DT-Web

DB06151 - Acetylcysteine


Identification
Name Acetylcysteine
Accession Number DB06151
Type small molecule
Description Acetylcysteine is the N-acetyl derivative of cysteine. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 163.195
Groups approved
Monoisotopic Weight 163.030313849
Pharmacology
Indication Acetylcysteine is used mainly as a mucolytic and in the management of paracetamol (acetaminophen) overdose.
Mechanism of action Acetylcysteine may protect against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione. It does this by producing the glutathione precursor cysteine. Glutathione is required to inactivate an intermediate metabolite (N-acetyl-p-benzoquinoneimine) of acetaminophen that is thought to be hepatotoxic. In acetaminophen overdose, excessive quantities of this metabolite are formed because the primary metabolic (glucuronide and sulfate conjugation) pathways become saturated. Acetylcysteine may act by reducing the metabolite to the parent compound and/or by providing sulfhydryl for conjugation of the metabolite. Experimental evidence also suggests that a sulfhydryl-containing compound such as acetylcysteine may also directly inactivate the metabolite. When inhaled, cetylcysteine exerts its mucolytic action through its free sulfhydryl group, which opens the disulfide bonds and lowers mucus viscosity. This action increases with increasing pH and is most significant at pH 7 to 9. The mucolytic action of acetylcysteine is not affected by the presence of DNA. Acetylcysteine is also an antioxidant and reduces oxidative stress.
Absorption Bioavailability is 6-10% following oral administration and less than 3% following topical administration.
Protein binding 83%
Biotransformation Hepatic. Deacetylated by the liver to cysteine and subsequently metabolized.
Route of elimination Not Available
Toxicity Single intravenous doses of acetylcysteine at 1000 mg/kg in mice, 2445 mg/kg in rats, 1500 mg/kg in guinea pigs, 1200 mg/kg in rabbits and 500 mg/kg in dogs were lethal. Symptoms of acute toxicity were ataxia, hypoactivity, labored respiration, cyanosis, loss of righting reflex and convulsions.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


N-acetyl-p-benzoquinoneimine
Name N-acetyl-p-benzoquinoneimine
Gene Name Not Available
Pharmacological action unknown
Actions reducer
References
  • Jones AL: Mechanism of action and value of N-acetylcysteine in the treatment of early and late acetaminophen poisoning: a critical review. J Toxicol Clin Toxicol. 1998;36(4):277-85. - Pubmed
  • Prescott LF, Critchley JA: The treatment of acetaminophen poisoning. Annu Rev Pharmacol Toxicol. 1983;23:87-101. - Pubmed
  • Marzullo L: An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children. Curr Opin Pediatr. 2005 Apr;17(2):239-45. - Pubmed
DTHybrid score Not Available

Transporters


Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions inhibitor
References
  • Daily A, Monks NR, Leggas M, Moscow JA: Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition. Toxicon. 2010 Apr 1;55(4):827-37. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1752
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions Not Available
References
  • Aslamkhan AG, Han YH, Yang XP, Zalups RK, Pritchard JB: Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells. Mol Pharmacol. 2003 Mar;63(3):590-6. - Pubmed
DTHybrid score 0.2484

