DT-Web

DB00181 - Baclofen


Identification
Name Baclofen
Accession Number DB00181 (APRD00551)
Type small molecule
Description Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. Baclofen stimulates GABA-B receptors leading to decreased frequency and amplitude of muscle spasms. It is especially useful in treating muscle spasticity associated with spinal cord injury. It appears to act primarily at the spinal cord level by inhibiting spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 213.661
Groups approved
Monoisotopic Weight 213.05565634
Pharmacology
Indication For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.
Mechanism of action Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect.
Absorption Rapidly and almost completely absorbed from the GI tract.
Protein binding 30%
Biotransformation ~ 15% of the dose is metabolized in the liver, primarily by deamination. 70-80% of the dose is excreted unchanged or as metabolites in urine and the remainder is excreted in feces.
Route of elimination In a study using radiolabeled baclofen, approximately 85% of the dose was excreted unchanged in the urine and feces. Baclofen is excreted primarily by the kidney as unchanged drug; 70 - 80% of a dose appears in the urine as unchanged drug. The remainder is excreted as unchanged drug in the feces or as metabolites in the urine and feces.
Toxicity LD50=45 mg/kg (male mice, IV); LD50=78 mg/kg (male rat, IV)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Triprolidine The CNS depressants, Triprolidine and Baclofen, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol.

Targets


Gamma-aminobutyric acid type B receptor, subunit 1
Name Gamma-aminobutyric acid type B receptor, subunit 1
Gene Name GABBR1
Pharmacological action yes
Actions agonist
References
  • Bowery NG: GABAB receptor pharmacology. Annu Rev Pharmacol Toxicol. 1993;33:109-47. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Garcia-Gil L, de Miguel R, Romero J, Perez A, Ramos JA, Fernandez-Ruiz JJ: Perinatal delta9-tetrahydrocannabinol exposure augmented the magnitude of motor inhibition caused by GABA(B), but not GABA(A), receptor agonists in adult rats. Neurotoxicol Teratol. 1999 May-Jun;21(3):277-83. - Pubmed
  • Lehmann A: GABAB receptors as drug targets to treat gastroesophageal reflux disease. Pharmacol Ther. 2009 Jun;122(3):239-45. Epub 2009 Mar 19. - Pubmed
  • Motalli R, Louvel J, Tancredi V, Kurcewicz I, Wan-Chow-Wah D, Pumain R, Avoli M: GABA(B) receptor activation promotes seizure activity in the juvenile rat hippocampus. J Neurophysiol. 1999 Aug;82(2):638-47. - Pubmed
  • Mott DD, Li Q, Okazaki MM, Turner DA, Lewis DV: GABAB-Receptor-mediated currents in interneurons of the dentate-hilus border. J Neurophysiol. 1999 Sep;82(3):1438-50. - Pubmed
  • Ogasawara T, Itoh Y, Tamura M, Mushiroi T, Ukai Y, Kise M, Kimura K: Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer. Pharmacol Biochem Behav. 1999 Sep;64(1):41-52. - Pubmed
  • Pittman QJ: The action is at the terminal. J Physiol. 1999 Nov 1;520 Pt 3:629. - Pubmed
  • Stringer JL, Lorenzo N: The reduction in paired-pulse inhibition in the rat hippocampus by gabapentin is independent of GABA(B) receptor receptor activation. Epilepsy Res. 1999 Feb;33(2-3):169-76. - Pubmed
DTHybrid score 1.0119
Gamma-aminobutyric acid type B receptor, subunit 2
Name Gamma-aminobutyric acid type B receptor, subunit 2
Gene Name GABBR2
Pharmacological action yes
Actions agonist
References
  • Belley M, Sullivan R, Reeves A, Evans J, O'Neill G, Ng GY: Synthesis of the nanomolar photoaffinity GABA(B) receptor ligand CGP 71872 reveals diversity in the tissue distribution of GABA(B) receptor forms. Bioorg Med Chem. 1999 Dec;7(12):2697-704. - Pubmed
  • Braun M, Wendt A, Buschard K, Salehi A, Sewing S, Gromada J, Rorsman P: GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin. J Physiol. 2004 Sep 1;559(Pt 2):397-409. Epub 2004 Jul 2. - Pubmed
  • Bowery NG: GABAB receptor pharmacology. Annu Rev Pharmacol Toxicol. 1993;33:109-47. - Pubmed
  • Filippov AK, Couve A, Pangalos MN, Walsh FS, Brown DA, Moss SJ: Heteromeric assembly of GABA(B)R1 and GABA(B)R2 receptor subunits inhibits Ca(2+) current in sympathetic neurons. J Neurosci. 2000 Apr 15;20(8):2867-74. - Pubmed
  • Lehmann A: GABAB receptors as drug targets to treat gastroesophageal reflux disease. Pharmacol Ther. 2009 Jun;122(3):239-45. Epub 2009 Mar 19. - Pubmed
  • Martin SC, Russek SJ, Farb DH: Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. Mol Cell Neurosci. 1999 Mar;13(3):180-91. - Pubmed
  • Pittman QJ: The action is at the terminal. J Physiol. 1999 Nov 1;520 Pt 3:629. - Pubmed
DTHybrid score 0.8685

