DT-Web

DB01204 - Mitoxantrone


Identification
Name Mitoxantrone
Accession Number DB01204 (APRD00371)
Type small molecule
Description An anthracenedione-derived antineoplastic agent. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 444.4809
Groups approved
Monoisotopic Weight 444.200884648
Pharmacology
Indication For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis
Mechanism of action Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.
Absorption Poorly absorbed following oral administration
Protein binding 78%
Biotransformation Hepatic
Route of elimination Not Available
Toxicity Severe leukopenia with infection.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions intercalation
References
  • Mazerski J, Martelli S, Borowski E: The geometry of intercalation complex of antitumor mitoxantrone and ametantrone with DNA: molecular dynamics simulations. Acta Biochim Pol. 1998;45(1):1-11. - Pubmed
  • Hajihassan Z, Rabbani-Chadegani A: Studies on the binding affinity of anticancer drug mitoxantrone to chromatin, DNA and histone proteins. J Biomed Sci. 2009 Mar 11;16:31. - Pubmed
DTHybrid score Not Available
DNA topoisomerase 2-alpha
Name DNA topoisomerase 2-alpha
Gene Name TOP2A
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Takeda K, Shinohara K, Kameda N, Ariyoshi K: A case of therapy-related acute myeloblastic leukemia with t(16;21)(q24;q22) after chemotherapy with DNA-topoisomerase II inhibitors, etoposide and mitoxantrone, and the alkylating agent, cyclophosphamide. Int J Hematol. 1998 Feb;67(2):179-86. - Pubmed
  • McPherson JP, Deffie AM, Jones NR, Brown GA, Deuchars KL, Goldenberg GJ: Selective sensitization of adriamycin-resistant P388 murine leukemia cells to antineoplastic agents following transfection with human DNA topoisomerase II alpha. Anticancer Res. 1997 Nov-Dec;17(6D):4243-52. - Pubmed
  • Wang H, Mao Y, Zhou N, Hu T, Hsieh TS, Liu LF: Atp-bound topoisomerase ii as a target for antitumor drugs. J Biol Chem. 2001 May 11;276(19):15990-5. Epub 2001 Feb 23. - Pubmed
  • Satherley K, de Souza L, Neale MH, Alexander RA, Myatt N, Foss AJ, Hungerford JL, Hickson ID, Cree IA: Relationship between expression of topoisomerase II isoforms and chemosensitivity in choroidal melanoma. J Pathol. 2000 Oct;192(2):174-81. - Pubmed
  • Mao Y, Yu C, Hsieh TS, Nitiss JL, Liu AA, Wang H, Liu LF: Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity. Biochemistry. 1999 Aug 17;38(33):10793-800. - Pubmed
  • Ko MW, Tamhankar MA, Volpe NJ, Porter D, McGrath C, Galetta SL: Acute promyelocytic leukemic involvement of the optic nerves following mitoxantrone treatment for multiple sclerosis. J Neurol Sci. 2008 Oct 15;273(1-2):144-7. Epub 2008 Aug 6. - Pubmed
DTHybrid score 0.4091

Enzymes


Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2379
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1699
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5032

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor,inducer
References
  • Schrenk D, Michalke A, Gant TW, Brown PC, Silverman JA, Thorgeirsson SS: Multidrug resistance gene expression in rodents and rodent hepatocytes treated with mitoxantrone. Biochem Pharmacol. 1996 Nov 8;52(9):1453-60. - Pubmed
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
  • Taipalensuu J, Tavelin S, Lazorova L, Svensson AC, Artursson P: Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker of MDR1-dependent drug efflux activity. Eur J Pharm Sci. 2004 Jan;21(1):69-75. - Pubmed
  • Noguchi K, Kawahara H, Kaji A, Katayama K, Mitsuhashi J, Sugimoto Y: Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib. Cancer Sci. 2009 Sep;100(9):1701-7. Epub 2009 May 12. - Pubmed
DTHybrid score 0.428
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions substrate,inhibitor
References
  • Morrow CS, Peklak-Scott C, Bishwokarma B, Kute TE, Smitherman PK, Townsend AJ: Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol Pharmacol. 2006 Apr;69(4):1499-505. Epub 2006 Jan 24. - Pubmed
  • Diah SK, Smitherman PK, Aldridge J, Volk EL, Schneider E, Townsend AJ, Morrow CS: Resistance to mitoxantrone in multidrug-resistant MCF7 breast cancer cells: evaluation of mitoxantrone transport and the role of multidrug resistance protein family proteins. Cancer Res. 2001 Jul 15;61(14):5461-7. - Pubmed
DTHybrid score 0.2499
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate,inhibitor
References
  • Volk EL, Schneider E: Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43. - Pubmed
  • Elahian F, Kalalinia F, Behravan J: Evaluation of indomethacin and dexamethasone effects on BCRP-mediated drug resistance in MCF-7 parental and resistant cell lines. Drug Chem Toxicol. 2010 Apr;33(2):113-9. - Pubmed
  • Morrow CS, Peklak-Scott C, Bishwokarma B, Kute TE, Smitherman PK, Townsend AJ: Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol Pharmacol. 2006 Apr;69(4):1499-505. Epub 2006 Jan 24. - Pubmed
  • Litman T, Brangi M, Hudson E, Fetsch P, Abati A, Ross DD, Miyake K, Resau JH, Bates SE: The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2). J Cell Sci. 2000 Jun;113 ( Pt 11):2011-21. - Pubmed
