DT-Web: DB00802

Identification

Name

Alfentanil

Accession Number

DB00802 (APRD00726)

Type

small molecule

Description

A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

416.5172

Groups

illicit

Monoisotopic Weight

416.25358892

Pharmacology

Indication

For the management of postoperative pain and the maintenance of general anesthesia.

Mechanism of action

Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Alfentanil's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Absorption

For intravenous injection or infusion only.

Protein binding

92%

Biotransformation

The liver is the major site of biotransformation.

Route of elimination

Only 1.0% of the dose is excreted as unchanged drug; urinary excretion is the major route of elimination of metabolites.

Toxicity

Symptoms of overexposure include characteristic rigidity of the skeletal muscles, cardiac and respiratory depression, and narrowing of the pupils.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Alvimopan	Increases levels by receptor binding competition. Discontinue opioid administration at least 7 days prior to administrating Alvimopan.
Cimetidine	Increases the effect of the narcotic
Erythromycin	The macrolide, erythromycin, may increase the effect and toxicity of alfentanil.
Fluconazole	Increases the effect and toxicity of alfentanil
Itraconazole	Itraconazole may increase the effect and toxicity of alfentanil.
Ketoconazole	Ketoconazole may increase the effect and toxicity of alfentanil.
Rifampin	Rifampin reduces levels and efficacy of alfentanil
Telithromycin	Telithromycin may reduce clearance of Alfentanil. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Alfentanil if Telithromycin is initiated, discontinued or dose changed.
Tranylcypromine	Possible increased risk of serotonin syndrome.
Triprolidine	The CNS depressants, Triprolidine and Alfentanil, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of alfentanil by decreasing its metabolism. Monitor for increased anesthetic and respiratory depressant effects and consider using lower alfentanil doses or alternate anesthetic.

Food Interactions

Not Available

Mu-type opioid receptor
Name	Mu-type opioid receptor
Gene Name	OPRM1
Pharmacological action	yes
Actions	agonist
References	Garrido M, Gubbens-Stibbe J, Tukker E, Cox E, von Frijtag J, Kunzel D, IJzerman A, Danhof M, van der Graaf PH: Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor - knockdown Lotsch J, Geisslinger G: Are mu-opioid receptor polymorphisms important for clinical opioid therapy? Trends Mol Med. 2005 Feb;11(2):82-9. - Pubmed Oertel BG, Schmidt R, Schneider A, Geisslinger G, Lotsch J: The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers. Pharmacogenet Genomics. 2006 Sep;16(9):625-36. - Pubmed Leung A, Wallace MS, Ridgeway B, Yaksh T: Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain. Pain. 2001 Mar;91(1-2):177-87. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.481

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Klees TM, Sheffels P, Dale O, Kharasch ED: Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug Metab Dispos. 2005 Mar;33(3):303-11. Epub 2004 Nov 22. - Pubmed
DTHybrid score	0.6189
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.3118
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Kharasch ED, Walker A, Isoherranen N, Hoffer C, Sheffels P, Thummel K, Whittington D, Ensign D: Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. Clin Pharmacol Ther. 2007 Oct;82(4):410-26. Epub 2007 Jun 6. - Pubmed Klees TM, Sheffels P, Dale O, Kharasch ED: Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug Metab Dispos. 2005 Mar;33(3):303-11. Epub 2004 Nov 22. - Pubmed Klees TM, Sheffels P, Thummel KE, Kharasch ED: Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5. Anesthesiology. 2005 Mar;102(3):550-6. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3845

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Wandel C, Kim R, Wood M, Wood A: Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology. 2002 Apr;96(4):913-20. - Pubmed
DTHybrid score	0.4225