Transporters


Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T: Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem. 2002 Oct;83(1):57-66. - Pubmed
  • Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T: Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003 Apr;23(4):432-40. - Pubmed
DTHybrid score 0.384

Predictions


Id Partner name Gene Name Score
593 Proton-coupled amino acid transporter 1 SLC36A1 0.1089
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.1053
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0971
1729 Solute carrier family 22 member 6 SLC22A6 0.0716
1024 Solute carrier family 22 member 11 SLC22A11 0.0581
6143 Solute carrier family 22 member 7 SLC22A7 0.041
587 Serum albumin ALB 0.02
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0195
2164 Multidrug resistance-associated protein 4 ABCC4 0.0194
118 Organic cation/carnitine transporter 2 SLC22A5 0.0181
4512 Cytochrome P450 3A4 CYP3A4 0.016
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0159
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0155
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0149
6145 Solute carrier family 22 member 1 SLC22A1 0.0142
1588 Multidrug resistance protein 1 ABCB1 0.0138
6144 Solute carrier family 22 member 2 SLC22A2 0.0137
4757 Cytochrome P450 2C9 CYP2C9 0.0133
290 Prostaglandin G/H synthase 2 PTGS2 0.0132
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0121
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0117
20 Prostaglandin G/H synthase 1 PTGS1 0.0116
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0115
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0115
2016 Dipeptidase 1 DPEP1 0.0115
159 Penicillin-binding protein 2B penA 0.0102
6121 Penicillin-binding protein 2B penA 0.0102
22 30S ribosomal protein S4 rpsD 0.0101
6714 30S ribosomal protein S4 rpsD 0.0101
833 Organic cation/carnitine transporter 1 SLC22A4 0.01
338 DNA polymerase UL30 0.01
379 DNA polymerase UL54 0.01
697 DNA polymerase ORF28 0.01
2482 DNA polymerase 43 0.01
4104 DNA polymerase BALF5 0.01
4924 Cytochrome P450 2C8 CYP2C8 0.0097
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0096
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0096
140 30S ribosomal protein S9 rpsI 0.0095
6719 30S ribosomal protein S9 rpsI 0.0095
6725 30S ribosomal protein S9 rpsI 0.0095
6136 Multidrug resistance-associated protein 5 ABCC5 0.0094
6016 Cytochrome P450 2C19 CYP2C19 0.0093
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0088
6141 Sodium/bile acid cotransporter SLC10A1 0.0087
543 Penicillin-binding protein 1B mrcB 0.0086
6186 Penicillin-binding protein 1B ponB 0.0086
6822 Penicillin-binding protein 1b pbp1b 0.0086
6844 Penicillin-binding protein 1b pbp1b 0.0086
124 Histamine H2 receptor HRH2 0.0086
645 Penicillin-binding protein 1A mrcA 0.0084
5805 Penicillin-binding protein 1A ponA 0.0084
6185 Penicillin-binding protein 1A mrcA 0.0084
6799 Penicillin-binding protein 1A pbpA 0.0084
862 Multidrug resistance-associated protein 1 ABCC1 0.0082
3947 Xanthine dehydrogenase/oxidase XDH 0.0082
6020 Aldehyde oxidase AOX1 0.0082
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0081
6147 Solute carrier family 22 member 3 SLC22A3 0.0079
738 Monocarboxylate transporter 1 SLC16A1 0.0077
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0075
776 Bile salt export pump ABCB11 0.0074
438 Taste receptor type 1 member 2 TAS1R2 0.0071
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0069
5626 Nucleoside diphosphate kinase B NME2 0.0067
4200 Cytochrome P450 1A2 CYP1A2 0.0066
3686 Acyl-CoA thioesterase I precursor tesA 0.0065
4118 Cytochrome P450 3A5 CYP3A5 0.006
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0059
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
887 DNA gyrase subunit B gyrB 0.0057
4150 DNA gyrase subunit B gyrB 0.0057
6225 DNA gyrase subunit B gyrB 0.0057
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0055
5294 Nucleoside diphosphate kinase A NME1 0.0055
4604 Liver carboxylesterase 1 CES1 0.0054
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0054
5353 Glutamate decarboxylase alpha gadA 0.0054
6167 Organic solute transporter subunit beta OSTB 0.005
6166 Organic solute transporter subunit alpha OSTA 0.005
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.005
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.005
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
6024 Cytochrome P450 1A1 CYP1A1 0.0047
1405 Thiopurine S-methyltransferase TPMT 0.0047
