DT-Web

DB08880 - Teriflunomide


Identification
Name Teriflunomide
Accession Number DB08880
Type small molecule
Description Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio(R) and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication Used in the treatment of relapsing forms of multiple sclerosis (MS).
Mechanism of action The exact mechanism by which teriflunomide acts in MS is not known. What is known is that teriflunomide prevents pyrimidine synthesis by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase, and this may be involved in its immunomodulatory effect in MS.
Absorption After oral administration of teriflunomide, maximum plasma concentrations are reached, on average, in 1-4 hours.
Protein binding Teriflunomide is extensively plasma protein bound(>99%).
Biotransformation Teriflunomide mainly undergoes hydrolyis to minor metabolites. Other minor metabolic pathways include oxidation, N-acetylation and sulfate conjugation. Teriflunomide is not metabolized by CYP450 or flavin monoamine oxidase.
Route of elimination Teriflunomide is eliminated unchanged and mainly through bile. Specifically 37.5% is eliminated in the feces and 22.6% in urine.
Toxicity Teriflunomide is contraindicated in pregnant women or women of childbearing age due to the risk of teratogenicity. Teriflunomide is also contraindicated in severe hepatic impairment due to reports of hepatotoxicity, hepatic failure, and death.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Leflunomide Avoid combination due to increased adverse effects of teriflunomide.
Natalizumab Avoid combination due to the increased risk of infection.
Pimecrolimus Avoid combination due to the increased toxic effects of immunosuppressants.
Tacrolimus Avoid combination due to the increased toxic effects of immunosuppressants.
Food Interactions
  • Food does not affect teriflunomide pharmacokinetics, so take with or without food.

Targets


Dihydroorotate dehydrogenase, mitochondrial
Name Dihydroorotate dehydrogenase, mitochondrial
Gene Name DHODH
Pharmacological action unknown
Actions inhibitor
References
  • Palmer AM: Teriflunomide, an inhibitor of dihydroorotate dehydrogenase for the potential oral treatment of multiple sclerosis. Curr Opin Investig Drugs. 2010 Nov;11(11):1313-23. - Pubmed
  • Davis JP, Cain GA, Pitts WJ, Magolda RL, Copeland RA: The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry. 1996 Jan 30;35(4):1270-3. - Pubmed
DTHybrid score 1.3889

Transporters


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Kis E, Nagy T, Jani M, Molnar E, Janossy J, Ujhellyi O, Nemet K, Heredi-Szabo K, Krajcsi P: Leflunomide and its metabolite A771726 are high affinity substrates of BCRP: implications for drug resistance. Ann Rheum Dis. 2009 Jul;68(7):1201-7. doi: 10.1136/ard.2007.086264. Epub 2008 Apr 8. - Pubmed
DTHybrid score 0.1788

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.0593
6532 Light-harvesting protein B-800/850 beta 1 chain B1 0.0419
4757 Cytochrome P450 2C9 CYP2C9 0.0393
4512 Cytochrome P450 3A4 CYP3A4 0.0383
6765 3-ketoacyl-CoA thiolase fadA 0.0314
6530 Pancreatic lipase-related protein 2 PNLIPRP2 0.0313
6764 Fatty acid oxidation complex subunit alpha fadB 0.0313
4200 Cytochrome P450 1A2 CYP1A2 0.0305
2387 Ferripyoverdine receptor fpvA 0.0273
862 Multidrug resistance-associated protein 1 ABCC1 0.0271
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0257
6016 Cytochrome P450 2C19 CYP2C19 0.0243
3680 Dihydroorotate dehydrogenase A pyrDA 0.024
3259 Autolysin lytA 0.0238
4924 Cytochrome P450 2C8 CYP2C8 0.0236
4118 Cytochrome P450 3A5 CYP3A5 0.0235
2775 Dihydroorotate dehydrogenase pyrD 0.0221
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0217
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0214
1227 Cytochrome b MT-CYB 0.0214
6386 Cytochrome b petB 0.0214
6937 Cytochrome b MT-CYB 0.0214
992 Protein tyrosine kinase 2 beta PTK2B 0.0202
2646 Dihydroorotase pyrC 0.019
2794 Orotate phosphoribosyltransferase pyrE 0.0178
2427 Ferrichrome-iron receptor fhuA 0.0176
4119 Cytochrome P450 2D6 CYP2D6 0.0161
6024 Cytochrome P450 1A1 CYP1A1 0.0152
6220 Aryl hydrocarbon receptor AHR 0.0148
587 Serum albumin ALB 0.0142
1898 Cytochrome P450 1B1 CYP1B1 0.014
1353 DNA topoisomerase 1 TOP1 0.0135
3552 DNA topoisomerase 1 topA 0.0135
844 Epidermal growth factor receptor EGFR 0.0134
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0134
