DT-Web

DB01237 - Bromodiphenhydramine


Identification
Name Bromodiphenhydramine
Accession Number DB01237 (APRD00710)
Type small molecule
Description Bromodiphenhydramine is an ethanolamine antihistamine with antimicrobial property. Bromodiphenhydramine is used in the control of cutaneous allergies. Ethanolamine antihistamines produce marked sedation in most patients
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 334.251
Groups approved
Monoisotopic Weight 333.072826914
Pharmacology
Indication For management of symptoms related to hay fever and other types of allergy and used to help bring up phlegm, thin secretions, and make a cough productive.
Mechanism of action Bromodiphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.
Absorption Well absorbed in the digestive tract.
Protein binding 96%
Biotransformation Hepatic (cytochrome P-450 system); some renal.
Route of elimination Not Available
Toxicity Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Bromodiphenhydramine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Trimethobenzamide Trimethobenzamide and Bromodiphenhydramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine Triprolidine and Bromodiphenhydramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Bromodiphenhydramine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Food Interactions Not Available

Targets


Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5139

Transporters


Multidrug and toxin extrusion protein 1
Name Multidrug and toxin extrusion protein 1
Gene Name SLC47A1
Actions inhibitor
References
  • Ullrich KJ, Rumrich G, David C, Fritzsch G: Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines. Pflugers Arch. 1993 Nov;425(3-4):280-99. - Pubmed
DTHybrid score 0.2323
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions Not Available
References
  • Ullrich KJ, Rumrich G, David C, Fritzsch G: Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines. Pflugers Arch. 1993 Nov;425(3-4):280-99. - Pubmed
DTHybrid score 0.2911

