosphoribosyltransferase	purF	0.0029
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0029
6043	Putative G-protein coupled receptor 44	GPR44	0.0029
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0029
6014	Cytochrome P450 2A13	CYP2A13	0.0028
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0028
346	Thyroid hormone receptor beta-1	THRB	0.0028
373	Transthyretin	TTR	0.0028
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0027
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0027
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0027
5126	Arginase	rocF	0.0027
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0026
3939	Amine oxidase [flavin-containing] B	MAOB	0.0026
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0026
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0026
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0026
76	Nitric-oxide synthase, brain	NOS1	0.0026
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0026
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0026
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0026
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0025
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0025
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0025
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0025
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0025
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0025
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0025
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0025
6559	Cytochrome c oxidase subunit 2	ctaC	0.0025
6669	Cytochrome c oxidase subunit 2	ctaC	0.0025
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0025
6558	Cytochrome c oxidase subunit 1	ctaD	0.0025
29	Tubulin beta-1 chain	TUBB1	0.0025
6106	Cytochrome P450 2C18	CYP2C18	0.0025
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0025
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0025
517	Alcohol dehydrogenase 1C	ADH1C	0.0025
740	Argininosuccinate synthase	ASS1	0.0025
865	Argininosuccinate synthase	ASS1	0.0025
2680	Argininosuccinate synthase	argG	0.0025
3194	Argininosuccinate synthase	argG	0.0025
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0025
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0025
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0024
193	Beta-1 adrenergic receptor	ADRB1	0.0024
1313	Lactoylglutathione lyase	GLO1	0.0024
766	Beta-2 adrenergic receptor	ADRB2	0.0024
3639	Thymidine phosphorylase	deoA	0.0024
3936	Thymidine phosphorylase	TYMP	0.0024
592	Carbonic anhydrase 4	CA4	0.0024
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0023
2540	Choloylglycine hydrolase	cbh	0.0023
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0023
489	Monocarboxylate transporter 2	SLC16A7	0.0023
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0023
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
295	Carbonic anhydrase 1	CA1	0.0022
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0022
6645	D-amino-acid oxidase	DAO	0.0022
6501	Fatty acid-binding protein, liver	FABP1	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
3830	Calreticulin	CALR	0.0022
6151	Monocarboxylate transporter 10	SLC16A10	0.0021
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0021
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0021
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.002
6034	Hydroxyindole O-methyltransferase	ASMT	0.002
6035	Nuclear receptor ROR-beta	RORB	0.002
6036	Eosinophil peroxidase	EPX	0.002
3809	Estrogen-related receptor gamma	ESRRG	0.002
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
3957	Adenosine deaminase	ADA	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
6085	Fatty acid-binding protein, intestinal	FABP2	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
6500	Phospholipase A2	PLA2G1B	0.0018
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0018
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0017
284	DNA-directed RNA polymerase beta chain	rpoB	0.0017
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0017
7	Nitric oxide synthase, inducible	NOS2	0.0017
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0017
816	Biliverdin reductase A	BLVRA	0.0017
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0017
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0017
765	Indoleamine 2,3-dioxygenase	IDO1	0.0017
714	Glutathione reductase, mitochondrial	GSR	0.0017
291	Nitric-oxide synthase, endothelial	NOS3	0.0017
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0017
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
571	Melatonin receptor type 1A	MTNR1A	0.0016
362	Melatonin receptor type 1B	MTNR1B	0.0016
5682	Ribonuclease pancreatic	RNASE1	0.0016
2300	Lysozyme	E	0.0016
3633	Lysozyme	R	0.0016
5597	Lysozyme	17	0.0016
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0016
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0016
2021	Thrombomodulin	THBD	0.0016
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0016
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0016
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0016
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0016
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0016
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0016
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0016
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0016
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0016
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0016
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0016
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0016
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0016
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0016
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0016
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0016
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0016
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0016
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0016
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0016
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0016
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0016
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0016
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0016
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0016
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0016
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0016
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0016
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0016
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0016
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0016
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0016
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0016
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0016
644	Heme oxygenase 2	HMOX2	0.0016
4982	Heme oxygenase 2	pbsA2	0.0016
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0016
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0016
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0016
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0016
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0016
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0016
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0016
729	GDP-L-fucose synthetase	TSTA3	0.0016
3463	GDP-L-fucose synthetase	fcl	0.0016
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0016
167	L-lactate dehydrogenase C chain	LDHC	0.0016
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0016
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0016
206	3-keto-steroid reductase	HSD17B7	0.0016
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0016
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0016
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0016
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0016
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0016
107	C-4 methylsterol oxidase	SC4MOL	0.0016