  • Wang X, Furukawa T, Nitanda T, Okamoto M, Sugimoto Y, Akiyama S, Baba M: Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol. 2003 Jan;63(1):65-72. - Pubmed
  • Sugimoto Y, Tsukahara S, Imai Y, Sugimoto Y, Ueda K, Tsuruo T: Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists. Mol Cancer Ther. 2003 Jan;2(1):105-12. - Pubmed
  • Maliepaard M, van Gastelen MA, de Jong LA, Pluim D, van Waardenburg RC, Ruevekamp-Helmers MC, Floot BG, Schellens JH: Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line. Cancer Res. 1999 Sep 15;59(18):4559-63. - Pubmed
  • Ozvegy C, Litman T, Szakacs G, Nagy Z, Bates S, Varadi A, Sarkadi B: Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7. - Pubmed
  • Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y: Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol. 2003 Sep;64(3):610-8. - Pubmed
  • Miwa M, Tsukahara S, Ishikawa E, Asada S, Imai Y, Sugimoto Y: Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants. Int J Cancer. 2003 Dec 10;107(5):757-63. - Pubmed
  • Nakanishi T, Doyle LA, Hassel B, Wei Y, Bauer KS, Wu S, Pumplin DW, Fang HB, Ross DD: Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the oocytes of Xenopus laevis. Mol Pharmacol. 2003 Dec;64(6):1452-62. - Pubmed
  • Allen JD, Van Dort SC, Buitelaar M, van Tellingen O, Schinkel AH: Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein. Cancer Res. 2003 Mar 15;63(6):1339-44. - Pubmed
  • Allen JD, Brinkhuis RF, Wijnholds J, Schinkel AH: The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin. Cancer Res. 1999 Sep 1;59(17):4237-41. - Pubmed
  • An Y, Ongkeko WM: ABCG2: the key to chemoresistance in cancer stem cells? Expert Opin Drug Metab Toxicol. 2009 Dec;5(12):1529-42. - Pubmed
  • Paturi DK, Kwatra D, Ananthula HK, Pal D, Mitra AK: Identification and functional characterization of breast cancer resistance protein in human bronchial epithelial cells (Calu-3). Int J Pharm. 2010 Jan 15;384(1-2):32-8. Epub 2009 Sep 25. - Pubmed
  • Ma Y, Wink M: The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells. Phytother Res. 2010 Jan;24(1):146-9. - Pubmed
  • Mahringer A, Delzer J, Fricker G: A fluorescence-based in vitro assay for drug interactions with breast cancer resistance protein (BCRP, ABCG2). Eur J Pharm Biopharm. 2009 Aug;72(3):605-13. - Pubmed
  • Nicolle E, Boccard J, Guilet D, Dijoux-Franca MG, Zelefac F, Macalou S, Grosselin J, Schmidt J, Carrupt PA, Di Pietro A, Boumendjel A: Breast cancer resistance protein (BCRP/ABCG2): new inhibitors and QSAR studies by a 3D linear solvation energy approach. Eur J Pharm Sci. 2009 Aug 12;38(1):39-46. Epub 2009 Jun 6. - Pubmed
  • Jani M, Szabo P, Kis E, Molnar E, Glavinas H, Krajcsi P: Kinetic characterization of sulfasalazine transport by human ATP-binding cassette G2. Biol Pharm Bull. 2009 Mar;32(3):497-9. - Pubmed
  • Karla PK, Earla R, Boddu SH, Johnston TP, Pal D, Mitra A: Molecular expression and functional evidence of a drug efflux pump (BCRP) in human corneal epithelial cells. Curr Eye Res. 2009 Jan;34(1):1-9. - Pubmed
  • Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR Jr, Chen X, Chen ZS: Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. Epub 2009 Apr 11. - Pubmed
  • Noguchi K, Kawahara H, Kaji A, Katayama K, Mitsuhashi J, Sugimoto Y: Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib. Cancer Sci. 2009 Sep;100(9):1701-7. Epub 2009 May 12. - Pubmed
  • Shi Z, Parmar S, Peng XX, Shen T, Robey RW, Bates SE, Fu LW, Shao Y, Chen YM, Zang F, Chen ZS: The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance. Oncol Rep. 2009 Feb;21(2):483-9. - Pubmed
  • Ross DD, Yang W, Abruzzo LV, Dalton WS, Schneider E, Lage H, Dietel M, Greenberger L, Cole SP, Doyle LA: Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. J Natl Cancer Inst. 1999 Mar 3;91(5):429-33. - Pubmed
  • Brangi M, Litman T, Ciotti M, Nishiyama K, Kohlhagen G, Takimoto C, Robey R, Pommier Y, Fojo T, Bates SE: Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells. Cancer Res. 1999 Dec 1;59(23):5938-46. - Pubmed
  • Rocchi E, Khodjakov A, Volk EL, Yang CH, Litman T, Bates SE, Schneider E: The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane. Biochem Biophys Res Commun. 2000 Apr 29;271(1):42-6. - Pubmed
  • Jonker JW, Smit JW, Brinkhuis RF, Maliepaard M, Beijnen JH, Schellens JH, Schinkel AH: Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. J Natl Cancer Inst. 2000 Oct 18;92(20):1651-6. - Pubmed
DTHybrid score 0.2822

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.2225
4119 Cytochrome P450 2D6 CYP2D6 0.2021
4757 Cytochrome P450 2C9 CYP2C9 0.1966
4118 Cytochrome P450 3A5 CYP3A5 0.182
6016 Cytochrome P450 2C19 CYP2C19 0.1747
4924 Cytochrome P450 2C8 CYP2C8 0.1556
477 DNA topoisomerase 4 subunit A parC 0.1472
886 DNA topoisomerase 4 subunit A parC 0.1472
6226 DNA topoisomerase 4 subunit A parC 0.1472
404 DNA gyrase subunit A gyrA 0.1446
6224 DNA gyrase subunit A gyrA 0.1446
6024 Cytochrome P450 1A1 CYP1A1 0.1302