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0127
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0124
6107 Cytochrome P450 3A7 CYP3A7 0.0122
776 Bile salt export pump ABCB11 0.0121
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0114
6030 Cytochrome P450 2B6 CYP2B6 0.0113
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0105
6137 Multidrug resistance-associated protein 6 ABCC6 0.0103
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0103
504 Mast/stem cell growth factor receptor KIT 0.0098
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0093
6148 Multidrug resistance-associated protein 7 ABCC10 0.0092
117 Sterol O-acyltransferase 1 SOAT1 0.009
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.009
817 DNA topoisomerase 2-alpha TOP2A 0.0088
1729 Solute carrier family 22 member 6 SLC22A6 0.0087
6013 Cytochrome P450 2E1 CYP2E1 0.0085
2164 Multidrug resistance-associated protein 4 ABCC4 0.0084
33 Cystine/glutamate transporter SLC7A11 0.0084
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0076
6145 Solute carrier family 22 member 1 SLC22A1 0.0076
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
4773 Deoxycytidine kinase DCK 0.0074
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0074
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0074
6142 Solute carrier family 22 member 8 SLC22A8 0.0073
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0072
6599 HTH-type transcriptional regulator ttgR ttgR 0.0071
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.007
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.007
228 Beta platelet-derived growth factor receptor PDGFRB 0.007
102 DNA topoisomerase I, mitochondrial TOP1MT 0.007
4120 NADPH--cytochrome P450 reductase POR 0.0069
6144 Solute carrier family 22 member 2 SLC22A2 0.0069
6147 Solute carrier family 22 member 3 SLC22A3 0.0064
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0063
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
1024 Solute carrier family 22 member 11 SLC22A11 0.0058
5718 Cytochrome P450 2A6 CYP2A6 0.0057
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0057
26 Vascular endothelial growth factor receptor 3 FLT4 0.0053
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0053
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0052
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
32 Vascular endothelial growth factor receptor 1 FLT1 0.0051
407 Vascular endothelial growth factor receptor 2 KDR 0.0051
6143 Solute carrier family 22 member 7 SLC22A7 0.0051
136 Estrogen receptor ESR1 0.005
1650 Heme carrier protein 1 SLC46A1 0.005
5787 Angiopoietin-1 receptor TEK 0.0049
20 Prostaglandin G/H synthase 1 PTGS1 0.0049
908 Glutathione S-transferase theta-1 GSTT1 0.0049
29 Tubulin beta-1 chain TUBB1 0.0049
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0048
2539 Tubulin alpha-1 chain TUBA4A 0.0045
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0043
468 Cytochrome P450 4A11 CYP4A11 0.0043
6141 Sodium/bile acid cotransporter SLC10A1 0.0043
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0043
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0042
869 Estrogen receptor beta ESR2 0.0042
6163 Copper-transporting ATPase 2 ATP7B 0.0041
6165 Copper-transporting ATPase 1 ATP7A 0.0041
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0041
904 Glutathione S-transferase P GSTP1 0.004
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.004
165 FL cytokine receptor FLT3 0.004
6146 High affinity copper uptake protein 1 SLC31A1 0.004
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0039
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0039
6106 Cytochrome P450 2C18 CYP2C18 0.0038
3811 Cytochrome P450 19A1 CYP19A1 0.0037
3947 Xanthine dehydrogenase/oxidase XDH 0.0037
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0036
731 HIV-1 protease HIV-1 protease 0.0036
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0035
896 Glutathione S-transferase Mu 1 GSTM1 0.0035
3917 Methylenetetrahydrofolate reductase MTHFR 0.0034
3856 Fibroblast growth factor receptor 3 FGFR3 0.0033
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0033
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0032
70 Type-1 angiotensin II receptor AGTR1 0.0032
461 Glycine receptor subunit alpha-3 GLRA3 0.0032
118 Organic cation/carnitine transporter 2 SLC22A5 0.0031
293 Gamma-glutamyl hydrolase GGH 0.0031