Predictions


Id Partner name Gene Name Score
6142 Solute carrier family 22 member 8 SLC22A8 0.0729
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0697
4512 Cytochrome P450 3A4 CYP3A4 0.0534
1588 Multidrug resistance protein 1 ABCB1 0.0509
1024 Solute carrier family 22 member 11 SLC22A11 0.0494
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0467
587 Serum albumin ALB 0.0444
4924 Cytochrome P450 2C8 CYP2C8 0.0422
4757 Cytochrome P450 2C9 CYP2C9 0.0414
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0406
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0347
6143 Solute carrier family 22 member 7 SLC22A7 0.0338
6016 Cytochrome P450 2C19 CYP2C19 0.0338
20 Prostaglandin G/H synthase 1 PTGS1 0.0325
4200 Cytochrome P450 1A2 CYP1A2 0.0307
4118 Cytochrome P450 3A5 CYP3A5 0.0259
290 Prostaglandin G/H synthase 2 PTGS2 0.025
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0249
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0248
2164 Multidrug resistance-associated protein 4 ABCC4 0.0246
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0233
862 Multidrug resistance-associated protein 1 ABCC1 0.0229
4119 Cytochrome P450 2D6 CYP2D6 0.0226
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0225
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0216
118 Organic cation/carnitine transporter 2 SLC22A5 0.0216
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0201
6107 Cytochrome P450 3A7 CYP3A7 0.0193
6145 Solute carrier family 22 member 1 SLC22A1 0.0191
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0181
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0174
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0169
776 Bile salt export pump ABCB11 0.0164
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0153
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0151
6024 Cytochrome P450 1A1 CYP1A1 0.015
633 Penicillin-binding proteins 1A/1B pbpA 0.0149
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
592 Carbonic anhydrase 4 CA4 0.0141
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0137
6030 Cytochrome P450 2B6 CYP2B6 0.0136
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0135
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0135
738 Monocarboxylate transporter 1 SLC16A1 0.0134
295 Carbonic anhydrase 1 CA1 0.0133
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0132
70 Type-1 angiotensin II receptor AGTR1 0.0128
6141 Sodium/bile acid cotransporter SLC10A1 0.0127
3587 Gastrotropin FABP6 0.0126
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
833 Organic cation/carnitine transporter 1 SLC22A4 0.0118
338 DNA polymerase UL30 0.0116
379 DNA polymerase UL54 0.0116
697 DNA polymerase ORF28 0.0116
2482 DNA polymerase 43 0.0116
4104 DNA polymerase BALF5 0.0116
357 Carbonic anhydrase 2 CA2 0.0116
4790 Glycosyltransferase GtfA gtfA 0.011
6144 Solute carrier family 22 member 2 SLC22A2 0.0104
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0102
645 Penicillin-binding protein 1A mrcA 0.01
5805 Penicillin-binding protein 1A ponA 0.01
6185 Penicillin-binding protein 1A mrcA 0.01
6799 Penicillin-binding protein 1A pbpA 0.01
758 Thyroid hormone receptor alpha THRA 0.0098
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0097
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0092
275 Arachidonate 5-lipoxygenase ALOX5 0.0091
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0088
346 Thyroid hormone receptor beta-1 THRB 0.0087
373 Transthyretin TTR 0.0085
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
6013 Cytochrome P450 2E1 CYP2E1 0.0083
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
6167 Organic solute transporter subunit beta OSTB 0.0083
6166 Organic solute transporter subunit alpha OSTA 0.0083
2016 Dipeptidase 1 DPEP1 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
6136 Multidrug resistance-associated protein 5 ABCC5 0.0081
5880 Thrombopoietin receptor MPL 0.0081
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0078
6148 Multidrug resistance-associated protein 7 ABCC10 0.0078
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0077
543 Penicillin-binding protein 1B mrcB 0.0077
6186 Penicillin-binding protein 1B ponB 0.0077
6822 Penicillin-binding protein 1b pbp1b 0.0077
6844 Penicillin-binding protein 1b pbp1b 0.0077
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0075
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0073
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
731 HIV-1 protease HIV-1 protease 0.0069
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
5718 Cytochrome P450 2A6 CYP2A6 0.0066
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0066
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
594 Thyroxine-binding globulin SERPINA7 0.0063
492 Histamine H1 receptor HRH1 0.0061
5626 Nucleoside diphosphate kinase B NME2 0.006
2320 Thymidine kinase, cytosolic TK1 0.0059
