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DB01574 - Attapulgite


Identification
Name Attapulgite
Accession Number DB01574
Type small molecule
Description Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States. When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Until 2003, it was the active ingredient used in Kaopectate, before that product was reformulated with bismuth subsalicylate.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Attapulgite is an adsorbent.
Mechanism of action Attapulgite adsorbs water, toxins and bacteria, contributing to firmer stools, reducing fluid loss from diarrhea.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Chloroquine The antiacid decreases the absorption of chloroquine
Clindamycin The aluminium salt decreases the absorption of lincosamides
Demeclocycline Formation of non-absorbable complexes
Doxycycline Formation of non-absorbable complexes
Lincomycin The aluminium salt decreases the absorption of lincosamides
Minocycline Formation of non-absorbable complexes
Penciclovir The multivalent agent decreases the effect of penicillamine
Tetracycline Formation of non-absorbable complexes
Food Interactions Not Available

Predictions


Id Partner name Gene Name Score
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