DT-Web

DB00970 - Dactinomycin


Identification
Name Dactinomycin
Accession Number DB00970 (APRD00124)
Type small molecule
Description A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 1255.417
Groups approved
Monoisotopic Weight 1254.628474764
Pharmacology
Indication For the treatment of Wilms' tumor, childhood rhabdomyosarcoma, Ewing's sarcoma and metastatic, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen
Mechanism of action Good evidence exists that this drug bind strongly, but reversibly, to DNA, interfering with synthesis of RNA (prevention of RNA polymerase elongation) and, consequently, with protein synthesis.
Absorption poorly absorbed from gastrointestinal tract
Protein binding 5%
Biotransformation hepatic
Route of elimination Not Available
Toxicity hepatoxicity
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions adduct
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Yang XL, Wang AH: Structural studies of atom-specific anticancer drugs acting on DNA. Pharmacol Ther. 1999 Sep;83(3):181-215. - Pubmed
  • Sobell HM: Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. - Pubmed
  • Hudson JS, Brooks SC, Graves DE: Interactions of actinomycin D with human telomeric G-quadruplex DNA. Biochemistry. 2009 Jun 2;48(21):4440-7. - Pubmed
DTHybrid score Not Available

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score 0.2176
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
  • Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I: Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8472-6. - Pubmed
DTHybrid score 0.3517
Multidrug resistance-associated protein 6
Name Multidrug resistance-associated protein 6
Gene Name ABCC6
Actions substrate
References
  • Belinsky MG, Chen ZS, Shchaveleva I, Zeng H, Kruh GD: Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7. - Pubmed
DTHybrid score 0.1478
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions substrate
References
  • Breuninger LM, Paul S, Gaughan K, Miki T, Chan A, Aaronson SA, Kruh GD: Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution. Cancer Res. 1995 Nov 15;55(22):5342-7. - Pubmed
DTHybrid score 0.2409
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Wang X, Furukawa T, Nitanda T, Okamoto M, Sugimoto Y, Akiyama S, Baba M: Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol. 2003 Jan;63(1):65-72. - Pubmed
DTHybrid score 0.2589

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1855
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1234
4757 Cytochrome P450 2C9 CYP2C9 0.1038
4118 Cytochrome P450 3A5 CYP3A5 0.1029
4119 Cytochrome P450 2D6 CYP2D6 0.1029
4200 Cytochrome P450 1A2 CYP1A2 0.0907
4924 Cytochrome P450 2C8 CYP2C8 0.0837
6016 Cytochrome P450 2C19 CYP2C19 0.0837
817 DNA topoisomerase 2-alpha TOP2A 0.0789
6144 Solute carrier family 22 member 2 SLC22A2 0.067
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0631
1729 Solute carrier family 22 member 6 SLC22A6 0.0617
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0594
6145 Solute carrier family 22 member 1 SLC22A1 0.0593
6107 Cytochrome P450 3A7 CYP3A7 0.0564
6030 Cytochrome P450 2B6 CYP2B6 0.0563
776 Bile salt export pump ABCB11 0.0563
587 Serum albumin ALB 0.0558
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0551
833 Organic cation/carnitine transporter 1 SLC22A4 0.052
6142 Solute carrier family 22 member 8 SLC22A8 0.0504
6024 Cytochrome P450 1A1 CYP1A1 0.0469
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0435
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0425
6148 Multidrug resistance-associated protein 7 ABCC10 0.0414
6147 Solute carrier family 22 member 3 SLC22A3 0.0399
2164 Multidrug resistance-associated protein 4 ABCC4 0.0397
1898 Cytochrome P450 1B1 CYP1B1 0.0385
6013 Cytochrome P450 2E1 CYP2E1 0.035
1024 Solute carrier family 22 member 11 SLC22A11 0.034
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0338
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0338
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0331
6143 Solute carrier family 22 member 7 SLC22A7 0.032
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0312
6136 Multidrug resistance-associated protein 5 ABCC5 0.0282
477 DNA topoisomerase 4 subunit A parC 0.027
886 DNA topoisomerase 4 subunit A parC 0.027
6226 DNA topoisomerase 4 subunit A parC 0.027
404 DNA gyrase subunit A gyrA 0.0266
6224 DNA gyrase subunit A gyrA 0.0266
5718 Cytochrome P450 2A6 CYP2A6 0.0245
6141 Sodium/bile acid cotransporter SLC10A1 0.0238
844 Epidermal growth factor receptor EGFR 0.0236
738 Monocarboxylate transporter 1 SLC16A1 0.0234
4120 NADPH--cytochrome P450 reductase POR 0.023
