DT-Web

DB03048 - 6-Carboxymethyluracil


Identification
Name 6-Carboxymethyluracil
Accession Number DB03048 (EXPT03164)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 170.1228
Groups experimental
Monoisotopic Weight 170.03275669
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Dihydropyrimidine dehydrogenase [NADP+]
Name Dihydropyrimidine dehydrogenase [NADP+]
Gene Name DPYD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7237

Predictions


Id Partner name Gene Name Score
3496 Uracil-DNA glycosylase UL2 0.0469
3512 Uracil-DNA glycosylase ung 0.0469
5257 Uracil-DNA glycosylase udg 0.0469
6272 Uracil-DNA glycosylase UNG 0.0469
5258 Pyrimidine-nucleoside phosphorylase pdp 0.0469
2344 Ribosomal small subunit pseudouridine synthase A rsuA 0.0404
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.0404
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0348
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0348
2826 Glucose--fructose oxidoreductase gfo 0.0347
2675 Pteridine reductase 1 PTR1 0.0343
3639 Thymidine phosphorylase deoA 0.0342
3936 Thymidine phosphorylase TYMP 0.0342
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0324
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0289
24 Thymidylate synthase TMP1 0.0282
359 Thymidylate synthase TYMS 0.0282
2626 Thymidylate synthase thyA 0.0282
2729 Thymidylate synthase thyA 0.0282
5352 Thymidylate synthase THYA 0.0282
3611 Cytidine deaminase cdd 0.0261
3707 Cytidine deaminase cdd 0.0261
4211 Cytidine deaminase CDA 0.0261
4604 Liver carboxylesterase 1 CES1 0.0199
4757 Cytochrome P450 2C9 CYP2C9 0.0139
4226 Uridine phosphorylase 2 UPP2 0.0127
4225 Uridine phosphorylase 1 UPP1 0.0122
413 Amidophosphoribosyltransferase PPAT 0.0098
2515 Amidophosphoribosyltransferase purF 0.0098
3714 Amidophosphoribosyltransferase purF 0.0098
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.007
3917 Methylenetetrahydrofolate reductase MTHFR 0.0068
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0064
6136 Multidrug resistance-associated protein 5 ABCC5 0.0062
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0055
6143 Solute carrier family 22 member 7 SLC22A7 0.0052
2164 Multidrug resistance-associated protein 4 ABCC4 0.0052
5201 FMN-binding protein DvMF_2023 0.0051
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0051
5178 Protein nrdI nrdI 0.0051
5200 NADH dehydrogenase nox 0.0051
5131 PhzG phzG 0.0051
3293 Flavodoxin Not Available 0.0051
4614 Flavodoxin DVU_2680 0.0051
5172 Flavodoxin isiB 0.0051
5173 Flavodoxin isiB 0.0051
5182 Flavodoxin fldA 0.0051
5193 Phenazine biosynthesis protein phzG phzG 0.0051
5198 Flavodoxin-1 fldA 0.0051
5179 Probable aromatic acid decarboxylase pad1 0.0051
5175 Hypothetical protein SMU.260 SMU_260 0.0051
5202 Nitroreductase family protein BC_1844 0.0051
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0051
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0051
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0051
5191 Morphinone reductase morB 0.0051
5190 Rubredoxin-oxygen oxidoreductase roo 0.0051
4037 Hypothetical protein GPX1 0.0051
4297 Hypothetical protein SP_1951 0.0051
4521 Hypothetical protein BC_2969 0.0051
4540 Hypothetical protein TM_1070 0.0051
4555 Hypothetical protein MT1739 0.0051
4569 Hypothetical protein mshD 0.0051
4578 Hypothetical protein PA3270 0.0051
4747 Hypothetical protein PA3967 0.0051
5177 Hypothetical protein TM_0096 0.0051
5194 Hypothetical protein PA1204 0.0051
5240 Hypothetical protein Rv2991 0.0051
5370 Hypothetical protein TM_1158 0.0051
5710 Hypothetical protein Tb927.5.1360 0.0051
5181 Hypothetical protein yhdA azr 0.0051
5170 Epidermin decarboxylase epiD 0.0051
4405 Nitric oxide reductase fprA 0.0051
4503 NADPH-flavin oxidoreductase frp 0.0046
5189 Trimethylamine dehydrogenase tmd 0.0046
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0046
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0046
5718 Cytochrome P450 2A6 CYP2A6 0.0046
3680 Dihydroorotate dehydrogenase A pyrDA 0.0045
5176 YtnJ moxC 0.0044
4407 FMN-dependent NADH-azoreductase azoR 0.0044
5169 FMN-dependent NADH-azoreductase azoR 0.0044
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0044
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0044
3507 Chorismate synthase aroC 0.0044
5171 Chorismate synthase aroC 0.0044
76 Nitric-oxide synthase, brain NOS1 0.0043
587 Serum albumin ALB 0.0042
2775 Dihydroorotate dehydrogenase pyrD 0.0041
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0041
4120 NADPH--cytochrome P450 reductase POR 0.004