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1269
6107 Cytochrome P450 3A7 CYP3A7 0.1161
6030 Cytochrome P450 2B6 CYP2B6 0.1058
587 Serum albumin ALB 0.0744
5718 Cytochrome P450 2A6 CYP2A6 0.0704
776 Bile salt export pump ABCB11 0.0669
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0652
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0632
4192 DNA topoisomerase 2-beta TOP2B 0.0557
1729 Solute carrier family 22 member 6 SLC22A6 0.0552
6137 Multidrug resistance-associated protein 6 ABCC6 0.0544
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0539
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0488
6148 Multidrug resistance-associated protein 7 ABCC10 0.0476
118 Organic cation/carnitine transporter 2 SLC22A5 0.047
6144 Solute carrier family 22 member 2 SLC22A2 0.0457
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0423
1353 DNA topoisomerase 1 TOP1 0.0419
3552 DNA topoisomerase 1 topA 0.0419
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0415
3811 Cytochrome P450 19A1 CYP19A1 0.0413
6145 Solute carrier family 22 member 1 SLC22A1 0.0413
3947 Xanthine dehydrogenase/oxidase XDH 0.0406
136 Estrogen receptor ESR1 0.0403
20 Prostaglandin G/H synthase 1 PTGS1 0.039
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0368
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0339
6142 Solute carrier family 22 member 8 SLC22A8 0.0329
2164 Multidrug resistance-associated protein 4 ABCC4 0.0326
871 Glucocorticoid receptor NR3C1 0.0323
731 HIV-1 protease HIV-1 protease 0.0318
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0313
6106 Cytochrome P450 2C18 CYP2C18 0.031
6143 Solute carrier family 22 member 7 SLC22A7 0.0308
4180 DNA-(apurinic or apyrimidinic site) lyase APEX1 0.0305
6147 Solute carrier family 22 member 3 SLC22A3 0.0303
161 Tubulin beta chain TUBB 0.0294
312 Tubulin beta chain TUB2 0.0294
492 Histamine H1 receptor HRH1 0.029
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0283
290 Prostaglandin G/H synthase 2 PTGS2 0.0283
556 Alpha-1A adrenergic receptor ADRA1A 0.0275
844 Epidermal growth factor receptor EGFR 0.0275
824 Sodium-dependent serotonin transporter SLC6A4 0.027
468 Cytochrome P450 4A11 CYP4A11 0.0264
833 Organic cation/carnitine transporter 1 SLC22A4 0.0259
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0253
540 Sodium-dependent noradrenaline transporter SLC6A2 0.025
29 Tubulin beta-1 chain TUBB1 0.0246
4120 NADPH--cytochrome P450 reductase POR 0.0241
2539 Tubulin alpha-1 chain TUBA4A 0.0234
723 Cytosolic phospholipase A2 PLA2G4A 0.023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.023
260 Cytochrome P450 51 ERG11 0.0222
761 Cytochrome P450 51 ERG11 0.0222
3163 Cytochrome P450 51 cyp51 0.0222
6141 Sodium/bile acid cotransporter SLC10A1 0.0222
831 D(2) dopamine receptor DRD2 0.0221
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0218
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0213
869 Estrogen receptor beta ESR2 0.0211
502 5-hydroxytryptamine 2A receptor HTR2A 0.0209
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0205
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0205
1024 Solute carrier family 22 member 11 SLC22A11 0.0202
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.02
6599 HTH-type transcriptional regulator ttgR ttgR 0.0198
373 Transthyretin TTR 0.0187
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0185
320 5-hydroxytryptamine 1A receptor HTR1A 0.0184
504 Mast/stem cell growth factor receptor KIT 0.0183
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0179
3923 Cholinesterase BCHE 0.0179
4604 Liver carboxylesterase 1 CES1 0.0177
1852 Microtubule-associated protein 2 MAP2 0.0174
992 Protein tyrosine kinase 2 beta PTK2B 0.0174
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0173
6220 Aryl hydrocarbon receptor AHR 0.0173
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.017
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0168
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0166
318 Alpha-2A adrenergic receptor ADRA2A 0.0165
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0165
632 Alpha-1B adrenergic receptor ADRA1B 0.0164
614 Progesterone receptor PGR 0.0163
5923 Microtubule-associated protein tau MAPT 0.0161
5924 Microtubule-associated protein 4 MAP4 0.0161
6031 Cytochrome P450 3A43 CYP3A43 0.0161
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.016
908 Glutathione S-transferase theta-1 GSTT1 0.0159
273 Apoptosis regulator Bcl-2 BCL2 0.0159
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0159
23 D(1A) dopamine receptor DRD1 0.0158
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0157
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0156
904 Glutathione S-transferase P GSTP1 0.0151
847 Mu-type opioid receptor OPRM1 0.015
380 Cytochrome P450 17A1 CYP17A1 0.0149
16 Adenosine A1 receptor ADORA1 0.0145
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0143
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0143
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0142