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0229
3947 Xanthine dehydrogenase/oxidase XDH 0.0224
731 HIV-1 protease HIV-1 protease 0.0222
20 Prostaglandin G/H synthase 1 PTGS1 0.0218
161 Tubulin beta chain TUBB 0.0212
312 Tubulin beta chain TUB2 0.0212
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0212
4192 DNA topoisomerase 2-beta TOP2B 0.0212
1353 DNA topoisomerase 1 TOP1 0.0203
3552 DNA topoisomerase 1 topA 0.0203
290 Prostaglandin G/H synthase 2 PTGS2 0.0201
908 Glutathione S-transferase theta-1 GSTT1 0.0198
6599 HTH-type transcriptional regulator ttgR ttgR 0.0198
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0185
3923 Cholinesterase BCHE 0.0176
6106 Cytochrome P450 2C18 CYP2C18 0.0169
492 Histamine H1 receptor HRH1 0.0168
6210 Tubulin delta chain TUBD1 0.0167
6212 Tubulin gamma-1 chain TUBG1 0.0167
6211 Tubulin epsilon chain TUBE1 0.0167
6085 Fatty acid-binding protein, intestinal FABP2 0.0164
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0163
4604 Liver carboxylesterase 1 CES1 0.0162
904 Glutathione S-transferase P GSTP1 0.0161
136 Estrogen receptor ESR1 0.0159
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0156
159 Penicillin-binding protein 2B penA 0.0153
6121 Penicillin-binding protein 2B penA 0.0153
556 Alpha-1A adrenergic receptor ADRA1A 0.0149
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0147
824 Sodium-dependent serotonin transporter SLC6A4 0.0145
2449 Tubulin alpha-3 chain TUBA1A 0.0143
871 Glucocorticoid receptor NR3C1 0.0142
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0141
29 Tubulin beta-1 chain TUBB1 0.0137
1757 Myeloperoxidase MPO 0.0136
1629 Transcription factor AP-1 JUN 0.0135
504 Mast/stem cell growth factor receptor KIT 0.0134
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0134
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0133
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0132
380 Cytochrome P450 17A1 CYP17A1 0.0131
468 Cytochrome P450 4A11 CYP4A11 0.013
3307 Acriflavine resistance protein B acrB 0.013
193 Beta-1 adrenergic receptor ADRB1 0.0129
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0127
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0126
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0121
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0121
33 Cystine/glutamate transporter SLC7A11 0.0119
6149 Solute carrier family 22 member 10 SLC22A10 0.0118
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0118
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0115
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0115
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0115
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0113
6168 Solute carrier family 22 member 16 SLC22A16 0.0112
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0109
992 Protein tyrosine kinase 2 beta PTK2B 0.0109
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0108
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0108
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0107
3811 Cytochrome P450 19A1 CYP19A1 0.0106
766 Beta-2 adrenergic receptor ADRB2 0.0106
869 Estrogen receptor beta ESR2 0.0106
6218 Pannexin-1 PANX1 0.0104
4773 Deoxycytidine kinase DCK 0.0104
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0104
633 Penicillin-binding proteins 1A/1B pbpA 0.0104
318 Alpha-2A adrenergic receptor ADRA2A 0.0104
6163 Copper-transporting ATPase 2 ATP7B 0.0103
6165 Copper-transporting ATPase 1 ATP7A 0.0103
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0103
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0102
474 Acetylcholinesterase ACHE 0.0102
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
117 Sterol O-acyltransferase 1 SOAT1 0.0099
6146 High affinity copper uptake protein 1 SLC31A1 0.0098
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0098
831 D(2) dopamine receptor DRD2 0.0098
632 Alpha-1B adrenergic receptor ADRA1B 0.0097
713 Sodium-dependent dopamine transporter SLC6A3 0.0097
228 Beta platelet-derived growth factor receptor PDGFRB 0.0097
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0096
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0095
5787 Angiopoietin-1 receptor TEK 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0095
3941 Amine oxidase [flavin-containing] A MAOA 0.0094
789 Alpha-1D adrenergic receptor ADRA1D 0.0094
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0094
629 Alpha-2B adrenergic receptor ADRA2B 0.0094
489 Monocarboxylate transporter 2 SLC16A7 0.0093
1852 Microtubule-associated protein 2 MAP2 0.0093