1757 Myeloperoxidase MPO 0.0031
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0031
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.003
738 Monocarboxylate transporter 1 SLC16A1 0.003
756 Sex hormone-binding globulin SHBG 0.003
5923 Microtubule-associated protein tau MAPT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
469 Annexin A1 ANXA1 0.003
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
4604 Liver carboxylesterase 1 CES1 0.0027
6136 Multidrug resistance-associated protein 5 ABCC5 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0027
373 Transthyretin TTR 0.0027
273 Apoptosis regulator Bcl-2 BCL2 0.0026
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0026
6689 TraN protein traN 0.0026
6671 Ig heavy chain V-III region VH26 Not Available 0.0026
6680 Cofilin-1 CFL1 0.0026
6404 Rhomboid protease glpG glpG 0.0026
6797 Rhomboid protease glpG glpG 0.0026
6670 Ig kappa chain V-I region Bi Not Available 0.0026
4905 Cytochrome c2 Not Available 0.0026
4939 Cytochrome c2 cycA 0.0026
4964 Cytochrome c2 cycA 0.0026
4979 Cytochrome c2 cycA 0.0026
6673 Cytochrome c2 cycA 0.0026
6690 BenF-like porin PFL_1329 0.0026
3710 Acyl-CoA thioesterase 2 tesB 0.0026
6672 Destrin DSTN 0.0026
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0026
6559 Cytochrome c oxidase subunit 2 ctaC 0.0026
6669 Cytochrome c oxidase subunit 2 ctaC 0.0026
6688 TraF protein traF 0.0026
6679 Colicin-Ia cia 0.0026
6681 Probable N-acetylneuraminic acid outer membrane channel protein nanC nanC 0.0026
6674 Nuclear factor erythroid 2-related factor 1 NFE2L1 0.0026
6687 TraO protein traO 0.0026
6685 Outer membrane protein II porB 0.0026
6668 Cytochrome c oxidase subunit 1-beta ctaDII 0.0026
6676 Fe(3+)-pyochelin receptor fptA 0.0026
115 Penicillin-binding protein 2 mrdA 0.0026
6069 Penicillin-binding protein 2 mrdA 0.0026
6118 Penicillin-binding protein 2 penA 0.0026
6187 Penicillin-binding protein 2 pbpA 0.0026
6686 Penicillin-binding protein 2 pbp2 0.0026
6939 Penicillin-binding protein 2 mrdA 0.0026
7163 Penicillin-binding protein 2 pbpA 0.0026
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0026
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0026
68 Cannabinoid receptor 1 CNR1 0.0026
4192 DNA topoisomerase 2-beta TOP2B 0.0026
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
290 Prostaglandin G/H synthase 2 PTGS2 0.0026
936 Ephrin type-A receptor 2 EPHA2 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
183 Vascular endothelial growth factor A VEGFA 0.0024
5198 Flavodoxin-1 fldA 0.0024
5175 Hypothetical protein SMU.260 SMU_260 0.0024
4405 Nitric oxide reductase fprA 0.0024
5179 Probable aromatic acid decarboxylase pad1 0.0024
5202 Nitroreductase family protein BC_1844 0.0024
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0024
5200 NADH dehydrogenase nox 0.0024
5201 FMN-binding protein DvMF_2023 0.0024
5193 Phenazine biosynthesis protein phzG phzG 0.0024
5178 Protein nrdI nrdI 0.0024
3293 Flavodoxin Not Available 0.0024
4614 Flavodoxin DVU_2680 0.0024
5172 Flavodoxin isiB 0.0024
5173 Flavodoxin isiB 0.0024
5182 Flavodoxin fldA 0.0024
5131 PhzG phzG 0.0024
4037 Hypothetical protein GPX1 0.0024
4297 Hypothetical protein SP_1951 0.0024
4521 Hypothetical protein BC_2969 0.0024
4540 Hypothetical protein TM_1070 0.0024
4555 Hypothetical protein MT1739 0.0024
4569 Hypothetical protein mshD 0.0024
4578 Hypothetical protein PA3270 0.0024
4747 Hypothetical protein PA3967 0.0024
5177 Hypothetical protein TM_0096 0.0024
5194 Hypothetical protein PA1204 0.0024
5240 Hypothetical protein Rv2991 0.0024
5370 Hypothetical protein TM_1158 0.0024
5710 Hypothetical protein Tb927.5.1360 0.0024
5181 Hypothetical protein yhdA azr 0.0024
5170 Epidermin decarboxylase epiD 0.0024
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0024
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0024
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0024
5191 Morphinone reductase morB 0.0024
5190 Rubredoxin-oxygen oxidoreductase roo 0.0024
1760 Aminopeptidase N ANPEP 0.0024
6843 Aminopeptidase N pepN 0.0024
3941 Amine oxidase [flavin-containing] A MAOA 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4760 Mll3241 protein mll3241 0.0023
3578 Protein crcA crcA 0.0023
6438 Outer membrane protein G ompG 0.0023
6474 Outer membrane protein W ompW 0.0023
2447 Ammonia channel amtB 0.0023
6675 Colicin-E3 ceaC 0.0023
2925 Long-chain fatty acid transport protein fadL 0.0023