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.4225

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.2755
467	Delta-type opioid receptor	OPRD1	0.2593
696	Kappa-type opioid receptor	OPRK1	0.242
4757	Cytochrome P450 2C9	CYP2C9	0.2058
6016	Cytochrome P450 2C19	CYP2C19	0.1883
4924	Cytochrome P450 2C8	CYP2C8	0.1768
4200	Cytochrome P450 1A2	CYP1A2	0.1688
6030	Cytochrome P450 2B6	CYP2B6	0.1151
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0969
6013	Cytochrome P450 2E1	CYP2E1	0.079
6024	Cytochrome P450 1A1	CYP1A1	0.0762
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0662
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0652
862	Multidrug resistance-associated protein 1	ABCC1	0.0627
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0583
20	Prostaglandin G/H synthase 1	PTGS1	0.054
6145	Solute carrier family 22 member 1	SLC22A1	0.0531
556	Alpha-1A adrenergic receptor	ADRA1A	0.0516
5718	Cytochrome P450 2A6	CYP2A6	0.0504
1729	Solute carrier family 22 member 6	SLC22A6	0.0499
824	Sodium-dependent serotonin transporter	SLC6A4	0.0489
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0483
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0476
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0453
492	Histamine H1 receptor	HRH1	0.0436
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0429
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0418
6106	Cytochrome P450 2C18	CYP2C18	0.0415
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0402
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0394
871	Glucocorticoid receptor	NR3C1	0.0379
831	D(2) dopamine receptor	DRD2	0.0373
6144	Solute carrier family 22 member 2	SLC22A2	0.0372
3811	Cytochrome P450 19A1	CYP19A1	0.0355
290	Prostaglandin G/H synthase 2	PTGS2	0.0342
1716	Tripartite motif-containing protein 13	TRIM13	0.0335
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0334
632	Alpha-1B adrenergic receptor	ADRA1B	0.0329
776	Bile salt export pump	ABCB11	0.0324
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0321
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0313
6142	Solute carrier family 22 member 8	SLC22A8	0.0309
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0306
1898	Cytochrome P450 1B1	CYP1B1	0.0305
6031	Cytochrome P450 3A43	CYP3A43	0.0293
6143	Solute carrier family 22 member 7	SLC22A7	0.029
789	Alpha-1D adrenergic receptor	ADRA1D	0.0281
2164	Multidrug resistance-associated protein 4	ABCC4	0.0276
844	Epidermal growth factor receptor	EGFR	0.0276
318	Alpha-2A adrenergic receptor	ADRA2A	0.0275
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0272
766	Beta-2 adrenergic receptor	ADRB2	0.0265
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0261
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0259
136	Estrogen receptor	ESR1	0.0258
1262	Corticotropin-lipotropin	POMC	0.0257
23	D(1A) dopamine receptor	DRD1	0.0256
193	Beta-1 adrenergic receptor	ADRB1	0.0256
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0247
731	HIV-1 protease	HIV-1 protease	0.0244
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0241
465	Calmodulin	CALM1	0.0231
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0225
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0225
118	Organic cation/carnitine transporter 2	SLC22A5	0.0224
891	Dihydropteroate synthase	folP	0.022
5359	Dihydropteroate synthase	folP	0.022
7175	Dihydropteroate synthase	sulI	0.022
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0219
614	Progesterone receptor	PGR	0.0217
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0208
3923	Cholinesterase	BCHE	0.0204
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0202
713	Sodium-dependent dopamine transporter	SLC6A3	0.0202
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0201
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.02
6147	Solute carrier family 22 member 3	SLC22A3	0.0198
1024	Solute carrier family 22 member 11	SLC22A11	0.0196
260	Cytochrome P450 51	ERG11	0.0194
761	Cytochrome P450 51	ERG11	0.0194
3163	Cytochrome P450 51	cyp51	0.0194
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0193
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0193
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0191
756	Sex hormone-binding globulin	SHBG	0.0191
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.019
638	D(3) dopamine receptor	DRD3	0.0189
6182	Cytochrome P450 2J2	CYP2J2	0.0189
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0188
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0186
174	Sigma 1-type opioid receptor	SIGMAR1	0.0184
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0183
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0183
817	DNA topoisomerase 2-alpha	TOP2A	0.0176
6148	Multidrug resistance-associated protein 7	ABCC10	0.0176
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0173
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0169
1389	Transforming growth factor beta-1	TGFB1	0.0169
737	Mineralocorticoid receptor	NR3C2	0.0169
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0166
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0166
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0165
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0164
768	FK506-binding protein 1A	FKBP1A	0.0163
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0161
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0157
4604	Liver carboxylesterase 1	CES1	0.0155
232	Corticosteroid-binding globulin	SERPINA6	0.0154
319	Opioid receptor, sigma 1	OPRS1	0.0154
4120	NADPH--cytochrome P450 reductase	POR	0.0153
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0153
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0152