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
273 Apoptosis regulator Bcl-2 BCL2 0.0091
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
461 Glycine receptor subunit alpha-3 GLRA3 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
896 Glutathione S-transferase Mu 1 GSTM1 0.0088
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0088
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0088
2539 Tubulin alpha-1 chain TUBA4A 0.0087
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0087
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0085
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0085
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0085
5923 Microtubule-associated protein tau MAPT 0.0084
5924 Microtubule-associated protein 4 MAP4 0.0084
952 Dipeptidyl peptidase 4 DPP4 0.0084
614 Progesterone receptor PGR 0.0083
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0083
26 Vascular endothelial growth factor receptor 3 FLT4 0.0083
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0081
175 Thiamin pyrophosphokinase 1 TPK1 0.008
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
32 Vascular endothelial growth factor receptor 1 FLT1 0.0079
737 Mineralocorticoid receptor NR3C2 0.0079
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0078
373 Transthyretin TTR 0.0078
124 Histamine H2 receptor HRH2 0.0078
624 Guanidinoacetate N-methyltransferase GAMT 0.0078
7 Nitric oxide synthase, inducible NOS2 0.0078
407 Vascular endothelial growth factor receptor 2 KDR 0.0077
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
6042 Prostaglandin reductase 2 PTGR2 0.0074
6182 Cytochrome P450 2J2 CYP2J2 0.0074
1636 Trace amine-associated receptor 1 TAAR1 0.0073
645 Penicillin-binding protein 1A mrcA 0.0073
5805 Penicillin-binding protein 1A ponA 0.0073
6185 Penicillin-binding protein 1A mrcA 0.0073
6799 Penicillin-binding protein 1A pbpA 0.0073
502 5-hydroxytryptamine 2A receptor HTR2A 0.0072
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0071
378 Alpha-2C adrenergic receptor ADRA2C 0.007
131 Synaptic vesicular amine transporter SLC18A2 0.0069
3939 Amine oxidase [flavin-containing] B MAOB 0.0069
723 Cytosolic phospholipase A2 PLA2G4A 0.0069
6043 Putative G-protein coupled receptor 44 GPR44 0.0069
291 Nitric-oxide synthase, endothelial NOS3 0.0067
4238 50S ribosomal protein L4 rplD 0.0067
5578 50S ribosomal protein L4 rplD 0.0067
6173 50S ribosomal protein L4 rplD 0.0067
6219 50S ribosomal protein L4 rplD 0.0067
320 5-hydroxytryptamine 1A receptor HTR1A 0.0066
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0066
2981 Phospholipase A2, membrane associated PLA2G2A 0.0065
1192 Sulfotransferase 1A1 SULT1A1 0.0065
183 Vascular endothelial growth factor A VEGFA 0.0065
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0065
6138 Multidrug resistance protein 3 ABCB4 0.0065
1650 Heme carrier protein 1 SLC46A1 0.0065
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0063
1313 Lactoylglutathione lyase GLO1 0.0062
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0062
4237 50S ribosomal protein L22 rplV 0.0062
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0061
70 Type-1 angiotensin II receptor AGTR1 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
756 Sex hormone-binding globulin SHBG 0.006
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
23 D(1A) dopamine receptor DRD1 0.0059
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0059
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0059
6167 Organic solute transporter subunit beta OSTB 0.0058
6166 Organic solute transporter subunit alpha OSTA 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
6220 Aryl hydrocarbon receptor AHR 0.0058
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0057
847 Mu-type opioid receptor OPRM1 0.0057
788 Creatine kinase M-type CKM 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
885 5-hydroxytryptamine 1B receptor HTR1B 0.0056
725 5-hydroxytryptamine 1D receptor HTR1D 0.0056
3810 Catechol O-methyltransferase COMT 0.0054
165 FL cytokine receptor FLT3 0.0054
467 Delta-type opioid receptor OPRD1 0.0053
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0053
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0053
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0052
76 Nitric-oxide synthase, brain NOS1 0.0052
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0051
6837 Serine/threonine-protein kinase 17B STK17B 0.0051
702 UMP-CMP kinase CMPK1 0.0051
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.005
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.005
2599 Tyrosine-protein kinase HCK HCK 0.005