228 Beta platelet-derived growth factor receptor PDGFRB 0.0142
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0141
6136 Multidrug resistance-associated protein 5 ABCC5 0.0141
274 Muscarinic acetylcholine receptor M5 CHRM5 0.014
465 Calmodulin CALM1 0.0139
3941 Amine oxidase [flavin-containing] A MAOA 0.0138
193 Beta-1 adrenergic receptor ADRB1 0.0137
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0137
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0136
789 Alpha-1D adrenergic receptor ADRA1D 0.0134
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0134
885 5-hydroxytryptamine 1B receptor HTR1B 0.0133
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0132
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0131
1178 Adenosine A2a receptor ADORA2A 0.0131
3307 Acriflavine resistance protein B acrB 0.013
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0129
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
766 Beta-2 adrenergic receptor ADRB2 0.0128
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0127
467 Delta-type opioid receptor OPRD1 0.0126
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0126
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0126
590 5-hydroxytryptamine 2C receptor HTR2C 0.0126
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0125
952 Dipeptidyl peptidase 4 DPP4 0.0124
33 Cystine/glutamate transporter SLC7A11 0.0122
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
725 5-hydroxytryptamine 1D receptor HTR1D 0.0121
756 Sex hormone-binding globulin SHBG 0.012
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0118
146 Androgen receptor AR 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0117
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0117
738 Monocarboxylate transporter 1 SLC16A1 0.0116
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0116
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0115
4228 Keratin, type II cytoskeletal 7 KRT7 0.0114
4773 Deoxycytidine kinase DCK 0.0113
1757 Myeloperoxidase MPO 0.0112
6182 Cytochrome P450 2J2 CYP2J2 0.011
1192 Sulfotransferase 1A1 SULT1A1 0.0109
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0109
341 5-hydroxytryptamine 3 receptor HTR3A 0.0109
696 Kappa-type opioid receptor OPRK1 0.0108
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0108
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0107
638 D(3) dopamine receptor DRD3 0.0107
5787 Angiopoietin-1 receptor TEK 0.0106
117 Sterol O-acyltransferase 1 SOAT1 0.0104
713 Sodium-dependent dopamine transporter SLC6A3 0.0104
407 Vascular endothelial growth factor receptor 2 KDR 0.0103
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0102
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0101
26 Vascular endothelial growth factor receptor 3 FLT4 0.0101
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0101
4203 Histamine N-methyltransferase HNMT 0.01
1629 Transcription factor AP-1 JUN 0.01
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0099
6138 Multidrug resistance protein 3 ABCB4 0.0099
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0098
4237 50S ribosomal protein L22 rplV 0.0097
32 Vascular endothelial growth factor receptor 1 FLT1 0.0097
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0097
461 Glycine receptor subunit alpha-3 GLRA3 0.0097
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0095
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0094
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
629 Alpha-2B adrenergic receptor ADRA2B 0.0092
6228 Nuclear receptor coactivator 1 NCOA1 0.0091
232 Corticosteroid-binding globulin SERPINA6 0.0091
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0091
777 Tumor necrosis factor TNF 0.0091
6241 Nuclear receptor coactivator 2 NCOA2 0.009
814 Ryanodine receptor 1 RYR1 0.0089
6085 Fatty acid-binding protein, intestinal FABP2 0.0089
1010 Cytochrome P450 51A1 CYP51A1 0.0089
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0088
378 Alpha-2C adrenergic receptor ADRA2C 0.0088
122 P2Y purinoceptor 12 P2RY12 0.0087
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0085
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0085
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0085
6146 High affinity copper uptake protein 1 SLC31A1 0.0085
6163 Copper-transporting ATPase 2 ATP7B 0.0085
6165 Copper-transporting ATPase 1 ATP7A 0.0085
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0085
4238 50S ribosomal protein L4 rplD 0.0085
5578 50S ribosomal protein L4 rplD 0.0085
6173 50S ribosomal protein L4 rplD 0.0085
6219 50S ribosomal protein L4 rplD 0.0085
818 50S ribosomal protein L10 rplJ 0.0085
7 Nitric oxide synthase, inducible NOS2 0.0084
183 Vascular endothelial growth factor A VEGFA 0.0083
70 Type-1 angiotensin II receptor AGTR1 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
896 Glutathione S-transferase Mu 1 GSTM1 0.0083
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0083
3939 Amine oxidase [flavin-containing] B MAOB 0.0082
737 Mineralocorticoid receptor NR3C2 0.0082