558 Solute carrier family 12 member 1 SLC12A1 0.0059
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0057
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0056
4604 Liver carboxylesterase 1 CES1 0.0056
26 Vascular endothelial growth factor receptor 3 FLT4 0.0055
3917 Methylenetetrahydrofolate reductase MTHFR 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
32 Vascular endothelial growth factor receptor 1 FLT1 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6106 Cytochrome P450 2C18 CYP2C18 0.005
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0049
6147 Solute carrier family 22 member 3 SLC22A3 0.0049
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0049
24 Thymidylate synthase TMP1 0.0049
359 Thymidylate synthase TYMS 0.0049
2626 Thymidylate synthase thyA 0.0049
2729 Thymidylate synthase thyA 0.0049
5352 Thymidylate synthase THYA 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0046
6149 Solute carrier family 22 member 10 SLC22A10 0.0045
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
1757 Myeloperoxidase MPO 0.0045
3941 Amine oxidase [flavin-containing] A MAOA 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0044
407 Vascular endothelial growth factor receptor 2 KDR 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0042
115 Penicillin-binding protein 2 mrdA 0.0041
6069 Penicillin-binding protein 2 mrdA 0.0041
6118 Penicillin-binding protein 2 penA 0.0041
6187 Penicillin-binding protein 2 pbpA 0.0041
6686 Penicillin-binding protein 2 pbp2 0.0041
6939 Penicillin-binding protein 2 mrdA 0.0041
7163 Penicillin-binding protein 2 pbpA 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
408 Riboflavin kinase RFK 0.0041
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
1 Peptidoglycan synthetase ftsI ftsI 0.0038
4155 Peptidoglycan synthetase ftsI ftsI 0.0038
563 Thyroid peroxidase TPO 0.0038
293 Gamma-glutamyl hydrolase GGH 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
33 Cystine/glutamate transporter SLC7A11 0.0037
244 Angiotensin-converting enzyme ACE 0.0036
199 Monocarboxylate transporter 8 SLC16A2 0.0036
6131 Carbonic anhydrase 14 CA14 0.0035
2539 Tubulin alpha-1 chain TUBA4A 0.0035
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0035
4148 Serine/threonine-protein kinase mTOR MTOR 0.0035
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
511 5-hydroxytryptamine 1F receptor HTR1F 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
1650 Heme carrier protein 1 SLC46A1 0.0034
65 Matrix metalloproteinase-9 Not Available 0.0033
1525 Heparin-binding growth factor 2 FGF2 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
29 Tubulin beta-1 chain TUBB1 0.0032
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0032
1760 Aminopeptidase N ANPEP 0.0032
6843 Aminopeptidase N pepN 0.0032
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0031
136 Estrogen receptor ESR1 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
117 Sterol O-acyltransferase 1 SOAT1 0.003
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
654 Flavin reductase BLVRB 0.0029
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0029
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0029
768 FK506-binding protein 1A FKBP1A 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
6043 Putative G-protein coupled receptor 44 GPR44 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
1867 Major prion protein PRNP 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
1025 Aquaporin-1 AQP1 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
468 Cytochrome P450 4A11 CYP4A11 0.0026
4773 Deoxycytidine kinase DCK 0.0026
6168 Solute carrier family 22 member 16 SLC22A16 0.0026
6151 Monocarboxylate transporter 10 SLC16A10 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0025
551 Carnitine O-acetyltransferase CRAT 0.0025
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0025
130 Prostacyclin synthase PTGIS 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
6031 Cytochrome P450 3A43 CYP3A43 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
3856 Fibroblast growth factor receptor 3 FGFR3 0.0025
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0024
725 5-hydroxytryptamine 1D receptor HTR1D 0.0024
1630 Integrin beta-2 ITGB2 0.0024
6207 30S ribosomal protein S14 rpsN 0.0024
6209 30S ribosomal protein S19 rpsS 0.0024
6712 30S ribosomal protein S19 rpsS 0.0024
6726 30S ribosomal protein S19 rpsS 0.0024
885 5-hydroxytryptamine 1B receptor HTR1B 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0024
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0024
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0023
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0023
4760 Mll3241 protein mll3241 0.0023
5818 Folate receptor alpha FOLR1 0.0022
3811 Cytochrome P450 19A1 CYP19A1 0.0022
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0022
