DT-Web

DB04047 - [Pterin-6-Yl Methanyl]-Phosphonophosphate


Identification
Name [Pterin-6-Yl Methanyl]-Phosphonophosphate
Accession Number DB04047 (EXPT01742)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 353.1226
Groups experimental
Monoisotopic Weight 352.992635313
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Dihydropteroate synthase
Name Dihydropteroate synthase
Gene Name folP
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.6361
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Name 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gene Name folK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3678

Predictions


Id Partner name Gene Name Score
891 Dihydropteroate synthase folP 1.6361
7175 Dihydropteroate synthase sulI 1.6361
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 1.3678
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 1.3678
3601 Dihydropteroate synthase 1 folP1 0.2822
3807 Dihydropteroate synthase 1 folP1 0.2822
2360 Dihydroneopterin aldolase folB 0.1135
4775 PROBABLE LIGNIN PEROXIDASE LIPJ lipJ 0.0399
4774 NTPase P4 Not Available 0.0377
4776 CarA carA 0.0348
4655 Adenylate cyclase cyaC 0.032
4759 Adenylate cyclase cyaB2 0.032
2532 Pantoate--beta-alanine ligase panC 0.0303
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0303
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0303
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0303
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0303
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.0302
5304 UPF0166 protein TM_0021 TM_0021 0.0034
5287 Signaling protein Not Available 0.0034
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0034
5293 Shikimate kinase 2 aroL 0.0034
5288 Shikimate kinase aroK 0.0034
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0034
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0034
3199 Phosphopantetheine adenylyltransferase coaD 0.0034
3543 Phosphopantetheine adenylyltransferase coaD 0.0034
3567 Phosphopantetheine adenylyltransferase coaD 0.0034
5289 Phosphopantetheine adenylyltransferase coaD 0.0034
2874 Nitrogenase iron protein 1 nifH1 0.0034
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0034
5276 Chromosomal replication initiator protein dnaA dnaA 0.0034
5292 Putative partitioning protein TT_C1605 0.0034
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0034
5266 Activator of hgdC 0.0034
5291 Glycogen synthase 1 glgA1 0.0034
4346 Polynucleotide kinase pseT 0.0034
5264 DNA replication protein REP 0.0034
5283 D-alanine--D-alanine ligase B ddlB 0.0034
5281 Plasmid segregation protein parM parM 0.0034
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0034
5299 D-alanine--D-alanine ligase ddl 0.0034
6598 D-alanine--D-alanine ligase ddl 0.0034
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0034
5259 Transcriptional regulator ntrC1 0.0034
6699 Transcriptional regulator Cgl2612 0.0034
5277 Preprotein translocase subunit secA secA 0.0034
5308 Preprotein translocase secA 1 subunit secA1 0.0034
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0034
5285 Kinesin heavy chain KIF5B 0.0034
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0034
5315 Chaperone protein htpG htpG 0.0034
5284 Large T antigen Not Available 0.0034
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0034
5261 Phosphoribosylformylglycinamidine synthase purL 0.0034
5646 Galactokinase GALK1 0.003
3390 Aminoglycoside 3'-phosphotransferase aphA 0.003
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.003
3470 Hypothetical protein MG245 homolog MPN_348 0.003
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.003
4837 Cag-alfa cag-alfa 0.003
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.003
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.003
4106 Guanylate kinase GUK1 0.003
4516 Guanylate kinase gmk 0.003
2270 Dephospho-CoA kinase coaE 0.003
2284 Adenylate kinase adk 0.003
2296 Adenylate kinase adk 0.003
2311 Adenylate kinase adk 0.003
2312 Adenylate kinase Not Available 0.003
3426 Glutamine synthetase glnA 0.003
3987 Glutamine synthetase GLUL 0.003
413 Amidophosphoribosyltransferase PPAT 0.003
2515 Amidophosphoribosyltransferase purF 0.003
3714 Amidophosphoribosyltransferase purF 0.003
5265 FtsH ftsH 0.003
4839 DNA polymerase III subunit tau dnaX 0.0029
5302 TrwB trwB 0.0029
6277 Heat shock cognate 71 kDa protein HSPA8 0.0029
4838 PMS1 protein homolog 2 PMS2 0.0029
3175 Glutamate--cysteine ligase gshA 0.0029
5189 Trimethylamine dehydrogenase tmd 0.0029
2683 Mono-ADP-ribosyltransferase C3 C3 0.0027
2390 Nonsecretory ribonuclease RNASE2 0.0027
2922 Glycerol kinase glpK 0.0027
5271 Focal adhesion kinase 1 PTK2 0.0027
5312 Kinesin-like protein KIF1A KIF1A 0.0027
340 Apoptotic protease-activating factor 1 APAF1 0.0026
2892 Acetylglutamate kinase argB 0.0026
3550 Acetylglutamate kinase argB 0.0026
3669 Ribokinase rbsK 0.0026
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0026
2371 Pantothenate kinase coaA 0.0026
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0026
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0026
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0026
2615 Chemotaxis protein cheA cheA 0.0026
1881 Hexokinase-1 HK1 0.0026
825 Arsenical pump-driving ATPase ASNA1 0.0026
3435 Arsenical pump-driving ATPase arsA 0.0026
2282 Protein recA recA 0.0025
2315 Protein recA recA 0.0025
2332 Protein recA recA 0.0025
5263 Protein recA recA 0.0025
408 Riboflavin kinase RFK 0.0025
5300 Antigen peptide transporter 1 TAP1 0.0025
2727 S-adenosylmethionine synthetase metK 0.0025
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0025
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0024
2697 Uridine-cytidine kinase 2 UCK2 0.0024
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0024
2334 Dethiobiotin synthetase bioD 0.0024
6555 Dethiobiotin synthetase bioD 0.0024
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0024
788 Creatine kinase M-type CKM 0.0023
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0022
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0022
6395 Myosin-14 MYH14 0.0022
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0022
48 Pyridoxal kinase PDXK 0.0021
2091 Endoplasmin HSP90B1 0.0021
2251 Thymidylate kinase tmk 0.0021
2254 Thymidylate kinase DTYMK 0.0021
3522 Thymidylate kinase tmk 0.0021
702 UMP-CMP kinase CMPK1 0.0021
1422 Serine/threonine-protein kinase 6 AURKA 0.0021
3379 Kinesin-like protein KIF11 KIF11 0.0021
3456 Heat shock protein HSP 90-beta HSP90AB1 0.002
3822 Actin, alpha skeletal muscle ACTA1 0.002
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.002
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.002
207 Glutathione synthetase GSS 0.002
5269 Glutathione synthetase gshB 0.002
509 Thymidine kinase TK 0.0019
570 Thymidine kinase TK 0.0019
2559 Thymidine kinase TK 0.0019
3430 Thymidine kinase tdk 0.0019
3518 Thymidine kinase TK 0.0019
5301 Thymidine kinase tdk 0.0019
5771 Thymidine kinase ORF36 0.0019
7009 Thymidine kinase ORF36 0.0019
504 Mast/stem cell growth factor receptor KIT 0.0019
5294 Nucleoside diphosphate kinase A NME1 0.0018
1721 Glycogen synthase kinase-3 beta GSK3B 0.0018
5682 Ribonuclease pancreatic RNASE1 0.0017
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0016
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0016
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0016
4773 Deoxycytidine kinase DCK 0.0016
↑