DT-Web

DB01606 - Tazobactam


Identification
Name Tazobactam
Accession Number DB01606 (EXPT03012)
Type small molecule
Description Tazobactam is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 300.291
Groups approved
Monoisotopic Weight 300.052840204
Pharmacology
Indication Used in combination with piperacillin to broaden the spectrum of piperacillin antibacterial action.
Mechanism of action Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Demeclocycline Possible antagonism of action
Doxycycline Possible antagonism of action
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Minocycline Possible antagonism of action
Tetracycline Possible antagonism of action
Food Interactions Not Available

Targets


Beta-lactamase SHV-1 precursor
Name Beta-lactamase SHV-1 precursor
Gene Name bla
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5162
Beta-lactamase TEM
Name Beta-lactamase TEM
Gene Name bla
Pharmacological action yes
Actions inhibitor
References
  • Yang Y, Rasmussen BA, Shlaes DM: Class A beta-lactamases--enzyme-inhibitor interactions and resistance. Pharmacol Ther. 1999 Aug;83(2):141-51. - Pubmed
DTHybrid score 1.0798

Predictions


Id Partner name Gene Name Score
6396 Beta-lactamase TEM bla 1.0798
3701 Beta-lactamase SHV-2 precursor bla 0.2002
6691 Beta-lactamase SHV-1 bla 0.0876
6897 Class C beta-lactamase Not Available 0.0848
4629 Beta-lactamase CTX-M-9a blaCTX-M-9a 0.0719
332 Beta-lactamase blaZ 0.0707
2478 Beta-lactamase ampC 0.0707
2613 Beta-lactamase ampC 0.0707
2635 Beta-lactamase ampC 0.0707
2700 Beta-lactamase penP 0.0707
5445 Beta-lactamase blaB 0.0707
6019 Beta-lactamase SHV-7 0.0707
6701 Beta-lactamase cphA 0.0707
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