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0082
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0082
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0082
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0082
6168 Solute carrier family 22 member 16 SLC22A16 0.0081
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0081
436 5-hydroxytryptamine 2B receptor HTR2B 0.0081
705 Glutamate receptor 1 GRIA1 0.008
2449 Tubulin alpha-3 chain TUBA1A 0.008
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
1650 Heme carrier protein 1 SLC46A1 0.0079
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0079
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0079
4122 Histone deacetylase 2 HDAC2 0.0079
811 Translocator protein TSPO 0.0078
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0078
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0078
482 Glycine receptor subunit alpha-1 GLRA1 0.0077
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0077
6014 Cytochrome P450 2A13 CYP2A13 0.0077
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0077
469 Annexin A1 ANXA1 0.0076
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0076
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0075
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0075
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0075
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0075
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0075
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0074
716 5-hydroxytryptamine 7 receptor HTR7 0.0074
3810 Catechol O-methyltransferase COMT 0.0073
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0073
474 Acetylcholinesterase ACHE 0.0073
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0073
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0073
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0072
936 Ephrin type-A receptor 2 EPHA2 0.0072
1050 Bile salt sulfotransferase SULT2A1 0.0072
68 Cannabinoid receptor 1 CNR1 0.0071
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0071
1569 G1/S-specific cyclin-D1 CCND1 0.0071
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0069
432 D(4) dopamine receptor DRD4 0.0069
537 ATP synthase delta chain, mitochondrial ATP5D 0.0068
244 Angiotensin-converting enzyme ACE 0.0068
124 Histamine H2 receptor HRH2 0.0068
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0068
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0067
1063 Signal transducer and activator of transcription 5B STAT5B 0.0067
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0067
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0065
3917 Methylenetetrahydrofolate reductase MTHFR 0.0065
6102 Arylamine N-acetyltransferase 2 NAT2 0.0065
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0065
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0065
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0065
293 Gamma-glutamyl hydrolase GGH 0.0064
6167 Organic solute transporter subunit beta OSTB 0.0064
6166 Organic solute transporter subunit alpha OSTA 0.0064
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0063
165 FL cytokine receptor FLT3 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0063
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0062
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0059
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
6020 Aldehyde oxidase AOX1 0.0057
6149 Solute carrier family 22 member 10 SLC22A10 0.0057
484 Tyrosine-protein kinase ABL2 ABL2 0.0057
1714 Mitogen-activated protein kinase 3 MAPK3 0.0057
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0057
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0056
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0056
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0056
2599 Tyrosine-protein kinase HCK HCK 0.0056
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0056
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0056
771 Pyruvate carboxylase, mitochondrial PC 0.0056
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0056
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0056
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0056
3809 Estrogen-related receptor gamma ESRRG 0.0055
291 Nitric-oxide synthase, endothelial NOS3 0.0054
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0054
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0054
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0054
2236 Casein kinase II subunit alpha CSNK2A1 0.0054
3932 Glutathione S-transferase A2 GSTA2 0.0054
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0053
3856 Fibroblast growth factor receptor 3 FGFR3 0.0053
365 Dihydrofolate reductase DHFR 0.0053
2381 Dihydrofolate reductase DFR1 0.0053
2833 Dihydrofolate reductase Not Available 0.0053
2931 Dihydrofolate reductase folA 0.0053
3544 Dihydrofolate reductase folA 0.0053
3682 Dihydrofolate reductase folA 0.0053
6642 Dihydrofolate reductase folA 0.0053
6756 Dihydrofolate reductase dfrA 0.0053
239 Coagulation factor X F10 0.0053