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0039
408 Riboflavin kinase RFK 0.0039
5180 L(+)-mandelate dehydrogenase mdlB 0.0038
4924 Cytochrome P450 2C8 CYP2C8 0.0038
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0037
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0037
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0037
4200 Cytochrome P450 1A2 CYP1A2 0.0036
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0036
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0035
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0035
4284 Pentaerythritol tetranitrate reductase onr 0.0034
5122 Mersacidin decarboxylase mrsD 0.0034
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0034
526 Thioredoxin reductase trxB 0.0034
3767 Thioredoxin reductase trxB 0.0034
5095 Putidaredoxin reductase camA 0.0034
3763 5,10-methylenetetrahydrofolate reductase metF 0.0034
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0034
5094 5,10-methylenetetrahydrofolate reductase metF 0.0034
5078 Amine oxidase, flavin-containing PSPTO1126 0.0034
5081 L-aspartate oxidase nadB 0.0034
5111 Phenylacetone monooxygenase pamO 0.0034
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0034
1410 Oxidoreductase HSD17B6 0.0034
4725 Oxidoreductase Not Available 0.0034
5124 Oxidoreductase Not Available 0.0034
5115 FkbI fkbI 0.0034
3133 UDP-galactopyranose mutase glf 0.0034
5099 UDP-galactopyranose mutase glf 0.0034
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0034
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0034
5083 Cryptochrome DASH cry 0.0034
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0034
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0034
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0034
5109 Outer membrane protein p64k or PM-6 m-6 0.0034
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0034
6268 Hydroxyacid oxidase 1 HAO1 0.0032
654 Flavin reductase BLVRB 0.0032
4486 Phenol 2-hydroxylase component B pheA2 0.0031
4439 Ferredoxin reductase bphA4 0.0031
4477 Dihydrolipoyl dehydrogenase lpdV 0.0031
5077 Dihydrolipoyl dehydrogenase Not Available 0.0031
5117 Dihydrolipoyl dehydrogenase lpd 0.0031
3594 Deoxyribodipyrimidine photo-lyase phr 0.003
5079 Deoxyribodipyrimidine photo-lyase phrB 0.003
5080 Deoxyribodipyrimidine photo-lyase phr 0.003
2470 Pyruvate oxidase pox5 0.0029
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0029
5073 Ferredoxin--NADP reductase petH 0.0029
5076 Ferredoxin--NADP reductase fpr 0.0029
5119 Ferredoxin--NADP reductase petH 0.0029
5121 Ferredoxin--NADP reductase fpr 0.0029
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0029
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0029
2526 NADPH-ferredoxin reductase fprA fprA 0.0029
5072 N,N-dimethylglycine oxidase dmg 0.0029
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0029
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0029
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0029
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0029
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0029
2268 Cholesterol oxidase choB 0.0029
2822 Cholesterol oxidase choA 0.0029
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0029
3102 Flavohemoprotein hmp 0.0028
4969 Flavohemoprotein hmp 0.0028
4440 NADH peroxidase npr 0.0028
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0027
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0027
2893 Glycine oxidase thiO 0.0027
2567 Thymidylate synthase thyX thyX 0.0026
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0026
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0026
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0026
2823 Trypanothione reductase TPR 0.0025
327 Glutathione reductase gor 0.0025
5110 Glutathione reductase GR2 0.0025
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0025
126 D-lactate dehydrogenase dld 0.0025
3545 D-lactate dehydrogenase Not Available 0.0025
4510 D-lactate dehydrogenase ldhA 0.0025
2769 P-hydroxybenzoate hydroxylase pobA 0.0024
2809 P-hydroxybenzoate hydroxylase pobA 0.0024
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
2380 Monomeric sarcosine oxidase soxA 0.0023
6645 D-amino-acid oxidase DAO 0.0022
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0018
714 Glutathione reductase, mitochondrial GSR 0.0018
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0016
3939 Amine oxidase [flavin-containing] B MAOB 0.0014
3947 Xanthine dehydrogenase/oxidase XDH 0.0013
3941 Amine oxidase [flavin-containing] A MAOA 0.0012
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