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0049
696 Kappa-type opioid receptor OPRK1 0.0049
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0049
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0048
293 Gamma-glutamyl hydrolase GGH 0.0047
6228 Nuclear receptor coactivator 1 NCOA1 0.0047
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0047
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0047
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0047
6241 Nuclear receptor coactivator 2 NCOA2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
342 P protein [Includes: DNA-directed DNA polymerase P 0.0046
612 P protein [Includes: DNA-directed DNA polymerase P 0.0046
2472 Voltage-gated potassium channel kcsA 0.0046
6366 Voltage-gated potassium channel kcsA 0.0046
465 Calmodulin CALM1 0.0046
1050 Bile salt sulfotransferase SULT2A1 0.0046
3856 Fibroblast growth factor receptor 3 FGFR3 0.0046
3917 Methylenetetrahydrofolate reductase MTHFR 0.0046
24 Thymidylate synthase TMP1 0.0045
359 Thymidylate synthase TYMS 0.0045
2626 Thymidylate synthase thyA 0.0045
2729 Thymidylate synthase thyA 0.0045
5352 Thymidylate synthase THYA 0.0045
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0045
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0044
3587 Gastrotropin FABP6 0.0044
638 D(3) dopamine receptor DRD3 0.0043
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0043
260 Cytochrome P450 51 ERG11 0.0043
761 Cytochrome P450 51 ERG11 0.0043
3163 Cytochrome P450 51 cyp51 0.0043
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0041
5626 Nucleoside diphosphate kinase B NME2 0.0041
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0041
469 Annexin A1 ANXA1 0.0041
511 5-hydroxytryptamine 1F receptor HTR1F 0.004
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
6031 Cytochrome P450 3A43 CYP3A43 0.004
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0039
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0038
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0038
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0038
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0038
106 Cannabinoid receptor 2 CNR2 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0037
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0037
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0037
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0037
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0036
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0036
3809 Estrogen-related receptor gamma ESRRG 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0036
4203 Histamine N-methyltransferase HNMT 0.0036
5126 Arginase rocF 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0036
239 Coagulation factor X F10 0.0035
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0035
164 Histamine H4 receptor HRH4 0.0035
936 Ephrin type-A receptor 2 EPHA2 0.0035
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0035
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0035
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0035
5294 Nucleoside diphosphate kinase A NME1 0.0034
1341 Histamine H3 receptor HRH3 0.0034
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0033
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0033
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0033
499 Arginine decarboxylase ADC 0.0033
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0033
1760 Aminopeptidase N ANPEP 0.0032
6843 Aminopeptidase N pepN 0.0032
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0032
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
976 Platelet glycoprotein IX GP9 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
1618 High affinity nerve growth factor receptor NTRK1 0.0032
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0032
2300 Lysozyme E 0.0032
3633 Lysozyme R 0.0032
5597 Lysozyme 17 0.0032
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
577 Argininosuccinate lyase ASL 0.0031
146 Androgen receptor AR 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
823 Fibroblast growth factor receptor 2 FGFR2 0.003
740 Argininosuccinate synthase ASS1 0.003
865 Argininosuccinate synthase ASS1 0.003
2680 Argininosuccinate synthase argG 0.003
3194 Argininosuccinate synthase argG 0.003
590 5-hydroxytryptamine 2C receptor HTR2C 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.003
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.003
275 Arachidonate 5-lipoxygenase ALOX5 0.003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.003