76 Nitric-oxide synthase, brain NOS1 0.0052
823 Fibroblast growth factor receptor 2 FGFR2 0.0052
24 Thymidylate synthase TMP1 0.0052
359 Thymidylate synthase TYMS 0.0052
2626 Thymidylate synthase thyA 0.0052
2729 Thymidylate synthase thyA 0.0052
5352 Thymidylate synthase THYA 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
284 DNA-directed RNA polymerase beta chain rpoB 0.0052
5773 DNA-directed RNA polymerase beta chain rpoB 0.0052
592 Carbonic anhydrase 4 CA4 0.0052
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
921 Glutamate receptor 2 GRIA2 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0051
6837 Serine/threonine-protein kinase 17B STK17B 0.0051
702 UMP-CMP kinase CMPK1 0.0051
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0051
3937 Fatty-acid amide hydrolase FAAH 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
444 Alcohol dehydrogenase 1B ADH1B 0.005
84 Nuclear receptor 0B1 NR0B1 0.005
80 Peroxisome proliferator-activated receptor alpha PPARA 0.005
275 Arachidonate 5-lipoxygenase ALOX5 0.005
1256 5-hydroxytryptamine 6 receptor HTR6 0.0048
295 Carbonic anhydrase 1 CA1 0.0048
268 Adenosine A2b receptor ADORA2B 0.0048
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0048
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0048
6766 O-GlcNAcase BT_4395 BT_4395 0.0048
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0047
6043 Putative G-protein coupled receptor 44 GPR44 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
342 P protein [Includes: DNA-directed DNA polymerase P 0.0046
612 P protein [Includes: DNA-directed DNA polymerase P 0.0046
489 Monocarboxylate transporter 2 SLC16A7 0.0046
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0045
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0045
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0045
1176 Mitogen-activated protein kinase 1 MAPK1 0.0045
718 Folate receptor gamma FOLR3 0.0045
804 Mitochondrial folate transporter/carrier SLC25A32 0.0045
299 Folate receptor beta FOLR2 0.0045
362 Melatonin receptor type 1B MTNR1B 0.0045
571 Melatonin receptor type 1A MTNR1A 0.0045
6212 Tubulin gamma-1 chain TUBG1 0.0045
6210 Tubulin delta chain TUBD1 0.0045
6211 Tubulin epsilon chain TUBE1 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0045
251 Alcohol dehydrogenase 1A ADH1A 0.0045
3830 Calreticulin CALR 0.0044
511 5-hydroxytryptamine 1F receptor HTR1F 0.0044
1618 High affinity nerve growth factor receptor NTRK1 0.0044
517 Alcohol dehydrogenase 1C ADH1C 0.0044
3587 Gastrotropin FABP6 0.0044
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0044
4116 Dihydropteroate synthetase Not Available 0.0044
106 Cannabinoid receptor 2 CNR2 0.0044
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0043
319 Opioid receptor, sigma 1 OPRS1 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
5626 Nucleoside diphosphate kinase B NME2 0.0041
528 5-hydroxytryptamine 1E receptor HTR1E 0.0041
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0041
1656 CYP2B protein CYP2B 0.0041
6034 Hydroxyindole O-methyltransferase ASMT 0.0041
6035 Nuclear receptor ROR-beta RORB 0.0041
6036 Eosinophil peroxidase EPX 0.0041
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0041
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
3957 Adenosine deaminase ADA 0.004
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.004
94 5-hydroxytryptamine 4 receptor HTR4 0.004
6824 Tyrosine-protein kinase Lyn LYN 0.0039
357 Carbonic anhydrase 2 CA2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0039
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0038
891 Dihydropteroate synthase folP 0.0038
5359 Dihydropteroate synthase folP 0.0038
7175 Dihydropteroate synthase sulI 0.0038
1760 Aminopeptidase N ANPEP 0.0038
6843 Aminopeptidase N pepN 0.0038
1483 Membrane copper amine oxidase AOC3 0.0038
153 Dopamine beta-hydroxylase DBH 0.0037
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0037
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0037
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0037
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0037
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0037
6126 Carbonic anhydrase 7 CA7 0.0036
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0036
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0036
3404 Exotoxin A eta 0.0036
765 Indoleamine 2,3-dioxygenase IDO1 0.0035
856 Vitamin D3 receptor VDR 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0035
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0035
5294 Nucleoside diphosphate kinase A NME1 0.0034
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0034
163 D(1B) dopamine receptor DRD5 0.0034
5934 Cytochrome P450 26A1 CYP26A1 0.0034
2981 Phospholipase A2, membrane associated PLA2G2A 0.0034
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0033
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0033
6432 Transporter snf 0.0032
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0032
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0032