6385 H subunit of photosynthetic reaction center complex puhA 0.0023
6480 Outer membrane usher protein papC papC 0.0023
3395 Iron(III) dicitrate transport protein fecA fecA 0.0023
6678 Colicin I receptor cirA 0.0023
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0023
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
823 Fibroblast growth factor receptor 2 FGFR2 0.0022
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0022
6182 Cytochrome P450 2J2 CYP2J2 0.0022
3810 Catechol O-methyltransferase COMT 0.0022
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0021
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0021
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0021
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0021
1618 High affinity nerve growth factor receptor NTRK1 0.0021
6524 Protein tonB tonB 0.0021
4503 NADPH-flavin oxidoreductase frp 0.0021
2679 Vitamin B12 transporter btuB btuB 0.0021
5189 Trimethylamine dehydrogenase tmd 0.0021
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0021
4407 FMN-dependent NADH-azoreductase azoR 0.0021
5169 FMN-dependent NADH-azoreductase azoR 0.0021
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0021
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0021
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0021
3507 Chorismate synthase aroC 0.0021
5171 Chorismate synthase aroC 0.0021
5176 YtnJ moxC 0.0021
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6677 Myelin P2 protein PMP2 0.002
1058 Cell division protein kinase 5 CDK5 0.002
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0019
76 Nitric-oxide synthase, brain NOS1 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
824 Sodium-dependent serotonin transporter SLC6A4 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0018
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0018
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0018
725 5-hydroxytryptamine 1D receptor HTR1D 0.0018
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0018
5180 L(+)-mandelate dehydrogenase mdlB 0.0018
885 5-hydroxytryptamine 1B receptor HTR1B 0.0018
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0018
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0018
871 Glucocorticoid receptor NR3C1 0.0018
3809 Estrogen-related receptor gamma ESRRG 0.0018
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0018
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0017
275 Arachidonate 5-lipoxygenase ALOX5 0.0017
6354 Reaction center protein M chain pufM 0.0017
6455 Reaction center protein M chain pufM 0.0017
6684 Reaction center protein M chain pufM 0.0017
6352 Reaction center protein H chain puhA 0.0017
6456 Reaction center protein H chain puhA 0.0017
6682 Reaction center protein H chain puhA 0.0017
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.0017
6353 Reaction center protein L chain pufL 0.0017
6454 Reaction center protein L chain pufL 0.0017
6683 Reaction center protein L chain pufL 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
408 Riboflavin kinase RFK 0.0017
2216 Fibroblast growth factor receptor 4 FGFR4 0.0017
6228 Nuclear receptor coactivator 1 NCOA1 0.0017
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0017
4217 Telomerase reverse transcriptase TERT 0.0017
1063 Signal transducer and activator of transcription 5B STAT5B 0.0017
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0017
6241 Nuclear receptor coactivator 2 NCOA2 0.0017
239 Coagulation factor X F10 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0017
342 P protein [Includes: DNA-directed DNA polymerase P 0.0017
612 P protein [Includes: DNA-directed DNA polymerase P 0.0017
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0017
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0017
161 Tubulin beta chain TUBB 0.0016
312 Tubulin beta chain TUB2 0.0016
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0016
2828 Squalene--hopene cyclase shc 0.0016
320 5-hydroxytryptamine 1A receptor HTR1A 0.0016
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0016
4284 Pentaerythritol tetranitrate reductase onr 0.0016
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0016
24 Thymidylate synthase TMP1 0.0016
359 Thymidylate synthase TYMS 0.0016
2626 Thymidylate synthase thyA 0.0016
2729 Thymidylate synthase thyA 0.0016
5352 Thymidylate synthase THYA 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