6148 Multidrug resistance-associated protein 7 ABCC10 0.0046
633 Penicillin-binding proteins 1A/1B pbpA 0.0046
332 Beta-lactamase blaZ 0.0046
2478 Beta-lactamase ampC 0.0046
2613 Beta-lactamase ampC 0.0046
2635 Beta-lactamase ampC 0.0046
2700 Beta-lactamase penP 0.0046
5445 Beta-lactamase blaB 0.0046
6019 Beta-lactamase SHV-7 0.0046
6701 Beta-lactamase cphA 0.0046
3811 Cytochrome P450 19A1 CYP19A1 0.0044
6149 Solute carrier family 22 member 10 SLC22A10 0.0044
342 P protein [Includes: DNA-directed DNA polymerase P 0.0042
612 P protein [Includes: DNA-directed DNA polymerase P 0.0042
756 Sex hormone-binding globulin SHBG 0.0042
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0041
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0039
1867 Major prion protein PRNP 0.0039
5482 Sialidase-2 NEU2 0.0039
558 Solute carrier family 12 member 1 SLC12A1 0.0039
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0039
3685 Catabolite gene activator crp 0.0038
4655 Adenylate cyclase cyaC 0.0038
4759 Adenylate cyclase cyaB2 0.0038
6030 Cytochrome P450 2B6 CYP2B6 0.0037
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
4119 Cytochrome P450 2D6 CYP2D6 0.0037
130 Prostacyclin synthase PTGIS 0.0036
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0035
115 Penicillin-binding protein 2 mrdA 0.0035
6069 Penicillin-binding protein 2 mrdA 0.0035
6118 Penicillin-binding protein 2 penA 0.0035
6187 Penicillin-binding protein 2 pbpA 0.0035
6686 Penicillin-binding protein 2 pbp2 0.0035
6939 Penicillin-binding protein 2 mrdA 0.0035
7163 Penicillin-binding protein 2 pbpA 0.0035
509 Thymidine kinase TK 0.0035
570 Thymidine kinase TK 0.0035
2559 Thymidine kinase TK 0.0035
3430 Thymidine kinase tdk 0.0035
3518 Thymidine kinase TK 0.0035
5301 Thymidine kinase tdk 0.0035
5771 Thymidine kinase ORF36 0.0035
7009 Thymidine kinase ORF36 0.0035
6209 30S ribosomal protein S19 rpsS 0.0034
6712 30S ribosomal protein S19 rpsS 0.0034
6726 30S ribosomal protein S19 rpsS 0.0034
6207 30S ribosomal protein S14 rpsN 0.0034
594 Thyroxine-binding globulin SERPINA7 0.0034
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0033
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0033
2249 Aspartate aminotransferase aspC 0.0033
2671 Aspartate aminotransferase aspC 0.0033
5490 Aspartate aminotransferase Not Available 0.0033
4760 Mll3241 protein mll3241 0.0032
1 Peptidoglycan synthetase ftsI ftsI 0.0032
4155 Peptidoglycan synthetase ftsI ftsI 0.0032
758 Thyroid hormone receptor alpha THRA 0.0031
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.003
3426 Glutamine synthetase glnA 0.003
3987 Glutamine synthetase GLUL 0.003
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.003
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0029
6033 High affinity interleukin-8 receptor A CXCR1 0.0029
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0029
527 Prostacyclin receptor PTGIR 0.0029
1198 Serum paraoxonase/arylesterase 1 PON1 0.0029
6223 Penicillin-binding protein 1C pbpC 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
672 Prostaglandin F2-alpha receptor PTGFR 0.0028
146 Androgen receptor AR 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
373 Transthyretin TTR 0.0028
5126 Arginase rocF 0.0027
867 Penicillin-binding protein 3 pbpC 0.0027
6119 Penicillin-binding protein 3 pbp3 0.0027
7154 Penicillin-binding protein 3 pbp3 0.0027
7157 Penicillin-binding protein 3 LMHCC_2184 0.0027
7162 Penicillin-binding protein 3 pbpB 0.0027
7172 Penicillin-binding protein 3 pbp3 0.0027
1654 Interleukin-1 beta IL1B 0.0026
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0025
1757 Myeloperoxidase MPO 0.0025
244 Angiotensin-converting enzyme ACE 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
663 Solute carrier family 12 member 4 SLC12A4 0.0024
53 Solute carrier family 12 member 5 SLC12A5 0.0024
275 Arachidonate 5-lipoxygenase ALOX5 0.0024
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0024
310 Solute carrier family 12 member 2 SLC12A2 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
1898 Cytochrome P450 1B1 CYP1B1 0.0022
494 Caspase-1 CASP1 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
6168 Solute carrier family 22 member 16 SLC22A16 0.0021
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
183 Vascular endothelial growth factor A VEGFA 0.0021
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
136 Estrogen receptor ESR1 0.0021
1507 Cytochrome c CYCS 0.0021
3587 Gastrotropin FABP6 0.002
6107 Cytochrome P450 3A7 CYP3A7 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.002