Predictions


Id Partner name Gene Name Score
6142 Solute carrier family 22 member 8 SLC22A8 0.0825
4119 Cytochrome P450 2D6 CYP2D6 0.0762
4512 Cytochrome P450 3A4 CYP3A4 0.0755
6145 Solute carrier family 22 member 1 SLC22A1 0.0534
1024 Solute carrier family 22 member 11 SLC22A11 0.047
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0462
1588 Multidrug resistance protein 1 ABCB1 0.0445
4757 Cytochrome P450 2C9 CYP2C9 0.0411
6144 Solute carrier family 22 member 2 SLC22A2 0.0393
4200 Cytochrome P450 1A2 CYP1A2 0.0377
118 Organic cation/carnitine transporter 2 SLC22A5 0.037
587 Serum albumin ALB 0.037
6147 Solute carrier family 22 member 3 SLC22A3 0.0366
338 DNA polymerase UL30 0.0343
379 DNA polymerase UL54 0.0343
697 DNA polymerase ORF28 0.0343
2482 DNA polymerase 43 0.0343
4104 DNA polymerase BALF5 0.0343
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0342
6143 Solute carrier family 22 member 7 SLC22A7 0.0334
6016 Cytochrome P450 2C19 CYP2C19 0.0327
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0316
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0299
4118 Cytochrome P450 3A5 CYP3A5 0.0289
6107 Cytochrome P450 3A7 CYP3A7 0.0278
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0277
20 Prostaglandin G/H synthase 1 PTGS1 0.0274
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0262
290 Prostaglandin G/H synthase 2 PTGS2 0.025
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0245
556 Alpha-1A adrenergic receptor ADRA1A 0.0245
4924 Cytochrome P450 2C8 CYP2C8 0.0233
502 5-hydroxytryptamine 2A receptor HTR2A 0.0224
4148 Serine/threonine-protein kinase mTOR MTOR 0.0221
6013 Cytochrome P450 2E1 CYP2E1 0.0193
1525 Heparin-binding growth factor 2 FGF2 0.0192
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0188
713 Sodium-dependent dopamine transporter SLC6A3 0.0182
1341 Histamine H3 receptor HRH3 0.0175
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0175
318 Alpha-2A adrenergic receptor ADRA2A 0.0172
450 Muscarinic acetylcholine receptor M4 CHRM4 0.017
590 5-hydroxytryptamine 2C receptor HTR2C 0.0169
516 Neurotensin receptor type 2 NTSR2 0.0168
768 FK506-binding protein 1A FKBP1A 0.0162
833 Organic cation/carnitine transporter 1 SLC22A4 0.0161
6030 Cytochrome P450 2B6 CYP2B6 0.0155
633 Penicillin-binding proteins 1A/1B pbpA 0.0149
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
2164 Multidrug resistance-associated protein 4 ABCC4 0.0142
592 Carbonic anhydrase 4 CA4 0.0141
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
831 D(2) dopamine receptor DRD2 0.0135
295 Carbonic anhydrase 1 CA1 0.0133
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0132
776 Bile salt export pump ABCB11 0.0131
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0127
124 Histamine H2 receptor HRH2 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
23 D(1A) dopamine receptor DRD1 0.0118
824 Sodium-dependent serotonin transporter SLC6A4 0.0116
357 Carbonic anhydrase 2 CA2 0.0116
4790 Glycosyltransferase GtfA gtfA 0.011
320 5-hydroxytryptamine 1A receptor HTR1A 0.0109
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
862 Multidrug resistance-associated protein 1 ABCC1 0.0101
645 Penicillin-binding protein 1A mrcA 0.01
5805 Penicillin-binding protein 1A ponA 0.01
6185 Penicillin-binding protein 1A mrcA 0.01
6799 Penicillin-binding protein 1A pbpA 0.01
6024 Cytochrome P450 1A1 CYP1A1 0.0099
432 D(4) dopamine receptor DRD4 0.0098
632 Alpha-1B adrenergic receptor ADRA1B 0.0097
1275 Estrogen sulfotransferase SULT1E1 0.0096
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0094
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
738 Monocarboxylate transporter 1 SLC16A1 0.009
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.009
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0086
638 D(3) dopamine receptor DRD3 0.0086
5718 Cytochrome P450 2A6 CYP2A6 0.0086
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0084
1656 CYP2B protein CYP2B 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.008
378 Alpha-2C adrenergic receptor ADRA2C 0.0078
629 Alpha-2B adrenergic receptor ADRA2B 0.0078
543 Penicillin-binding protein 1B mrcB 0.0077
6186 Penicillin-binding protein 1B ponB 0.0077
6822 Penicillin-binding protein 1b pbp1b 0.0077
6844 Penicillin-binding protein 1b pbp1b 0.0077
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0075
6106 Cytochrome P450 2C18 CYP2C18 0.0073
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0073
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0072
716 5-hydroxytryptamine 7 receptor HTR7 0.0072
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0069
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0068
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0068
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0066
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
789 Alpha-1D adrenergic receptor ADRA1D 0.0063
5626 Nucleoside diphosphate kinase B NME2 0.006
2320 Thymidine kinase, cytosolic TK1 0.0059
558 Solute carrier family 12 member 1 SLC12A1 0.0059
1256 5-hydroxytryptamine 6 receptor HTR6 0.0058
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0056
466 Solute carrier family 12 member 3 SLC12A3 0.0055
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0054
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0054
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
6136 Multidrug resistance-associated protein 5 ABCC5 0.0052
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6182 Cytochrome P450 2J2 CYP2J2 0.005
6097 Protein S100-A2 S100A2 0.005
1810 Protein S100-A1 S100A1 0.005
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
725 5-hydroxytryptamine 1D receptor HTR1D 0.0047
341 5-hydroxytryptamine 3 receptor HTR3A 0.0046
373 Transthyretin TTR 0.0046
3917 Methylenetetrahydrofolate reductase MTHFR 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0043
1048 Protein S100-A13 S100A13 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0043
2226 Protein S100-A12 S100A12 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0042
115 Penicillin-binding protein 2 mrdA 0.0041
6069 Penicillin-binding protein 2 mrdA 0.0041
6118 Penicillin-binding protein 2 penA 0.0041
6187 Penicillin-binding protein 2 pbpA 0.0041
6686 Penicillin-binding protein 2 pbp2 0.0041
6939 Penicillin-binding protein 2 mrdA 0.0041
7163 Penicillin-binding protein 2 pbpA 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
408 Riboflavin kinase RFK 0.0041
6141 Sodium/bile acid cotransporter SLC10A1 0.0041
24 Thymidylate synthase TMP1 0.0041