6141	Sodium/bile acid cotransporter	SLC10A1	0.015
378	Alpha-2C adrenergic receptor	ADRA2C	0.0149
380	Cytochrome P450 17A1	CYP17A1	0.0148
833	Organic cation/carnitine transporter 1	SLC22A4	0.0148
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0146
629	Alpha-2B adrenergic receptor	ADRA2B	0.0146
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0146
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0142
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0141
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0141
811	Translocator protein	TSPO	0.014
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0137
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0137
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0136
504	Mast/stem cell growth factor receptor	KIT	0.0136
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0136
1517	Beta-3 adrenergic receptor	ADRB3	0.0135
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0135
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0132
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.013
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0129
3941	Amine oxidase [flavin-containing] A	MAOA	0.0128
705	Glutamate receptor 1	GRIA1	0.0128
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0126
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0124
468	Cytochrome P450 4A11	CYP4A11	0.0124
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0124
818	50S ribosomal protein L10	rplJ	0.0122
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0121
1656	CYP2B protein	CYP2B	0.012
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.012
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.012
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.012
228	Beta platelet-derived growth factor receptor	PDGFRB	0.012
1050	Bile salt sulfotransferase	SULT2A1	0.0118
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0117
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0115
4137	Nociceptin receptor	OPRL1	0.0113
146	Androgen receptor	AR	0.0113
738	Monocarboxylate transporter 1	SLC16A1	0.0112
29	Tubulin beta-1 chain	TUBB1	0.0111
122	P2Y purinoceptor 12	P2RY12	0.0111
3939	Amine oxidase [flavin-containing] B	MAOB	0.011
477	DNA topoisomerase 4 subunit A	parC	0.0109
886	DNA topoisomerase 4 subunit A	parC	0.0109
6226	DNA topoisomerase 4 subunit A	parC	0.0109
183	Vascular endothelial growth factor A	VEGFA	0.0109
432	D(4) dopamine receptor	DRD4	0.0108
404	DNA gyrase subunit A	gyrA	0.0108
6224	DNA gyrase subunit A	gyrA	0.0108
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0106
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0105
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0105
6137	Multidrug resistance-associated protein 6	ABCC6	0.0105
2211	Fatty acid-binding protein, heart	FABP3	0.0105
716	5-hydroxytryptamine 7 receptor	HTR7	0.0105
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0104
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0104
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0103
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.01
869	Estrogen receptor beta	ESR2	0.01
952	Dipeptidyl peptidase 4	DPP4	0.01
26	Vascular endothelial growth factor receptor 3	FLT4	0.0099
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0097
124	Histamine H2 receptor	HRH2	0.0097
6136	Multidrug resistance-associated protein 5	ABCC5	0.0097
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0097
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0097
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0097
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0097
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0097
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0096
407	Vascular endothelial growth factor receptor 2	KDR	0.0096
4237	50S ribosomal protein L22	rplV	0.0095
70	Type-1 angiotensin II receptor	AGTR1	0.0095
161	Tubulin beta chain	TUBB	0.0095
312	Tubulin beta chain	TUB2	0.0095
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0095
566	Serotransferrin	TF	0.0094
32	Vascular endothelial growth factor receptor 1	FLT1	0.0094
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0094
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0094
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0094
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0093
5787	Angiopoietin-1 receptor	TEK	0.0092
94	5-hydroxytryptamine 4 receptor	HTR4	0.0091
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0091
1353	DNA topoisomerase 1	TOP1	0.0089
3552	DNA topoisomerase 1	topA	0.0089
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0089
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0087
723	Cytosolic phospholipase A2	PLA2G4A	0.0087
373	Transthyretin	TTR	0.0086
244	Angiotensin-converting enzyme	ACE	0.0084
6085	Fatty acid-binding protein, intestinal	FABP2	0.0084
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0083
4238	50S ribosomal protein L4	rplD	0.0083
5578	50S ribosomal protein L4	rplD	0.0083
6173	50S ribosomal protein L4	rplD	0.0083
6219	50S ribosomal protein L4	rplD	0.0083
1618	High affinity nerve growth factor receptor	NTRK1	0.0083
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0083
6020	Aldehyde oxidase	AOX1	0.0081
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.008
1291	cAMP response element-binding protein	CREB1	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.008
1852	Microtubule-associated protein 2	MAP2	0.0079
4210	Toll-like receptor 4	TLR4	0.0079
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0079
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0078
777	Tumor necrosis factor	TNF	0.0078
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0077