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0031
65 Matrix metalloproteinase-9 Not Available 0.0031
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.003
164 Histamine H4 receptor HRH4 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.003
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.003
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.003
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0029
5818 Folate receptor alpha FOLR1 0.0029
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0029
2290 ADP-ribosyl cyclase 2 BST1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0028
4103 Proteasome subunit beta type 2 PSMB2 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
2216 Fibroblast growth factor receptor 4 FGFR4 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4217 Telomerase reverse transcriptase TERT 0.0027
2298 Cytochrome P450-cam camC 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
518 Peroxidase/catalase T katG 0.0027
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0026
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0026
49 Endothelin B receptor EDNRB 0.0026
427 Substance-P receptor TACR1 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
2021 Thrombomodulin THBD 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
563 Thyroid peroxidase TPO 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0025
1517 Beta-3 adrenergic receptor ADRB3 0.0024
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
54 Prothrombin F2 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
976 Platelet glycoprotein IX GP9 0.0024
6218 Pannexin-1 PANX1 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
1374 Natriuretic peptides B NPPB 0.0023
1827 Gap junction alpha-1 protein GJA1 0.0023
5816 Cadherin-5 CDH5 0.0023
1908 Vascular cell adhesion protein 1 VCAM1 0.0023
358 Cystathionine beta-synthase CBS 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
5798 Mitogen-activated protein kinase 11 MAPK11 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0022
1313 Lactoylglutathione lyase GLO1 0.0022
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0021
174 Sigma 1-type opioid receptor SIGMAR1 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
1864 RET proto-oncogene RET 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
3601 Dihydropteroate synthase 1 folP1 0.0021
3807 Dihydropteroate synthase 1 folP1 0.0021
3808 Dihydropteroate synthase 2 folP2 0.0021
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0021
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0021
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0021
780 Retinoic acid receptor RXR-gamma RXRG 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.002
760 Fibroblast growth factor 1 FGF1 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1058 Cell division protein kinase 5 CDK5 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
3913 Glutamic acid decarboxylase GAD65 0.0019
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0019
6459 Glycodelin PAEP 0.0019
4311 tRNA TRDMT1 0.0019
4325 tRNA trmD 0.0019
4328 tRNA trmD 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
6042 Prostaglandin reductase 2 PTGR2 0.0019
88 Retinoic acid receptor RXR-beta RXRB 0.0019
2112 Toll-like receptor 9 TLR9 0.0018
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0018
4041 Microsomal glutathione S-transferase 2 MGST2 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
2391 Ferrochelatase hemH 0.0018
6502 Ferrochelatase DKFZp686P18130 0.0018
1591 Ferrochelatase, mitochondrial FECH 0.0018
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0018
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
1792 Tissue-type plasminogen activator PLAT 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
131 Synaptic vesicular amine transporter SLC18A2 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
1275 Estrogen sulfotransferase SULT1E1 0.0017
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
6174 50S ribosomal protein L32 rpmF 0.0016
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0016
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0016
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0016
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0016
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0016
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
735 Alanine aminotransferase 1 GPT 0.0016
3904 Alanine aminotransferase 2 GPT2 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0016
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0015
6493 Cytochrome c oxidase subunit 6C COX6C 0.0015
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0015
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0015
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0015
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0015
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0015
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0015
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
3233 Bile acid receptor NR1H4 0.0015
