DT-Web

DB04356 - 9-Deazaguanine


Identification
Name 9-Deazaguanine
Accession Number DB04356 (EXPT00356)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 149.1301
Groups experimental
Monoisotopic Weight 149.046335802
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Hypoxanthine-guanine phosphoribosyltransferase
Name Hypoxanthine-guanine phosphoribosyltransferase
Gene Name HPRT1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7161

Predictions


Id Partner name Gene Name Score
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0809
2164 Multidrug resistance-associated protein 4 ABCC4 0.0611
4271 Anthranilate phosphoribosyltransferase trpD 0.0437
2794 Orotate phosphoribosyltransferase pyrE 0.0423
1405 Thiopurine S-methyltransferase TPMT 0.0408
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0388
128 Adenine phosphoribosyltransferase APRT 0.0353
3947 Xanthine dehydrogenase/oxidase XDH 0.0323
4031 Glutathione S-transferase A1 GSTA1 0.0257
896 Glutathione S-transferase Mu 1 GSTM1 0.0233
3932 Glutathione S-transferase A2 GSTA2 0.0226
6171 Solute carrier family 28 member 3 SLC28A3 0.0173
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0152
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
2757 Inorganic pyrophosphatase ppa 0.0146
6238 Inorganic pyrophosphatase ppa 0.0146
6968 Inorganic pyrophosphatase PPA1 0.0146
6020 Aldehyde oxidase AOX1 0.0141
6136 Multidrug resistance-associated protein 5 ABCC5 0.0134
2755 Hypoxanthine-guanine-xanthine phosphoribosyltransferase LACZ 0.013
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.013
2647 RNA-directed RNA polymerase P2 0.0128
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0125
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0125
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0119
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0119
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0119
3010 Regulatory protein blaR1 blaR1 0.0116
2149 Angiogenin ANG 0.0115
2727 S-adenosylmethionine synthetase metK 0.0112
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.011
4600 Malonamidase E2 Not Available 0.0109
2717 Folylpolyglutamate synthase fgs 0.0107
2428 Thiamine-phosphate pyrophosphorylase thiE 0.0099
6142 Solute carrier family 22 member 8 SLC22A8 0.0098
6395 Myosin-14 MYH14 0.0096
5294 Nucleoside diphosphate kinase A NME1 0.0083
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0077
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