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0077
1757	Myeloperoxidase	MPO	0.0077
2539	Tubulin alpha-1 chain	TUBA4A	0.0076
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0075
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0075
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0074
427	Substance-P receptor	TACR1	0.0074
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0074
1192	Sulfotransferase 1A1	SULT1A1	0.0073
474	Acetylcholinesterase	ACHE	0.0073
1010	Cytochrome P450 51A1	CYP51A1	0.0073
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0072
482	Glycine receptor subunit alpha-1	GLRA1	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
3932	Glutathione S-transferase A2	GSTA2	0.0071
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.007
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0069
6432	Transporter	snf	0.0069
6220	Aryl hydrocarbon receptor	AHR	0.0069
1525	Heparin-binding growth factor 2	FGF2	0.0069
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0068
165	FL cytokine receptor	FLT3	0.0067
36	Insulin receptor	INSR	0.0066
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0066
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0066
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0066
6102	Arylamine N-acetyltransferase 2	NAT2	0.0065
163	D(1B) dopamine receptor	DRD5	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0063
273	Apoptosis regulator Bcl-2	BCL2	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0062
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0062
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0062
814	Ryanodine receptor 1	RYR1	0.0061
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0061
208	DNA-directed RNA polymerase beta' chain	rpoC	0.006
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.006
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
469	Annexin A1	ANXA1	0.0059
5923	Microtubule-associated protein tau	MAPT	0.0059
5924	Microtubule-associated protein 4	MAP4	0.0059
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
6043	Putative G-protein coupled receptor 44	GPR44	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
239	Coagulation factor X	F10	0.0058
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0058
1864	RET proto-oncogene	RET	0.0057
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0057
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0057
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0055
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0054
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0054
594	Thyroxine-binding globulin	SERPINA7	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0052
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0052
780	Retinoic acid receptor RXR-gamma	RXRG	0.0052
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
5300	Antigen peptide transporter 1	TAP1	0.0051
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
3947	Xanthine dehydrogenase/oxidase	XDH	0.0049
758	Thyroid hormone receptor alpha	THRA	0.0049
1483	Membrane copper amine oxidase	AOC3	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
4773	Deoxycytidine kinase	DCK	0.0048
88	Retinoic acid receptor RXR-beta	RXRB	0.0047
459	Retinoic acid receptor RXR-alpha	RXRA	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
68	Cannabinoid receptor 1	CNR1	0.0045
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0045
54	Prothrombin	F2	0.0045
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
284	DNA-directed RNA polymerase beta chain	rpoB	0.0044
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0044
346	Thyroid hormone receptor beta-1	THRB	0.0044
1178	Adenosine A2a receptor	ADORA2A	0.0044
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0043
6014	Cytochrome P450 2A13	CYP2A13	0.0043
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0042
1196	Complement decay-accelerating factor	CD55	0.0042
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
295	Carbonic anhydrase 1	CA1	0.0041
5934	Cytochrome P450 26A1	CYP26A1	0.0041
904	Glutathione S-transferase P	GSTP1	0.0041
84	Nuclear receptor 0B1	NR0B1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
558	Solute carrier family 12 member 1	SLC12A1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
6149	Solute carrier family 22 member 10	SLC22A10	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0039
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
24	Thymidylate synthase	TMP1	0.0039
359	Thymidylate synthase	TYMS	0.0039
2626	Thymidylate synthase	thyA	0.0039
2729	Thymidylate synthase	thyA	0.0039
5352	Thymidylate synthase	THYA	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
6677	Myelin P2 protein	PMP2	0.0038
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
162	Retinoic acid receptor gamma-1	RARG	0.0038
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0038
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0037
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0036
2808	Chloramphenicol acetyltransferase 3	cat3	0.0036
751	Potassium channel subfamily K member 6	KCNK6	0.0036
2112	Toll-like receptor 9	TLR9	0.0036
4203	Histamine N-methyltransferase	HNMT	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0036
16	Adenosine A1 receptor	ADORA1	0.0036
33	Cystine/glutamate transporter	SLC7A11	0.0036
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0035
856	Vitamin D3 receptor	VDR	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0035
1630	Integrin beta-2	ITGB2	0.0035
939	50S ribosomal protein L3	rplC	0.0035
976	Platelet glycoprotein IX	GP9	0.0034
4122	Histone deacetylase 2	HDAC2	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
131	Synaptic vesicular amine transporter	SLC18A2	0.0034