6824 Tyrosine-protein kinase Lyn LYN 0.003
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
5818 Folate receptor alpha FOLR1 0.0029
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0029
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0029
683 Potassium transporter GK0582 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0028
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
558 Solute carrier family 12 member 1 SLC12A1 0.0027
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0027
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
777 Tumor necrosis factor TNF 0.0027
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
365 Dihydrofolate reductase DHFR 0.0027
2381 Dihydrofolate reductase DFR1 0.0027
2833 Dihydrofolate reductase Not Available 0.0027
2931 Dihydrofolate reductase folA 0.0027
3544 Dihydrofolate reductase folA 0.0027
3682 Dihydrofolate reductase folA 0.0027
6642 Dihydrofolate reductase folA 0.0027
6756 Dihydrofolate reductase dfrA 0.0027
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0026
818 50S ribosomal protein L10 rplJ 0.0026
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
6151 Monocarboxylate transporter 10 SLC16A10 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
2021 Thrombomodulin THBD 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0025
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0025
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0025
6014 Cytochrome P450 2A13 CYP2A13 0.0025
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0025
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0024
432 D(4) dopamine receptor DRD4 0.0024
6432 Transporter snf 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
2216 Fibroblast growth factor receptor 4 FGFR4 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
1063 Signal transducer and activator of transcription 5B STAT5B 0.0023
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
4217 Telomerase reverse transcriptase TERT 0.0023
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0022
484 Tyrosine-protein kinase ABL2 ABL2 0.0022
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0021
751 Potassium channel subfamily K member 6 KCNK6 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
163 D(1B) dopamine receptor DRD5 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
5682 Ribonuclease pancreatic RNASE1 0.002
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
1656 CYP2B protein CYP2B 0.002
2240 Cell division protein kinase 2 CDK2 0.002
1360 Sphingomyelin phosphodiesterase SMPD1 0.002
1058 Cell division protein kinase 5 CDK5 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
172 Potassium channel subfamily K member 1 KCNK1 0.0019
357 Carbonic anhydrase 2 CA2 0.0019
5798 Mitogen-activated protein kinase 11 MAPK11 0.0019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0019
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0019
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0018
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0018
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
2391 Ferrochelatase hemH 0.0018
6502 Ferrochelatase DKFZp686P18130 0.0018
1591 Ferrochelatase, mitochondrial FECH 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
1864 RET proto-oncogene RET 0.0018
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0018
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0018
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0018
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0018
1792 Tissue-type plasminogen activator PLAT 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
6020 Aldehyde oxidase AOX1 0.0017
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0017
284 DNA-directed RNA polymerase beta chain rpoB 0.0016
5773 DNA-directed RNA polymerase beta chain rpoB 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0016
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0015
6493 Cytochrome c oxidase subunit 6C COX6C 0.0015
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0015
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0015
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0015
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0015
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0015
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0015
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0015
6558 Cytochrome c oxidase subunit 1 ctaD 0.0015
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0015
6755 Poliovirus receptor PVR 0.0015
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0015