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0016
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0016
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0016
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0016
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0016
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0016
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0016
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0016
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0016
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0016
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0016
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0016
34	7-dehydrocholesterol reductase	DHCR7	0.0016
711	UDP-glucose 6-dehydrogenase	UGDH	0.0016
3672	UDP-glucose 6-dehydrogenase	hasB	0.0016
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0016
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0016
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0016
643	Peroxisomal bifunctional enzyme	EHHADH	0.0016
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0016
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0016
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0016
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0015
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0015
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0015
328	Sorbitol dehydrogenase	SORD	0.0015
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0015
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0015
597	Dihydropteridine reductase	QDPR	0.0015
396	Alcohol dehydrogenase 4	ADH4	0.0015
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0015
2693	Heat-labile enterotoxin B chain	eltB	0.0014
199	Monocarboxylate transporter 8	SLC16A2	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0014
666	NADP-dependent malic enzyme	ME1	0.0014
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0014
857	Malate dehydrogenase, mitochondrial	MDH2	0.0014
6026	Alcohol dehydrogenase 6	ADH6	0.0014
77	L-lactate dehydrogenase B chain	LDHB	0.0014
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0014
12	Alcohol dehydrogenase class 3	ADH5	0.0014
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0013
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0013
626	Cysteine dioxygenase type 1	CDO1	0.0013
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0013
627	11-cis retinol dehydrogenase	RDH5	0.0013
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0013
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0013
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0013
569	Retinal dehydrogenase 2	ALDH1A2	0.0013
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0013
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
473	L-lactate dehydrogenase A chain	LDHA	0.0013
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0013
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0013
4486	Phenol 2-hydroxylase component B	pheA2	0.0013
4439	Ferredoxin reductase	bphA4	0.0013
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0013
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0013
5117	Dihydrolipoyl dehydrogenase	lpd	0.0013
13	Aminomethyltransferase, mitochondrial	AMT	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0013
751	Potassium channel subfamily K member 6	KCNK6	0.0013
611	Retinal dehydrogenase 1	ALDH1A1	0.0012
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0012
5122	Mersacidin decarboxylase	mrsD	0.0012
526	Thioredoxin reductase	trxB	0.0012
3767	Thioredoxin reductase	trxB	0.0012
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0012
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0012
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0012
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0012
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0012
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0012
5115	FkbI	fkbI	0.0012
3133	UDP-galactopyranose mutase	glf	0.0012
5099	UDP-galactopyranose mutase	glf	0.0012
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0012
5095	Putidaredoxin reductase	camA	0.0012
5083	Cryptochrome DASH	cry	0.0012
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0012
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0012
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0012
5081	L-aspartate oxidase	nadB	0.0012
5111	Phenylacetone monooxygenase	pamO	0.0012
5109	Outer membrane protein p64k or PM-6	m-6	0.0012
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0012
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0012
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0012
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0012
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0012
251	Alcohol dehydrogenase 1A	ADH1A	0.0012
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
279	Tyrosinase	TYR	0.0012
172	Potassium channel subfamily K member 1	KCNK1	0.0012
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0011
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
3102	Flavohemoprotein	hmp	0.0011
4969	Flavohemoprotein	hmp	0.0011
4440	NADH peroxidase	npr	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
654	Flavin reductase	BLVRB	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0011
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0011
5072	N,N-dimethylglycine oxidase	dmg	0.0011
5073	Ferredoxin--NADP reductase	petH	0.0011
5076	Ferredoxin--NADP reductase	fpr	0.0011
5119	Ferredoxin--NADP reductase	petH	0.0011
5121	Ferredoxin--NADP reductase	fpr	0.0011
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0011
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0011
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0011
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0011
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0011
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0011
2526	NADPH-ferredoxin reductase fprA	fprA	0.0011
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0011
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0011
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0011
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0011
810	Heme oxygenase 1	HMOX1	0.0011
3391	Heme oxygenase 1	pbsA1	0.0011
2470	Pyruvate oxidase	pox5	0.0011
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0011
444	Alcohol dehydrogenase 1B	ADH1B	0.0011
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.001
2268	Cholesterol oxidase	choB	0.001
2822	Cholesterol oxidase	choA	0.001
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.001
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.001
380	Cytochrome P450 17A1	CYP17A1	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
126	D-lactate dehydrogenase	dld	0.001
3545	D-lactate dehydrogenase	Not Available	0.001
4510	D-lactate dehydrogenase	ldhA	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
605	Fumarate reductase flavoprotein subunit	frdA	0.001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.001
3673	Fumarate reductase flavoprotein subunit	fccA	0.001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.001
6549	Fumarate reductase flavoprotein subunit	frdA	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.001
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.001
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.001
2893	Glycine oxidase	thiO	0.001
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0009
2567	Thymidylate synthase thyX	thyX	0.0009
33	Cystine/glutamate transporter	SLC7A11	0.0009
2823	Trypanothione reductase	TPR	0.0009
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0009
2769	P-hydroxybenzoate hydroxylase	pobA	0.0009
2809	P-hydroxybenzoate hydroxylase	pobA	0.0009
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0009
2380	Monomeric sarcosine oxidase	soxA	0.0008
822	Aldose reductase	AKR1B1	0.0008
3810	Catechol O-methyltransferase	COMT	0.0008
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0007

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00437 - Allopurinol

Targets

Enzymes

Transporters

Predictions