357	Carbonic anhydrase 2	CA2	0.0034
275	Arachidonate 5-lipoxygenase	ALOX5	0.0034
6824	Tyrosine-protein kinase Lyn	LYN	0.0033
3601	Dihydropteroate synthase 1	folP1	0.0033
3807	Dihydropteroate synthase 1	folP1	0.0033
3808	Dihydropteroate synthase 2	folP2	0.0033
2417	Chloramphenicol acetyltransferase	cat	0.0033
3278	Chloramphenicol acetyltransferase	cat	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
823	Fibroblast growth factor receptor 2	FGFR2	0.0033
172	Potassium channel subfamily K member 1	KCNK1	0.0033
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0033
707	72 kDa type IV collagenase	MMP2	0.0033
2810	Dr hemagglutinin structural subunit	draA	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0032
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0032
1867	Major prion protein	PRNP	0.0032
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0032
3086	Plasmepsin-2	Not Available	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
153	Dopamine beta-hydroxylase	DBH	0.0031
199	Monocarboxylate transporter 8	SLC16A2	0.0031
3913	Glutamic acid decarboxylase	GAD65	0.0031
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0031
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
4192	DNA topoisomerase 2-beta	TOP2B	0.003
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.003
6048	Troponin C, skeletal muscle	TNNC2	0.003
1714	Mitogen-activated protein kinase 3	MAPK3	0.0029
6103	Arylamine N-acetyltransferase 1	NAT1	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
1629	Transcription factor AP-1	JUN	0.0029
6044	Serum paraoxonase/lactonase 3	PON3	0.0028
3856	Fibroblast growth factor receptor 3	FGFR3	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0028
65	Matrix metalloproteinase-9	Not Available	0.0028
365	Dihydrofolate reductase	DHFR	0.0028
2381	Dihydrofolate reductase	DFR1	0.0028
2833	Dihydrofolate reductase	Not Available	0.0028
2931	Dihydrofolate reductase	folA	0.0028
3544	Dihydrofolate reductase	folA	0.0028
3682	Dihydrofolate reductase	folA	0.0028
6642	Dihydrofolate reductase	folA	0.0028
6756	Dihydrofolate reductase	dfrA	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0028
4103	Proteasome subunit beta type 2	PSMB2	0.0027
4102	Proteasome subunit beta type 5	PSMB5	0.0027
4101	Proteasome subunit beta type 1	PSMB1	0.0027
3809	Estrogen-related receptor gamma	ESRRG	0.0027
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4311	tRNA	TRDMT1	0.0027
4325	tRNA	trmD	0.0027
4328	tRNA	trmD	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0027
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0026
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0026
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0026
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0026
3904	Alanine aminotransferase 2	GPT2	0.0026
735	Alanine aminotransferase 1	GPT	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
605	Fumarate reductase flavoprotein subunit	frdA	0.0026
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0026
3673	Fumarate reductase flavoprotein subunit	fccA	0.0026
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0026
6549	Fumarate reductase flavoprotein subunit	frdA	0.0026
572	Integrin alpha-L	ITGAL	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0026
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0026
49	Endothelin B receptor	EDNRB	0.0026
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
229	Retinoic acid receptor beta	RARB	0.0025
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0025
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0025
3426	Glutamine synthetase	glnA	0.0025
3987	Glutamine synthetase	GLUL	0.0025
730	Retinoic acid receptor alpha	RARA	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
3616	Fatty acid-binding protein, epidermal	FABP5	0.0024
5431	Lipid binding protein	Not Available	0.0024
5433	UPF0230 protein TM_1468	TM_1468	0.0024
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
1992	Vitamin D-binding protein	GC	0.0024
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0024
6231	Pepsin A	PGA3	0.0024
719	Retinoic acid receptor responder protein 1	RARRES1	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
770	Retinoic acid-induced protein 3	GPRC5A	0.0024
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0024
6459	Glycodelin	PAEP	0.0024
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0024
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0024
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0023
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0023
936	Ephrin type-A receptor 2	EPHA2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
6501	Fatty acid-binding protein, liver	FABP1	0.0023
2207	Rhodopsin	RHO	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0022
4217	Telomerase reverse transcriptase	TERT	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0022
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
1650	Heme carrier protein 1	SLC46A1	0.0021
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0021
569	Retinal dehydrogenase 2	ALDH1A2	0.0021
267	Plasminogen activator inhibitor 1	SERPINE1	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
7	Nitric oxide synthase, inducible	NOS2	0.0021
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
6151	Monocarboxylate transporter 10	SLC16A10	0.002
283	SEC14-like protein 2	SEC14L2	0.002
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.002
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
921	Glutamate receptor 2	GRIA2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6755	Poliovirus receptor	PVR	0.002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
611	Retinal dehydrogenase 1	ALDH1A1	0.0019