713 Sodium-dependent dopamine transporter SLC6A3 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0015
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0015
6171 Solute carrier family 28 member 3 SLC28A3 0.0015
6268 Hydroxyacid oxidase 1 HAO1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
5626 Nucleoside diphosphate kinase B NME2 0.0015
6031 Cytochrome P450 3A43 CYP3A43 0.0015
2207 Rhodopsin RHO 0.0015
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0015
654 Flavin reductase BLVRB 0.0015
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0014
484 Tyrosine-protein kinase ABL2 ABL2 0.0014
3923 Cholinesterase BCHE 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
2320 Thymidine kinase, cytosolic TK1 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0013
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0013
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0013
6824 Tyrosine-protein kinase Lyn LYN 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0013
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0013
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
1864 RET proto-oncogene RET 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
789 Alpha-1D adrenergic receptor ADRA1D 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0013
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0013
7 Nitric oxide synthase, inducible NOS2 0.0012
5294 Nucleoside diphosphate kinase A NME1 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0012
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
632 Alpha-1B adrenergic receptor ADRA1B 0.0011
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
2240 Cell division protein kinase 2 CDK2 0.0011
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0011
3939 Amine oxidase [flavin-containing] B MAOB 0.0011
3587 Gastrotropin FABP6 0.0011
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.001
5818 Folate receptor alpha FOLR1 0.001
833 Organic cation/carnitine transporter 1 SLC22A4 0.001
556 Alpha-1A adrenergic receptor ADRA1A 0.001
6149 Solute carrier family 22 member 10 SLC22A10 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
84 Nuclear receptor 0B1 NR0B1 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
467 Delta-type opioid receptor OPRD1 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.001
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.001
696 Kappa-type opioid receptor OPRK1 0.001
6168 Solute carrier family 22 member 16 SLC22A16 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
847 Mu-type opioid receptor OPRM1 0.0009
6014 Cytochrome P450 2A13 CYP2A13 0.0009
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0009
380 Cytochrome P450 17A1 CYP17A1 0.0008
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0008
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0008
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0008
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0008
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0008
6085 Fatty acid-binding protein, intestinal FABP2 0.0008
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0007
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0007
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0006
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0006
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0006
6020 Aldehyde oxidase AOX1 0.0006
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0006
146 Androgen receptor AR 0.0006
291 Nitric-oxide synthase, endothelial NOS3 0.0006
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0006
365 Dihydrofolate reductase DHFR 0.0006
2381 Dihydrofolate reductase DFR1 0.0006
2833 Dihydrofolate reductase Not Available 0.0006
2931 Dihydrofolate reductase folA 0.0006
3544 Dihydrofolate reductase folA 0.0006
3682 Dihydrofolate reductase folA 0.0006
6642 Dihydrofolate reductase folA 0.0006
6756 Dihydrofolate reductase dfrA 0.0006
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0006
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0006
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0005
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0005
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0005
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0005
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0005
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