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0015
6558 Cytochrome c oxidase subunit 1 ctaD 0.0015
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
751 Potassium channel subfamily K member 6 KCNK6 0.0015
6755 Poliovirus receptor PVR 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
1360 Sphingomyelin phosphodiesterase SMPD1 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
4031 Glutathione S-transferase A1 GSTA1 0.0014
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0014
1541 Metalloproteinase mmp20 0.0014
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
2540 Choloylglycine hydrolase cbh 0.0014
172 Potassium channel subfamily K member 1 KCNK1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
3221 Cytochrome c4 cc4 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0013
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0013
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0013
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
6501 Fatty acid-binding protein, liver FABP1 0.0013
2207 Rhodopsin RHO 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0013
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0012
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0012
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
85 Growth hormone receptor GHR 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
6859 Protein S100-A4 S100A4 0.0012
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0012
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
6500 Phospholipase A2 PLA2G1B 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
2802 Endoglucanase G celCCG 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
1630 Integrin beta-2 ITGB2 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
3007 Carbonic anhydrase 12 CA12 0.001
4205 Carbonic anhydrase 9 CA9 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
1928 Leukotriene C4 synthase LTC4S 0.001
4043 Glutaredoxin-2, mitochondrial GLRX2 0.001
4034 Glutaredoxin-1 GLRX 0.001
910 Epididymal secretory glutathione peroxidase GPX5 0.001
4036 Glutathione peroxidase 6 GPX6 0.001
4037 Hypothetical protein GPX1 0.001
4297 Hypothetical protein SP_1951 0.001
4521 Hypothetical protein BC_2969 0.001
4540 Hypothetical protein TM_1070 0.001
4555 Hypothetical protein MT1739 0.001
4569 Hypothetical protein mshD 0.001
4578 Hypothetical protein PA3270 0.001
4747 Hypothetical protein PA3967 0.001
5177 Hypothetical protein TM_0096 0.001
5194 Hypothetical protein PA1204 0.001
5240 Hypothetical protein Rv2991 0.001
5370 Hypothetical protein TM_1158 0.001
5710 Hypothetical protein Tb927.5.1360 0.001
4029 Microsomal glutathione S-transferase 3 MGST3 0.001
900 Glutathione S-transferase A4 GSTA4 0.001
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.001
911 Glutathione peroxidase 3 GPX3 0.001
4040 Glutathione peroxidase 7 GPX7 0.001
907 Glutathione peroxidase 2 GPX2 0.001
4032 Microsomal glutathione S-transferase 1 MGST1 0.001
906 Glutathione peroxidase 1 GPX1 0.001
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.001
4035 Glutathione S-transferase Mu 5 GSTM5 0.001
903 Glutathione S-transferase A5 GSTA5 0.001
4042 Glutathione transferase omega-2 GSTO2 0.001
4033 S-formylglutathione hydrolase ESD 0.001
4038 Glutathione peroxidase 4 GPX4 0.001
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.001
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
162 Retinoic acid receptor gamma-1 RARG 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
3319 Hydroxyacylglutathione hydrolase HAGH 0.0009
798 Osteocalcin BGLAP 0.0009
898 Glutathione S-transferase A3 GSTA3 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
897 Glutathione S-transferase kappa 1 GSTK1 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
909 Maleylacetoacetate isomerase GSTZ1 0.0009
6044 Serum paraoxonase/lactonase 3 PON3 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
899 Glutathione S-transferase Mu 3 GSTM3 0.0008
905 Glutathione transferase omega-1 GSTO1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
572 Integrin alpha-L ITGAL 0.0008
229 Retinoic acid receptor beta RARB 0.0008
369 Coagulation factor VII F7 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
2165 Glutathione S-transferase Mu 2 GSTM2 0.0008
1593 Mucin-2 MUC2 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
207 Glutathione synthetase GSS 0.0008
5269 Glutathione synthetase gshB 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
901 Glutathione S-transferase Mu 4 GSTM4 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
714 Glutathione reductase, mitochondrial GSR 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
6677 Myelin P2 protein PMP2 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1341 Histamine H3 receptor HRH3 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
1992 Vitamin D-binding protein GC 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
1039 Histone deacetylase 9 HDAC9 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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