3932 Glutathione S-transferase A2 GSTA2 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
1178 Adenosine A2a receptor ADORA2A 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
2540 Choloylglycine hydrolase cbh 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
6501 Fatty acid-binding protein, liver FABP1 0.0013
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0012
694 Matrix protein 2 M 0.0012
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0012
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0012
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0012
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0012
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0011
6500 Phospholipase A2 PLA2G1B 0.0011
6459 Glycodelin PAEP 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
427 Substance-P receptor TACR1 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.001
6174 50S ribosomal protein L32 rpmF 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.001
811 Translocator protein TSPO 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
517 Alcohol dehydrogenase 1C ADH1C 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
1928 Leukotriene C4 synthase LTC4S 0.001
4043 Glutaredoxin-2, mitochondrial GLRX2 0.001
4034 Glutaredoxin-1 GLRX 0.001
910 Epididymal secretory glutathione peroxidase GPX5 0.001
4036 Glutathione peroxidase 6 GPX6 0.001
4037 Hypothetical protein GPX1 0.001
4297 Hypothetical protein SP_1951 0.001
4521 Hypothetical protein BC_2969 0.001
4540 Hypothetical protein TM_1070 0.001
4555 Hypothetical protein MT1739 0.001
4569 Hypothetical protein mshD 0.001
4578 Hypothetical protein PA3270 0.001
4747 Hypothetical protein PA3967 0.001
5177 Hypothetical protein TM_0096 0.001
5194 Hypothetical protein PA1204 0.001
5240 Hypothetical protein Rv2991 0.001
5370 Hypothetical protein TM_1158 0.001
5710 Hypothetical protein Tb927.5.1360 0.001
4029 Microsomal glutathione S-transferase 3 MGST3 0.001
900 Glutathione S-transferase A4 GSTA4 0.001
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.001
911 Glutathione peroxidase 3 GPX3 0.001
4040 Glutathione peroxidase 7 GPX7 0.001
907 Glutathione peroxidase 2 GPX2 0.001
4032 Microsomal glutathione S-transferase 1 MGST1 0.001
906 Glutathione peroxidase 1 GPX1 0.001
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.001
4035 Glutathione S-transferase Mu 5 GSTM5 0.001
903 Glutathione S-transferase A5 GSTA5 0.001
4042 Glutathione transferase omega-2 GSTO2 0.001
4033 S-formylglutathione hydrolase ESD 0.001
4038 Glutathione peroxidase 4 GPX4 0.001
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.001
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.001
3957 Adenosine deaminase ADA 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
921 Glutamate receptor 2 GRIA2 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
3319 Hydroxyacylglutathione hydrolase HAGH 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
898 Glutathione S-transferase A3 GSTA3 0.0009
897 Glutathione S-transferase kappa 1 GSTK1 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
909 Maleylacetoacetate isomerase GSTZ1 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
54 Prothrombin F2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
899 Glutathione S-transferase Mu 3 GSTM3 0.0008
905 Glutathione transferase omega-1 GSTO1 0.0008
4041 Microsomal glutathione S-transferase 2 MGST2 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
2165 Glutathione S-transferase Mu 2 GSTM2 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
207 Glutathione synthetase GSS 0.0008
5269 Glutathione synthetase gshB 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
901 Glutathione S-transferase Mu 4 GSTM4 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
4031 Glutathione S-transferase A1 GSTA1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
1630 Integrin beta-2 ITGB2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
714 Glutathione reductase, mitochondrial GSR 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0006
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
341 5-hydroxytryptamine 3 receptor HTR3A 0.0006
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2207 Rhodopsin RHO 0.0005
572 Integrin alpha-L ITGAL 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
4122 Histone deacetylase 2 HDAC2 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
6102 Arylamine N-acetyltransferase 2 NAT2 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
295 Carbonic anhydrase 1 CA1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
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