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0022
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0022
3809 Estrogen-related receptor gamma ESRRG 0.0022
320 5-hydroxytryptamine 1A receptor HTR1A 0.0022
3426 Glutamine synthetase glnA 0.0021
3987 Glutamine synthetase GLUL 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0021
1198 Serum paraoxonase/arylesterase 1 PON1 0.0021
6223 Penicillin-binding protein 1C pbpC 0.0021
527 Prostacyclin receptor PTGIR 0.0021
672 Prostaglandin F2-alpha receptor PTGFR 0.002
146 Androgen receptor AR 0.002
1898 Cytochrome P450 1B1 CYP1B1 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
6044 Serum paraoxonase/lactonase 3 PON3 0.002
950 Alpha platelet-derived growth factor receptor PDGFRA 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
1654 Interleukin-1 beta IL1B 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
572 Integrin alpha-L ITGAL 0.0018
228 Beta platelet-derived growth factor receptor PDGFRB 0.0018
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
1353 DNA topoisomerase 1 TOP1 0.0018
3552 DNA topoisomerase 1 topA 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
6014 Cytochrome P450 2A13 CYP2A13 0.0018
267 Plasminogen activator inhibitor 1 SERPINE1 0.0017
6085 Fatty acid-binding protein, intestinal FABP2 0.0017
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0017
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0017
504 Mast/stem cell growth factor receptor KIT 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
4122 Histone deacetylase 2 HDAC2 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
3947 Xanthine dehydrogenase/oxidase XDH 0.0016
6221 Steroid hormone receptor ERR1 ESRRA 0.0016
3810 Catechol O-methyltransferase COMT 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0015
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0015
494 Caspase-1 CASP1 0.0015
751 Potassium channel subfamily K member 6 KCNK6 0.0015
183 Vascular endothelial growth factor A VEGFA 0.0015
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0015
1507 Cytochrome c CYCS 0.0015
1405 Thiopurine S-methyltransferase TPMT 0.0015
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0014
4217 Telomerase reverse transcriptase TERT 0.0014
172 Potassium channel subfamily K member 1 KCNK1 0.0014
6220 Aryl hydrocarbon receptor AHR 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
822 Aldose reductase AKR1B1 0.0014
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
6020 Aldehyde oxidase AOX1 0.0013
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
2077 Caspase-3 CASP3 0.0013
819 Penicillin-binding protein 4 dacB 0.0012
365 Dihydrofolate reductase DHFR 0.0012
2381 Dihydrofolate reductase DFR1 0.0012
2833 Dihydrofolate reductase Not Available 0.0012
2931 Dihydrofolate reductase folA 0.0012
3544 Dihydrofolate reductase folA 0.0012
3682 Dihydrofolate reductase folA 0.0012
6642 Dihydrofolate reductase folA 0.0012
6756 Dihydrofolate reductase dfrA 0.0012
284 DNA-directed RNA polymerase beta chain rpoB 0.0012
5773 DNA-directed RNA polymerase beta chain rpoB 0.0012
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
702 UMP-CMP kinase CMPK1 0.0012
2981 Phospholipase A2, membrane associated PLA2G2A 0.0012
6137 Multidrug resistance-associated protein 6 ABCC6 0.0012
2021 Thrombomodulin THBD 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0011
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0011
3923 Cholinesterase BCHE 0.0011
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0011
2540 Choloylglycine hydrolase cbh 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
997 Protein kinase C beta type PRKCB 0.001
6501 Fatty acid-binding protein, liver FABP1 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
6218 Pannexin-1 PANX1 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
1039 Histone deacetylase 9 HDAC9 0.0009
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0009
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
952 Dipeptidyl peptidase 4 DPP4 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
756 Sex hormone-binding globulin SHBG 0.0009
6500 Phospholipase A2 PLA2G1B 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
869 Estrogen receptor beta ESR2 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0008
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0008
273 Apoptosis regulator Bcl-2 BCL2 0.0008
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0008
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0007
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0007
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0006
124 Histamine H2 receptor HRH2 0.0006
489 Monocarboxylate transporter 2 SLC16A7 0.0006
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0006
824 Sodium-dependent serotonin transporter SLC6A4 0.0005
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