359 Thymidylate synthase TYMS 0.0041
2626 Thymidylate synthase thyA 0.0041
2729 Thymidylate synthase thyA 0.0041
5352 Thymidylate synthase THYA 0.0041
2132 Protein S100-B S100B 0.004
275 Arachidonate 5-lipoxygenase ALOX5 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.004
1 Peptidoglycan synthetase ftsI ftsI 0.0038
4155 Peptidoglycan synthetase ftsI ftsI 0.0038
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0038
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0037
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
528 5-hydroxytryptamine 1E receptor HTR1E 0.0036
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0036
244 Angiotensin-converting enzyme ACE 0.0036
6131 Carbonic anhydrase 14 CA14 0.0035
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0035
6148 Multidrug resistance-associated protein 7 ABCC10 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
885 5-hydroxytryptamine 1B receptor HTR1B 0.0034
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
163 D(1B) dopamine receptor DRD5 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0032
6149 Solute carrier family 22 member 10 SLC22A10 0.0032
164 Histamine H4 receptor HRH4 0.0031
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
465 Calmodulin CALM1 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.003
436 5-hydroxytryptamine 2B receptor HTR2B 0.003
654 Flavin reductase BLVRB 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
6043 Putative G-protein coupled receptor 44 GPR44 0.0028
1757 Myeloperoxidase MPO 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
1867 Major prion protein PRNP 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
1025 Aquaporin-1 AQP1 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
293 Gamma-glutamyl hydrolase GGH 0.0026
4773 Deoxycytidine kinase DCK 0.0026
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0026
130 Prostacyclin synthase PTGIS 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0024
6207 30S ribosomal protein S14 rpsN 0.0024
6209 30S ribosomal protein S19 rpsS 0.0024
6712 30S ribosomal protein S19 rpsS 0.0024
6726 30S ribosomal protein S19 rpsS 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0023
1650 Heme carrier protein 1 SLC46A1 0.0023
6167 Organic solute transporter subunit beta OSTB 0.0023
4760 Mll3241 protein mll3241 0.0023
6166 Organic solute transporter subunit alpha OSTA 0.0023
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0022
3426 Glutamine synthetase glnA 0.0021
3987 Glutamine synthetase GLUL 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
3941 Amine oxidase [flavin-containing] A MAOA 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
527 Prostacyclin receptor PTGIR 0.0021
696 Kappa-type opioid receptor OPRK1 0.0021
672 Prostaglandin F2-alpha receptor PTGFR 0.002
146 Androgen receptor AR 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.002
198 Sodium channel protein type 10 subunit alpha SCN10A 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
4203 Histamine N-methyltransferase HNMT 0.0019
1654 Interleukin-1 beta IL1B 0.0019
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0018
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0018
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0018
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0018
6432 Transporter snf 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0018
6014 Cytochrome P450 2A13 CYP2A13 0.0018
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
6031 Cytochrome P450 3A43 CYP3A43 0.0016
494 Caspase-1 CASP1 0.0015
183 Vascular endothelial growth factor A VEGFA 0.0015
1507 Cytochrome c CYCS 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
4217 Telomerase reverse transcriptase TERT 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
822 Aldose reductase AKR1B1 0.0014
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0013
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0013
2077 Caspase-3 CASP3 0.0013
193 Beta-1 adrenergic receptor ADRB1 0.0013
766 Beta-2 adrenergic receptor ADRB2 0.0012
819 Penicillin-binding protein 4 dacB 0.0012
1360 Sphingomyelin phosphodiesterase SMPD1 0.0012
702 UMP-CMP kinase CMPK1 0.0012
2981 Phospholipase A2, membrane associated PLA2G2A 0.0012
6137 Multidrug resistance-associated protein 6 ABCC6 0.0012
2021 Thrombomodulin THBD 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0011
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0011
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
997 Protein kinase C beta type PRKCB 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
6218 Pannexin-1 PANX1 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
1039 Histone deacetylase 9 HDAC9 0.0009
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0009
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
3923 Cholinesterase BCHE 0.0009
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
1618 High affinity nerve growth factor receptor NTRK1 0.0008
5818 Folate receptor alpha FOLR1 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0008
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0008
3587 Gastrotropin FABP6 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
273 Apoptosis regulator Bcl-2 BCL2 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0007
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0007
6085 Fatty acid-binding protein, intestinal FABP2 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0007
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0007
33 Cystine/glutamate transporter SLC7A11 0.0007
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0006
489 Monocarboxylate transporter 2 SLC16A7 0.0006
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0006
3810 Catechol O-methyltransferase COMT 0.0006
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0006
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0005
467 Delta-type opioid receptor OPRD1 0.0005
4604 Liver carboxylesterase 1 CES1 0.0005
3811 Cytochrome P450 19A1 CYP19A1 0.0005
6020 Aldehyde oxidase AOX1 0.0005
136 Estrogen receptor ESR1 0.0005
365 Dihydrofolate reductase DHFR 0.0004
2381 Dihydrofolate reductase DFR1 0.0004
2833 Dihydrofolate reductase Not Available 0.0004
2931 Dihydrofolate reductase folA 0.0004
3544 Dihydrofolate reductase folA 0.0004
3682 Dihydrofolate reductase folA 0.0004
6642 Dihydrofolate reductase folA 0.0004
6756 Dihydrofolate reductase dfrA 0.0004
1898 Cytochrome P450 1B1 CYP1B1 0.0004
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