484	Tyrosine-protein kinase ABL2	ABL2	0.0019
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6167	Organic solute transporter subunit beta	OSTB	0.0019
6166	Organic solute transporter subunit alpha	OSTA	0.0019
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
6221	Steroid hormone receptor ERR1	ESRRA	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
712	Tubulin alpha chain	TUB1	0.0018
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0018
2320	Thymidine kinase, cytosolic	TK1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
908	Glutathione S-transferase theta-1	GSTT1	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6218	Pannexin-1	PANX1	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
2021	Thrombomodulin	THBD	0.0015
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1541	Metalloproteinase	mmp20	0.0014
3937	Fatty-acid amide hydrolase	FAAH	0.0014
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
489	Monocarboxylate transporter 2	SLC16A7	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
3810	Catechol O-methyltransferase	COMT	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0012
822	Aldose reductase	AKR1B1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
694	Matrix protein 2	M	0.0012
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
4226	Uridine phosphorylase 2	UPP2	0.0012
3957	Adenosine deaminase	ADA	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6859	Protein S100-A4	S100A4	0.0012
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0011
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0011
1268	Neuropeptide S receptor	NPSR1	0.0011
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0011
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0011
6042	Prostaglandin reductase 2	PTGR2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4225	Uridine phosphorylase 1	UPP1	0.0011
5818	Folate receptor alpha	FOLR1	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1792	Tissue-type plasminogen activator	PLAT	0.001
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
413	Amidophosphoribosyltransferase	PPAT	0.001
2515	Amidophosphoribosyltransferase	purF	0.001
3714	Amidophosphoribosyltransferase	purF	0.001
6073	Potassium channel subfamily K member 9	KCNK9	0.001
6072	Potassium channel subfamily K member 3	KCNK3	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
293	Gamma-glutamyl hydrolase	GGH	0.001
1039	Histone deacetylase 9	HDAC9	0.0009
164	Histamine H4 receptor	HRH4	0.0009
6228	Nuclear receptor coactivator 1	NCOA1	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
1313	Lactoylglutathione lyase	GLO1	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
518	Peroxidase/catalase T	katG	0.0009
2132	Protein S100-B	S100B	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
291	Nitric-oxide synthase, endothelial	NOS3	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
3639	Thymidine phosphorylase	deoA	0.0008
3936	Thymidine phosphorylase	TYMP	0.0008
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
2298	Cytochrome P450-cam	camC	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
1275	Estrogen sulfotransferase	SULT1E1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
760	Fibroblast growth factor 1	FGF1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6146	High affinity copper uptake protein 1	SLC31A1	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
3221	Cytochrome c4	cc4	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0006
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0006
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
563	Thyroid peroxidase	TPO	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
634	Squalene monooxygenase	SQLE	0.0006
7196	Squalene monooxygenase	ERG1	0.0006
76	Nitric-oxide synthase, brain	NOS1	0.0005
5626	Nucleoside diphosphate kinase B	NME2	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
517	Alcohol dehydrogenase 1C	ADH1C	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6524	Protein tonB	tonB	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
4943	Cytochrome c6	petJ	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
5000	HemO	hemO	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4935	Cytochrome c-554	cycA1	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
4961	Hemophore HasA	hasA	0.0004
4909	CooA protein	cooA	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4972	P450cin	cinA	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4952	Catalase/peroxidase	katA	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
3093	Catalase HPII	katE	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
4920	Peroxidase/catalase	katG	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
4990	PpcA	ppcA	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
4037	Hypothetical protein	GPX1	0.0003
4297	Hypothetical protein	SP_1951	0.0003
4521	Hypothetical protein	BC_2969	0.0003
4540	Hypothetical protein	TM_1070	0.0003
4555	Hypothetical protein	MT1739	0.0003
4569	Hypothetical protein	mshD	0.0003
4578	Hypothetical protein	PA3270	0.0003
4747	Hypothetical protein	PA3967	0.0003
5177	Hypothetical protein	TM_0096	0.0003
5194	Hypothetical protein	PA1204	0.0003
5240	Hypothetical protein	Rv2991	0.0003
5370	Hypothetical protein	TM_1158	0.0003
5710	Hypothetical protein	Tb927.5.1360	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
2230	Catalase	CAT	0.0003
3249	Catalase	katA	0.0003
3625	Catalase	katA	0.0003
4539	Catalase	katA	0.0003
4941	Catalase	katB	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
358	Cystathionine beta-synthase	CBS	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00802 - Alfentanil

Targets

Enzymes

Transporters

Carriers

Predictions