3760 Penicillin-binding protein 5 precursor dacA 0.0019
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0019
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
2077 Caspase-3 CASP3 0.0018
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0018
65 Matrix metalloproteinase-9 Not Available 0.0018
819 Penicillin-binding protein 4 dacB 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2981 Phospholipase A2, membrane associated PLA2G2A 0.0017
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0016
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0016
6137 Multidrug resistance-associated protein 6 ABCC6 0.0016
2021 Thrombomodulin THBD 0.0016
6013 Cytochrome P450 2E1 CYP2E1 0.0016
2320 Thymidine kinase, cytosolic TK1 0.0015
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0015
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0015
357 Carbonic anhydrase 2 CA2 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
6645 D-amino-acid oxidase DAO 0.0014
5718 Cytochrome P450 2A6 CYP2A6 0.0014
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0014
6106 Cytochrome P450 2C18 CYP2C18 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
6218 Pannexin-1 PANX1 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
6042 Prostaglandin reductase 2 PTGR2 0.0012
5818 Folate receptor alpha FOLR1 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0012
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0011
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0011
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
1792 Tissue-type plasminogen activator PLAT 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
465 Calmodulin CALM1 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0011
273 Apoptosis regulator Bcl-2 BCL2 0.0011
6014 Cytochrome P450 2A13 CYP2A13 0.001
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.001
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.001
293 Gamma-glutamyl hydrolase GGH 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.001
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.001
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.001
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.001
6493 Cytochrome c oxidase subunit 6C COX6C 0.001
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.001
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.001
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.001
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.001
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.001
6559 Cytochrome c oxidase subunit 2 ctaC 0.001
6669 Cytochrome c oxidase subunit 2 ctaC 0.001
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.001
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.001
371 Cytochrome c oxidase subunit 1 MT-CO1 0.001
6558 Cytochrome c oxidase subunit 1 ctaD 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0009
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0009
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0009
33 Cystine/glutamate transporter SLC7A11 0.0009
1313 Lactoylglutathione lyase GLO1 0.0009
1650 Heme carrier protein 1 SLC46A1 0.0009
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0009
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0009
2540 Choloylglycine hydrolase cbh 0.0009
489 Monocarboxylate transporter 2 SLC16A7 0.0009
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
6031 Cytochrome P450 3A43 CYP3A43 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0008
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0008
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0008
3917 Methylenetetrahydrofolate reductase MTHFR 0.0007
3809 Estrogen-related receptor gamma ESRRG 0.0007
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0007
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0007
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
3941 Amine oxidase [flavin-containing] A MAOA 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
365 Dihydrofolate reductase DHFR 0.0006
2381 Dihydrofolate reductase DFR1 0.0006
2833 Dihydrofolate reductase Not Available 0.0006
2931 Dihydrofolate reductase folA 0.0006
3544 Dihydrofolate reductase folA 0.0006
3682 Dihydrofolate reductase folA 0.0006
6642 Dihydrofolate reductase folA 0.0006
6756 Dihydrofolate reductase dfrA 0.0006
869 Estrogen receptor beta ESR2 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0006
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